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ONTOLOGY REPORT - ANNOTATIONS


Term:heart valve morphogenesis
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Accession:GO:0003179 term browser browse the term
Definition:The process in which the structure of a heart valve is generated and organized.
Synonyms:narrow_synonym: heart valve remodeling;   heart valve remodelling


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heart valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif 9 involved_in ISO (MGI:4452308|PMID:20096780) BHF-UCL PMID:20096780 MGI:4452308 NCBI chrNW_004936637:1,787,987...1,946,250 JBrowse link
G Fgfrl1 fibroblast growth factor receptor like 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3848851|PMID:19383940) MGI
Ensembl
PMID:19383940 GO_REF:0000107 MGI:3848851 NCBI chrNW_004936477:22,177,473...22,189,554 JBrowse link
G Mtor mechanistic target of rapamycin kinase acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5632243|PMID:25139234) MGI
Ensembl
PMID:25139234 GO_REF:0000107 MGI:5632243 NCBI chrNW_004936474:158,376...282,310 JBrowse link
G Nfatc1 nuclear factor of activated T cells 1 acts_upstream_of_or_within ISO (MGI:1197816|PMID:9515963) MGI PMID:9515963 MGI:1197816 NCBI chrNW_004936616:484,062...584,950 JBrowse link
G Scx scleraxis bHLH transcription factor involved_in ISO (MGI:4413438|PMID:18802027) UniProt PMID:18802027 MGI:4413438 NCBI chrNW_004936470:7,966,096...7,972,379 JBrowse link
G Sox9 SRY-box transcription factor 9 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3709829|PMID:17350610) Ensembl
MGI
PMID:17350610 GO_REF:0000107 MGI:3709829 NCBI chrNW_004936655:1,849,044...1,852,648 JBrowse link
G Tgfb1 transforming growth factor beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936661:3,742,080...3,758,266 JBrowse link
G Tgfb2 transforming growth factor beta 2 involved_in
acts_upstream_of_or_within
ISO (MGI:3609313|PMID:11390347)
(MGI:5140242|PMID:21780244)
BHF-UCL
MGI
PMID:11390347 PMID:21780244 MGI:3609313 MGI:5140242 NCBI chrNW_004936628:310,720...394,002 JBrowse link
aortic valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936697:1,054,237...1,061,468 JBrowse link
G Efna1 ephrin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:4,654,503...4,660,950 JBrowse link
G Emilin1 elastin microfibril interfacer 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936493:5,455,369...5,463,205 JBrowse link
G Gata3 GATA binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936484:6,780,692...6,800,883 JBrowse link
G Gata4 GATA binding protein 4 involved_in ISO (PMID:29325903) BHF-UCL PMID:29325903 NCBI chrNW_004936675:3,408,549...3,420,828 JBrowse link
G Gata5 GATA binding protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936514:10,061,675...10,070,541 JBrowse link
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 involved_in ISO (MGI:6158746|PMID:22110751) BHF-UCL PMID:22110751 MGI:6158746 NCBI chrNW_004936871:666,961...670,910 JBrowse link
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936639:3,705,225...3,714,696 JBrowse link
G Nfatc1 nuclear factor of activated T cells 1 acts_upstream_of_or_within ISO (MGI:1197815|PMID:9515964) MGI PMID:9515964 MGI:1197815 NCBI chrNW_004936616:484,062...584,950 JBrowse link
G Nos3 nitric oxide synthase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936527:6,427,147...6,445,770 JBrowse link
G Notch1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936669:1,292,016...1,334,061 JBrowse link
G Rb1 RB transcriptional corepressor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936565:1,596,227...1,746,706 JBrowse link
G Robo1 roundabout guidance receptor 1 involved_in ISO (MGI:5913048|PMID:25691540) BHF-UCL PMID:25691540 MGI:5913048 NCBI chrNW_004936505:4,329,428...4,711,310 JBrowse link
G Robo2 roundabout guidance receptor 2 involved_in ISO (MGI:5913048|PMID:25691540) BHF-UCL PMID:25691540 MGI:5913048 NCBI chrNW_004936505:5,544,011...6,747,417 JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:26634652) BHF-UCL PMID:26634652 NCBI chrNW_004936550:730,462...874,601 JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 involved_in ISO (PMID:26634652) BHF-UCL PMID:26634652 NCBI chrNW_004936532:7,142,580...7,284,722 JBrowse link
