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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of membrane depolarization
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Accession:GO:0003254 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.



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regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2 microglobulin involved_in ISO (PMID:23144825) RGD PMID:23144825 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta involved_in ISO (PMID:22514276) RGD PMID:22514276 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
JBrowse link
G Cftr CF transmembrane conductance regulator NOT|involved_in ISO (MGI:5640937|PMID:24885604) RGD PMID:24885604 MGI:5640937 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Fgf12 fibroblast growth factor 12 involved_in IDA PMID:12401812 BHF-UCL PMID:12401812 RGD:6484231 NCBI chr11:71,997,049...72,564,965
Ensembl chr11:71,997,099...72,562,607
JBrowse link
G Fhl1 four and a half LIM domains 1 involved_in ISO (PMID:18281375) RGD PMID:18281375 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 involved_in IDA
IEA
ISO
GO_REF:0000107
(PMID:16043489)
Ensembl
RGD
PMID:16043489 PMID:20806410 GO_REF:0000107, RGD:9686372 NCBI chr 2:49,495,771...49,899,702
Ensembl chr 2:49,495,771...49,899,774
JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 involved_in
acts_upstream_of_or_within
ISO
IEA
(PMID:16043489)
(PMID:12968185)
GO_REF:0000107
RGD
Ensembl
PMID:12968185 PMID:16043489 GO_REF:0000107 NCBI chr 7:9,969,801...9,988,839
Ensembl chr 7:9,970,368...9,988,841
JBrowse link
G Hcn3 hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 involved_in ISO
IEA
(PMID:16043489)
GO_REF:0000107
RGD
Ensembl
PMID:16043489 GO_REF:0000107 NCBI chr 2:174,551,866...174,567,459
Ensembl chr 2:174,551,680...174,565,966
JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 involved_in IEA
ISO
GO_REF:0000107
(PMID:12750403), (PMID:16043489)
Ensembl
RGD
PMID:12750403 PMID:16043489 GO_REF:0000107 NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639
JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase involved_in ISO (PMID:15217910) RGD PMID:15217910 NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137
JBrowse link
G Npff neuropeptide FF-amide peptide precursor IDA RGD PMID:17289819 RGD:2316567 NCBI chr 7:133,654,530...133,655,319 JBrowse link
G Ntsr1 neurotensin receptor 1 IMP RGD PMID:15120846 RGD:9743930 NCBI chr 3:167,606,215...167,656,377
Ensembl chr 3:167,606,215...167,656,377
JBrowse link
G Rangrf RAN guanine nucleotide release factor involved_in ISO
IBA
(PMID:18184654), (PMID:23420830)
PMID:21873635
(MGI:5508678|PMID:23420830)
RGD PMID:18184654 PMID:23420830 PMID:21873635 MGI:5508678, RGD:13792537 NCBI chr10:53,677,467...53,678,880
Ensembl chr10:53,677,467...53,678,840
JBrowse link
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO (MGI:5613732|PMID:25257915) RGD PMID:25257915 MGI:5613732 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
JBrowse link
negative regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796062|PMID:27098698) RGD PMID:27098698 MGI:5796062 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 IMP RGD PMID:29215467 RGD:13504824 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Hsh2d hematopoietic SH2 domain containing acts_upstream_of_or_within ISO (MGI:3574118|PMID:15569688) RGD PMID:15569688 MGI:3574118 NCBI chr16:17,630,519...17,649,932
Ensembl chr16:17,635,322...17,647,991
JBrowse link
G Ngfr nerve growth factor receptor IMP RGD PMID:19457114 RGD:5508731 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:19767770) RGD PMID:19767770 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
positive regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3 involved_in IMP PMID:18180363 BHF-UCL PMID:18180363 RGD:6767295 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
JBrowse link
positive regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type IMP RGD PMID:15564577 RGD:2313870 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
JBrowse link
