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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac conduction system development
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Accession:GO:0003161 term browser browse the term
Definition:The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.
Synonyms:exact_synonym: cardiac impulse conducting system development;   heart conduction system development


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cardiac conduction system development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A involved_in ISO (MGI:3653945|PMID:16037571) RGD PMID:16037571 MGI:3653945 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616
JBrowse link
G Cdc42 cell division cycle 42 acts_upstream_of_or_within ISO MGI:97350 (MGI:5052204|PMID:21690310) RGD PMID:21690310 MGI:5052204 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Gja5 gap junction protein, alpha 5 acts_upstream_of_or_within ISO MGI:2445466 (MGI:4412358|PMID:18599871), (MGI:5304955|PMID:22203979) RGD PMID:18599871 PMID:22203979 MGI:4412358 MGI:5304955 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
JBrowse link
G Mir1 microRNA 1 acts_upstream_of_or_within ISO (MGI:5575655|PMID:17397913) RGD PMID:17397913 MGI:5575655 NCBI chr18:1,887,537...1,887,623 JBrowse link
G Nkx2-5 NK2 homeobox 5 acts_upstream_of_or_within
involved_in
ISO MGI:106211 (MGI:5052204|PMID:21690310)
(PMID:15109497)
(PMID:27207958)
RGD PMID:15109497 PMID:21690310 PMID:27207958 MGI:5052204 NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934
JBrowse link
G Nrg1 neuregulin 1 acts_upstream_of_or_within ISO (MGI:2384269|PMID:12149465) RGD PMID:12149465 MGI:2384269 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
JBrowse link
atrioventricular bundle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irx3 iroquois homeobox 3 involved_in ISO (MGI:6101691|PMID:26786475) RGD PMID:26786475 MGI:6101691 NCBI chr19:15,211,882...15,215,323
Ensembl chr19:15,211,878...15,215,317
JBrowse link
G Tbx3 T-box transcription factor 3 acts_upstream_of_or_within ISO MGI:3710254 (MGI:3847383|PMID:18467625) RGD PMID:18467625 MGI:3847383 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
JBrowse link
G Tbx5 T-box transcription factor 5 involved_in IEA
ISO
GO_REF:0000107
(MGI:3051695|PMID:15289437)
Ensembl
RGD
PMID:15289437 GO_REF:0000107 MGI:3051695 NCBI chr12:36,686,344...36,739,253
Ensembl chr12:36,688,014...36,734,885
JBrowse link
atrioventricular node cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A involved_in ISO (MGI:3822612|PMID:17998461) RGD PMID:17998461 MGI:3822612 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616
JBrowse link
G Maml1 mastermind-like transcriptional coactivator 1 involved_in ISO (MGI:5000164|PMID:21266778) RGD PMID:21266778 MGI:5000164 NCBI chr10:34,588,639...34,624,298
Ensembl chr10:34,588,646...34,623,338
JBrowse link
G Nkx2-5 NK2 homeobox 5 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3042511 (MGI:4355491|PMID:19546853)
Ensembl
RGD
PMID:19546853 GO_REF:0000107 MGI:4355491 NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934
JBrowse link
G Tbx5 T-box transcription factor 5 involved_in IEA
ISO
GO_REF:0000107
(MGI:3051695|PMID:15289437)
Ensembl
RGD
PMID:15289437 GO_REF:0000107 MGI:3051695 NCBI chr12:36,686,344...36,739,253
Ensembl chr12:36,688,014...36,734,885
JBrowse link
atrioventricular node cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx2-5 NK2 homeobox 5 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3042511 (MGI:3040116|PMID:15109497)
Ensembl
RGD
PMID:15109497 GO_REF:0000107 MGI:3040116 NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934
JBrowse link
G Tbx5 T-box transcription factor 5 involved_in IEA
ISO
GO_REF:0000107
(MGI:3051695|PMID:15289437)
Ensembl
RGD
PMID:15289437 GO_REF:0000107 MGI:3051695 NCBI chr12:36,686,344...36,739,253
Ensembl chr12:36,688,014...36,734,885
JBrowse link
atrioventricular node development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx2-5 NK2 homeobox 5 involved_in ISO (MGI:3829107|PMID:18689573) RGD PMID:18689573 MGI:3829107 NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934
JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:5000164|PMID:21266778) RGD PMID:21266778 MGI:5000164 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
bundle of His development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Id2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO MGI:2384134 (MGI:3716040|PMID:17604724) RGD PMID:17604724 MGI:3716040 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Nkx2-5 NK2 homeobox 5 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:102541 (MGI:3716040|PMID:17604724)
Ensembl
RGD
PMID:17604724 GO_REF:0000107 MGI:3716040 NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934
