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ONTOLOGY REPORT - ANNOTATIONS


Term:endocardial cushion development
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Accession:GO:0003197 term browser browse the term
Definition:The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.



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endocardial cushion development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,134...183,792,417
JBrowse link
G BMPR2 bone morphogenetic protein receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:105,971,577...106,132,496
Ensembl chr15:105,970,427...106,135,730
JBrowse link
G CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3574743|PMID:15750185) Ensembl
MGI
PMID:15750185 GO_REF:0000107 MGI:3574743 NCBI chr 1:25,155,652...25,158,517
Ensembl chr 1:25,155,664...25,160,279
JBrowse link
G EPHA3 EPH receptor A3 involved_in ISO (MGI:3703403|PMID:17046737) UniProt PMID:17046737 MGI:3703403 NCBI chr13:166,592,492...166,942,791
Ensembl chr13:166,591,686...166,942,767
JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1194988|PMID:9362461) Ensembl
MGI
PMID:9362461 GO_REF:0000107 MGI:1194988 NCBI chr 5:21,474,218...21,495,040
Ensembl chr 5:21,431,656...21,496,279
JBrowse link
G ERG ETS transcription factor ERG acts_upstream_of_or_within ISO (MGI:5442628|PMID:22932696) MGI PMID:22932696 MGI:5442628 NCBI chr13:201,999,237...202,302,572
Ensembl chr13:202,000,985...202,302,577
JBrowse link
G FOXF1 forkhead box F1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:2,579,348...2,598,122
Ensembl chr 6:2,592,993...2,597,659
JBrowse link
G GATA4 GATA binding protein 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3833786|PMID:19084512) Ensembl
MGI
PMID:19084512 GO_REF:0000107 MGI:3833786 NCBI chr14:14,858,470...14,938,156
Ensembl chr14:14,858,159...14,939,941
JBrowse link
G NEDD4 NEDD4 E3 ubiquitin protein ligase acts_upstream_of_or_within ISO (MGI:4452597|PMID:20026598) MGI PMID:20026598 MGI:4452597 NCBI chr 1:115,941,945...116,069,884
Ensembl chr 1:115,941,937...116,070,317
JBrowse link
G NFATC1 nuclear factor of activated T cells 1 involved_in ISO (MGI:5319103|PMID:22300732) BHF-UCL PMID:22300732 MGI:5319103 NCBI chr 1:145,940,099...146,002,897
Ensembl chr 1:145,911,045...146,017,701
JBrowse link
G NOTCH1 notch receptor 1 acts_upstream_of_or_within ISO (MGI:3027664|PMID:14701881) MGI PMID:14701881 MGI:3027664
G RBM24 RNA binding motif protein 24 involved_in ISO (MGI:6149097|PMID:29358667) UniProt PMID:29358667 MGI:6149097 NCBI chr 7:13,126,518...13,139,504 JBrowse link
G TBX5 T-box transcription factor 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3833786|PMID:19084512) Ensembl
MGI
PMID:19084512 GO_REF:0000107 MGI:3833786 NCBI chr14:37,772,205...37,826,015
Ensembl chr14:37,773,605...37,824,400
JBrowse link
G THBS1 thrombospondin 1 acts_upstream_of_or_within ISO (MGI:4452597|PMID:20026598) MGI PMID:20026598 MGI:4452597 NCBI chr 1:131,728,781...131,746,098
Ensembl chr 1:131,728,781...131,746,115
JBrowse link
G TMEM100 transmembrane protein 100 acts_upstream_of_or_within ISO (MGI:5613881|PMID:25318679) MGI PMID:25318679 MGI:5613881 NCBI chr12:32,008,007...32,014,094
Ensembl chr12:32,008,007...32,013,981
JBrowse link
apoptotic process involved in endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 NOT|involved_in ISO (MGI:3814273|PMID:18924235) BHF-UCL PMID:18924235 MGI:3814273 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,134...183,792,417
JBrowse link
cell migration involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DCHS1 dachsous cadherin-related 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:3,099,525...3,134,825
Ensembl chr 9:3,113,451...3,134,821
JBrowse link
G ENG endoglin involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4368063|PMID:19703439) Ensembl
MGI
PMID:19703439 GO_REF:0000107 MGI:4368063 NCBI chr 1:268,309,379...268,343,861
Ensembl chr 1:268,306,120...268,343,827
JBrowse link
G NOTCH1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107