G Cck cholecystokinin IDA apoptotic RGD PMID:11964411 RGD:625521 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Dcn decorin acts_upstream_of_or_within ISO UniProtKB:P35968 (PMID:23798385) RGD PMID:23798385 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Kdr kinase insert domain receptor acts_upstream_of_or_within
involved_in
ISO
IEA
UniProtKB:P07585 (PMID:23798385)
GO_REF:0000107
RGD
Ensembl
PMID:23798385 GO_REF:0000107 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Mllt11 MLLT11, transcription factor 7 cofactor involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:18852119)
UniProt
RGD
PMID:18852119 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 2:182,795,790...182,804,960
Ensembl chr 2:182,795,790...182,797,199
JBrowse link
G Myoc myocilin involved_in ISO
IEA
ISS
(PMID:17516541)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:17516541 GO_REF:0000024 GO_REF:0000107 NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127
JBrowse link
G Oga O-GlcNAcase IMP RGD PMID:19139380 RGD:2305938 NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359
JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO MGI:2386080 (MGI:3607437|PMID:16198349) RGD PMID:16198349 MGI:3607437 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 IMP protein:increased activity:brain: RGD PMID:21616968 RGD:10413888 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rack1 receptor for activated C kinase 1 involved_in ISO (PMID:19767770) RGD PMID:19767770 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975
JBrowse link
G Tspo translocator protein IDA RGD PMID:15183124 RGD:2317155 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
JBrowse link
positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IMP RGD PMID:20826763 RGD:10003037 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
JBrowse link
regulation of atrial cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2182962 (MGI:3714901|PMID:16690884)
Ensembl
RGD
PMID:16690884 GO_REF:0000107 MGI:3714901 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
JBrowse link
G Gja1 gap junction protein, alpha 1 acts_upstream_of_or_within ISO MGI:1857177 (MGI:3639795|PMID:10969038) RGD PMID:10969038 MGI:3639795 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gja5 gap junction protein, alpha 5 involved_in
acts_upstream_of_or_within
ISO (PMID:22247482), (PMID:23348765)
MGI:2445238 (MGI:1197846|PMID:9501070), (MGI:3639795|PMID:10969038), (MGI:3696497|PMID:10515563)
RGD PMID:9501070 PMID:10515563 PMID:10969038 PMID:22247482 PMID:23348765 MGI:1197846 MGI:3639795 MGI:3696497 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in
acts_upstream_of_or_within
ISO (PMID:20062061), (PMID:21041692)
MGI:2180183 (MGI:4848026|PMID:20062061)
RGD PMID:20062061 PMID:21041692 MGI:4848026 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614
JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO (PMID:19808477), (PMID:22247482) RGD PMID:19808477 PMID:22247482 NCBI chr 1:86,353,917...86,363,836
Ensembl chr 1:86,353,917...86,363,739
JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in ISO (PMID:19808477) RGD PMID:19808477 NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:21051419)
(MGI:5294533|PMID:19796257)
RGD PMID:19796257 PMID:21051419 MGI:5294533 NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in IBA
IEA
ISS
ISO
PMID:21873635
GO_REF:0000107
GO_REF:0000024
(PMID:19167345), (PMID:22247482)
Ensembl
BHF-UCL
RGD
PMID:19167345 PMID:22247482 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Tbx5 T-box transcription factor 5 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
UniProtKB:Q9JJV9 (MGI:5449667|PMID:22728936)
Ensembl
RGD
PMID:22728936 GO_REF:0000107 MGI:5449667 NCBI chr12:36,686,344...36,739,253
Ensembl chr12:36,688,014...36,734,885
JBrowse link
regulation of membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 involved_in ISO (PMID:16930557) RGD PMID:16930557 NCBI chr 5:71,908,520...72,027,323
Ensembl chr 5:71,911,135...72,065,443
JBrowse link
regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO
IBA
(PMID:17275750)
PMID:21873635
RGD PMID:17275750 PMID:21873635 RGD:13792537 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
JBrowse link
