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ONTOLOGY REPORT - ANNOTATIONS


Term:endocardial cushion formation
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Accession:GO:0003272 term browser browse the term
Definition:The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.



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endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor involved_in IMP (MGI:5584055|PMID:23603510) BHF-UCL PMID:23603510 MGI:5584055 NCBI chr 2:85,136,360...85,139,923
Ensembl chr 2:85,136,225...85,139,923
JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in IMP (MGI:3640731|PMID:16730346) BHF-UCL PMID:16730346 MGI:3640731 NCBI chr 2:133,552,159...133,562,896
Ensembl chr 2:133,552,159...133,562,885
JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in IGI (MGI:1332253|PMID:10079236) BHF-UCL PMID:10079236 MGI:1332253 NCBI chr 9:75,775,365...75,900,316
Ensembl chr 9:75,775,364...75,900,310
JBrowse link
G Bmp7 bone morphogenetic protein 7 involved_in IGI (MGI:1332253|PMID:10079236) BHF-UCL PMID:10079236 MGI:1332253 NCBI chr 2:172,868,012...172,940,321
Ensembl chr 2:172,868,012...172,940,321
JBrowse link
G Bmpr1a bone morphogenetic protein receptor, type 1A acts_upstream_of_or_within IMP (MGI:3611958|PMID:16314491) MGI PMID:16314491 MGI:3611958 NCBI chr14:34,411,061...34,503,336
Ensembl chr14:34,410,734...34,503,341
JBrowse link
G Robo1 roundabout guidance receptor 1 involved_in IGI (MGI:5913048|PMID:25691540) BHF-UCL PMID:25691540 MGI:5913048 NCBI chr16:72,027,518...73,047,491
Ensembl chr16:72,308,306...73,046,095
JBrowse link
G Robo2 roundabout guidance receptor 2 involved_in IGI (MGI:5913048|PMID:25691540) BHF-UCL PMID:25691540 MGI:5913048 NCBI chr16:73,891,976...75,447,443
Ensembl chr16:73,891,839...74,411,825
JBrowse link
G Tbx2 T-box 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr11:85,832,615...85,841,948
Ensembl chr11:85,832,551...85,841,948
JBrowse link
G Tbx20 T-box 20 involved_in IMP (MGI:3604925|PMID:15843409), (MGI:5299248|PMID:21983003) BHF-UCL PMID:15843409 PMID:21983003 MGI:3604925 MGI:5299248 NCBI chr 9:24,720,812...24,774,303
Ensembl chr 9:24,718,138...24,774,303
JBrowse link
G Tbx3 T-box 3 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 5:119,670,534...119,684,724
Ensembl chr 5:119,670,669...119,684,724
JBrowse link
cell migration involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dchs1 dachsous cadherin related 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 7:105,752,989...105,788,355
Ensembl chr 7:105,752,990...105,787,654
JBrowse link
G Eng endoglin acts_upstream_of_or_within IMP (MGI:4368063|PMID:19703439) MGI PMID:19703439 MGI:4368063 NCBI chr 2:32,646,595...32,682,669
Ensembl chr 2:32,646,595...32,682,669
JBrowse link
G Notch1 notch 1 involved_in IMP (MGI:4837019|PMID:20890042) BHF-UCL PMID:20890042 MGI:4837019 NCBI chr 2:26,457,902...26,503,822
Ensembl chr 2:26,457,903...26,516,663
JBrowse link
G Snai2 snail family zinc finger 2 involved_in IMP (MGI:3808643|PMID:18663143) BHF-UCL PMID:18663143 MGI:3808643 NCBI chr16:14,705,852...14,709,395
Ensembl chr16:14,705,852...14,709,385
JBrowse link
epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 NOT|involved_in IMP (MGI:3814273|PMID:18924235) BHF-UCL PMID:18924235 MGI:3814273 NCBI chr14:46,383,525...46,390,669
Ensembl chr14:46,383,520...46,390,669
JBrowse link
G Eng endoglin involved_in IMP (MGI:4368063|PMID:19703439) BHF-UCL PMID:19703439 MGI:4368063 NCBI chr 2:32,646,595...32,682,669
Ensembl chr 2:32,646,595...32,682,669
JBrowse link
G Fgf8 fibroblast growth factor 8 acts_upstream_of_or_within
involved_in
IDA
IMP
(MGI:5002778|PMID:21364285)
(MGI:4359139|PMID:19509466)
MGI
BHF-UCL
PMID:19509466 PMID:21364285 MGI:4359139 MGI:5002778 NCBI chr19:45,736,491...45,742,941
Ensembl chr19:45,736,798...45,742,915
JBrowse link
G Hey1 hairy/enhancer-of-split related with YRPW motif 1 acts_upstream_of_or_within IGI (MGI:3783952|PMID:17303760) MGI PMID:17303760 MGI:3783952 NCBI chr 3:8,663,359...8,667,038
Ensembl chr 3:8,663,359...8,667,256
JBrowse link
G Heyl hairy/enhancer-of-split related with YRPW motif-like acts_upstream_of_or_within IGI (MGI:3783952|PMID:17303760) MGI PMID:17303760 MGI:3783952 NCBI chr 4:123,233,556...123,249,870
Ensembl chr 4:123,233,556...123,249,875
JBrowse link
G Msx1 msh homeobox 1 acts_upstream_of_or_within IGI (MGI:3810851|PMID:18667074) MGI PMID:18667074 MGI:3810851 NCBI chr 5:37,820,491...37,824,585
