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ONTOLOGY REPORT - ANNOTATIONS

Term:skeletal muscle contraction
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Accession:GO:0003009 term browser browse the term
Definition:A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.

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skeletal muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccdc78 coiled-coil domain containing 78 involved_in ISO (PMID:22818856) UniProt PMID:22818856 NCBI chrNW_004955442:16,478,219...16,482,452
Ensembl chrNW_004955442:16,478,795...16,482,263 		JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit involved_in ISO (PMID:8872460) RGD
BHF-UCL		 PMID:8872460 PMID:22461452 RGD:8549758 NCBI chrNW_004955449:661,310...683,873
Ensembl chrNW_004955449:661,304...683,873 		JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit ISO RGD PMID:22461452 RGD:8549758 NCBI chrNW_004955467:9,471,962...9,482,370
Ensembl chrNW_004955467:9,471,962...9,482,370 		JBrowse link
G Chrnd cholinergic receptor nicotinic delta subunit ISO RGD PMID:22461452 RGD:8549758 NCBI chrNW_004955453:3,433,915...3,440,534
Ensembl chrNW_004955453:3,433,341...3,440,269 		JBrowse link
G Chrne cholinergic receptor nicotinic epsilon subunit ISO RGD PMID:22461452 RGD:8549758 NCBI chrNW_004955467:10,312,620...10,318,700
Ensembl chrNW_004955467:10,312,620...10,318,638 		JBrowse link
G Chrng cholinergic receptor nicotinic gamma subunit ISO RGD PMID:22461452 RGD:8549758 NCBI chrNW_004955453:3,425,603...3,432,695
Ensembl chrNW_004955453:3,425,603...3,432,695 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO RGD PMID:15888549 RGD:2298664 NCBI chrNW_004955507:6,066,026...6,102,066
Ensembl chrNW_004955507:6,067,203...6,102,001 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 ISO RGD PMID:19188248 RGD:10401231 NCBI chrNW_004955495:4,800,103...4,807,714
Ensembl chrNW_004955495:4,799,922...4,807,252 		JBrowse link
G Homer1 homer scaffold protein 1 acts_upstream_of_or_within ISO (PMID:18268005) MGI PMID:18268005 NCBI chrNW_004955425:21,644,577...21,774,843
Ensembl chrNW_004955425:21,644,571...21,775,735 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO functional overload RGD PMID:20851858 RGD:5686398 NCBI chrNW_004955538:1,469,544...1,475,010
Ensembl chrNW_004955538:1,469,544...1,475,019 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO RGD PMID:15888549 RGD:2298664 NCBI chrNW_004955536:611,965...658,647
Ensembl chrNW_004955536:612,774...658,647 		JBrowse link
G LOC102003853 myosin-3 involved_in ISO (PMID:16642020) BHF-UCL PMID:16642020 NCBI chrNW_004955467:6,561,609...6,583,228
Ensembl chrNW_004955467:6,561,617...6,583,089 		JBrowse link
G Myh14 myosin heavy chain 14 involved_in ISO (PMID:21480433) UniProt PMID:21480433 NCBI chrNW_004955559:796,455...856,082
Ensembl chrNW_004955559:797,107...853,053 		JBrowse link
G Rcsd1 RCSD domain containing 1 involved_in ISO PMID:15850461 BHF-UCL PMID:15850461 RGD:8693359 NCBI chrNW_004955462:9,321,624...9,383,962
Ensembl chrNW_004955462:9,318,218...9,384,637 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO RGD PMID:15033970 RGD:1643024 NCBI chrNW_004955451:3,181,085...3,225,610 JBrowse link
G Ryr1 ryanodine receptor 1 ISO RGD PMID:21993782 RGD:13782070 NCBI chrNW_004955468:879,807...1,000,118
Ensembl chrNW_004955468:879,951...1,000,036 		JBrowse link
G Stac3 SH3 and cysteine rich domain 3 involved_in ISO (PMID:23736855) UniProt PMID:23736855 NCBI chrNW_004955458:4,971,450...4,980,262
Ensembl chrNW_004955458:4,971,450...4,980,262 		JBrowse link
G Tcap titin-cap involved_in ISO (PMID:9817758) BHF-UCL PMID:9817758 NCBI chrNW_004955451:14,413,657...14,414,735
Ensembl chrNW_004955451:14,413,657...14,414,735 		JBrowse link
G Tlr4 toll like receptor 4 ISO RGD PMID:20007518 RGD:4144081 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
G Tnf tumor necrosis factor ISO RGD PMID:20007518 RGD:4144081 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
