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ONTOLOGY REPORT - ANNOTATIONS


Term:endothelium development
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Accession:GO:0003158 term browser browse the term
Definition:The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.


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endothelium development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd34 CD34 molecule involved_in ISO (PMID:17261663) UniProt PMID:17261663 NCBI chrNW_004936557:5,030,788...5,051,864 JBrowse link
G Gja1 gap junction protein alpha 1 ISO RGD PMID:10990491 RGD:7207853 NCBI chrNW_004936658:3,920,043...3,932,987 JBrowse link
G Gja4 gap junction protein alpha 4 ISO RGD PMID:10990491 RGD:7207853 NCBI chrNW_004936474:17,439,250...17,440,829 JBrowse link
G Gja5 gap junction protein alpha 5 ISO RGD PMID:10990491 RGD:7207853 NCBI chrNW_004936867:269,477...279,549 JBrowse link
G Kdr kinase insert domain receptor involved_in ISO (MGI:74276|PMID:7596435) UniProt PMID:7596435 MGI:74276 NCBI chrNW_004936482:17,537,697...17,581,320 JBrowse link
G Slc40a1 solute carrier family 40 member 1 acts_upstream_of_or_within ISO (MGI:3578034|PMID:15342464) MGI PMID:15342464 MGI:3578034 NCBI chrNW_004936506:8,396,593...8,415,069 JBrowse link
arterial endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hey1 hes related family bHLH transcription factor with YRPW motif 1 involved_in ISO (MGI:3040159|PMID:15107403) BHF-UCL PMID:15107403 MGI:3040159 NCBI chrNW_004936871:666,961...670,910 JBrowse link
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 involved_in ISO (MGI:3040159|PMID:15107403) BHF-UCL PMID:15107403 MGI:3040159 NCBI chrNW_004936639:3,705,225...3,714,696 JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:3040159|PMID:15107403) BHF-UCL PMID:15107403 MGI:3040159 NCBI chrNW_004936669:1,292,016...1,334,061 JBrowse link
G Tmem100 transmembrane protein 100 acts_upstream_of_or_within ISO (MGI:5432418|PMID:22783020) MGI PMID:22783020 MGI:5432418 NCBI chrNW_004936490:6,958,064...6,963,888 JBrowse link
arterial endothelial cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (MGI:3056004|PMID:15466160) BHF-UCL PMID:15466160 MGI:3056004 NCBI chrNW_004936477:3,354,336...3,445,248 JBrowse link
blood vessel endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccm2 CCM2 scaffold protein acts_upstream_of_or_within ISO (MGI:3837878|PMID:19151727) MGI PMID:19151727 MGI:3837878 NCBI chrNW_004936478:19,820,092...19,882,358 JBrowse link
blood vessel endothelial cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (MGI:3056004|PMID:15466160) BHF-UCL PMID:15466160 MGI:3056004 NCBI chrNW_004936477:3,354,336...3,445,248 JBrowse link
blood vessel lumenization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll4 delta like canonical Notch ligand 4 involved_in ISO (MGI:3056004|PMID:15466160) BHF-UCL PMID:15466160 MGI:3056004 NCBI chrNW_004936471:4,320,235...4,330,251 JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (MGI:3056004|PMID:15466160) BHF-UCL PMID:15466160 MGI:3056004 NCBI chrNW_004936477:3,354,336...3,445,248 JBrowse link
endocardial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 involved_in ISO (MGI:4837019|PMID:20890042) BHF-UCL PMID:20890042 MGI:4837019 NCBI chrNW_004936669:1,292,016...1,334,061 JBrowse link
G Nrg1 neuregulin 1 involved_in ISO (PMID:17336907) BHF-UCL PMID:17336907 NCBI chrNW_004936766:1,104,841...1,306,368 JBrowse link
G Smad4 SMAD family member 4 involved_in ISO (MGI:4946551|PMID:21330551) BHF-UCL PMID:21330551 MGI:4946551 NCBI chrNW_004936497:12,242,869...12,278,012 JBrowse link
G Sox17 SRY-box transcription factor 17 acts_upstream_of_or_within ISO (MGI:3716256|PMID:17610846) MGI PMID:17610846 MGI:3716256 NCBI chrNW_004936496:1,248,582...1,251,406 JBrowse link
