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ONTOLOGY REPORT - ANNOTATIONS


Term:endocardial cushion formation
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Accession:GO:0003272 term browser browse the term
Definition:The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.



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endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLNR apelin receptor involved_in ISS
IEA
BHF-UCL
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr11:57,233,591...57,237,250
Ensembl chr11:57,233,577...57,237,250
JBrowse link
G BMP2 bone morphogenetic protein 2 involved_in ISS
IEA
BHF-UCL
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 6:55,753,653...55,875,590
Ensembl chr 6:55,753,653...55,875,590
JBrowse link
G BMP7 bone morphogenetic protein 7 involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr20:57,168,753...57,266,641
Ensembl chr20:57,168,753...57,266,641
JBrowse link
G BMPR1A bone morphogenetic protein receptor type 1A involved_in
acts_upstream_of_or_within
ISS
IEA
ISO
(MGI:3611958|PMID:16314491) BHF-UCL
BHF-UCL
Ensembl
MGI
PMID:16314491 GO_REF:0000024 GO_REF:0000107 MGI:3611958 NCBI chr10:86,755,786...86,927,969
Ensembl chr10:86,756,601...86,932,825
JBrowse link
G ROBO1 roundabout guidance receptor 1 involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr 3:78,597,239...79,767,998
Ensembl chr 3:78,597,239...79,767,998
JBrowse link
G ROBO2 roundabout guidance receptor 2 involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr 3:75,906,675...77,649,964
Ensembl chr 3:75,906,695...77,649,964
JBrowse link
G TBX2 T-box transcription factor 2 involved_in IMP (PMID:22130515) BHF-UCL
BHF-UCL
PMID:22130515 NCBI chr17:61,399,843...61,409,466
Ensembl chr17:61,399,843...61,409,466
JBrowse link
G TBX20 T-box transcription factor 20 involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 7:35,199,936...35,254,100
Ensembl chr 7:35,202,430...35,254,100
JBrowse link
G TBX3 T-box transcription factor 3 involved_in IMP (PMID:22130515) BHF-UCL
BHF-UCL
PMID:22130515 NCBI chr12:114,670,255...114,684,175
Ensembl chr12:114,670,255...114,684,175
JBrowse link
cell migration involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DCHS1 dachsous cadherin-related 1 involved_in IMP (PMID:26258302) UniProt
UniProt
PMID:26258302 NCBI chr11:6,621,330...6,655,809
Ensembl chr11:6,621,330...6,655,809
JBrowse link
G ENG endoglin involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4368063|PMID:19703439) Ensembl
Ensembl
MGI
PMID:19703439 GO_REF:0000107 MGI:4368063 NCBI chr 9:127,815,012...127,854,773
Ensembl chr 9:127,815,013...127,854,658
JBrowse link
G NOTCH1 notch receptor 1 involved_in ISS
IEA
BHF-UCL
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740
JBrowse link
epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 NOT|involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761
JBrowse link
G ENG endoglin involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 9:127,815,012...127,854,773
Ensembl chr 9:127,815,013...127,854,658
JBrowse link
G FGF8 fibroblast growth factor 8 involved_in
acts_upstream_of_or_within
ISS
IEA
ISO
(MGI:5002778|PMID:21364285) BHF-UCL
Ensembl
BHF-UCL
MGI
PMID:21364285 GO_REF:0000024 GO_REF:0000107 MGI:5002778 NCBI chr10:101,770,109...101,780,369
Ensembl chr10:101,770,109...101,780,371
JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO (MGI:3783952|PMID:17303760) MGI PMID:17303760 MGI:3783952 NCBI chr 8:79,764,010...79,767,767
Ensembl chr 8:79,762,371...79,767,857
JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 involved_in TAS (PMID:20951801) BHF-UCL
BHF-UCL
PMID:20951801 NCBI chr 6:125,747,639...125,762,243
Ensembl chr 6:125,747,664...125,761,269
JBrowse link
G HEYL hes related family bHLH transcription factor with YRPW motif like involved_in
acts_upstream_of_or_within
