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ONTOLOGY REPORT - ANNOTATIONS


Term:epithelial to mesenchymal transition involved in endocardial cushion formation
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Accession:GO:0003198 term browser browse the term
Definition:A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion.



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epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 NOT|involved_in ISO (MGI:3814273|PMID:18924235) RGD PMID:18924235 MGI:3814273 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Eng endoglin involved_in ISO (MGI:4368063|PMID:19703439) RGD PMID:19703439 MGI:4368063 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Fgf8 fibroblast growth factor 8 involved_in
acts_upstream_of_or_within
ISO (MGI:4359139|PMID:19509466)
(MGI:5002778|PMID:21364285)
RGD PMID:19509466 PMID:21364285 MGI:4359139 MGI:5002778 NCBI chr 1:244,584,477...244,590,359
Ensembl chr 1:244,584,652...244,590,359
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO MGI:1860511 (MGI:3783952|PMID:17303760) RGD PMID:17303760 MGI:3783952 NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312
JBrowse link
G Heyl hes-related family bHLH transcription factor with YRPW motif-like acts_upstream_of_or_within ISO MGI:1341800 (MGI:3783952|PMID:17303760) RGD PMID:17303760 MGI:3783952 NCBI chr 5:135,508,160...135,525,152
Ensembl chr 5:135,508,160...135,525,152
JBrowse link
G Msx1 msh homeobox 1 acts_upstream_of_or_within ISO MGI:97169 (MGI:3810851|PMID:18667074) RGD PMID:18667074 MGI:3810851 NCBI chr14:72,961,170...72,964,970
Ensembl chr14:72,961,148...72,964,966
JBrowse link
G Msx2 msh homeobox 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:97168 (MGI:3810851|PMID:18667074)
Ensembl
RGD
PMID:18667074 GO_REF:0000107 MGI:3810851 NCBI chr17:11,097,214...11,102,879
Ensembl chr17:11,097,103...11,102,879
JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:3027664|PMID:14701881) RGD PMID:14701881 MGI:3027664 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (MGI:3027664|PMID:14701881) RGD PMID:14701881 MGI:3027664 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO
GO_REF:0000107
(MGI:4946551|PMID:21330551)
Ensembl
RGD
PMID:21330551 GO_REF:0000107 MGI:4946551 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Snai1 snail family transcriptional repressor 1 involved_in ISO UniProtKB:Q3UZ96 (MGI:3808643|PMID:18663143) RGD PMID:18663143 MGI:3808643 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 acts_upstream_of_or_within ISO MGI:2447175 (MGI:3808643|PMID:18663143) RGD PMID:18663143 MGI:3808643 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Tmem100 transmembrane protein 100 acts_upstream_of_or_within ISO MGI:5432904 (MGI:5613881|PMID:25318679) RGD PMID:25318679 MGI:5613881 NCBI chr10:74,854,779...74,861,147
Ensembl chr10:74,854,468...74,862,941
JBrowse link
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nog noggin involved_in IEA
ISO
GO_REF:0000107
(MGI:3783944|PMID:17218603)
Ensembl
RGD
PMID:17218603 GO_REF:0000107 MGI:3783944 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO (MGI:3830400|PMID:19161227) RGD PMID:19161227 MGI:3830400 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in ISO (MGI:3610266|PMID:16140292) RGD PMID:16140292 MGI:3610266 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241
JBrowse link
G Eng endoglin involved_in ISO (MGI:4368063|PMID:19703439) RGD PMID:19703439 MGI:4368063 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO (MGI:3830400|PMID:19161227) RGD PMID:19161227 MGI:3830400 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in ISO (MGI:3820811|PMID:18718461) RGD PMID:18718461 MGI:3820811 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 involved_in ISO (MGI:3801267|PMID:17050629) RGD PMID:17050629 MGI:3801267 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb1 transforming growth factor, beta 1 NOT|involved_in ISO (MGI:3830400|PMID:19161227) RGD PMID:19161227 MGI:3830400 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb3 transforming growth factor, beta 3 NOT|involved_in ISO (MGI:3830400|PMID:19161227) RGD PMID:19161227 MGI:3830400 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    developmental process 6893
      anatomical structure formation involved in morphogenesis 1332
        endocardial cushion formation 31
          epithelial to mesenchymal transition involved in endocardial cushion formation 20
            negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation 2
            positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation 5
            regulation of epithelial to mesenchymal transition involved in endocardial cushion formation + 8
Path 2
Term Annotations click to browse term
  biological_process 18734
    developmental process 6893
      anatomical structure development 6368
        multicellular organism development 5437
          system development 4939
            circulatory system development 1324
              heart development 716
                endocardial cushion development 54
                  endocardial cushion morphogenesis 41
                    endocardial cushion formation 31
                      epithelial to mesenchymal transition involved in endocardial cushion formation 20
                        negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation 2
                        positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation 5
                        regulation of epithelial to mesenchymal transition involved in endocardial cushion formation + 8
paths to the root