G Sox18 SRY-box transcription factor 18 acts_upstream_of_or_within ISO (MGI:3716256|PMID:17610846) MGI PMID:17610846 MGI:3716256 NCBI chrNW_004936514:11,231,327...11,233,292 JBrowse link
endocardial cushion cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in ISO (PMID:19506109) BHF-UCL PMID:19506109 NCBI chrNW_004936469:20,743,195...20,811,567 JBrowse link
endothelial cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccm2 CCM2 scaffold protein acts_upstream_of_or_within ISO (MGI:3837878|PMID:19151727) MGI PMID:19151727 MGI:3837878 NCBI chrNW_004936478:19,820,092...19,882,358 JBrowse link
G Gpx1 glutathione peroxidase 1 acts_upstream_of_or_within ISO (MGI:3698597|PMID:16373599) MGI PMID:16373599 MGI:3698597 NCBI chrNW_004936529:997,943...999,123 JBrowse link
G Heg1 heart development protein with EGF like domains 1 acts_upstream_of_or_within ISO (MGI:3837878|PMID:19151727) MGI PMID:19151727 MGI:3837878 NCBI chrNW_004936725:261,809...336,390 JBrowse link
G Vezf1 vascular endothelial zinc finger 1 acts_upstream_of_or_within ISO (MGI:3581991|PMID:15882861) MGI PMID:15882861 MGI:3581991 NCBI chrNW_004936490:5,074,832...5,090,019 JBrowse link
endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcr4 C-X-C motif chemokine receptor 4 ISO RGD PMID:24955809 RGD:11352686 NCBI chrNW_004936469:39,794,613...39,798,448 JBrowse link
G Fstl1 follistatin like 1 involved_in ISO (MGI:4457221|PMID:20054002) UniProt PMID:20054002 MGI:4457221 NCBI chrNW_004936536:7,132,369...7,186,951 JBrowse link
G Hoxb5 homeobox B5 acts_upstream_of_or_within ISO (MGI:2670246|PMID:12897140) MGI PMID:12897140 MGI:2670246 NCBI chrNW_004936490:12,793,485...12,796,219 JBrowse link
G Kdm6b lysine demethylase 6B involved_in ISO (MGI:5574281|PMID:23856522) BHF-UCL PMID:23856522 MGI:5574281 NCBI chrNW_004936595:1,077,318...1,099,082 JBrowse link
G Kdr kinase insert domain receptor acts_upstream_of_or_within ISO (MGI:2670246|PMID:12897140)
(MGI:5543371|PMID:18772315)
MGI PMID:12897140 PMID:18772315 MGI:2670246 MGI:5543371 NCBI chrNW_004936482:17,537,697...17,581,320 JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (PMID:18297060) BHF-UCL PMID:18297060 NCBI chrNW_004936483:15,533,264...15,534,576 JBrowse link
G Notch4 notch receptor 4 ISO RGD PMID:10964583 RGD:1304484 NCBI chrNW_004936727:1,386,842...1,409,823 JBrowse link
G Prox1 prospero homeobox 1 acts_upstream_of_or_within ISO (MGI:2177970|PMID:11927535) MGI PMID:11927535 MGI:2177970 NCBI chrNW_004936628:4,185,712...4,240,680 JBrowse link
G Ptn pleiotrophin ISO RGD PMID:20830586 RGD:9686141 NCBI chrNW_004936592:1,706,979...1,806,345 JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 ISO RGD PMID:7959012 RGD:61573 NCBI chrNW_004936748:1,244,962...1,250,093 JBrowse link
endothelial cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hoxa13 homeobox A13 acts_upstream_of_or_within ISO (MGI:3797428|PMID:18483557) MGI PMID:18483557 MGI:3797428 NCBI chrNW_004936478:3,824,715...3,827,277 JBrowse link
endothelial cell morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef26 Rho guanine nucleotide exchange factor 26 acts_upstream_of_or_within ISO (MGI:5486234|PMID:23372835) MGI PMID:23372835 MGI:5486234 NCBI chrNW_004936519:1,841,549...1,934,898 JBrowse link
G Clic4 chloride intracellular channel 4 acts_upstream_of_or_within ISO (MGI:3837628|PMID:19197003) MGI PMID:19197003 MGI:3837628 NCBI chrNW_004936474:9,664,872...9,711,036 JBrowse link
G Cnmd chondromodulin acts_upstream_of_or_within ISO (MGI:2656472|PMID:12714610) MGI PMID:12714610 MGI:2656472 NCBI chrNW_004936667:599,703...624,821 JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain acts_upstream_of_or_within ISO (MGI:3046127|PMID:15188432) MGI PMID:15188432 MGI:3046127 NCBI chrNW_004936778:847,473...943,038 JBrowse link