G Tnnc2 troponin C2, fast skeletal type involved_in ISO (PMID:17194691)
(PMID:33755597)		 UniProt PMID:17194691 PMID:33755597 NCBI chrNW_004955445:11,466,579...11,469,123
Ensembl chrNW_004955445:11,466,579...11,469,123 		JBrowse link
G Tnni2 troponin I2, fast skeletal type involved_in ISO (PMID:17194691) UniProt PMID:17194691 NCBI chrNW_004955422:13,649,827...13,652,342
Ensembl chrNW_004955422:13,650,515...13,652,247 		JBrowse link
G Tnnt1 troponin T1, slow skeletal type involved_in ISO (PMID:10952871) UniProt PMID:10952871 NCBI chrNW_004955567:1,039,625...1,050,581
Ensembl chrNW_004955567:1,043,026...1,055,039 		JBrowse link
G Tnnt3 troponin T3, fast skeletal type involved_in ISO (PMID:17194691) UniProt PMID:17194691 NCBI chrNW_004955422:13,702,015...13,718,915
Ensembl chrNW_004955422:13,702,015...13,718,915 		JBrowse link
diaphragm contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 ISO RGD PMID:17362795 RGD:4145100 NCBI chrNW_004955415:5,515,157...5,517,198
Ensembl chrNW_004955415:5,515,697...5,516,980 		JBrowse link
G Gaa alpha glucosidase involved_in
acts_upstream_of_or_within		 ISO (PMID:16917947)
(PMID:15169761)		 BHF-UCL
MGI		 PMID:15169761 PMID:16917947 NCBI chrNW_004955506:2,764,959...2,783,231
Ensembl chrNW_004955506:2,764,959...2,783,231 		JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type ISO RGD PMID:14985239 RGD:1598612 NCBI chrNW_004955430:2,438,644...2,441,596
Ensembl chrNW_004955430:2,434,874...2,441,596 		JBrowse link
fast-twitch skeletal muscle fiber contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Synm synemin acts_upstream_of_or_within ISO (PMID:25567810) MGI PMID:25567810 NCBI chrNW_004955416:26,554,074...26,579,804
Ensembl chrNW_004955416:26,554,703...26,578,761 		JBrowse link
neurotransmitter secretion involved in regulation of skeletal muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr4a1 nuclear receptor subfamily 4 group A member 1 ISO RGD PMID:29530712 RGD:40924655 NCBI chrNW_004955547:2,404,532...2,426,882
Ensembl chrNW_004955547:2,404,532...2,431,050 		JBrowse link
positive regulation of fast-twitch skeletal muscle fiber contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 involved_in ISO (MGI:3778600|PMID:18178581) UniProt PMID:18178581 MGI:3778600 NCBI chrNW_004955422:18,799,372...18,812,458
Ensembl chrNW_004955422:18,799,372...18,812,711 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 involved_in ISO (PMID:12479237) UniProt PMID:12479237 NCBI chrNW_004955493:6,559,995...6,578,461
Ensembl chrNW_004955493:6,559,995...6,578,461 		JBrowse link
G Mylk2 myosin light chain kinase 2 ISO RGD PMID:12748068 RGD:1580242 NCBI chrNW_004955422:29,141,699...29,154,927
Ensembl chrNW_004955422:29,141,348...29,154,927 		JBrowse link
regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmpk DM1 protein kinase acts_upstream_of_or_within ISO (PMID:11526199) MGI PMID:11526199 NCBI chrNW_004955574:225,615...237,526
Ensembl chrNW_004955574:226,292...237,526 		JBrowse link
regulation of skeletal muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO (PMID:17524427) BHF-UCL PMID:17524427 NCBI chrNW_004955561:326,008...335,911
Ensembl chrNW_004955561:325,944...335,914 		JBrowse link
G Dmd dystrophin involved_in ISO (MGI:3837615|PMID:19198614) BHF-UCL PMID:19198614 MGI:3837615 NCBI chrNW_004955535:1,283,084...3,297,015
Ensembl chrNW_004955535:1,283,523...3,299,542 		JBrowse link
G LOC102009926 chromosome unknown open reading frame, human C12orf57 involved_in ISO (PMID:23453665), (PMID:23633300), (PMID:24798461) UniProt PMID:23453665 PMID:23633300 PMID:24798461 NCBI chrNW_004955413:4,524,236...4,525,760
Ensembl chrNW_004955413:4,524,236...4,525,760 		JBrowse link
G Slc8a3 solute carrier family 8 member A3 involved_in ISO (MGI:3027331|PMID:14722618) UniProt PMID:14722618 MGI:3027331 NCBI chrNW_004955466:220,346...359,627
Ensembl chrNW_004955466:220,099...360,851 		JBrowse link