G SNAI2 snail family transcriptional repressor 2 involved_in ISO (MGI:3808643|PMID:18663143) BHF-UCL PMID:18663143 MGI:3808643 NCBI chr 4:79,264,880...79,268,475
Ensembl chr 4:79,264,878...79,268,475
JBrowse link
cell proliferation involved in endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFBR2 transforming growth factor beta receptor 2 NOT|involved_in ISO (MGI:4821522|PMID:20652948) BHF-UCL PMID:20652948 MGI:4821522 NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,491...16,878,165
JBrowse link
endocardial cushion cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G JAG1 jagged canonical Notch ligand 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:19,591,248...19,629,659
Ensembl chr17:19,591,252...19,630,085
JBrowse link
endocardial cushion cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:64,749,478...64,891,653
Ensembl chr15:64,748,761...64,892,153
JBrowse link
endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLNR apelin receptor involved_in ISO (MGI:5584055|PMID:23603510) BHF-UCL PMID:23603510 MGI:5584055
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:15,750,487...15,762,982
Ensembl chr17:15,749,835...15,761,215
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in ISO (MGI:1332253|PMID:10079236) BHF-UCL PMID:10079236 MGI:1332253 NCBI chr 7:25,344,924...25,468,430
Ensembl chr 7:25,344,822...25,470,470
JBrowse link
G BMP7 bone morphogenetic protein 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:57,567,770...57,676,516
Ensembl chr17:57,584,091...57,676,944
JBrowse link
G BMPR1A bone morphogenetic protein receptor type 1A involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3611958|PMID:16314491) Ensembl
MGI
PMID:16314491 GO_REF:0000107 MGI:3611958 NCBI chr14:87,743,270...87,891,790
Ensembl chr14:87,742,459...87,891,793
JBrowse link
G ROBO1 roundabout guidance receptor 1 involved_in ISO (MGI:5913048|PMID:25691540) BHF-UCL PMID:25691540 MGI:5913048 NCBI chr13:175,348,223...176,479,482
Ensembl chr13:175,505,366...176,479,482
JBrowse link
G ROBO2 roundabout guidance receptor 2 involved_in ISO (MGI:5913048|PMID:25691540) BHF-UCL PMID:25691540 MGI:5913048 NCBI chr13:177,365,712...179,040,027
Ensembl chr13:177,365,717...179,013,542
JBrowse link
G TBX2 T-box transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:36,878,662...36,887,513
Ensembl chr12:36,878,675...36,887,513
JBrowse link
G TBX20 T-box transcription factor 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:38,635,603...38,681,690
Ensembl chr18:38,635,617...38,677,208
JBrowse link
G TBX3 T-box transcription factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:37,582,704...37,596,767
Ensembl chr14:37,582,822...37,596,767
JBrowse link
endocardial cushion fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:64,749,478...64,891,653
Ensembl chr15:64,748,761...64,892,153
JBrowse link
G GATA5 GATA binding protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:61,824,891...61,834,742
Ensembl chr17:61,824,899...61,834,267
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISO (MGI:3609313|PMID:11390347) BHF-UCL PMID:11390347 MGI:3609313 NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,424...8,405,771
JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,491...16,878,165
JBrowse link
endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 involved_in ISO (MGI:3610266|PMID:16140292) BHF-UCL PMID:16140292 MGI:3610266 NCBI chr15:64,749,478...64,891,653
Ensembl chr15:64,748,761...64,892,153
JBrowse link
G ACVRL1 activin A receptor like type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:17,267,483...17,284,155
Ensembl chr 5:17,263,907...17,286,276
JBrowse link
G BMP2 bone morphogenetic protein 2 involved_in
acts_upstream_of_or_within
ISO (MGI:4837019|PMID:20890042)
(MGI:3611958|PMID:16314491)
BHF-UCL
MGI
PMID:16314491 PMID:20890042 MGI:3611958 MGI:4837019 NCBI chr17:15,750,487...15,762,982
Ensembl chr17:15,749,835...15,761,215
JBrowse link
G BMPR1A bone morphogenetic protein receptor type 1A involved_in ISO (MGI:2175930|PMID:11854453), (MGI:3040576|PMID:15073157) BHF-UCL PMID:11854453 PMID:15073157 MGI:2175930 MGI:3040576 NCBI chr14:87,743,270...87,891,790