G Heg1 heart development protein with EGF like domains 1 acts_upstream_of_or_within ISO (MGI:3837878|PMID:19151727) MGI PMID:19151727 MGI:3837878 NCBI chrNW_004936725:261,809...336,390 JBrowse link
G Hoxa13 homeobox A13 acts_upstream_of_or_within ISO (MGI:3797428|PMID:18483557) MGI PMID:18483557 MGI:3797428 NCBI chrNW_004936478:3,824,715...3,827,277 JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein acts_upstream_of_or_within ISO (MGI:3759000|PMID:17717145) MGI PMID:17717145 MGI:3759000 NCBI chrNW_004936485:18,610,721...18,611,889 JBrowse link
G Ift88 intraflagellar transport 88 acts_upstream_of_or_within ISO (MGI:4940123|PMID:21285373) MGI PMID:21285373 MGI:4940123 NCBI chrNW_004936720:1,041,216...1,168,725 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase involved_in ISO (PMID:14500721) UniProt PMID:14500721 NCBI chrNW_004936589:2,280,803...2,390,179 JBrowse link
G Notch4 notch receptor 4 ISO RGD PMID:10964583 RGD:1304484 NCBI chrNW_004936727:1,386,842...1,409,823 JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 acts_upstream_of_or_within ISO (MGI:3723364|PMID:17563397) MGI PMID:17563397 MGI:3723364 NCBI chrNW_004936541:4,873,459...4,919,787 JBrowse link
G Plod3 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 acts_upstream_of_or_within ISO (MGI:3618677|PMID:16467571) MGI PMID:16467571 MGI:3618677 NCBI chrNW_004936543:1,090,268...1,097,170 JBrowse link
G Stc1 stanniocalcin 1 involved_in ISO (PMID:14500721) UniProt PMID:14500721 NCBI chrNW_004936555:7,240,649...7,251,668 JBrowse link
G Tnmd tenomodulin acts_upstream_of_or_within ISO (MGI:2656472|PMID:12714610) MGI PMID:12714610 MGI:2656472 NCBI chrNW_004936584:5,803,309...5,818,643 JBrowse link
endothelial tip cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 involved_in ISO (MGI:5466218|PMID:22282195) UniProt PMID:22282195 MGI:5466218 NCBI chrNW_004937098:212,704...220,589 JBrowse link
endothelial tube lumen extension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rhoa ras homolog family member A acts_upstream_of_or_within ISO (PMID:20208559) MGI PMID:20208559 NCBI chrNW_004936529:1,000,050...1,045,655 JBrowse link
G Stard13 StAR related lipid transfer domain containing 13 acts_upstream_of_or_within ISO (PMID:20208559) MGI PMID:20208559 NCBI chrNW_004936472:27,683,939...28,158,362 JBrowse link
endothelial tube morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 involved_in ISO (PMID:19592636) BHF-UCL PMID:19592636 NCBI chrNW_004936512:9,364,551...9,379,131 JBrowse link
G Bsg basigin (Ok blood group) involved_in ISO (PMID:19837976) UniProt PMID:19837976 NCBI chrNW_004936588:181,688...189,795 JBrowse link
G Ccm2 CCM2 scaffold protein acts_upstream_of_or_within ISO (PMID:19151727) MGI PMID:19151727 NCBI chrNW_004936478:19,820,092...19,882,358 JBrowse link
G Csnk2b casein kinase 2 beta involved_in ISO (PMID:19592636) BHF-UCL PMID:19592636 NCBI chrNW_004936727:1,857,596...1,862,551 JBrowse link
G Ctnnb1 catenin beta 1 involved_in ISO (PMID:20123964) BHF-UCL PMID:20123964 NCBI chrNW_004936473:29,999,542...30,034,610 JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO RGD PMID:24955809 RGD:11352686 NCBI chrNW_004936469:39,794,613...39,798,448 JBrowse link
G Kdr kinase insert domain receptor ISO RGD PMID:25942475 RGD:126925211 NCBI chrNW_004936482:17,537,697...17,581,320 JBrowse link
G Rhob ras homolog family member B involved_in ISO (PMID:21347332) BHF-UCL PMID:21347332 NCBI chrNW_004936493:10,987,801...10,990,207 JBrowse link
establishment of blood-nerve barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within ISO (MGI:2385816|PMID:9734405) MGI PMID:9734405 MGI:2385816 NCBI chrNW_004936484:19,713,299...19,721,144 JBrowse link