G Slit2 slit guidance ligand 2 involved_in ISO (MGI:5913048|PMID:25691540) BHF-UCL PMID:25691540 MGI:5913048 NCBI chrNW_004936477:8,111,212...8,448,567 JBrowse link
G Slit3 slit guidance ligand 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936622:191,165...756,552 JBrowse link
G Smad6 SMAD family member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:26,781,420...26,856,556 JBrowse link
G Sox9 SRY-box transcription factor 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936655:1,849,044...1,852,648 JBrowse link
G Tbx20 T-box transcription factor 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936478:10,887,900...10,939,510 JBrowse link
G Tgfb1 transforming growth factor beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936661:3,742,080...3,758,266 JBrowse link
G Tie1 tyrosine kinase with immunoglobulin like and EGF like domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:24,709,424...24,729,246 JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936546:5,331,220...5,332,669 JBrowse link
atrioventricular valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata4 GATA binding protein 4 involved_in ISO (MGI:4946551|PMID:21330551) BHF-UCL PMID:21330551 MGI:4946551 NCBI chrNW_004936675:3,408,549...3,420,828 JBrowse link
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 involved_in ISO (MGI:3703467|PMID:17259303) BHF-UCL PMID:17259303 MGI:3703467 NCBI chrNW_004936871:666,961...670,910 JBrowse link
G Smad4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:12,242,869...12,278,012 JBrowse link
atrioventricular valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936469:20,743,195...20,811,567 JBrowse link
G Bmp2 bone morphogenetic protein 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3611958|PMID:16314491) MGI
Ensembl
PMID:16314491 GO_REF:0000107 MGI:3611958 NCBI chrNW_004936485:12,428,765...12,439,570 JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 NOT|involved_in ISO (MGI:2429424|PMID:12441304) BHF-UCL PMID:12441304 MGI:2429424 NCBI chrNW_004936726:1,543,263...1,711,422 JBrowse link
G Ccn1 cellular communication network factor 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3761425|PMID:17023674) MGI
Ensembl
PMID:17023674 GO_REF:0000107 MGI:3761425 NCBI chrNW_004936608:152,174...155,123 JBrowse link
G Gata4 GATA binding protein 4 acts_upstream_of_or_within ISO (MGI:3833786|PMID:19084512) MGI PMID:19084512 MGI:3833786 NCBI chrNW_004936675:3,408,549...3,420,828 JBrowse link
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 involved_in ISO (MGI:3783952|PMID:17303760) BHF-UCL PMID:17303760 MGI:3783952 NCBI chrNW_004936871:666,961...670,910 JBrowse link
G Heyl hes related family bHLH transcription factor with YRPW motif like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:21,503,763...21,513,392 JBrowse link
G Mdm2 MDM2 proto-oncogene acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5440773|PMID:22821713) MGI
Ensembl
PMID:22821713 GO_REF:0000107 MGI:5440773 NCBI chrNW_004936545:6,709,903...6,732,334 JBrowse link
G Mdm4 MDM4 regulator of p53 acts_upstream_of_or_within ISO (MGI:5440773|PMID:22821713) MGI PMID:22821713 MGI:5440773 NCBI chrNW_004936567:268,151...299,494 JBrowse link
G Notch1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936669:1,292,016...1,334,061 JBrowse link
G Slit3 slit guidance ligand 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936622:191,165...756,552 JBrowse link
G Tbx5 T-box transcription factor 5 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3833786|PMID:19084512) MGI
Ensembl
PMID:19084512 GO_REF:0000107 MGI:3833786 NCBI chrNW_004936558:7,408,229...7,454,897 JBrowse link
G Tgfb2 transforming growth factor beta 2 involved_in ISO (MGI:894212|PMID:9217007) BHF-UCL PMID:9217007 MGI:894212 NCBI chrNW_004936628:310,720...394,002 JBrowse link
G Tgfbr2 transforming growth factor beta receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:21,324,669...21,409,430 JBrowse link
