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ONTOLOGY REPORT - ANNOTATIONS


Term:muscle hypertrophy in response to stress
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Accession:GO:0003299 term browser browse the term
Definition:The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis.


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cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO (MGI:MGI:5576864|PMID:24137001) RGD PMID:24137001 MGI:MGI:5576864 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Camta2 calmodulin binding transcription activator 2 ISO (PMID:16678093) RGD PMID:16678093 NCBI chr10:57,291,192...57,309,638
Ensembl chr10:57,291,192...57,309,298
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO (MGI:MGI:5576864|PMID:24137001) RGD PMID:24137001 MGI:MGI:5576864 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G Gata4 GATA binding protein 4 ISO MGI:MGI:3054171|MGI:MGI:3778685 (MGI:MGI:5002493|PMID:20705924) RGD PMID:20705924 MGI:MGI:5002493 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gata6 GATA binding protein 6 ISO
IEA
MGI:MGI:3054171|MGI:MGI:3654150 (MGI:MGI:5002493|PMID:20705924)
GO_REF:0000107
RGD
Ensembl
PMID:20705924 GO_REF:0000107, MGI:MGI:5002493 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 ISO (MGI:MGI:3624193|PMID:16603706) RGD PMID:16603706 MGI:MGI:3624193 NCBI chr 1:29,191,170...29,201,257
Ensembl chr 1:29,191,192...29,201,531
JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F ISO MGI:MGI:4128518 (MGI:MGI:4943859|PMID:19875726) RGD PMID:19875726 MGI:MGI:4943859 NCBI chr 1:200,037,749...200,116,524
Ensembl chr 1:200,037,749...200,116,524
JBrowse link
G Kdm4a lysine demethylase 4A ISO (MGI:MGI:5050547|PMID:21555854) RGD PMID:21555854 MGI:MGI:5050547 NCBI chr 5:136,967,650...137,014,402
Ensembl chr 5:136,967,650...137,014,430
JBrowse link
G Klf15 Kruppel-like factor 15 ISO (MGI:MGI:3709247|PMID:17438289) RGD PMID:17438289 MGI:MGI:3709247 NCBI chr 4:122,364,688...122,377,690
Ensembl chr 4:122,365,093...122,377,659
JBrowse link
G Mef2c myocyte enhancer factor 2C ISO
IEA
(MGI:MGI:1346950|PMID:10531040)
GO_REF:0000107
RGD
Ensembl
PMID:10531040 GO_REF:0000107, MGI:MGI:1346950 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Mir208b microRNA 208b ISO (MGI:MGI:5576864|PMID:24137001) RGD PMID:24137001 MGI:MGI:5576864 NCBI chr15:33,639,510...33,639,621
Ensembl chr15:33,639,510...33,639,621
JBrowse link
G Myh6 myosin heavy chain 6 ISO
IEA
(MGI:MGI:5576864|PMID:24137001)
GO_REF:0000107
RGD
Ensembl
PMID:24137001 GO_REF:0000107, MGI:MGI:5576864 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Myh7 myosin heavy chain 7 ISO
IEA
(MGI:MGI:5576864|PMID:24137001)
GO_REF:0000107
RGD
Ensembl
PMID:24137001 GO_REF:0000107, MGI:MGI:5576864 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 ISO MGI:MGI:107164 (MGI:MGI:2388546|PMID:12370307) RGD PMID:12370307 MGI:MGI:2388546 NCBI chr19:38,039,542...38,114,003
Ensembl chr19:38,039,564...38,114,003
JBrowse link
G Nppa natriuretic peptide A ISO MGI:MGI:1857231 (MGI:MGI:3606834|PMID:14985074), (MGI:MGI:3610438|PMID:15452027), (MGI:MGI:5576864|PMID:24137001) RGD PMID:14985074, PMID:15452027, PMID:24137001 MGI:MGI:3606834, MGI:MGI:3610438, MGI:MGI:5576864 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B ISO (MGI:MGI:5576864|PMID:24137001) RGD PMID:24137001 MGI:MGI:5576864 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha ISO MGI:MGI:103296 (MGI:MGI:2388546|PMID:12370307) RGD PMID:12370307 MGI:MGI:2388546 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
G Tcap titin-cap ISO
IEA
(PMID:12507422)
GO_REF:0000107
RGD
Ensembl
PMID:12507422 GO_REF:0000107 NCBI chr10:86,337,705...86,338,414
Ensembl chr10:86,337,728...86,338,411
JBrowse link
negative regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 ISO (PMID:19287093)
(MGI:MGI:3848765|PMID:19287093)
RGD PMID:19287093 MGI:MGI:3848765 NCBI chr13:50,091,644...50,153,808
Ensembl chr13:50,091,430...50,153,823
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 IDA RGD PMID:19204184 RGD:9685562 NCBI chr 5:167,951,564...167,966,011
Ensembl chr 5:167,952,728...167,966,009
JBrowse link
G Foxo1 forkhead box O1 IMP PMID:26436652 UniProt PMID:26436652 RGD:13210548 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Lmna lamin A/C IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5700584|PMID:26436652)
Ensembl
UniProt
RGD
PMID:26436652 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5700584 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G Mlip muscular LMNA-interacting protein ISO (MGI:MGI:5700584|PMID:26436652), (MGI:MGI:5908525|PMID:26359501) RGD PMID:26359501, PMID:26436652 MGI:MGI:5700584, MGI:MGI:5908525 NCBI chr 8:84,409,957...84,634,637
Ensembl chr 8:84,434,784...84,632,817
JBrowse link
G Smad3 SMAD family member 3 IGI PMID:27038547 BHF-UCL PMID:27038547 RGD:11535100 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
positive regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp3ca protein phosphatase 3 catalytic subunit alpha ISO (MGI:MGI:3848765|PMID:19287093) RGD PMID:19287093 MGI:MGI:3848765 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 ISO
IEA
(PMID:19287093)
GO_REF:0000107
RGD
Ensembl
PMID:19287093 GO_REF:0000107 NCBI chr 2:123,329,954...123,467,574
Ensembl chr 2:123,329,875...123,407,496
JBrowse link
regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp10 bone morphogenetic protein 10 ISO
IEA
(PMID:17921333)
GO_REF:0000107
RGD
Ensembl
PMID:17921333 GO_REF:0000107 NCBI chr 4:119,224,906...119,230,534
Ensembl chr 4:119,225,040...119,230,728
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to stress 4061
        muscle hypertrophy in response to stress 26
          cardiac muscle hypertrophy in response to stress + 26
Path 2
Term Annotations click to browse term
  biological_process 20027
    multicellular organismal process 9068
      system process 3453
        muscle system process 460
          muscle hypertrophy 115
            muscle hypertrophy in response to stress 26
              cardiac muscle hypertrophy in response to stress + 26
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.