G Cldn1 claudin 1 ISO RGD PMID:22733753 RGD:11341802 NCBI chrNW_004936578:98,489...113,125 JBrowse link
G Dmd dystrophin acts_upstream_of_or_within ISO (MGI:3612931|PMID:12673830) MGI PMID:12673830 MGI:3612931 NCBI chrNW_004936553:7,157,526...7,943,703 JBrowse link
G Hapln2 hyaluronan and proteoglycan link protein 2 acts_upstream_of_or_within ISO (MGI:4437139|PMID:20181608) MGI PMID:20181608 MGI:4437139 NCBI chrNW_004936580:5,792,421...5,811,096 JBrowse link
G Ren renin NOT|acts_upstream_of_or_within ISO (MGI:1351364|PMID:10617578) MGI PMID:10617578 MGI:1351364 NCBI chrNW_004936567:598,044...607,628 JBrowse link
establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cldn5 claudin 5 involved_in ISO (PMID:24280217) AgBase PMID:24280217 NCBI chrNW_004936619:3,455,508...3,457,053 JBrowse link
G Ednra endothelin receptor type A involved_in ISO (MGI:6437578|PMID:27026367) MGI PMID:27026367 MGI:6437578 NCBI chrNW_004936535:1,950,117...2,005,786 JBrowse link
G Ednrb endothelin receptor type B involved_in ISO (MGI:6437578|PMID:27026367) MGI PMID:27026367 MGI:6437578 NCBI chrNW_004936511:3,446,864...3,478,434 JBrowse link
G Ezr ezrin involved_in ISO (PMID:23264465) UniProt PMID:23264465 NCBI chrNW_004936489:10,413,374...10,457,771 JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:20826780) UniProt PMID:20826780 NCBI chrNW_004936549:142,281...153,575 JBrowse link
G Hpse heparanase involved_in ISO (MGI:6437578|PMID:27026367) MGI PMID:27026367 MGI:6437578 NCBI chrNW_004936738:1,308,350...1,341,421 JBrowse link
G Icam1 intercellular adhesion molecule 1 involved_in ISO (PMID:23264465) UniProt PMID:23264465 NCBI chrNW_004936659:616,570...627,172 JBrowse link
G LOC101973720 rap guanine nucleotide exchange factor 3 involved_in ISO (PMID:21840392) UniProt PMID:21840392 NCBI chrNW_004936512:5,636,197...5,659,606 JBrowse link
G Marveld2 MARVEL domain containing 2 involved_in ISO (PMID:23073616) UniProt PMID:23073616 NCBI chrNW_004936480:191,526...216,163 JBrowse link
G Msn moesin involved_in ISO (PMID:23264465) UniProt PMID:23264465 NCBI chrNW_004936635:2,390,390...2,461,870 JBrowse link
G Myadm myeloid associated differentiation marker involved_in ISO (PMID:23264465) UniProt PMID:23264465 NCBI chrNW_004936994:78,989...83,536 JBrowse link
G Pde2a phosphodiesterase 2A involved_in ISO PMID:20139324 UniProt PMID:20139324 RGD:8553884 NCBI chrNW_004936498:1,856,256...1,944,405 JBrowse link
G Pde4d phosphodiesterase 4D involved_in ISO PMID:20139324 UniProt PMID:20139324 RGD:8553884 NCBI chrNW_004936480:8,123,437...9,235,586 JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 involved_in ISO (PMID:7589563) ARUK-UCL PMID:7589563 NCBI chrNW_004936541:4,873,459...4,919,787 JBrowse link
G Ppp1r16b protein phosphatase 1 regulatory subunit 16B involved_in
acts_upstream_of_or_within
ISO (PMID:18586956)
(MGI:5604907|PMID:21907835)
GO_Central
MGI
PMID:18586956 PMID:21907835 MGI:5604907 NCBI chrNW_004936561:2,552,168...2,654,085 JBrowse link
G Rap1a RAP1A, member of RAS oncogene family involved_in ISO (PMID:21840392) UniProt PMID:21840392 NCBI chrNW_004936690:275,840...363,752 JBrowse link
G Rap1b RAP1B, member of RAS oncogene family involved_in ISO (PMID:21840392) UniProt PMID:21840392 NCBI chrNW_004936545:6,567,873...6,578,404 JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 involved_in ISO (PMID:21840392) UniProt PMID:21840392 NCBI chrNW_004936487:18,305,537...18,411,170 JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in ISO (PMID:21840392) UniProt PMID:21840392 NCBI chrNW_004936576:5,583,847...5,746,583 JBrowse link
