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ONTOLOGY REPORT - ANNOTATIONS


Term:type B pancreatic cell differentiation
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Accession:GO:0003309 term browser browse the term
Definition:The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
Synonyms:exact_synonym: pancreatic B cell differentiation;   pancreatic beta cell differentiation


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type B pancreatic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3701716|PMID:16887115)
Ensembl
RGD
PMID:16887115 GO_REF:0000107 MGI:3701716 NCBI chr18:2,188,121...2,219,532 JBrowse link
G Insm1 INSM transcriptional repressor 1 involved_in ISO (MGI:3619850|PMID:16511571) RGD PMID:16511571 MGI:3619850 NCBI chr 3:133,639,790...133,642,963 JBrowse link
G Men1 menin 1 IMP RGD PMID:24157940 RGD:9589069 NCBI chr 1:203,638,905...203,644,871 JBrowse link
G Mir7-1 microRNA 7-1 acts_upstream_of_or_within ISO (MGI:5437569|PMID:22764048) RGD PMID:22764048 MGI:5437569 NCBI chr17:6,273,264...6,273,360 JBrowse link
G Pax6 paired box 6 acts_upstream_of_or_within
involved_in
IMP
ISO
IEA
MGI:1934347 (MGI:5437569|PMID:22764048)
GO_REF:0000107
RGD
Ensembl
PMID:22764048, PMID:22403172 GO_REF:0000107 MGI:5437569, RGD:8552355 NCBI chr 3:92,128,772...92,157,022 JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 involved_in IMP
IBA
ISO
PMID:21108535
PMID:21873635
(PMID:12124776), (PMID:24567802)
RGD PMID:12124776 PMID:24567802, PMID:21108535, PMID:21873635 RGD:8553608, RGD:13792537 NCBI chr12:7,757,865...7,763,064 JBrowse link
G Reg1a regenerating family member 1 alpha involved_in ISO
IEA
MGI:2446480 (MGI:3615755|PMID:16405968)
GO_REF:0000107
RGD
Ensembl
PMID:16405968 GO_REF:0000107 MGI:3615755 NCBI chr 4:110,892,451...110,895,115 JBrowse link
G Rfx6 regulatory factor X, 6 involved_in ISO (MGI:4422104|PMID:20148032) RGD PMID:20148032 MGI:4422104 NCBI chr20:31,020,221...31,073,266 JBrowse link
G Vhl von Hippel-Lindau tumor suppressor acts_upstream_of_or_within ISO MGI:2136645|MGI:3608931 (MGI:5618205|PMID:25186293) RGD PMID:25186293 MGI:5618205 NCBI chr 4:146,772,483...146,779,376 JBrowse link
G Zbed6 zinc finger, BED-type containing 6 involved_in ISO (MGI:5511070|PMID:24043816) RGD PMID:24043816 MGI:5511070 NCBI chr13:45,107,489...45,113,141 JBrowse link
negative regulation of type B pancreatic cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator IMP RGD PMID:23178930 RGD:11567224 NCBI chr 4:46,561,269...46,728,759 JBrowse link
positive regulation of type B pancreatic cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death involved_in ISS
ISO
GO_REF:0000024
(MGI:3778846|PMID:18223655)
UniProt
RGD
PMID:18223655 GO_REF:0000024 MGI:3778846 NCBI chr 1:204,133,502...204,142,829 JBrowse link
G Rfx3 regulatory factor X3 involved_in ISO (MGI:4941444|PMID:20413507) RGD PMID:20413507 MGI:4941444 NCBI chr 1:225,449,872...225,709,622 JBrowse link
regulation of type B pancreatic cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arntl aryl hydrocarbon receptor nuclear translocator-like involved_in ISS
ISO
GO_REF:0000024
(MGI:4819446|PMID:20562852)
UniProt
RGD
PMID:20562852 GO_REF:0000024 MGI:4819446 NCBI chr 1:167,331,756...167,430,235 JBrowse link
G Clock clock circadian regulator involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:4819446|PMID:20562852)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:20562852 GO_REF:0000024 GO_REF:0000107 MGI:4819446 NCBI chr14:31,908,542...31,992,673 JBrowse link
G Rheb Ras homolog, mTORC1 binding involved_in ISO
IEA
(PMID:19258434)
GO_REF:0000107
RGD
Ensembl
PMID:19258434 GO_REF:0000107 NCBI chr 4:10,278,970...10,320,160 JBrowse link
type B pancreatic cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in ISO
IEA
ISS
(PMID:11865031)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:11865031 GO_REF:0000024 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494 JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:11865031) RGD PMID:11865031 NCBI chr 8:76,517,164...76,639,925 JBrowse link
G Bmp6 bone morphogenetic protein 6 involved_in ISO (PMID:11865031) RGD PMID:11865031 NCBI chr17:26,318,121...26,469,034 JBrowse link