G Gja5 gap junction protein, alpha 5 acts_upstream_of_or_within ISO MGI:2445238 (MGI:1197846|PMID:9501070) RGD PMID:9501070 MGI:1197846 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
JBrowse link
G Rangrf RAN guanine nucleotide release factor involved_in ISO (PMID:21621375) RGD PMID:21621375 NCBI chr10:53,677,467...53,678,880
Ensembl chr10:53,677,467...53,678,840
JBrowse link
G Slmap sarcolemma associated protein involved_in ISO
IBA
(PMID:23064965)
PMID:21873635
RGD PMID:23064965 PMID:21873635 RGD:13792537 NCBI chr16:1,667,205...1,785,200
Ensembl chr16:1,667,208...1,785,149
JBrowse link
regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 involved_in ISO (MGI:5790173|PMID:25583114) RGD PMID:25583114 MGI:5790173 NCBI chr  X:151,428,334...151,450,115
Ensembl chr  X:151,428,578...151,450,115
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit acts_upstream_of_or_within ISO MGI:104995 (MGI:3047441|PMID:15288121) RGD PMID:15288121 MGI:3047441 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit acts_upstream_of_or_within ISO MGI:104990 (MGI:3047441|PMID:15288121) RGD PMID:15288121 MGI:3047441 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO (PMID:22736029) RGD PMID:22736029 NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma acts_upstream_of_or_within ISO MGI:3759678 (MGI:3589325|PMID:16129705) RGD PMID:16129705 MGI:3589325 NCBI chr 6:72,647,025...72,670,885
Ensembl chr 6:72,647,025...72,672,491
JBrowse link
regulation of ventricular cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO (PMID:17060380) RGD PMID:17060380 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
JBrowse link
G Gja1 gap junction protein, alpha 1 acts_upstream_of_or_within ISO MGI:1857177|MGI:95716 (MGI:3639795|PMID:10969038), (MGI:86953|PMID:9109444) RGD PMID:9109444 PMID:10969038 MGI:3639795 MGI:86953 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gja5 gap junction protein, alpha 5 acts_upstream_of_or_within ISO MGI:2445238|MGI:95713 (MGI:1197846|PMID:9501070), (MGI:3639795|PMID:10969038), (MGI:3696497|PMID:10515563)
(MGI:6101691|PMID:26786475)
RGD PMID:9501070 PMID:10515563 PMID:10969038 PMID:26786475 MGI:1197846 MGI:3639795 MGI:3696497 MGI:6101691 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
JBrowse link
G Gpd1l glycerol-3-phosphate dehydrogenase 1-like involved_in ISO (PMID:17967977), (PMID:19666841) RGD PMID:17967977 PMID:19666841 NCBI chr 8:114,591,103...114,620,771
Ensembl chr 8:114,588,487...114,620,723
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:20042427) RGD PMID:20042427 NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO
IEA
ISS
(PMID:18065446), (PMID:22529811), (PMID:7889574)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:7889574 PMID:18065446 PMID:22529811 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    regulation of biological process 12866
      regulation of cellular process 12336
        regulation of membrane depolarization 49
          negative regulation of membrane depolarization + 6
          positive regulation of membrane depolarization + 13
          regulation of atrial cardiac muscle cell membrane depolarization 9
          regulation of membrane depolarization during action potential + 6
          regulation of mitochondrial depolarization + 21
          regulation of ventricular cardiac muscle cell membrane depolarization 6
Path 2
Term Annotations click to browse term
  biological_process 19497
    biological regulation 13606
      regulation of biological quality 4205
        homeostatic process 2024
          chemical homeostasis 1380
            ion homeostasis 885
              regulation of membrane depolarization 49
                negative regulation of membrane depolarization + 6
                positive regulation of membrane depolarization + 13
                regulation of atrial cardiac muscle cell membrane depolarization 9
                regulation of membrane depolarization during action potential + 6
                regulation of mitochondrial depolarization + 21
                regulation of ventricular cardiac muscle cell membrane depolarization 6
paths to the root