ISS
TAS
IEA
ISO
(PMID:20951801)
(MGI:3783952|PMID:17303760)
UniProt
UniProt
BHF-UCL
Ensembl
MGI
BHF-UCL
PMID:17303760 PMID:20951801 GO_REF:0000024 GO_REF:0000107 MGI:3783952 NCBI chr 1:39,623,435...39,639,643
Ensembl chr 1:39,623,435...39,639,643
JBrowse link
G MSX1 msh homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3810851|PMID:18667074) Ensembl
Ensembl
MGI
PMID:18667074 GO_REF:0000107 MGI:3810851 NCBI chr 4:4,859,665...4,863,936
Ensembl chr 4:4,859,665...4,863,936
JBrowse link
G MSX2 msh homeobox 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3810851|PMID:18667074) MGI
Ensembl
Ensembl
PMID:18667074 GO_REF:0000107 MGI:3810851 NCBI chr 5:174,724,582...174,730,896
Ensembl chr 5:174,724,582...174,730,896
JBrowse link
G NOTCH1 notch receptor 1 involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 4:26,163,458...26,435,131
Ensembl chr 4:26,163,455...26,435,131
JBrowse link
G SMAD4 SMAD family member 4 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,394...51,085,045
JBrowse link
G SNAI1 snail family transcriptional repressor 1 involved_in ISS
TAS
IEA
(PMID:20951801) BHF-UCL
BHF-UCL
Ensembl
PMID:20951801 GO_REF:0000024 GO_REF:0000107 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in
acts_upstream_of_or_within
TAS
ISS
IEA
ISO
(PMID:20951801)
(MGI:3808643|PMID:18663143)
BHF-UCL
BHF-UCL
Ensembl
MGI
PMID:18663143 PMID:20951801 GO_REF:0000024 GO_REF:0000107 MGI:3808643 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740
JBrowse link
G TMEM100 transmembrane protein 100 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5613881|PMID:25318679) Ensembl
Ensembl
MGI
PMID:25318679 GO_REF:0000107 MGI:5613881 NCBI chr17:55,719,627...55,732,081
Ensembl chr17:55,719,627...55,732,121
JBrowse link
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOG noggin involved_in ISS
IEA
BHF-UCL
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr17:56,593,699...56,595,611
Ensembl chr17:56,593,699...56,595,611
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 involved_in ISS
IEA
BHF-UCL
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr 2:157,736,446...157,876,330
Ensembl chr 2:157,736,251...157,876,330
JBrowse link
G ENG endoglin involved_in ISS
IEA
BHF-UCL
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr 9:127,815,012...127,854,773
Ensembl chr 9:127,815,013...127,854,658
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 9:99,104,038...99,154,192
Ensembl chr 9:99,104,038...99,154,192
JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 3:30,606,472...30,694,142
Ensembl chr 3:30,606,601...30,694,142
JBrowse link
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFB1 transforming growth factor beta 1 NOT|involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TGFB3 transforming growth factor beta 3 NOT|involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18659
    developmental process 7349
      anatomical structure formation involved in morphogenesis 1302
        endocardial cushion formation 32
          cell migration involved in endocardial cushion formation 4
          epithelial to mesenchymal transition involved in endocardial cushion formation + 21
Path 2
Term Annotations click to browse term
  biological_process 18659
    developmental process 7349
      anatomical structure development 6675
        multicellular organism development 6044
          system development 5692
            animal organ development 4337
              mesenchyme development 323
                endocardial cushion development 54
                  endocardial cushion morphogenesis 40
                    endocardial cushion formation 32
                      cell migration involved in endocardial cushion formation 4
                      epithelial to mesenchymal transition involved in endocardial cushion formation + 21
paths to the root