G Rdx radixin involved_in ISO (PMID:23264465) UniProt PMID:23264465 NCBI chrNW_004936612:3,992,542...4,060,598 JBrowse link
G Robo4 roundabout guidance receptor 4 involved_in ISO (PMID:30455415) UniProt PMID:30455415 NCBI chrNW_004936743:1,321,816...1,336,682 JBrowse link
G Sox18 SRY-box transcription factor 18 involved_in ISO (PMID:18065521) UniProt PMID:18065521 NCBI chrNW_004936514:11,231,327...11,233,292 JBrowse link
establishment of endothelial blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cldn3 claudin 3 involved_in ISO (MGI:6368952|PMID:12734665) ARUK-UCL PMID:12734665 MGI:6368952 NCBI chrNW_004936543:2,952,054...2,953,313 JBrowse link
G Foxp3 forkhead box P3 ISO RGD PMID:31027862 RGD:38549575 NCBI chrNW_004936721:1,118,376...1,125,282 JBrowse link
establishment of endothelial intestinal barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afdn afadin, adherens junction formation factor involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004936489:16,878,423...16,971,229 JBrowse link
G Cldn1 claudin 1 ISO RGD PMID:22684624 RGD:11341733 NCBI chrNW_004936578:98,489...113,125 JBrowse link
G F11r F11 receptor involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004936903:317,975...338,892 JBrowse link
G Fasn fatty acid synthase acts_upstream_of_or_within ISO (MGI:5630041|PMID:25565205) MGI PMID:25565205 MGI:5630041 NCBI chrNW_004936594:5,591,785...5,609,886 JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO RGD PMID:10201790 RGD:11520782 NCBI chrNW_004936659:616,570...627,172 JBrowse link
G Myd88 MYD88 innate immune signal transduction adaptor acts_upstream_of_or_within ISO (MGI:5306517|PMID:22155109) MGI PMID:22155109 MGI:5306517 NCBI chrNW_004936473:27,672,237...27,676,339 JBrowse link
G Ptprs protein tyrosine phosphatase receptor type S acts_upstream_of_or_within ISO (MGI:5550154|PMID:24385580) MGI PMID:24385580 MGI:5550154 NCBI chrNW_004936588:3,021,418...3,073,080 JBrowse link
G Rab1a RAB1A, member RAS oncogene family NOT|involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004936491:9,858,645...9,891,674 JBrowse link
G Rab1b RAB1B, member RAS oncogene family NOT|involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004936599:3,317,258...3,324,208 JBrowse link
G Rap2b RAP2B, member of RAS oncogene family NOT|involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004936519:1,115,865...1,121,196 JBrowse link
G Rap2c RAP2C, member of RAS oncogene family involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004936691:2,628,563...2,645,133 JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004936576:5,583,847...5,746,583 JBrowse link
G Rapgef6 Rap guanine nucleotide exchange factor 6 NOT|involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004936647:3,434,409...3,647,116 JBrowse link
G Tjp1 tight junction protein 1 involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004936483:1,814,870...2,045,802 JBrowse link
G Tjp2 tight junction protein 2 involved_in ISO (PMID:23885123) UniProt PMID:23885123 NCBI chrNW_004936503:5,414,330...5,539,895 JBrowse link
glomerular endothelium development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd34 CD34 molecule involved_in ISO (PMID:17464107) UniProt PMID:17464107 NCBI chrNW_004936557:5,030,788...5,051,864 JBrowse link
G Ednra endothelin receptor type A involved_in ISO (MGI:6472022|PMID:31402170) MGI PMID:31402170 MGI:6472022 NCBI chrNW_004936535:1,950,117...2,005,786 JBrowse link
G Foxc2 forkhead box C2 acts_upstream_of_or_within ISO (MGI:3619287|PMID:16498405) MGI PMID:16498405 MGI:3619287 NCBI chrNW_004936641:2,236,224...2,238,501 JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 involved_in ISO (PMID:17464107) UniProt PMID:17464107 NCBI chrNW_004936541:4,873,459...4,919,787 JBrowse link
