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ONTOLOGY REPORT - ANNOTATIONS

Term:endocardial cushion to mesenchymal transition involved in heart valve formation
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Accession:GO:0003199 term browser browse the term
Definition:A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.
Synonyms:exact_synonym: endocardial cushion to mesenchymal transition involved in valve formation


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endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EFNA1 ephrin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:42,373,197...42,381,161
Ensembl chr 7:42,373,639...42,378,946 		JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO (PMID:15680351) MGI PMID:15680351 NCBI chr29:27,185,191...27,188,121
Ensembl chr29:27,185,191...27,188,121 		JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:64,630,656...64,646,546 JBrowse link
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TWIST1 twist family bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22141
    developmental process 6924
      anatomical structure formation involved in morphogenesis 1373
        heart valve formation 16
          endocardial cushion to mesenchymal transition involved in heart valve formation 4
            negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 0
            positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 1
            regulation of endocardial cushion to mesenchymal transition involved in heart valve formation + 1
Path 2
Term Annotations click to browse term
  biological_process 22141
    developmental process 6924
      anatomical structure development 6488
        multicellular organism development 5248
          system development 4574
            circulatory system development 1376
              heart development 747
                heart valve development 74
                  heart valve morphogenesis 61
                    heart valve formation 16
                      endocardial cushion to mesenchymal transition involved in heart valve formation 4
                        negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 0
                        positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation 1
                        regulation of endocardial cushion to mesenchymal transition involved in heart valve formation + 1
paths to the root