G Zfpm1 zinc finger protein, FOG family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936641:1,130,073...1,162,022 JBrowse link
coronary sinus valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936669:1,292,016...1,334,061 JBrowse link
endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Efna1 ephrin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:4,654,503...4,660,950 JBrowse link
G Erg ETS transcription factor ERG acts_upstream_of_or_within ISO (MGI:5442628|PMID:22932696) MGI PMID:22932696 MGI:5442628 NCBI chrNW_004936500:4,459,298...4,623,290 JBrowse link
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO (MGI:3530185|PMID:15680351) MGI PMID:15680351 MGI:3530185 NCBI chrNW_004936871:666,961...670,910 JBrowse link
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3530185|PMID:15680351) MGI
Ensembl
PMID:15680351 GO_REF:0000107 MGI:3530185 NCBI chrNW_004936639:3,705,225...3,714,696 JBrowse link
heart valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scx scleraxis bHLH transcription factor involved_in ISO (MGI:4413438|PMID:18802027) UniProt PMID:18802027 MGI:4413438 NCBI chrNW_004936470:7,966,096...7,972,379 JBrowse link
G Sox9 SRY-box transcription factor 9 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3709829|PMID:17350610) MGI
Ensembl
PMID:17350610 GO_REF:0000107 MGI:3709829 NCBI chrNW_004936655:1,849,044...1,852,648 JBrowse link
mitral valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dchs1 dachsous cadherin-related 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936842:677,416...697,013 JBrowse link
G Notch1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936669:1,292,016...1,334,061 JBrowse link
G Zfpm1 zinc finger protein, FOG family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936641:1,130,073...1,162,022 JBrowse link
mitral valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936469:20,743,195...20,811,567 JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936804:52,435...115,289 JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936726:1,543,263...1,711,422 JBrowse link
G Dchs1 dachsous cadherin-related 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5694502|PMID:26258302) MGI
Ensembl
PMID:26258302 GO_REF:0000107 MGI:5694502 NCBI chrNW_004936842:677,416...697,013 JBrowse link
G Efna1 ephrin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:4,654,503...4,660,950 JBrowse link
G Smad6 SMAD family member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:26,781,420...26,856,556 JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936546:5,331,220...5,332,669 JBrowse link
negative regulation of cell proliferation involved in heart valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936726:1,543,263...1,711,422 JBrowse link
G Notch1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936669:1,292,016...1,334,061 JBrowse link
positive regulation of cell proliferation involved in heart valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:12,242,869...12,278,012 JBrowse link
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Twist1 twist family bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936546:5,331,220...5,332,669 JBrowse link
pulmonary valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 involved_in ISO (PMID:22199024) BHF-UCL PMID:22199024 NCBI chrNW_004936867:269,477...279,549 JBrowse link
G Tbx20 T-box transcription factor 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936478:10,887,900...10,939,510 JBrowse link
pulmonary valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936697:1,054,237...1,061,468 JBrowse link
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 involved_in ISO (MGI:3783952|PMID:17303760) BHF-UCL PMID:17303760 MGI:3783952 NCBI chrNW_004936871:666,961...670,910 JBrowse link
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936639:3,705,225...3,714,696 JBrowse link
G Heyl hes related family bHLH transcription factor with YRPW motif like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:21,503,763...21,513,392 JBrowse link
G Jag1 jagged canonical Notch ligand 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:8,857,688...8,894,270 JBrowse link
