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ONTOLOGY REPORT - ANNOTATIONS

Term:endocardial cushion morphogenesis
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Accession:GO:0003203 term browser browse the term
Definition:The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.


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endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor, type II-like 1 involved_in IMP (MGI:2674189|PMID:12941632) BHF-UCL PMID:12941632 MGI:2674189 NCBI chr15:101,026,403...101,043,217
Ensembl chr15:101,026,403...101,043,217 		JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5 involved_in IGI (MGI:5693221|PMID:23531444) BHF-UCL PMID:23531444 MGI:5693221 NCBI chr16:85,655,045...85,698,013
Ensembl chr16:85,653,061...85,698,716 		JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in
acts_upstream_of_or_within		 IMP (MGI:4837019|PMID:20890042)
(PMID:16314491)		 BHF-UCL
MGI		 PMID:16314491 PMID:20890042 MGI:4837019 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor, type 1A involved_in IMP (MGI:2175930|PMID:11854453), (MGI:3040576|PMID:15073157) BHF-UCL PMID:11854453 PMID:15073157 MGI:2175930 MGI:3040576 NCBI chr14:34,133,018...34,225,335
Ensembl chr14:34,132,691...34,225,298 		JBrowse link
G Eng endoglin involved_in IMP (MGI:2674189|PMID:12941632), (MGI:4368063|PMID:19703439) BHF-UCL PMID:12941632 PMID:19703439 MGI:2674189 MGI:4368063 NCBI chr 2:32,536,607...32,572,681
Ensembl chr 2:32,536,607...32,572,681 		JBrowse link
G Hey1 hairy/enhancer-of-split related with YRPW motif 1 involved_in IGI (MGI:3783952|PMID:17303760) BHF-UCL PMID:17303760 MGI:3783952 NCBI chr 3:8,728,419...8,732,098
Ensembl chr 3:8,728,419...8,732,316 		JBrowse link
G Heyl hairy/enhancer-of-split related with YRPW motif-like involved_in IGI (MGI:3783952|PMID:17303760) BHF-UCL PMID:17303760 MGI:3783952 NCBI chr 4:123,127,349...123,143,663
Ensembl chr 4:123,127,349...123,143,668 		JBrowse link
G Isl1 ISL1 transcription factor, LIM/homeodomain involved_in IGI (MGI:3829137|PMID:17519333) BHF-UCL PMID:17519333 MGI:3829137 NCBI chr13:116,434,806...116,446,224
Ensembl chr13:116,434,817...116,446,225 		JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 acts_upstream_of_or_within IMP
IGI		 (PMID:22821713) MGI PMID:22821713 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663 		JBrowse link
G Mdm4 transformed mouse 3T3 cell double minute 4 acts_upstream_of_or_within IGI (PMID:22821713) MGI PMID:22821713 NCBI chr 1:132,913,843...132,958,325
Ensembl chr 1:132,887,222...132,958,299 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell involved_in IGI (MGI:6158784|PMID:27107132) BHF-UCL PMID:27107132 MGI:6158784 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Notch1 notch 1 involved_in IGI
IMP		 (MGI:6158784|PMID:27107132)
(MGI:3027664|PMID:14701881)		 BHF-UCL PMID:14701881 PMID:27107132 MGI:3027664 MGI:6158784 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675 		JBrowse link
G Smad2 SMAD family member 2 involved_in IGI (MGI:5693221|PMID:23531444) BHF-UCL PMID:23531444 MGI:5693221 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 acts_upstream_of_or_within IMP (PMID:11951052) MGI PMID:11951052 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
G Tbx2 T-box 2 involved_in IMP (MGI:3487212|PMID:15459098) BHF-UCL PMID:15459098 MGI:3487212 NCBI chr11:85,723,441...85,732,774
Ensembl chr11:85,723,377...85,732,774 		JBrowse link
G Tbx20 T-box 20 involved_in IMP (MGI:3579960|PMID:15901664) BHF-UCL PMID:15901664 MGI:3579960 NCBI chr 9:24,632,108...24,685,580
