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ONTOLOGY REPORT - ANNOTATIONS

Term:muscle hypertrophy in response to stress
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Accession:GO:0003299 term browser browse the term
Definition:The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis.


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cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 acts_upstream_of_or_within ISO
IEA		 (PMID:24137001)
GO_REF:0000107		 RGD
Ensembl		 PMID:24137001 GO_REF:0000107 NCBI chr12:39,733,519...39,782,942
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Bmp2 bone morphogenetic protein 2 IMP RGD PMID:26873969 RGD:11526363 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp4 bone morphogenetic protein 4 IMP RGD PMID:26873969 RGD:11526363 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Camta2 calmodulin binding transcription activator 2 acts_upstream_of_or_within ISO
IEA		 (PMID:16678093)
GO_REF:0000107		 RGD
Ensembl		 PMID:16678093 GO_REF:0000107 NCBI chr10:55,882,071...55,900,575
Ensembl chr10:55,383,450...55,401,558 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit acts_upstream_of_or_within ISO
IEA		 (PMID:24137001)
GO_REF:0000107		 RGD
Ensembl		 PMID:24137001 GO_REF:0000107 NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Gata4 GATA binding protein 4 acts_upstream_of_or_within ISO MGI:3054171|MGI:3778685 (PMID:20705924) RGD PMID:20705924 NCBI chr15:41,635,572...41,707,252
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gata6 GATA binding protein 6 acts_upstream_of_or_within ISO MGI:3054171|MGI:3654150 (PMID:20705924) RGD PMID:20705924 NCBI chr18:2,460,909...2,492,322
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO
IEA		 (PMID:16603706)
GO_REF:0000107		 RGD
Ensembl		 PMID:16603706 GO_REF:0000107 NCBI chr 1:28,641,100...28,651,187
Ensembl chr 1:26,822,131...26,832,218 		JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F acts_upstream_of_or_within ISO
IEA		 MGI:4128518 (PMID:19875726)
GO_REF:0000107		 RGD
Ensembl		 PMID:19875726 GO_REF:0000107 NCBI chr 1:192,620,891...192,700,681
Ensembl chr 1:183,190,480...183,270,276 		JBrowse link
G Kdm4a lysine demethylase 4A acts_upstream_of_or_within ISO (PMID:21555854) RGD PMID:21555854 NCBI chr 5:136,958,178...137,004,942
Ensembl chr 5:131,672,754...131,719,501 		JBrowse link
G Klf15 KLF transcription factor 15 involved_in ISO
IEA		 (PMID:17438289)
GO_REF:0000107		 RGD
Ensembl		 PMID:17438289 GO_REF:0000107 NCBI chr 4:124,522,652...124,535,613
Ensembl chr 4:122,965,807...122,978,374 		JBrowse link
G Mef2c myocyte enhancer factor 2C acts_upstream_of_or_within ISO (PMID:10531040) RGD PMID:10531040 NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Mir208b microRNA 208b acts_upstream_of_or_within ISO (PMID:24137001) RGD PMID:24137001 NCBI chr15:32,421,615...32,421,726
Ensembl chr15:28,451,638...28,451,749 		JBrowse link
G Myh6 myosin heavy chain 6 acts_upstream_of_or_within ISO
IEA		 (PMID:24137001)
GO_REF:0000107		 RGD
Ensembl		 PMID:24137001 GO_REF:0000107 NCBI chr15:32,388,102...32,413,663
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 acts_upstream_of_or_within ISO
IEA		 (PMID:24137001)
GO_REF:0000107		 RGD
Ensembl		 PMID:24137001 GO_REF:0000107 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 acts_upstream_of_or_within ISO MGI:107164 (PMID:12370307) RGD PMID:12370307 NCBI chr19:50,870,464...50,944,992
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Nppa natriuretic peptide A acts_upstream_of
acts_upstream_of_or_within		 ISO
IEA		 MGI:1857231 (PMID:26536903)
GO_REF:0000107
MGI:1857231 (PMID:14985074), (PMID:15452027), (PMID:24137001)		 RGD
Ensembl		 PMID:14985074 PMID:15452027 PMID:24137001 PMID:26536903 GO_REF:0000107 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B acts_upstream_of_or_within ISO (PMID:24137001) RGD PMID:24137001 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha acts_upstream_of_or_within ISO MGI:103296 (PMID:12370307) RGD PMID:12370307 NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Smad1 SMAD family member 1 IMP RGD PMID:26873969 RGD:11526363 NCBI chr19:45,417,430...45,477,962
Ensembl chr19:28,513,131...28,573,651 		JBrowse link
G Smad4 SMAD family member 4 IMP RGD PMID:26873969 RGD:11526363 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Tcap titin-cap involved_in ISO (PMID:12507422) RGD PMID:12507422 NCBI chr10:83,878,006...83,879,174
Ensembl chr10:83,381,719...83,382,887 		JBrowse link
negative regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in ISO
IEA		 (PMID:19287093)
GO_REF:0000107		 RGD
Ensembl		 PMID:19287093 GO_REF:0000107 NCBI chr13:47,708,157...47,807,389
Ensembl chr13:45,156,146...45,255,246 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 IDA RGD PMID:19204184 RGD:9685562 NCBI chr 5:166,606,841...166,620,124
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Foxo1 forkhead box O1 involved_in IMP PMID:26436652 UniProt PMID:26436652 RGD:13210548 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Lmna lamin A/C involved_in ISS
ISO		 GO_REF:0000024
(PMID:26436652)		 UniProt
RGD		 PMID:26436652 GO_REF:0000024 NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Mlip muscular LMNA-interacting protein involved_in ISO
IEA		 (PMID:26359501), (PMID:26436652)
GO_REF:0000107		 RGD
Ensembl		 PMID:26359501 PMID:26436652 GO_REF:0000107 NCBI chr 8:86,815,491...87,085,117
Ensembl chr 8:77,935,079...78,204,254 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma acts_upstream_of_or_within IDA PMID:29695452 BHF-UCL PMID:29695452 RGD:150521636 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Smad3 SMAD family member 3 involved_in IGI PMID:27038547 BHF-UCL PMID:27038547 RGD:11535100 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
positive regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in ISO (PMID:19287093) RGD PMID:19287093 NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 involved_in ISO
IEA		 (PMID:19287093)
GO_REF:0000107		 RGD
Ensembl		 PMID:19287093 GO_REF:0000107 NCBI chr 2:121,409,436...121,487,095
Ensembl chr 2:119,481,400...119,558,855 		JBrowse link
regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acacb acetyl-CoA carboxylase beta IMP RGD PMID:31709908 RGD:329901803 NCBI chr12:48,026,394...48,138,214
Ensembl chr12:42,366,548...42,457,655 		JBrowse link
G Bmp10 bone morphogenetic protein 10 involved_in ISO
IEA		 (PMID:17921333)
GO_REF:0000107		 RGD
Ensembl		 PMID:17921333 GO_REF:0000107 NCBI chr 4:121,423,936...121,439,094
Ensembl chr 4:119,872,045...119,878,627 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20567
    response to stimulus 11081
      response to stress 4353
        muscle hypertrophy in response to stress 32
          cardiac muscle hypertrophy in response to stress + 32
Path 2
Term Annotations click to browse term
  biological_process 20567
    multicellular organismal process 9031
      system process 3586
        muscle system process 496
          muscle hypertrophy 136
            muscle hypertrophy in response to stress 32
              cardiac muscle hypertrophy in response to stress + 32
paths to the root