lymphatic endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin A receptor type 2B involved_in ISO (MGI:4436974|PMID:19903896) BHF-UCL PMID:19903896 MGI:4436974 NCBI chrNW_004936473:27,816,366...27,822,555 JBrowse link
G Acvrl1 activin A receptor like type 1 involved_in ISO (PMID:19903896)
(MGI:4436974|PMID:19903896)
BHF-UCL PMID:19903896 MGI:4436974 NCBI chrNW_004936512:9,364,551...9,379,131 JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (MGI:4436974|PMID:19903896) BHF-UCL PMID:19903896 MGI:4436974 NCBI chrNW_004936726:1,543,263...1,711,422 JBrowse link
G Prox1 prospero homeobox 1 involved_in
acts_upstream_of_or_within
ISO (PMID:12198161)
(MGI:3820329|PMID:19056883)
BHF-UCL
MGI
PMID:12198161 PMID:19056883 MGI:3820329 NCBI chrNW_004936628:4,185,712...4,240,680 JBrowse link
G Sox18 SRY-box transcription factor 18 acts_upstream_of_or_within ISO (MGI:3828192|PMID:18931657) MGI PMID:18931657 MGI:3828192 NCBI chrNW_004936514:11,231,327...11,233,292 JBrowse link
G Tie1 tyrosine kinase with immunoglobulin like and EGF like domains 1 acts_upstream_of_or_within ISO (MGI:4439415|PMID:20223757) BHF-UCL PMID:20223757 MGI:4439415 NCBI chrNW_004936474:24,709,424...24,729,246 JBrowse link
lymphatic endothelial cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr2f2 nuclear receptor subfamily 2 group F member 2 involved_in ISO (PMID:18815287) BHF-UCL PMID:18815287 NCBI chrNW_004936483:6,886,447...6,900,986 JBrowse link
G Pdpn podoplanin involved_in ISO (MGI:4453945|PMID:20110424) UniProt PMID:20110424 MGI:4453945 NCBI chrNW_004936474:1,751,159...1,779,011 JBrowse link
G Prox1 prospero homeobox 1 involved_in ISO (PMID:18815287) BHF-UCL PMID:18815287 NCBI chrNW_004936628:4,185,712...4,240,680 JBrowse link
metanephric glomerular endothelium development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfb platelet derived growth factor subunit B acts_upstream_of_or_within ISO (PMID:9693135) UniProt PMID:9693135 NCBI chrNW_004936492:2,353,840...2,368,573 JBrowse link
negative regulation of blood vessel endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxj2 forkhead box J2 involved_in ISO (PMID:24792364) BHF-UCL PMID:24792364 NCBI chrNW_004936892:324,103...344,739 JBrowse link
negative regulation of endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 involved_in ISO (MGI:4830635|PMID:20406889) DFLAT PMID:20406889 MGI:4830635 NCBI chrNW_004936512:9,364,551...9,379,131 JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein ISO RGD PMID:20830586 RGD:9686141 NCBI chrNW_004936485:18,610,721...18,611,889 JBrowse link
G Jag1 jagged canonical Notch ligand 1 involved_in ISO (MGI:5661129|PMID:25535084) BHF-UCL PMID:25535084 MGI:5661129 NCBI chrNW_004936485:8,857,688...8,894,270 JBrowse link
G Notch4 notch receptor 4 involved_in ISO (MGI:1934537|PMID:11344305) UniProt PMID:11344305 MGI:1934537 NCBI chrNW_004936727:1,386,842...1,409,823 JBrowse link
G Tgfbr1 transforming growth factor beta receptor 1 ISO RGD PMID:17450384 RGD:2302022 NCBI chrNW_004936524:7,656,523...7,680,043 JBrowse link
G Vhl von Hippel-Lindau tumor suppressor acts_upstream_of_or_within ISO (MGI:5618205|PMID:25186293) MGI PMID:25186293 MGI:5618205 NCBI chrNW_004936602:3,135,790...3,140,622 JBrowse link
G Xdh xanthine dehydrogenase involved_in ISO (PMID:18386220) UniProt PMID:18386220 NCBI chrNW_004936493:1,762,814...1,824,501 JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 involved_in ISO (PMID:23765923) BHF-UCL PMID:23765923 NCBI chrNW_004936574:17,643...175,762 JBrowse link
negative regulation of establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G S1pr3 sphingosine-1-phosphate receptor 3 involved_in ISO (PMID:24851274) UniProt PMID:24851274 NCBI chrNW_004937645:39,690...40,790 JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO (PMID:20048167) ARUK-UCL PMID:20048167 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