JBrowse link
G Tbx5 T-box transcription factor 5 acts_upstream_of_or_within
involved_in
ISO MGI:97350 (MGI:3716040|PMID:17604724)
(MGI:5449667|PMID:22728936)
RGD PMID:17604724 PMID:22728936 MGI:3716040 MGI:5449667 NCBI chr12:36,686,344...36,739,253
Ensembl chr12:36,688,014...36,734,885
JBrowse link
His-Purkinje system cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irx3 iroquois homeobox 3 involved_in ISO (MGI:6101691|PMID:26786475) RGD PMID:26786475 MGI:6101691 NCBI chr19:15,211,882...15,215,323
Ensembl chr19:15,211,878...15,215,317
JBrowse link
Purkinje myocyte development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dsg2 desmoglein 2 involved_in ISO (PMID:16505173) RGD PMID:16505173 NCBI chr18:11,846,207...11,904,630
Ensembl chr18:11,846,183...11,904,156
JBrowse link
G Irx3 iroquois homeobox 3 involved_in ISO (MGI:6101691|PMID:26786475) RGD PMID:26786475 MGI:6101691 NCBI chr19:15,211,882...15,215,323
Ensembl chr19:15,211,878...15,215,317
JBrowse link
Purkinje myocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx2-5 NK2 homeobox 5 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857618 (MGI:3785685|PMID:17250822)
Ensembl
RGD
PMID:17250822 GO_REF:0000107 MGI:3785685 NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934
JBrowse link
sinoatrial node cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bves blood vessel epicardial substance acts_upstream_of_or_within ISO MGI:2385915 (MGI:5424322|PMID:22354168) RGD PMID:22354168 MGI:5424322 NCBI chr20:48,819,241...48,860,282
Ensembl chr20:48,822,308...48,857,472
JBrowse link
G Isl1 ISL LIM homeobox 1 involved_in ISO (MGI:5688210|PMID:26193633) RGD PMID:26193633 MGI:5688210 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584
JBrowse link
G Popdc2 popeye domain containing 2 acts_upstream_of_or_within ISO MGI:3773727 (MGI:5424322|PMID:22354168) RGD PMID:22354168 MGI:5424322 NCBI chr11:62,351,843...62,398,688
Ensembl chr11:62,374,759...62,390,756
JBrowse link
G Shox2 short stature homeobox 2 involved_in ISO (MGI:5285465|PMID:21640717) RGD PMID:21640717 MGI:5285465 NCBI chr 2:151,217,049...151,227,180
Ensembl chr 2:151,217,552...151,227,143
JBrowse link
G Tbx18 T-box transcription factor 18 involved_in ISO (PMID:23242162) RGD PMID:23242162 NCBI chr 8:88,652,054...88,680,081
Ensembl chr 8:88,652,054...88,680,058
JBrowse link
G Tbx3 T-box transcription factor 3 involved_in
acts_upstream_of_or_within
ISO (PMID:22130515)
MGI:3710254 (MGI:4366226|PMID:19096026)
RGD PMID:19096026 PMID:22130515 MGI:4366226 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
JBrowse link
sinoatrial node cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (PMID:18297060) RGD PMID:18297060 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875
JBrowse link
sinoatrial node cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tbx18 T-box transcription factor 18 involved_in ISO (PMID:23242162) RGD PMID:23242162 NCBI chr 8:88,652,054...88,680,081
Ensembl chr 8:88,652,054...88,680,058
JBrowse link
sinoatrial node development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 involved_in ISO MGI:2177784 (MGI:6492391|PMID:33443158) RGD PMID:33443158 MGI:6492391 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Shox2 short stature homeobox 2 involved_in ISO (MGI:3836832|PMID:19166829) RGD PMID:19166829 MGI:3836832 NCBI chr 2:151,217,049...151,227,180
Ensembl chr 2:151,217,552...151,227,143
JBrowse link
G Tbx18 T-box transcription factor 18 acts_upstream_of_or_within ISO MGI:3714982 (MGI:4366226|PMID:19096026) RGD PMID:19096026 MGI:4366226 NCBI chr 8:88,652,054...88,680,081
Ensembl chr 8:88,652,054...88,680,058
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19494
    developmental process 6773
      anatomical structure development 6199
        animal organ development 4063
          heart development 696
            cardiac muscle tissue development 261
              cardiac conduction system development 20
                His-Purkinje system development + 6
                atrioventricular node development + 5
                sinoatrial node development + 8
Path 2
Term Annotations click to browse term
  biological_process 19494
    developmental process 6773
      anatomical structure development 6199
        multicellular organism development 5635
          system development 5303
            animal organ development 4063
              heart development 696
                cardiac muscle tissue development 261
                  cardiac conduction system development 20
                    His-Purkinje system development + 6
                    atrioventricular node development + 5
                    sinoatrial node development + 8
paths to the root