Ensembl chr 9:24,629,434...24,685,599 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in IMP (MGI:3609313|PMID:11390347), (MGI:3830400|PMID:19161227) BHF-UCL PMID:11390347 PMID:19161227 MGI:3609313 MGI:3830400 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Twist1 twist basic helix-loop-helix transcription factor 1 acts_upstream_of_or_within IMP (PMID:18539270) MGI PMID:18539270 NCBI chr12:34,007,670...34,009,830
Ensembl chr12:34,007,670...34,009,828 		JBrowse link
apoptotic process involved in endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 NOT|involved_in IMP (MGI:3814273|PMID:18924235) BHF-UCL PMID:18924235 MGI:3814273 NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126 		JBrowse link
cell migration involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dchs1 dachsous cadherin related 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:105,402,196...105,437,562
Ensembl chr 7:105,402,197...105,436,861 		JBrowse link
G Eng endoglin acts_upstream_of_or_within IMP (PMID:19703439) MGI PMID:19703439 NCBI chr 2:32,536,607...32,572,681
Ensembl chr 2:32,536,607...32,572,681 		JBrowse link
G Notch1 notch 1 involved_in IMP (MGI:4837019|PMID:20890042) BHF-UCL PMID:20890042 MGI:4837019 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675 		JBrowse link
G Snai2 snail family zinc finger 2 involved_in IMP (MGI:3808643|PMID:18663143) BHF-UCL PMID:18663143 MGI:3808643 NCBI chr16:14,523,716...14,527,259
Ensembl chr16:14,523,716...14,527,249 		JBrowse link
cell proliferation involved in endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfbr2 transforming growth factor, beta receptor II NOT|involved_in IMP (MGI:4821522|PMID:20652948) BHF-UCL PMID:20652948 MGI:4821522 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor, type 1 involved_in IMP (MGI:3610266|PMID:16140292) BHF-UCL PMID:16140292 MGI:3610266 NCBI chr 2:58,336,450...58,456,840
Ensembl chr 2:58,278,656...58,457,169 		JBrowse link
G Aplnr apelin receptor involved_in IMP (MGI:5584055|PMID:23603510) BHF-UCL PMID:23603510 MGI:5584055 NCBI chr 2:84,966,704...84,970,267
Ensembl chr 2:84,966,569...84,970,267 		JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in IMP (MGI:3640731|PMID:16730346) BHF-UCL PMID:16730346 MGI:3640731 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805 		JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in IGI (MGI:1332253|PMID:10079236) BHF-UCL PMID:10079236 MGI:1332253 NCBI chr 9:75,682,647...75,807,598
Ensembl chr 9:75,682,646...75,807,592 		JBrowse link
G Bmp7 bone morphogenetic protein 7 involved_in IGI (MGI:1332253|PMID:10079236) BHF-UCL PMID:10079236 MGI:1332253 NCBI chr 2:172,709,805...172,782,114
Ensembl chr 2:172,709,805...172,782,114 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor, type 1A acts_upstream_of_or_within IMP (PMID:16314491) MGI PMID:16314491 NCBI chr14:34,133,018...34,225,335
Ensembl chr14:34,132,691...34,225,298 		JBrowse link
G Nog noggin involved_in IMP (MGI:3783944|PMID:17218603) BHF-UCL PMID:17218603 MGI:3783944 NCBI chr11:89,191,464...89,193,385
Ensembl chr11:89,191,464...89,193,158 		JBrowse link
G Robo1 roundabout guidance receptor 1 involved_in IGI (MGI:5913048|PMID:25691540) BHF-UCL PMID:25691540 MGI:5913048 NCBI chr16:71,824,406...72,844,379
Ensembl chr16:72,105,194...72,842,983 		JBrowse link
G Robo2 roundabout guidance receptor 2 involved_in IGI (MGI:5913048|PMID:25691540) BHF-UCL PMID:25691540 MGI:5913048 NCBI chr16:73,688,725...75,244,331