Ensembl chr14:87,742,459...87,891,793
JBrowse link
G ENG endoglin involved_in ISO (MGI:2674189|PMID:12941632), (MGI:4368063|PMID:19703439) BHF-UCL PMID:12941632 PMID:19703439 MGI:2674189 MGI:4368063 NCBI chr 1:268,309,379...268,343,861
Ensembl chr 1:268,306,120...268,343,827
JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 involved_in ISO (MGI:3783952|PMID:17303760) BHF-UCL PMID:17303760 MGI:3783952 NCBI chr 4:56,859,640...56,863,807
Ensembl chr 4:56,859,663...56,863,789
JBrowse link
G HEYL hes related family bHLH transcription factor with YRPW motif like involved_in ISO (MGI:3783952|PMID:17303760) BHF-UCL PMID:17303760 MGI:3783952 NCBI chr 6:95,442,655...95,459,597
Ensembl chr 6:95,442,661...95,459,575
JBrowse link
G ISL1 ISL LIM homeobox 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:30,962,994...30,974,201
Ensembl chr16:30,963,000...30,973,907
JBrowse link
G MDM2 MDM2 proto-oncogene involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5440773|PMID:22821713) Ensembl
MGI
PMID:22821713 GO_REF:0000107 MGI:5440773 NCBI chr 5:33,105,717...33,137,602
Ensembl chr 5:33,086,994...33,178,089
JBrowse link
G MDM4 MDM4 regulator of p53 acts_upstream_of_or_within ISO (MGI:5440773|PMID:22821713) MGI PMID:22821713 MGI:5440773 NCBI chr 9:65,175,488...65,219,747
Ensembl chr 9:65,175,377...65,223,132
JBrowse link
G NOG noggin involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:32,891,321...32,892,206
Ensembl chr12:32,891,321...32,892,206
JBrowse link
G NOS3 nitric oxide synthase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
G NOTCH1 notch receptor 1 involved_in ISO (MGI:3027664|PMID:14701881)
(MGI:6158784|PMID:27107132)
BHF-UCL PMID:14701881 PMID:27107132 MGI:3027664 MGI:6158784
G SOX9 SRY-box transcription factor 9 involved_in
acts_upstream_of_or_within
IEA
ISO
ISS
(MGI:3709802|PMID:11951052) Ensembl
MGI
UniProt
PMID:11951052 GO_REF:0000024 GO_REF:0000107 MGI:3709802 NCBI chr12:8,642,154...8,647,315
Ensembl chr12:8,642,158...8,647,315
JBrowse link
G TBX2 T-box transcription factor 2 involved_in ISO (MGI:3487212|PMID:15459098) BHF-UCL PMID:15459098 MGI:3487212 NCBI chr12:36,878,662...36,887,513
Ensembl chr12:36,878,675...36,887,513
JBrowse link
G TBX20 T-box transcription factor 20 involved_in ISO (MGI:3579960|PMID:15901664) BHF-UCL PMID:15901664 MGI:3579960 NCBI chr18:38,635,603...38,681,690
Ensembl chr18:38,635,617...38,677,208
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISO (MGI:3609313|PMID:11390347), (MGI:3830400|PMID:19161227) BHF-UCL PMID:11390347 PMID:19161227 MGI:3609313 MGI:3830400 NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,424...8,405,771
JBrowse link
G TWIST1 twist family bHLH transcription factor 1 acts_upstream_of_or_within ISO (MGI:3805126|PMID:18539270) MGI PMID:18539270 MGI:3805126 NCBI chr 9:88,286,911...88,290,131 JBrowse link
epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 NOT|involved_in ISO (MGI:3814273|PMID:18924235) BHF-UCL PMID:18924235 MGI:3814273 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,134...183,792,417
JBrowse link
G ENG endoglin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:268,309,379...268,343,861
Ensembl chr 1:268,306,120...268,343,827
JBrowse link
G FGF8 fibroblast growth factor 8 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5002778|PMID:21364285) Ensembl
MGI
PMID:21364285 GO_REF:0000107 MGI:5002778 NCBI chr14:112,808,215...112,814,225
Ensembl chr14:112,808,210...112,814,134
JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO (MGI:3783952|PMID:17303760) MGI PMID:17303760 MGI:3783952 NCBI chr 4:56,859,640...56,863,807
Ensembl chr 4:56,859,663...56,863,789
JBrowse link
G HEYL hes related family bHLH transcription factor with YRPW motif like involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3783952|PMID:17303760) Ensembl
MGI
PMID:17303760 GO_REF:0000107 MGI:3783952 NCBI chr 6:95,442,655...95,459,597
Ensembl chr 6:95,442,661...95,459,575
JBrowse link
G MSX1 msh homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3810851|PMID:18667074) Ensembl
MGI
PMID:18667074 GO_REF:0000107 MGI:3810851 NCBI chr 8:5,628,381...5,632,375
