Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Community Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:muscle hypertrophy in response to stress
go back to main search page
Accession:GO:0003299 term browser browse the term
Definition:The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis.


show annotations for term's descendants           Sort by:
cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5576864|PMID:24137001)
GO_REF:0000107		 RGD
Ensembl		 PMID:24137001 GO_REF:0000107 MGI:5576864 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Bmp2 bone morphogenetic protein 2 IMP RGD PMID:26873969 RGD:11526363 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp4 bone morphogenetic protein 4 IMP RGD PMID:26873969 RGD:11526363 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Camta2 calmodulin binding transcription activator 2 acts_upstream_of_or_within ISO (PMID:16678093) RGD PMID:16678093 NCBI chr10:55,383,450...55,401,838
Ensembl chr10:55,383,450...55,401,558 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit acts_upstream_of_or_within ISO (MGI:5576864|PMID:24137001) RGD PMID:24137001 MGI:5576864 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Gata4 GATA binding protein 4 acts_upstream_of_or_within ISO MGI:3054171|MGI:3778685 (MGI:5002493|PMID:20705924) RGD PMID:20705924 MGI:5002493 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gata6 GATA binding protein 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3054171|MGI:3654150 (MGI:5002493|PMID:20705924)		 Ensembl
RGD		 PMID:20705924 GO_REF:0000107 MGI:5002493 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO (MGI:3624193|PMID:16603706) RGD PMID:16603706 MGI:3624193 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218 		JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F acts_upstream_of_or_within ISO MGI:4128518 (MGI:4943859|PMID:19875726) RGD PMID:19875726 MGI:4943859 NCBI chr 1:183,190,480...183,270,276
Ensembl chr 1:183,190,480...183,270,276 		JBrowse link
G Kdm4a lysine demethylase 4A acts_upstream_of_or_within ISO (MGI:5050547|PMID:21555854) RGD PMID:21555854 MGI:5050547 NCBI chr 5:131,672,754...131,719,534
Ensembl chr 5:131,672,754...131,719,501 		JBrowse link
G Klf15 KLF transcription factor 15 involved_in ISO (MGI:3709247|PMID:17438289) RGD PMID:17438289 MGI:3709247 NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374 		JBrowse link
G Mef2c myocyte enhancer factor 2C acts_upstream_of_or_within ISO (MGI:1346950|PMID:10531040) RGD PMID:10531040 MGI:1346950 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Mir208b microRNA 208b acts_upstream_of_or_within ISO (MGI:5576864|PMID:24137001) RGD PMID:24137001 MGI:5576864 NCBI chr15:28,451,638...28,451,749
Ensembl chr15:28,451,638...28,451,749 		JBrowse link
G Myh6 myosin heavy chain 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:5576864|PMID:24137001)		 Ensembl
RGD		 PMID:24137001 GO_REF:0000107 MGI:5576864 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5576864|PMID:24137001)
GO_REF:0000107		 RGD
Ensembl		 PMID:24137001 GO_REF:0000107 MGI:5576864 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 acts_upstream_of_or_within ISO MGI:107164 (MGI:2388546|PMID:12370307) RGD PMID:12370307 MGI:2388546 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Nppa natriuretic peptide A acts_upstream_of_or_within ISO MGI:1857231 (MGI:3606834|PMID:14985074), (MGI:3610438|PMID:15452027), (MGI:5576864|PMID:24137001)
MGI:1857231 (MGI:5816190|PMID:26536903)		 RGD PMID:14985074 PMID:15452027 PMID:24137001 PMID:26536903 MGI:3606834 MGI:3610438 MGI:5576864 MGI:5816190 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B acts_upstream_of_or_within ISO (MGI:5576864|PMID:24137001) RGD PMID:24137001 MGI:5576864 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha acts_upstream_of_or_within ISO MGI:103296 (MGI:2388546|PMID:12370307) RGD PMID:12370307 MGI:2388546 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Smad1 SMAD family member 1 IMP RGD PMID:26873969 RGD:11526363 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651 		JBrowse link
G Smad4 SMAD family member 4 IMP RGD PMID:26873969 RGD:11526363 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Tcap titin-cap involved_in ISO (PMID:12507422) RGD PMID:12507422 NCBI chr10:83,381,719...83,382,887
Ensembl chr10:83,381,719...83,382,887 		JBrowse link
negative regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in ISO (PMID:19287093)
(MGI:3848765|PMID:19287093)		 RGD PMID:19287093 MGI:3848765 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 IDA RGD PMID:19204184 RGD:9685562 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Foxo1 forkhead box O1 involved_in IMP PMID:26436652 UniProt PMID:26436652 RGD:13210548 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Lmna lamin A/C involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:5700584|PMID:26436652)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:26436652 GO_REF:0000024 GO_REF:0000107 MGI:5700584 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Mlip muscular LMNA-interacting protein involved_in ISO (MGI:5700584|PMID:26436652), (MGI:5908525|PMID:26359501) RGD PMID:26359501 PMID:26436652 MGI:5700584 MGI:5908525 NCBI chr 8:77,935,087...78,204,725
Ensembl chr 8:77,935,079...78,204,254 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma acts_upstream_of_or_within IDA PMID:29695452 BHF-UCL PMID:29695452 RGD:150521636 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Smad3 SMAD family member 3 involved_in IGI PMID:27038547 BHF-UCL PMID:27038547 RGD:11535100 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
positive regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in ISO (MGI:3848765|PMID:19287093) RGD PMID:19287093 MGI:3848765 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 involved_in ISO (PMID:19287093) RGD PMID:19287093 NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855 		JBrowse link
regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acacb acetyl-CoA carboxylase beta IMP RGD PMID:31709908 RGD:329901803 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655 		JBrowse link
G Bmp10 bone morphogenetic protein 10 involved_in ISO
IEA		 (PMID:17921333)
GO_REF:0000107		 RGD
Ensembl		 PMID:17921333 GO_REF:0000107 NCBI chr 4:119,872,066...119,877,694
Ensembl chr 4:119,872,045...119,878,627 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19553
    response to stimulus 10408
      response to stress 4215
        muscle hypertrophy in response to stress 32
          cardiac muscle hypertrophy in response to stress + 32
Path 2
Term Annotations click to browse term
  biological_process 19553
    multicellular organismal process 9177
      system process 3477
        muscle system process 484
          muscle hypertrophy 133
            muscle hypertrophy in response to stress 32
              cardiac muscle hypertrophy in response to stress + 32
paths to the root