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ONTOLOGY REPORT - ANNOTATIONS

Term:Wnt signaling pathway involved in heart development
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Accession:GO:0003306 term browser browse the term
Definition:The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.
Synonyms:exact_synonym: Wnt receptor signaling pathway involved in heart development;   Wnt receptor signalling pathway involved in heart development;   Wnt-activated signaling pathway involved in heart development


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canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
G Wnt8a Wnt family member 8A involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr18:26,137,690...26,143,283
Ensembl chr18:26,137,690...26,143,283 		JBrowse link
canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:2156191 (MGI:4413394|PMID:19705442) RGD PMID:19705442 MGI:4413394 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:2446944|PMID:12464179)		 Ensembl
RGD		 PMID:12464179 GO_REF:0000107 MGI:2446944 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:2156191 (MGI:4413394|PMID:19705442) RGD PMID:19705442 MGI:4413394 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
negative regulation of heart induction by canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A involved_in ISO (PMID:19736317) RGD PMID:19736317 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:98958 (MGI:4830282|PMID:19056682) RGD PMID:19056682 MGI:4830282 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:98958 (MGI:4830282|PMID:19056682) RGD PMID:19056682 MGI:4830282 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:98958 (MGI:4830282|PMID:19056682) RGD PMID:19056682 MGI:4830282 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:98958 (MGI:4830282|PMID:19056682) RGD PMID:19056682 MGI:4830282 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:98958 (MGI:4830282|PMID:19056682) RGD PMID:19056682 MGI:4830282 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
negative regulation of Wnt signaling pathway involved in heart development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpk2 alpha-kinase 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:29888752)		 UniProt
RGD		 PMID:29888752 GO_REF:0000024 NCBI chr18:58,775,603...58,906,150
Ensembl chr18:58,775,605...58,906,258 		JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18545679)		 UniProt
RGD		 PMID:18545679 GO_REF:0000024 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Sox17 SRY-box transcription factor 17 involved_in ISO (MGI:3703823|PMID:17360443) RGD PMID:17360443 MGI:3703823 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228 		JBrowse link
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt5a Wnt family member 5A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857617 (MGI:4830282|PMID:19056682)		 Ensembl
RGD		 PMID:19056682 GO_REF:0000107 MGI:4830282 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
planar cell polarity pathway involved in cardiac right atrium morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt5a Wnt family member 5A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857617 (MGI:4830282|PMID:19056682)		 Ensembl
RGD		 PMID:19056682 GO_REF:0000107 MGI:4830282 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
planar cell polarity pathway involved in heart morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO MGI:5558098 (MGI:5544506|PMID:24302887) RGD PMID:24302887 MGI:5544506 NCBI chr13:84,462,731...84,489,404
Ensembl chr13:84,465,527...84,489,378 		JBrowse link
planar cell polarity pathway involved in outflow tract morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt5a Wnt family member 5A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857617 (MGI:4830282|PMID:19056682)		 Ensembl
RGD		 PMID:19056682 GO_REF:0000107 MGI:4830282 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
planar cell polarity pathway involved in pericardium morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt5a Wnt family member 5A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857617 (MGI:4830282|PMID:19056682)		 Ensembl
RGD		 PMID:19056682 GO_REF:0000107 MGI:4830282 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
planar cell polarity pathway involved in ventricular septum morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt5a Wnt family member 5A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857617 (MGI:4830282|PMID:19056682)		 Ensembl
RGD		 PMID:19056682 GO_REF:0000107 MGI:4830282 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region acts_upstream_of_or_within ISO MGI:3583755 (MGI:5432296|PMID:22711842) RGD PMID:22711842 MGI:5432296 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353 		JBrowse link
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (MGI:3835736|PMID:18297060) RGD PMID:18297060 MGI:3835736 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:3835736|PMID:18297060) RGD PMID:18297060 MGI:3835736 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
G Wnt11 Wnt family member 11 involved_in ISO UniProtKB:P22725 (MGI:5424267|PMID:22569553) RGD PMID:22569553 MGI:5424267 NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294 		JBrowse link
G Wnt5a Wnt family member 5A involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P48615 (MGI:5424267|PMID:22569553)		 Ensembl
RGD		 PMID:22569553 GO_REF:0000107 MGI:5424267 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
regulation of heart induction by regulation of canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pou5f1 POU class 5 homeobox 1 involved_in ISO (PMID:19736317) RGD PMID:19736317 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19834
    signaling 7588
      cell-cell signaling 1765
        cell-cell signaling by wnt 445
          Wnt signaling pathway 442
            Wnt signaling pathway involved in heart development 14
              canonical Wnt signaling pathway involved in heart development + 6
              negative regulation of Wnt signaling pathway involved in heart development + 8
              non-canonical Wnt signaling pathway involved in heart development + 3
              regulation of Wnt signaling pathway involved in heart development + 10
Path 2
Term Annotations click to browse term
  biological_process 19834
    biological regulation 13775
      regulation of biological process 13033
        regulation of cellular process 12501
          signal transduction 6997
            cell surface receptor signaling pathway 2831
              cell surface receptor signaling pathway involved in cell-cell signaling 569
                Wnt signaling pathway 442
                  Wnt signaling pathway involved in heart development 14
                    canonical Wnt signaling pathway involved in heart development + 6
                    negative regulation of Wnt signaling pathway involved in heart development + 8
                    non-canonical Wnt signaling pathway involved in heart development + 3
                    regulation of Wnt signaling pathway involved in heart development + 10
paths to the root