G Cdh2 cadherin 2 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:6216737|PMID:26750727)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:26750727 GO_REF:0000024 GO_REF:0000107 MGI:6216737 NCBI chr18:7,776,704...7,990,934 JBrowse link
G Cdk6 cyclin-dependent kinase 6 involved_in ISO (PMID:20668294) RGD PMID:20668294 NCBI chr 4:30,637,650...30,829,688 JBrowse link
G Dll1 delta like canonical Notch ligand 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5426345|PMID:22529374)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:22529374 GO_REF:0000024 GO_REF:0000107 MGI:5426345 NCBI chr 1:56,312,062...56,320,177 JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:152,186,787...152,248,320 JBrowse link
G Insm1 INSM transcriptional repressor 1 acts_upstream_of_or_within ISO MGI:3656035 (MGI:3655758|PMID:16951258) RGD PMID:16951258 MGI:3655758 NCBI chr 3:133,639,790...133,642,963 JBrowse link
G Mir375 microRNA 375 acts_upstream_of_or_within ISO (MGI:3775688|PMID:17804764) RGD PMID:17804764 MGI:3775688 NCBI chr 9:76,457,911...76,457,985 JBrowse link
G Mir503 microRNA 503 acts_upstream_of_or_within ISO (MGI:3775688|PMID:17804764) RGD PMID:17804764 MGI:3775688 NCBI chr  X:132,806,303...132,806,373 JBrowse link
G Mir541 microRNA 541 acts_upstream_of_or_within ISO (MGI:3775688|PMID:17804764) RGD PMID:17804764 MGI:3775688 NCBI chr 6:128,757,016...128,757,105 JBrowse link
G Nkx2-2 NK2 homeobox 2 acts_upstream_of_or_within ISO MGI:1932100 (MGI:3703458|PMID:17202186), (MGI:3761395|PMID:17456846) RGD PMID:17202186 PMID:17456846 MGI:3703458 MGI:3761395 NCBI chr 3:134,619,701...134,630,282 JBrowse link
G Nkx6-1 NK6 homeobox 1 IEP RGD PMID:9603781 RGD:2326025 NCBI chr14:7,969,756...7,976,689 JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 involved_in ISO (MGI:4365695|PMID:19635472) RGD PMID:19635472 MGI:4365695 NCBI chr10:13,105,435...13,182,664 JBrowse link
G Sidt2 SID1 transmembrane family, member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5532825 (MGI:5529865|PMID:23776622)
Ensembl
RGD
PMID:23776622 GO_REF:0000107 MGI:5529865 NCBI chr 8:46,232,379...46,248,913 JBrowse link
G Smo smoothened, frizzled class receptor involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2176256|MGI:2684317 (MGI:4833770|PMID:20185815)
Ensembl
RGD
PMID:20185815 GO_REF:0000107 MGI:4833770 NCBI chr 4:58,344,101...58,372,828 JBrowse link
G Wnt5a Wnt family member 5A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857617 (MGI:3663526|PMID:16246260)
Ensembl
RGD
PMID:16246260 GO_REF:0000107 MGI:3663526 NCBI chr16:3,695,667...3,718,234 JBrowse link
type B pancreatic cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx2-2 NK2 homeobox 2 acts_upstream_of_or_within ISO MGI:1932100 (MGI:3703458|PMID:17202186), (MGI:3768695|PMID:17988662) RGD PMID:17202186 PMID:17988662 MGI:3703458 MGI:3768695 NCBI chr 3:134,619,701...134,630,282 JBrowse link
type B pancreatic cell maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rfx3 regulatory factor X3 involved_in ISO (MGI:4941444|PMID:20413507) RGD PMID:20413507 MGI:4941444 NCBI chr 1:225,449,872...225,709,622 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    developmental process 6768
      anatomical structure development 6195
        endocrine pancreas development 54
          type B pancreatic cell differentiation 32
            type B pancreatic cell development + 23
            type B pancreatic cell fate commitment 1
Path 2
Term Annotations click to browse term
  biological_process 19492
    developmental process 6768
      anatomical structure development 6195
        tissue development 2074
          epithelium development 1278
            epithelial cell differentiation 714
              columnar/cuboidal epithelial cell differentiation 105
                glandular epithelial cell differentiation 61
                  enteroendocrine cell differentiation 36
                    type B pancreatic cell differentiation 32
                      type B pancreatic cell development + 23
                      type B pancreatic cell fate commitment 1
paths to the root