Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:endocardial cushion development
go back to main search page
Accession:GO:0003197 term browser browse the term
Definition:The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.



show annotations for term's descendants           Sort by:
 
endocardial cushion development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761
JBrowse link
G BMPR2 bone morphogenetic protein receptor type 2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 2:202,376,310...202,567,751
Ensembl chr 2:202,376,327...202,567,751
JBrowse link
G CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3574743|PMID:15750185) Ensembl
MGI
PMID:15750185 GO_REF:0000107 MGI:3574743 NCBI chr 6:139,371,807...139,374,648
Ensembl chr 6:139,371,807...139,374,648
JBrowse link
G CRELD1 cysteine rich with EGF like domains 1 involved_in TAS (PMID:18076106) BHF-UCL PMID:18076106 NCBI chr 3:9,933,788...9,945,406
Ensembl chr 3:9,933,793...9,945,413
JBrowse link
G EPHA3 EPH receptor A3 involved_in ISO (MGI:3703403|PMID:17046737) UniProt PMID:17046737 MGI:3703403 NCBI chr 3:89,107,621...89,482,134
Ensembl chr 3:89,107,621...89,482,134
JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 acts_upstream_of_or_within ISO (MGI:1194988|PMID:9362461) MGI PMID:9362461 MGI:1194988 NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505
JBrowse link
G ERG ETS transcription factor ERG acts_upstream_of_or_within ISO (MGI:5442628|PMID:22932696) MGI PMID:22932696 MGI:5442628 NCBI chr21:38,367,261...38,661,783
Ensembl chr21:38,380,027...38,661,780
JBrowse link
G FOXF1 forkhead box F1 involved_in IMP (PMID:19500772) DFLAT PMID:19500772 NCBI chr16:86,510,527...86,515,422
Ensembl chr16:86,510,527...86,515,422
JBrowse link
G GATA4 GATA binding protein 4 involved_in
acts_upstream_of_or_within
IMP
ISO
ISS
(PMID:21330551)
(MGI:3833786|PMID:19084512)
BHF-UCL
MGI
PMID:19084512 PMID:21330551 GO_REF:0000024 MGI:3833786 NCBI chr 8:11,676,935...11,760,002
Ensembl chr 8:11,676,959...11,760,002
JBrowse link
G NEDD4 NEDD4 E3 ubiquitin protein ligase acts_upstream_of_or_within ISO (MGI:4452597|PMID:20026598) MGI PMID:20026598 MGI:4452597 NCBI chr15:55,826,917...55,993,612
Ensembl chr15:55,826,922...55,993,660
JBrowse link
G NFATC1 nuclear factor of activated T cells 1 involved_in ISO (MGI:5319103|PMID:22300732) BHF-UCL PMID:22300732 MGI:5319103 NCBI chr18:79,395,930...79,529,323
Ensembl chr18:79,395,856...79,529,325
JBrowse link
G NOTCH1 notch receptor 1 acts_upstream_of_or_within ISO (MGI:3027664|PMID:14701881) MGI PMID:14701881 MGI:3027664 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G RBM24 RNA binding motif protein 24 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:17,281,361...17,293,875
Ensembl chr 6:17,281,361...17,293,871
JBrowse link
G TBX5 T-box transcription factor 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3833786|PMID:19084512) Ensembl
MGI
PMID:19084512 GO_REF:0000107 MGI:3833786 NCBI chr12:114,353,911...114,408,708
Ensembl chr12:114,353,911...114,408,442
JBrowse link
G THBS1 thrombospondin 1 acts_upstream_of_or_within ISO (MGI:4452597|PMID:20026598) MGI PMID:20026598 MGI:4452597 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466
JBrowse link
G TMEM100 transmembrane protein 100 acts_upstream_of_or_within ISO (MGI:5613881|PMID:25318679) MGI PMID:25318679 MGI:5613881 NCBI chr17:55,719,627...55,732,081
Ensembl chr17:55,719,627...55,732,121
JBrowse link
apoptotic process involved in endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 NOT|involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761
JBrowse link
cell migration involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DCHS1 dachsous cadherin-related 1 involved_in IMP (PMID:26258302) UniProt PMID:26258302 NCBI chr11:6,621,330...6,655,809
Ensembl chr11:6,621,330...6,655,809
JBrowse link
G ENG endoglin involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4368063|PMID:19703439) Ensembl
MGI
PMID:19703439 GO_REF:0000107 MGI:4368063 NCBI chr 9:127,815,012...127,854,773
Ensembl chr 9:127,815,013...127,854,658
JBrowse link
G NOTCH1 notch receptor 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740
JBrowse link
cell proliferation involved in endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFBR2 transforming growth factor beta receptor 2 NOT|involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 3:30,606,472...30,694,142
Ensembl chr 3:30,606,601...30,694,142
JBrowse link
endocardial cushion cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G JAG1 jagged canonical Notch ligand 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr20:10,637,684...10,673,999
Ensembl chr20:10,637,684...10,673,999
JBrowse link
endocardial cushion cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 involved_in IMP (PMID:19506109) BHF-UCL PMID:19506109 NCBI chr 2:157,736,446...157,876,330
Ensembl chr 2:157,736,251...157,876,330
JBrowse link
endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLNR apelin receptor involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr11:57,233,591...57,237,250
Ensembl chr11:57,233,577...57,237,235
JBrowse link
G BMP2 bone morphogenetic protein 2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 6:55,753,653...55,875,590
Ensembl chr 6:55,753,653...55,875,590
JBrowse link
G BMP7 bone morphogenetic protein 7 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr20:57,168,753...57,266,641
Ensembl chr20:57,168,753...57,266,641
JBrowse link
G BMPR1A bone morphogenetic protein receptor type 1A involved_in
acts_upstream_of_or_within
ISS
ISO
(MGI:3611958|PMID:16314491) BHF-UCL
MGI
PMID:16314491 GO_REF:0000024 MGI:3611958 NCBI chr10:86,755,786...86,927,969
Ensembl chr10:86,756,601...86,932,825
JBrowse link
G ROBO1 roundabout guidance receptor 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 3:78,597,239...79,767,998
Ensembl chr 3:78,597,239...79,767,998
JBrowse link
G ROBO2 roundabout guidance receptor 2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 3:75,906,675...77,649,964
Ensembl chr 3:75,906,695...77,649,964
JBrowse link
G TBX2 T-box transcription factor 2 involved_in IMP (PMID:22130515) BHF-UCL PMID:22130515 NCBI chr17:61,399,843...61,409,466
Ensembl chr17:61,399,843...61,409,466
JBrowse link
G TBX20 T-box transcription factor 20 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 7:35,199,936...35,254,100
Ensembl chr 7:35,202,430...35,254,100
JBrowse link
G TBX3 T-box transcription factor 3 involved_in IMP (PMID:22130515) BHF-UCL PMID:22130515 NCBI chr12:114,670,255...114,684,175
Ensembl chr12:114,670,255...114,684,175
JBrowse link
endocardial cushion fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 2:157,736,446...157,876,330
Ensembl chr 2:157,736,251...157,876,330
JBrowse link
G GATA5 GATA binding protein 5 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr20:62,463,497...62,475,995
Ensembl chr20:62,463,497...62,475,995
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 3:30,606,472...30,694,142
Ensembl chr 3:30,606,601...30,694,142
JBrowse link
endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 2:157,736,446...157,876,330
Ensembl chr 2:157,736,251...157,876,330
JBrowse link
G ACVRL1 activin A receptor like type 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr12:51,906,913...51,923,361
Ensembl chr12:51,906,908...51,923,361
JBrowse link
G BMP2 bone morphogenetic protein 2 involved_in
acts_upstream_of_or_within
ISS
ISO
(MGI:3611958|PMID:16314491) UniProt
MGI
PMID:16314491 GO_REF:0000024 MGI:3611958 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
JBrowse link
G BMPR1A bone morphogenetic protein receptor type 1A involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr10:86,755,786...86,927,969
Ensembl chr10:86,756,601...86,932,825
JBrowse link
G ENG endoglin involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 9:127,815,012...127,854,773
Ensembl chr 9:127,815,013...127,854,658
JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 8:79,764,010...79,767,767
Ensembl chr 8:79,762,371...79,767,857
JBrowse link
G HEYL hes related family bHLH transcription factor with YRPW motif like involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 1:39,623,435...39,639,643
Ensembl chr 1:39,623,435...39,639,643
JBrowse link
G ISL1 ISL LIM homeobox 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 5:51,383,448...51,394,730
Ensembl chr 5:51,383,448...51,394,730
JBrowse link
G MDM2 MDM2 proto-oncogene involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5440773|PMID:22821713) Ensembl
MGI
PMID:22821713 GO_REF:0000107 MGI:5440773 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,845,544
JBrowse link
G MDM4 MDM4 regulator of p53 acts_upstream_of_or_within ISS BHF-UCL GO_REF:0000024 NCBI chr 1:204,516,377...204,558,120
Ensembl chr 1:204,516,379...204,558,120
JBrowse link
G NOG noggin involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr17:56,593,699...56,595,611
Ensembl chr17:56,593,699...56,595,611
JBrowse link
G NOS3 nitric oxide synthase 3 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G NOTCH1 notch receptor 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G SOX9 SRY-box transcription factor 9 involved_in
acts_upstream_of_or_within
ISS
ISO
(MGI:3709802|PMID:11951052) UniProt
MGI
PMID:11951052 GO_REF:0000024 MGI:3709802 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416
JBrowse link
G TBX2 T-box transcription factor 2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr17:61,399,843...61,409,466
Ensembl chr17:61,399,843...61,409,466
JBrowse link
G TBX20 T-box transcription factor 20 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 7:35,199,936...35,254,100
Ensembl chr 7:35,202,430...35,254,100
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G TWIST1 twist family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3805126|PMID:18539270) Ensembl
MGI
PMID:18539270 GO_REF:0000107 MGI:3805126 NCBI chr 7:19,113,047...19,117,636