Ensembl chr16:73,688,727...74,208,713 		JBrowse link
G Tbx2 T-box 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:85,723,441...85,732,774
Ensembl chr11:85,723,377...85,732,774 		JBrowse link
G Tbx20 T-box 20 involved_in IMP (MGI:3604925|PMID:15843409), (MGI:5299248|PMID:21983003) BHF-UCL PMID:15843409 PMID:21983003 MGI:3604925 MGI:5299248 NCBI chr 9:24,632,108...24,685,580
Ensembl chr 9:24,629,434...24,685,599 		JBrowse link
G Tbx3 T-box 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:119,808,600...119,822,789
Ensembl chr 5:119,808,734...119,822,789 		JBrowse link
endocardial cushion fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor, type 1 involved_in IMP (MGI:3610266|PMID:16140292) BHF-UCL PMID:16140292 MGI:3610266 NCBI chr 2:58,336,450...58,456,840
Ensembl chr 2:58,278,656...58,457,169 		JBrowse link
G Cplane2 ciliogenesis and planar polarity effector 2 acts_upstream_of_or_within IMP (PMID:29038301) MGI PMID:29038301 NCBI chr 4:140,941,249...140,947,425
Ensembl chr 4:140,941,267...140,954,067 		JBrowse link
G Gata5 GATA binding protein 5 involved_in IMP (MGI:5286818|PMID:21633169) BHF-UCL PMID:21633169 MGI:5286818 NCBI chr 2:179,966,881...179,977,296
Ensembl chr 2:179,966,926...179,976,492 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in IMP (MGI:3609313|PMID:11390347) BHF-UCL PMID:11390347 MGI:3609313 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II involved_in IMP (MGI:4821522|PMID:20652948) BHF-UCL PMID:20652948 MGI:4821522 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 NOT|involved_in IMP (MGI:3814273|PMID:18924235) BHF-UCL PMID:18924235 MGI:3814273 NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126 		JBrowse link
G Eng endoglin involved_in IMP (MGI:4368063|PMID:19703439) BHF-UCL PMID:19703439 MGI:4368063 NCBI chr 2:32,536,607...32,572,681
Ensembl chr 2:32,536,607...32,572,681 		JBrowse link
G Fgf8 fibroblast growth factor 8 involved_in
acts_upstream_of_or_within		 IMP
IDA		 (MGI:4359139|PMID:19509466)
(PMID:21364285)		 BHF-UCL
MGI		 PMID:19509466 PMID:21364285 MGI:4359139 NCBI chr19:45,724,930...45,731,380
Ensembl chr19:45,725,237...45,731,354 		JBrowse link
G Hey1 hairy/enhancer-of-split related with YRPW motif 1 acts_upstream_of_or_within IGI (PMID:17303760) MGI PMID:17303760 NCBI chr 3:8,728,419...8,732,098
Ensembl chr 3:8,728,419...8,732,316 		JBrowse link
G Heyl hairy/enhancer-of-split related with YRPW motif-like acts_upstream_of_or_within IGI (PMID:17303760) MGI PMID:17303760 NCBI chr 4:123,127,349...123,143,663
Ensembl chr 4:123,127,349...123,143,668 		JBrowse link
G Msx1 msh homeobox 1 acts_upstream_of_or_within IGI (PMID:18667074) MGI PMID:18667074 NCBI chr 5:37,977,835...37,981,929
Ensembl chr 5:37,977,829...37,981,927 		JBrowse link
G Msx2 msh homeobox 2 acts_upstream_of_or_within IGI (PMID:18667074) MGI PMID:18667074 NCBI chr13:53,620,917...53,626,816
Ensembl chr13:53,620,920...53,627,110 		JBrowse link
G Notch1 notch 1 involved_in IMP (MGI:3027664|PMID:14701881) BHF-UCL PMID:14701881 MGI:3027664 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in IMP (MGI:3027664|PMID:14701881) BHF-UCL PMID:14701881 MGI:3027664 NCBI chr 5:53,713,121...53,814,787
Ensembl chr 5:53,623,494...53,814,704 		JBrowse link
G Smad4 SMAD family member 4 involved_in IMP (MGI:4946551|PMID:21330551) BHF-UCL PMID:21330551 MGI:4946551 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851 		JBrowse link