Ensembl chr 8:5,628,377...5,632,608
JBrowse link
G MSX2 msh homeobox 2 acts_upstream_of_or_within ISO (MGI:3810851|PMID:18667074) MGI PMID:18667074 MGI:3810851 NCBI chr16:49,765,587...49,771,745
Ensembl chr16:49,766,897...49,771,634
JBrowse link
G NOTCH1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107
G RBPJ recombination signal binding protein for immunoglobulin kappa J region involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:19,933,035...20,166,746
Ensembl chr 8:19,922,779...20,166,755
JBrowse link
G SMAD4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,514,791...100,628,029
JBrowse link
G SNAI1 snail family transcriptional repressor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:51,546,446...51,552,498
Ensembl chr17:51,546,393...51,552,504
JBrowse link
G SNAI2 snail family transcriptional repressor 2 acts_upstream_of_or_within ISO (MGI:3808643|PMID:18663143) MGI PMID:18663143 MGI:3808643 NCBI chr 4:79,264,880...79,268,475
Ensembl chr 4:79,264,878...79,268,475
JBrowse link
G TMEM100 transmembrane protein 100 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5613881|PMID:25318679) Ensembl
MGI
PMID:25318679 GO_REF:0000107 MGI:5613881 NCBI chr12:32,008,007...32,014,094
Ensembl chr12:32,008,007...32,013,981
JBrowse link
inferior endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFBR2 transforming growth factor beta receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,491...16,878,165
JBrowse link
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOG noggin involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:32,891,321...32,892,206
Ensembl chr12:32,891,321...32,892,206
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISO (MGI:3830400|PMID:19161227) BHF-UCL PMID:19161227 MGI:3830400 NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,424...8,405,771
JBrowse link
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:64,749,478...64,891,653
Ensembl chr15:64,748,761...64,892,153
JBrowse link
G ENG endoglin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:268,309,379...268,343,861
Ensembl chr 1:268,306,120...268,343,827
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISO (MGI:3830400|PMID:19161227) BHF-UCL PMID:19161227 MGI:3830400 NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,424...8,405,771
JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:240,842,735...240,918,267
Ensembl chr 1:240,859,270...240,918,528
JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,491...16,878,165
JBrowse link
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFB1 transforming growth factor beta 1 NOT|involved_in ISO (MGI:3830400|PMID:19161227) BHF-UCL PMID:19161227 MGI:3830400 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
G TGFB3 transforming growth factor beta 3 NOT|involved_in ISO (MGI:3830400|PMID:19161227) BHF-UCL PMID:19161227 MGI:3830400 NCBI chr 7:99,133,873...99,162,239
Ensembl chr 7:99,133,511...99,162,232
JBrowse link
superior endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFBR2 transforming growth factor beta receptor 2 NOT|involved_in ISO (MGI:3801267|PMID:17050629) BHF-UCL PMID:17050629 MGI:3801267 NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,491...16,878,165
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16581
    developmental process 6319
      anatomical structure development 5836
        tissue development 1995
          mesenchyme development 291
            endocardial cushion development 52
              endocardial cushion cell differentiation + 2
              endocardial cushion morphogenesis + 39
Path 2
Term Annotations click to browse term
  biological_process 16581
    developmental process 6319
      anatomical structure development 5836
        multicellular organism development 5308
          system development 4999
            circulatory system development 1203
              heart development 679
                endocardial cushion development 52
                  endocardial cushion cell differentiation + 2
                  endocardial cushion morphogenesis + 39
paths to the root