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ONTOLOGY REPORT - ANNOTATIONS

Term:epithelial to mesenchymal transition involved in endocardial cushion formation
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Accession:GO:0003198 term browser browse the term
Definition:A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion.


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epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 NOT|involved_in ISO (PMID:18924235) BHF-UCL PMID:18924235 NCBI chr 8:29,997,563...30,254,307
Ensembl chr 8:29,997,569...30,004,557 		JBrowse link
G ENG endoglin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:55,558,246...55,590,081
Ensembl chr 9:55,558,305...55,589,064 		JBrowse link
G FGF8 fibroblast growth factor 8 acts_upstream_of_or_within
involved_in		 IEA
ISO		 (PMID:19509466) Ensembl
BHF-UCL		 PMID:19509466 GO_REF:0000107 NCBI chr28:14,362,407...14,367,109
Ensembl chr28:14,362,109...14,367,468 		JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO (PMID:17303760) MGI PMID:17303760 NCBI chr29:27,185,191...27,188,121
Ensembl chr29:27,185,191...27,188,121 		JBrowse link
G HEYL hes related family bHLH transcription factor with YRPW motif like acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr15:3,242,738...3,257,275
Ensembl chr15:3,235,611...3,303,445 		JBrowse link
G MSX1 msh homeobox 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:70,232,790...70,236,295
Ensembl chr 3:70,232,052...70,236,447 		JBrowse link
G MSX2 msh homeobox 2 acts_upstream_of_or_within ISO (PMID:18667074) MGI PMID:18667074 NCBI chr 4:38,002,724...38,007,407
Ensembl chr 4:38,002,428...38,007,407 		JBrowse link
G NOTCH1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277 		JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:84,060,417...84,286,008
Ensembl chr 3:84,064,440...84,286,360 		JBrowse link
G SMAD4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:23,875,989...23,930,027
Ensembl chr 1:23,882,139...23,969,405 		JBrowse link
G SNAI1 snail family transcriptional repressor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:36,498,343...36,503,623
Ensembl chr24:36,498,062...36,503,628 		JBrowse link
G SNAI2 snail family transcriptional repressor 2 acts_upstream_of_or_within
involved_in		 ISO (PMID:18663143) MGI
BHF-UCL		 PMID:18663143 NCBI chr29:1,154,132...1,156,653
Ensembl chr29:1,154,036...1,156,653 		JBrowse link
G TMEM100 transmembrane protein 100 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:30,695,711...30,701,730
Ensembl chr 9:30,696,765...30,697,169 		JBrowse link
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFB2 transforming growth factor beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:13,430,832...13,511,655
Ensembl chr38:13,429,148...13,510,242 		JBrowse link
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENG endoglin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:55,558,246...55,590,081
Ensembl chr 9:55,558,305...55,589,064 		JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:13,430,832...13,511,655
Ensembl chr38:13,429,148...13,510,242 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:56,191,383...56,223,042
Ensembl chr11:56,161,772...56,218,594 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:13,886,869...13,946,480
Ensembl chr23:13,889,000...13,977,636 		JBrowse link
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B9D2 B9 domain containing 2 NOT|involved_in ISO (PMID:19161227) BHF-UCL PMID:19161227 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G TGFB3 transforming growth factor beta 3 NOT|involved_in ISO (PMID:19161227) BHF-UCL PMID:19161227 NCBI chr 8:48,920,874...48,946,037
Ensembl chr 8:48,923,423...48,945,816 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22141
    developmental process 6924
      anatomical structure formation involved in morphogenesis 1373
        endocardial cushion formation 32
          epithelial to mesenchymal transition involved in endocardial cushion formation 18
            negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation 1
            positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation 4
            regulation of epithelial to mesenchymal transition involved in endocardial cushion formation + 6
Path 2
Term Annotations click to browse term
  biological_process 22141
    developmental process 6924
      anatomical structure development 6488
        multicellular organism development 5248
          system development 4574
            circulatory system development 1376
              heart development 747
                endocardial cushion development 56
                  endocardial cushion morphogenesis 44
                    endocardial cushion formation 32
                      epithelial to mesenchymal transition involved in endocardial cushion formation 18
                        negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation 1
                        positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation 4
                        regulation of epithelial to mesenchymal transition involved in endocardial cushion formation + 6
paths to the root