Notch signaling pathway involved in arterial endothelial cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 involved_in ISO (MGI:3847069|PMID:19144989) UniProt PMID:19144989 MGI:3847069 NCBI chrNW_004937098:212,704...220,589 JBrowse link
positive regulation of endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 involved_in ISO (MGI:4830635|PMID:20406889) DFLAT PMID:20406889 MGI:4830635 NCBI chrNW_004936512:9,364,551...9,379,131 JBrowse link
G Atoh8 atonal bHLH transcription factor 8 involved_in ISO (PMID:24463812) UniProt PMID:24463812 NCBI chrNW_004936712:1,529,508...1,552,148 JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in ISO (MGI:4830635|PMID:20406889) DFLAT PMID:20406889 MGI:4830635 NCBI chrNW_004936697:1,054,237...1,061,468 JBrowse link
G Bmp6 bone morphogenetic protein 6 involved_in ISO (MGI:4830635|PMID:20406889) DFLAT PMID:20406889 MGI:4830635 NCBI chrNW_004936534:4,707,658...4,871,865 JBrowse link
G Btg1 BTG anti-proliferation factor 1 involved_in ISO (PMID:15033446) UniProt PMID:15033446 NCBI chrNW_004936507:8,789,952...8,797,247 JBrowse link
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within ISO (MGI:3773938|PMID:18231602) MGI PMID:18231602 MGI:3773938 NCBI chrNW_004936473:29,999,542...30,034,610 JBrowse link
G Etv2 ETS variant transcription factor 2 acts_upstream_of_or_within ISO (MGI:4415813|PMID:18462699) MGI PMID:18462699 MGI:4415813 NCBI chrNW_004936570:671,152...673,768 JBrowse link
G Gdf2 growth differentiation factor 2 involved_in ISO (MGI:4830635|PMID:20406889) DFLAT PMID:20406889 MGI:4830635 NCBI chrNW_004936554:7,307,461...7,322,048 JBrowse link
G Notch1 notch receptor 1 ISO RGD PMID:19109527 RGD:2325303 NCBI chrNW_004936669:1,292,016...1,334,061 JBrowse link
G Tmem100 transmembrane protein 100 involved_in ISO (MGI:5432418|PMID:22783020) UniProt PMID:22783020 MGI:5432418 NCBI chrNW_004936490:6,958,064...6,963,888 JBrowse link
G Vezf1 vascular endothelial zinc finger 1 involved_in ISO (PMID:27538588) BHF-UCL PMID:27538588 NCBI chrNW_004936490:5,074,832...5,090,019 JBrowse link
positive regulation of endothelial tube morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgax integrin subunit alpha X involved_in ISO (PMID:30873824) ARUK-UCL PMID:30873824 NCBI chrNW_004936543:8,424,095...8,442,850 JBrowse link
G Lcn2 lipocalin 2 ISO RGD PMID:25557118 RGD:126790477 NCBI chrNW_004936487:15,721,752...15,725,396 JBrowse link
positive regulation of establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Add1 adducin 1 involved_in ISO (PMID:25978380)
(MGI:5796260|PMID:25978380)
CAFA PMID:25978380 MGI:5796260 NCBI chrNW_004936477:20,695,109...20,766,053 JBrowse link
G Akap11 A-kinase anchoring protein 11 ISO RGD PMID:25188285 RGD:14348953 NCBI chrNW_004936747:1,479,241...1,526,915 JBrowse link
G Cdh5 cadherin 5 involved_in ISO (PMID:23288152) UniProt PMID:23288152 NCBI chrNW_004936475:16,738,772...16,775,000 JBrowse link
G Cldn5 claudin 5 involved_in ISO (PMID:23288152) UniProt PMID:23288152 NCBI chrNW_004936619:3,455,508...3,457,053 JBrowse link
G Dicer1 dicer 1, ribonuclease III ISO RGD PMID:23239824 RGD:149735901 NCBI chrNW_004936846:528,768...584,599 JBrowse link
G F11r F11 receptor involved_in ISO (PMID:26985018) ARUK-UCL PMID:26985018 NCBI chrNW_004936903:317,975...338,892 JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa involved_in ISO (PMID:25651845) UniProt PMID:25651845 NCBI chrNW_004936469:43,841,989...43,850,322 JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 involved_in ISO (PMID:24851274) UniProt PMID:24851274 NCBI chrNW_004936659:579,771...587,077 JBrowse link
