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ONTOLOGY REPORT - ANNOTATIONS


Term:epithelial to mesenchymal transition involved in endocardial cushion formation
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Accession:GO:0003198 term browser browse the term
Definition:A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion.



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epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 NOT|involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761
JBrowse link
G ENG endoglin involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 9:127,815,012...127,854,773
Ensembl chr 9:127,815,013...127,854,658
JBrowse link
G FGF8 fibroblast growth factor 8 involved_in
acts_upstream_of_or_within
ISS
IEA
ISO
(MGI:5002778|PMID:21364285) BHF-UCL
Ensembl
BHF-UCL
MGI
PMID:21364285 GO_REF:0000024 GO_REF:0000107 MGI:5002778 NCBI chr10:101,770,109...101,780,369
Ensembl chr10:101,770,109...101,780,371
JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO (MGI:3783952|PMID:17303760) MGI PMID:17303760 MGI:3783952 NCBI chr 8:79,764,010...79,767,767
Ensembl chr 8:79,762,371...79,767,857
JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 involved_in TAS (PMID:20951801) BHF-UCL
BHF-UCL
PMID:20951801 NCBI chr 6:125,749,632...125,761,269
Ensembl chr 6:125,747,664...125,761,269
JBrowse link
G HEYL hes related family bHLH transcription factor with YRPW motif like involved_in
acts_upstream_of_or_within
ISS
TAS
IEA
ISO
(PMID:20951801)
(MGI:3783952|PMID:17303760)
UniProt
UniProt
BHF-UCL
Ensembl
MGI
BHF-UCL
PMID:17303760 PMID:20951801 GO_REF:0000024 GO_REF:0000107 MGI:3783952 NCBI chr 1:39,623,435...39,639,643
Ensembl chr 1:39,623,435...39,639,643
JBrowse link
G MSX1 msh homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3810851|PMID:18667074) Ensembl
Ensembl
MGI
PMID:18667074 GO_REF:0000107 MGI:3810851 NCBI chr 4:4,859,665...4,863,936
Ensembl chr 4:4,859,665...4,863,936
JBrowse link
G MSX2 msh homeobox 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3810851|PMID:18667074) MGI
Ensembl
Ensembl
PMID:18667074 GO_REF:0000107 MGI:3810851 NCBI chr 5:174,724,582...174,730,896
Ensembl chr 5:174,724,582...174,730,896
JBrowse link
G NOTCH1 notch receptor 1 involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 4:26,105,449...26,435,131
Ensembl chr 4:26,163,455...26,435,131
JBrowse link
G SMAD4 SMAD family member 4 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,394...51,085,045
JBrowse link
G SNAI1 snail family transcriptional repressor 1 involved_in ISS
TAS
IEA
(PMID:20951801) BHF-UCL
BHF-UCL
Ensembl
PMID:20951801 GO_REF:0000024 GO_REF:0000107 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in
acts_upstream_of_or_within
TAS
ISS
IEA
ISO
(PMID:20951801)
(MGI:3808643|PMID:18663143)
BHF-UCL
BHF-UCL
Ensembl
MGI
PMID:18663143 PMID:20951801 GO_REF:0000024 GO_REF:0000107 MGI:3808643 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740
JBrowse link
G TMEM100 transmembrane protein 100 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5613881|PMID:25318679) Ensembl
Ensembl
MGI
PMID:25318679 GO_REF:0000107 MGI:5613881 NCBI chr17:55,719,627...55,732,081
Ensembl chr17:55,719,627...55,732,121
JBrowse link
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOG noggin involved_in ISS
IEA
BHF-UCL
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr17:56,593,699...56,595,611
Ensembl chr17:56,593,699...56,595,611
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 2:157,736,446...157,876,330
Ensembl chr 2:157,736,251...157,876,330
JBrowse link
G ENG endoglin involved_in ISS
IEA
BHF-UCL
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr 9:127,815,012...127,854,773
Ensembl chr 9:127,815,013...127,854,658
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 involved_in ISS
IEA
BHF-UCL
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr 9:99,104,038...99,154,192
Ensembl chr 9:99,104,038...99,154,192
JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 involved_in ISS
IEA
BHF-UCL
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,601...30,694,142
JBrowse link
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFB1 transforming growth factor beta 1 NOT|involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TGFB3 transforming growth factor beta 3 NOT|involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19640
    developmental process 7522
      anatomical structure formation involved in morphogenesis 1428
        endocardial cushion formation 32
          epithelial to mesenchymal transition involved in endocardial cushion formation 21
            negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation 2
            positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation 5
            regulation of epithelial to mesenchymal transition involved in endocardial cushion formation + 8
Path 2
Term Annotations click to browse term
  biological_process 19640
    developmental process 7522
      anatomical structure development 6883
        multicellular organism development 5803
          system development 5332
            circulatory system development 1434
              heart development 760
                endocardial cushion development 55
                  endocardial cushion morphogenesis 41
                    endocardial cushion formation 32
                      epithelial to mesenchymal transition involved in endocardial cushion formation 21
                        negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation 2
                        positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation 5
                        regulation of epithelial to mesenchymal transition involved in endocardial cushion formation + 8
paths to the root