G Snai1 snail family zinc finger 1 involved_in IGI (MGI:3808643|PMID:18663143) BHF-UCL PMID:18663143 MGI:3808643 NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734 		JBrowse link
G Snai2 snail family zinc finger 2 acts_upstream_of_or_within IMP (PMID:18663143) MGI PMID:18663143 NCBI chr16:14,523,716...14,527,259
Ensembl chr16:14,523,716...14,527,249 		JBrowse link
G Tmem100 transmembrane protein 100 acts_upstream_of_or_within IMP (PMID:25318679) MGI PMID:25318679 NCBI chr11:89,921,174...89,927,334
Ensembl chr11:89,921,174...89,927,334 		JBrowse link
inferior endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfbr2 transforming growth factor, beta receptor II involved_in IMP (MGI:3801267|PMID:17050629) BHF-UCL PMID:17050629 MGI:3801267 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb2 transforming growth factor, beta 2 involved_in IMP (MGI:3830400|PMID:19161227) BHF-UCL PMID:19161227 MGI:3830400 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eng endoglin involved_in IMP (MGI:4368063|PMID:19703439) BHF-UCL PMID:19703439 MGI:4368063 NCBI chr 2:32,536,607...32,572,681
Ensembl chr 2:32,536,607...32,572,681 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in IMP (MGI:3830400|PMID:19161227) BHF-UCL PMID:19161227 MGI:3830400 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor I involved_in IMP (MGI:3820811|PMID:18718461) BHF-UCL PMID:18718461 MGI:3820811 NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II involved_in IMP (MGI:3801267|PMID:17050629) BHF-UCL PMID:17050629 MGI:3801267 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb1 transforming growth factor, beta 1 NOT|involved_in IMP (MGI:3830400|PMID:19161227) BHF-UCL PMID:19161227 MGI:3830400 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 NOT|involved_in IMP (MGI:3830400|PMID:19161227) BHF-UCL PMID:19161227 MGI:3830400 NCBI chr12:86,103,517...86,125,815
Ensembl chr12:86,103,519...86,125,815 		JBrowse link
superior endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfbr2 transforming growth factor, beta receptor II NOT|involved_in IMP (MGI:3801267|PMID:17050629) BHF-UCL PMID:17050629 MGI:3801267 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    developmental process 7369
      anatomical structure morphogenesis 3041
        tissue morphogenesis 720
          mesenchyme morphogenesis 59
            endocardial cushion morphogenesis 42
              apoptotic process involved in endocardial cushion morphogenesis 1
              cell proliferation involved in endocardial cushion morphogenesis 1
              endocardial cushion formation + 31
              endocardial cushion fusion 5
              inferior endocardial cushion morphogenesis 1
              superior endocardial cushion morphogenesis 1
Path 2
Term Annotations click to browse term
  biological_process 28573
    developmental process 7369
      anatomical structure development 6841
        multicellular organism development 5433
          system development 4660
            circulatory system development 1425
              heart development 756
                endocardial cushion development 54
                  endocardial cushion morphogenesis 42
                    apoptotic process involved in endocardial cushion morphogenesis 1
                    cell proliferation involved in endocardial cushion morphogenesis 1
                    endocardial cushion formation + 31
                    endocardial cushion fusion 5
                    inferior endocardial cushion morphogenesis 1
                    superior endocardial cushion morphogenesis 1
paths to the root