pulmonary artery endothelial tube morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in ISO (PMID:17992660) UniProt PMID:17992660 NCBI chrNW_004936697:1,054,237...1,061,468 JBrowse link
regulation of endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apold1 apolipoprotein L domain containing 1 ISO RGD PMID:15102925 RGD:1303988 NCBI chrNW_004936587:4,512,440...4,517,183 JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A NOT|involved_in ISO (MGI:4830635|PMID:20406889) DFLAT PMID:20406889 MGI:4830635 NCBI chrNW_004936804:52,435...115,289 JBrowse link
G LOC101954488 CEA cell adhesion molecule 1 involved_in ISO (MGI:3640069|PMID:16680193) UniProt PMID:16680193 MGI:3640069 NCBI chrNW_004936706:37,480...53,306 JBrowse link
G Vegfa vascular endothelial growth factor A acts_upstream_of_or_within ISO (MGI:5543371|PMID:18772315) MGI PMID:18772315 MGI:5543371 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
regulation of endothelial tube morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif 12 involved_in ISO (PMID:17895370) BHF-UCL PMID:17895370 NCBI chrNW_004936518:7,180,262...7,483,416 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 involved_in ISO (PMID:16484616) CACAO PMID:16484616 NCBI chrNW_004936676:60,869...63,028 JBrowse link
G Fgf1 fibroblast growth factor 1 involved_in ISO (PMID:23469107) UniProt PMID:23469107 NCBI chrNW_004936504:11,590,687...11,684,410 JBrowse link
G Foxp1 forkhead box P1 involved_in ISO (PMID:24023716) UniProt PMID:24023716 NCBI chrNW_004936603:2,631,781...3,146,104 JBrowse link
regulation of establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta involved_in ISO (PMID:25816133) UniProt PMID:25816133 NCBI chrNW_004936785:358,128...406,751 JBrowse link
G Il1b interleukin 1 beta involved_in ISO (PMID:25816133) UniProt PMID:25816133 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Plcb1 phospholipase C beta 1 involved_in ISO (MGI:5904576|PMID:27653213) UniProt PMID:27653213 MGI:5904576 NCBI chrNW_004936485:10,548,966...11,254,139 JBrowse link
G Ppp1r12a protein phosphatase 1 regulatory subunit 12A NOT|involved_in ISO (PMID:25816133) UniProt PMID:25816133 NCBI chrNW_004936698:811,399...948,631 JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:25816133) UniProt PMID:25816133 NCBI chrNW_004936550:730,462...874,601 JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 involved_in ISO (PMID:25816133) UniProt PMID:25816133 NCBI chrNW_004936532:7,142,580...7,284,722 JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:25816133) UniProt PMID:25816133 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A involved_in ISO (PMID:25816133) UniProt PMID:25816133 NCBI chrNW_004936709:1,407,327...1,421,448 JBrowse link
G Vcl vinculin involved_in ISO (PMID:26923917) ARUK-UCL PMID:26923917 NCBI chrNW_004936521:5,051,077...5,163,036 JBrowse link
G Zdhhc21 zinc finger DHHC-type palmitoyltransferase 21 involved_in ISO (MGI:5904576|PMID:27653213) UniProt PMID:27653213 MGI:5904576 NCBI chrNW_004936539:8,243,134...8,304,811 JBrowse link
venous endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 involved_in ISO (MGI:4837019|PMID:20890042) BHF-UCL PMID:20890042 MGI:4837019 NCBI chrNW_004936669:1,292,016...1,334,061 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12295
    developmental process 5793
      anatomical structure development 5417
        tissue development 1875
          epithelium development 1164
            endothelium development 135
              endocardial endothelium development 0
              endothelial cell differentiation + 116
              glomerular endothelium development + 5
              morphogenesis of an endothelium + 19
paths to the root