Ensembl chr 7:19,020,991...19,117,636
JBrowse link
epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 NOT|involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761
JBrowse link
G ENG endoglin involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 9:127,815,012...127,854,773
Ensembl chr 9:127,815,013...127,854,658
JBrowse link
G FGF8 fibroblast growth factor 8 involved_in
acts_upstream_of_or_within
ISS
ISO
(MGI:5002778|PMID:21364285) BHF-UCL
MGI
PMID:21364285 GO_REF:0000024 MGI:5002778 NCBI chr10:101,770,109...101,780,369
Ensembl chr10:101,770,109...101,780,371
JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO (MGI:3783952|PMID:17303760) MGI PMID:17303760 MGI:3783952 NCBI chr 8:79,764,010...79,767,767
Ensembl chr 8:79,762,371...79,767,857
JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 involved_in TAS (PMID:20951801) BHF-UCL PMID:20951801 NCBI chr 6:125,747,639...125,762,243
Ensembl chr 6:125,747,664...125,761,269
JBrowse link
G HEYL hes related family bHLH transcription factor with YRPW motif like involved_in
acts_upstream_of_or_within
ISS
ISO
TAS
(MGI:3783952|PMID:17303760)
(PMID:20951801)
UniProt
MGI
BHF-UCL
PMID:17303760 PMID:20951801 GO_REF:0000024 MGI:3783952 NCBI chr 1:39,623,435...39,639,643
Ensembl chr 1:39,623,435...39,639,643
JBrowse link
G MSX1 msh homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3810851|PMID:18667074) Ensembl
MGI
PMID:18667074 GO_REF:0000107 MGI:3810851 NCBI chr 4:4,859,665...4,863,936
Ensembl chr 4:4,859,665...4,863,936
JBrowse link
G MSX2 msh homeobox 2 acts_upstream_of_or_within ISO (MGI:3810851|PMID:18667074) MGI PMID:18667074 MGI:3810851 NCBI chr 5:174,724,582...174,730,896
Ensembl chr 5:174,724,582...174,730,896
JBrowse link
G NOTCH1 notch receptor 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 4:26,163,458...26,435,131
Ensembl chr 4:26,163,455...26,435,131
JBrowse link
G SMAD4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,394...51,085,045
JBrowse link
G SNAI1 snail family transcriptional repressor 1 involved_in ISS
TAS
(PMID:20951801) BHF-UCL PMID:20951801 GO_REF:0000024 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in
acts_upstream_of_or_within
TAS
ISO
ISS
(PMID:20951801)
(MGI:3808643|PMID:18663143)
BHF-UCL
MGI
PMID:18663143 PMID:20951801 GO_REF:0000024 MGI:3808643 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740
JBrowse link
G TMEM100 transmembrane protein 100 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5613881|PMID:25318679) Ensembl
MGI
PMID:25318679 GO_REF:0000107 MGI:5613881 NCBI chr17:55,719,627...55,732,081
Ensembl chr17:55,719,627...55,732,121
JBrowse link
inferior endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFBR2 transforming growth factor beta receptor 2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 3:30,606,472...30,694,142
Ensembl chr 3:30,606,601...30,694,142
JBrowse link
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOG noggin involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr17:56,593,699...56,595,611
Ensembl chr17:56,593,699...56,595,611
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 2:157,736,446...157,876,330
Ensembl chr 2:157,736,251...157,876,330
JBrowse link
G ENG endoglin involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 9:127,815,012...127,854,773
Ensembl chr 9:127,815,013...127,854,658
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 9:99,104,038...99,154,192
Ensembl chr 9:99,104,038...99,154,192
JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 3:30,606,472...30,694,142
Ensembl chr 3:30,606,601...30,694,142
JBrowse link
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFB1 transforming growth factor beta 1 NOT|involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TGFB3 transforming growth factor beta 3 NOT|involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011
JBrowse link
superior endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFBR2 transforming growth factor beta receptor 2 NOT|involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 3:30,606,472...30,694,142
Ensembl chr 3:30,606,601...30,694,142
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18539
    developmental process 7231
      anatomical structure development 6554
        tissue development 2229
          mesenchyme development 317
            endocardial cushion development 54
              endocardial cushion cell differentiation + 2
              endocardial cushion morphogenesis + 40
Path 2
Term Annotations click to browse term
  biological_process 18539
    developmental process 7231
      anatomical structure development 6554
        multicellular organism development 5926
          system development 5600
            circulatory system development 1309
              heart development 727
                endocardial cushion development 54
                  endocardial cushion cell differentiation + 2
                  endocardial cushion morphogenesis + 40
paths to the root