Ensembl chr 5:37,820,485...37,824,583
JBrowse link
G Msx2 msh homeobox 2 acts_upstream_of_or_within IGI (MGI:3810851|PMID:18667074) MGI PMID:18667074 MGI:3810851 NCBI chr13:53,466,881...53,472,780
Ensembl chr13:53,466,884...53,473,074
JBrowse link
G Notch1 notch 1 involved_in IMP (MGI:3027664|PMID:14701881) BHF-UCL PMID:14701881 MGI:3027664 NCBI chr 2:26,457,902...26,503,822
Ensembl chr 2:26,457,903...26,516,663
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in IMP (MGI:3027664|PMID:14701881) BHF-UCL PMID:14701881 MGI:3027664 NCBI chr 5:53,555,779...53,657,445
Ensembl chr 5:53,466,152...53,657,362
JBrowse link
G Smad4 SMAD family member 4 involved_in IMP (MGI:4946551|PMID:21330551) BHF-UCL PMID:21330551 MGI:4946551 NCBI chr18:73,634,790...73,703,791
Ensembl chr18:73,639,009...73,703,780
JBrowse link
G Snai1 snail family zinc finger 1 involved_in IGI (MGI:3808643|PMID:18663143) BHF-UCL PMID:18663143 MGI:3808643 NCBI chr 2:167,538,195...167,542,814
Ensembl chr 2:167,538,195...167,542,814
JBrowse link
G Snai2 snail family zinc finger 2 acts_upstream_of_or_within IMP (MGI:3808643|PMID:18663143) MGI PMID:18663143 MGI:3808643 NCBI chr16:14,705,852...14,709,395
Ensembl chr16:14,705,852...14,709,385
JBrowse link
G Tmem100 transmembrane protein 100 acts_upstream_of_or_within IMP (MGI:5613881|PMID:25318679) MGI PMID:25318679 MGI:5613881 NCBI chr11:90,030,348...90,036,508
Ensembl chr11:90,030,348...90,036,508
JBrowse link
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nog noggin involved_in IMP (MGI:3783944|PMID:17218603) BHF-UCL PMID:17218603 MGI:3783944 NCBI chr11:89,300,638...89,302,559
Ensembl chr11:89,300,638...89,302,332
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in IMP (MGI:3830400|PMID:19161227) BHF-UCL PMID:19161227 MGI:3830400 NCBI chr 1:186,622,787...186,709,697
Ensembl chr 1:186,622,792...186,705,989
JBrowse link
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor, type 1 involved_in IMP (MGI:3610266|PMID:16140292) BHF-UCL PMID:16140292 MGI:3610266 NCBI chr 2:58,446,438...58,566,828
Ensembl chr 2:58,388,644...58,567,157
JBrowse link
G Eng endoglin involved_in IMP (MGI:4368063|PMID:19703439) BHF-UCL PMID:19703439 MGI:4368063 NCBI chr 2:32,646,595...32,682,669
Ensembl chr 2:32,646,595...32,682,669
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in IMP (MGI:3830400|PMID:19161227) BHF-UCL PMID:19161227 MGI:3830400 NCBI chr 1:186,622,787...186,709,697
Ensembl chr 1:186,622,792...186,705,989
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor I involved_in IMP (MGI:3820811|PMID:18718461) BHF-UCL PMID:18718461 MGI:3820811 NCBI chr 4:47,353,222...47,414,926
Ensembl chr 4:47,353,222...47,414,931
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II involved_in IMP (MGI:3801267|PMID:17050629) BHF-UCL PMID:17050629 MGI:3801267 NCBI chr 9:116,087,695...116,175,363
Ensembl chr 9:116,084,293...116,175,360
JBrowse link
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb1 transforming growth factor, beta 1 NOT|involved_in IMP (MGI:3830400|PMID:19161227) BHF-UCL PMID:19161227 MGI:3830400 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tgfb3 transforming growth factor, beta 3 NOT|involved_in IMP (MGI:3830400|PMID:19161227) BHF-UCL PMID:19161227 MGI:3830400 NCBI chr12:86,056,743...86,079,041
Ensembl chr12:86,056,745...86,079,041
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28652
    developmental process 7168
      anatomical structure formation involved in morphogenesis 1277
        endocardial cushion formation 31
          cell migration involved in endocardial cushion formation 4
          epithelial to mesenchymal transition involved in endocardial cushion formation + 20
Path 2
Term Annotations click to browse term
  biological_process 28652
    developmental process 7168
      anatomical structure development 6551
        multicellular organism development 5902
          system development 5528
            animal organ development 4263
              mesenchyme development 303
                endocardial cushion development 52
                  endocardial cushion morphogenesis 39
                    endocardial cushion formation 31
                      cell migration involved in endocardial cushion formation 4
                      epithelial to mesenchymal transition involved in endocardial cushion formation + 20
paths to the root