regulation of skeletal muscle contraction by action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn4a sodium voltage-gated channel alpha subunit 4 involved_in ISO (PMID:12766226) UniProt PMID:12766226 NCBI chrNW_004955478:7,861,585...7,906,192
Ensembl chrNW_004955478:7,861,585...7,906,192 		JBrowse link
regulation of skeletal muscle contraction by calcium ion signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmpk DM1 protein kinase involved_in ISO (MGI:1097019|PMID:9294109) UniProt PMID:9294109 MGI:1097019 NCBI chrNW_004955574:225,615...237,526
Ensembl chrNW_004955574:226,292...237,526 		JBrowse link
G Rem1 RRAD and GEM like GTPase 1 acts_upstream_of_or_within ISO (PMID:26078055) MGI PMID:26078055 NCBI chrNW_004955422:29,434,477...29,443,172
Ensembl chrNW_004955422:29,429,908...29,443,273 		JBrowse link
regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkd1 protein kinase D1 ISO RGD PMID:21041300 RGD:243065274 NCBI chrNW_004955409:30,554,095...30,860,588
Ensembl chrNW_004955409:30,554,013...30,860,649 		JBrowse link
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casq1 calsequestrin 1 involved_in
acts_upstream_of_or_within		 ISO (MGI:5306707|PMID:22049211)
(PMID:17627988)		 UniProt
MGI		 PMID:17627988 PMID:22049211 MGI:5306707 NCBI chrNW_004955468:11,967,678...11,978,836
Ensembl chrNW_004955468:11,967,678...11,978,836 		JBrowse link
G Dmd dystrophin involved_in ISO (MGI:3837615|PMID:19198614) BHF-UCL PMID:19198614 MGI:3837615 NCBI chrNW_004955535:1,283,084...3,297,015
Ensembl chrNW_004955535:1,283,523...3,299,542 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A involved_in ISO (PMID:7592869) BHF-UCL PMID:7592869 NCBI chrNW_004955596:580,106...606,210
Ensembl chrNW_004955596:580,106...603,255 		JBrowse link
regulation of skeletal muscle contraction via regulation of action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnj2 potassium inwardly rectifying channel subfamily J member 2 involved_in ISO (PMID:11371347) BHF-UCL PMID:11371347 NCBI chrNW_004955478:2,734,795...2,745,217
Ensembl chrNW_004955478:2,734,795...2,745,217 		JBrowse link
regulation of the force of skeletal muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 involved_in ISO (MGI:3759354|PMID:17828264) UniProt PMID:17828264 MGI:3759354 NCBI chrNW_004955422:18,799,372...18,812,458
Ensembl chrNW_004955422:18,799,372...18,812,711 		JBrowse link
G Kbtbd13 kelch repeat and BTB domain containing 13 acts_upstream_of_or_within ISO (PMID:31671076) MGI PMID:31671076 NCBI chrNW_004955450:10,344,020...10,347,686
Ensembl chrNW_004955450:10,345,753...10,347,129 		JBrowse link
slow-twitch skeletal muscle fiber contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mb myoglobin ISO RGD PMID:15981298 RGD:1582404 NCBI chrNW_004955405:43,215,404...43,221,606
Ensembl chrNW_004955405:43,215,007...43,222,052 		JBrowse link
G Tnnt1 troponin T1, slow skeletal type ISO RGD PMID:15788488 RGD:1599482 NCBI chrNW_004955567:1,039,625...1,050,581
Ensembl chrNW_004955567:1,043,026...1,055,039 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12346
    multicellular organismal process 6182
      multicellular organismal movement 64
        musculoskeletal movement 60
          skeletal muscle contraction 45
            involuntary skeletal muscle contraction + 3
            regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction 1
            regulation of skeletal muscle contraction + 16
            voluntary skeletal muscle contraction + 6
Path 2
Term Annotations click to browse term
  biological_process 12346
    multicellular organismal process 6182
      system process 1685
        muscle system process 426
          muscle contraction 293
            striated muscle contraction 170
              skeletal muscle contraction 45
                involuntary skeletal muscle contraction + 3
                regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction 1
                regulation of skeletal muscle contraction + 16
                voluntary skeletal muscle contraction + 6
paths to the root