G LOC101965998 notch receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936872:454,273...539,544 JBrowse link
G Nfatc1 nuclear factor of activated T cells 1 acts_upstream_of_or_within ISO (MGI:1197815|PMID:9515964) MGI PMID:9515964 MGI:1197815 NCBI chrNW_004936616:484,062...584,950 JBrowse link
G Nos3 nitric oxide synthase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936527:6,427,147...6,445,770 JBrowse link
G Notch1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936669:1,292,016...1,334,061 JBrowse link
G Robo1 roundabout guidance receptor 1 involved_in ISO (MGI:5913048|PMID:25691540) BHF-UCL PMID:25691540 MGI:5913048 NCBI chrNW_004936505:4,329,428...4,711,310 JBrowse link
G Robo2 roundabout guidance receptor 2 involved_in ISO (MGI:5913048|PMID:25691540) BHF-UCL PMID:25691540 MGI:5913048 NCBI chrNW_004936505:5,544,011...6,747,417 JBrowse link
G Slit2 slit guidance ligand 2 involved_in ISO (MGI:5913048|PMID:25691540) BHF-UCL PMID:25691540 MGI:5913048 NCBI chrNW_004936477:8,111,212...8,448,567 JBrowse link
G Smad6 SMAD family member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:26,781,420...26,856,556 JBrowse link
G Stra6 signaling receptor and transporter of retinol STRA6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:33,224,174...33,245,076 JBrowse link
G Tgfb2 transforming growth factor beta 2 involved_in ISO (MGI:894212|PMID:9217007) BHF-UCL PMID:9217007 MGI:894212 NCBI chrNW_004936628:310,720...394,002 JBrowse link
sinoatrial valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mef2c myocyte enhancer factor 2C involved_in ISO (MGI:3830899|PMID:16680724) UniProt PMID:16680724 MGI:3830899 NCBI chrNW_004936469:7,060,480...7,225,497 JBrowse link
tricuspid valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3574376|PMID:15297376) MGI
Ensembl
PMID:15297376 GO_REF:0000107 MGI:3574376 NCBI chrNW_004936639:3,705,225...3,714,696 JBrowse link
G Zfpm1 zinc finger protein, FOG family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936641:1,130,073...1,162,022 JBrowse link
tricuspid valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936804:52,435...115,289 JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936726:1,543,263...1,711,422 JBrowse link
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936639:3,705,225...3,714,696 JBrowse link
G Tgfbr2 transforming growth factor beta receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:21,324,669...21,409,430 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14984
    developmental process 6002
      anatomical structure morphogenesis 2647
        heart valve morphogenesis 48
          aortic valve morphogenesis + 24
          apoptotic process involved in heart valve morphogenesis 0
          atrioventricular valve morphogenesis + 22
          cell proliferation involved in heart valve morphogenesis + 3
          coronary sinus valve morphogenesis + 1
          heart valve formation + 14
          pulmonary valve morphogenesis + 17
          sinoatrial valve morphogenesis + 1
          ventriculo bulbo valve morphogenesis + 0
Path 2
Term Annotations click to browse term
  biological_process 14984
    developmental process 6002
      anatomical structure development 5620
        multicellular organism development 4621
          system development 3986
            circulatory system development 1155
              heart development 656
                heart valve development 59
                  heart valve morphogenesis 48
                    aortic valve morphogenesis + 24
                    apoptotic process involved in heart valve morphogenesis 0
                    atrioventricular valve morphogenesis + 22
                    cell proliferation involved in heart valve morphogenesis + 3
                    coronary sinus valve morphogenesis + 1
                    heart valve formation + 14
                    pulmonary valve morphogenesis + 17
                    sinoatrial valve morphogenesis + 1
                    ventriculo bulbo valve morphogenesis + 0
paths to the root