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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of myeloid leukocyte differentiation
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Accession:GO:0002762 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.
Synonyms:exact_synonym: down regulation of myeloid leukocyte differentiation;   downregulation of myeloid leukocyte differentiation
 narrow_synonym: inhibition of myeloid leukocyte differentiation



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negative regulation of myeloid leukocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (MGI:2152233|PMID:11672542) RGD PMID:11672542 MGI:2152233 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 IDA RGD PMID:7737424 RGD:2299083 NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 IDA RGD PMID:7737424 RGD:2299083 NCBI chr10:78,898,097...78,903,600
Ensembl chr10:78,897,770...78,903,538
JBrowse link
negative regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO
ISS
(PMID:10961870)
GO_REF:0000024
RGD
UniProt
PMID:10961870 GO_REF:0000024 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G C1qc complement C1q C chain involved_in ISO
IEA
(PMID:10961870)
GO_REF:0000107
RGD
Ensembl
PMID:10961870 GO_REF:0000107 NCBI chr 5:149,127,424...149,130,732
Ensembl chr 5:149,127,415...149,131,017
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:4837548|PMID:21029969)
UniProt
RGD
PMID:21029969 GO_REF:0000024 MGI:4837548 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Cul4a cullin 4A acts_upstream_of_or_within ISO (MGI:3691926|PMID:12393421) RGD PMID:12393421 MGI:3691926 NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within ISO MGI:2386884 (MGI:1266928|PMID:9620849) RGD PMID:9620849 MGI:1266928 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
JBrowse link
G Prdm16 PR/SET domain 16 involved_in ISO (PMID:12816872) RGD PMID:12816872 NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601
JBrowse link
G Rara retinoic acid receptor, alpha involved_in ISO (PMID:19917671) RGD PMID:19917671 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Runx1 RUNX family transcription factor 1 involved_in ISO (PMID:9199349) RGD PMID:9199349 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
JBrowse link
G Zbtb46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within ISO MGI:5320483 (MGI:5320487|PMID:22615127) RGD PMID:22615127 MGI:5320487 NCBI chr 3:168,497,294...168,567,799
Ensembl chr 3:168,499,583...168,568,782
JBrowse link
negative regulation of macrophage differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO
ISS
(PMID:10961870)
GO_REF:0000024
RGD
UniProt
PMID:10961870 GO_REF:0000024 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G C1qc complement C1q C chain involved_in ISO
IEA
(PMID:10961870)
GO_REF:0000107
RGD
Ensembl
PMID:10961870 GO_REF:0000107 NCBI chr 5:149,127,424...149,130,732
Ensembl chr 5:149,127,415...149,131,017
JBrowse link
G Gata2 GATA binding protein 2 acts_upstream_of_or_within ISO (MGI:3769271|PMID:16254139) RGD PMID:16254139 MGI:3769271 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:3629372|PMID:16705167)
UniProt
RGD
PMID:16705167 GO_REF:0000024 MGI:3629372 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
JBrowse link
G Thoc5 THO complex 5 acts_upstream_of_or_within ISO (MGI:1349551|PMID:10597251) RGD PMID:10597251 MGI:1349551 NCBI chr14:79,758,805...79,792,718
Ensembl chr14:79,758,917...79,792,718
JBrowse link
G Zbtb46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within ISO MGI:5320483 (MGI:5320487|PMID:22615127) RGD PMID:22615127 MGI:5320487 NCBI chr 3:168,497,294...168,567,799
Ensembl chr 3:168,499,583...168,568,782
JBrowse link
negative regulation of mast cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zfpm1 zinc finger protein, multitype 1 involved_in ISO (MGI:3773481|PMID:18063754) RGD PMID:18063754 MGI:3773481 NCBI chr19:50,334,352...50,391,029
Ensembl chr19:50,334,682...50,390,591
JBrowse link
negative regulation of monocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apcs amyloid P component, serum involved_in IEA
ISO
GO_REF:0000107
(PMID:14607961)
Ensembl
RGD
PMID:14607961 GO_REF:0000107 NCBI chr13:85,373,338...85,374,134
Ensembl chr13:85,373,220...85,374,298
JBrowse link
G Cdk6 cyclin-dependent kinase 6 involved_in ISO (PMID:26542173) RGD PMID:26542173 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Gpr68 G protein-coupled receptor 68 acts_upstream_of_or_within ISO MGI:3849457 (MGI:3848292|PMID:19479052) RGD PMID:19479052 MGI:3848292 NCBI chr 6:120,135,620...120,166,089
Ensembl chr 6:120,135,436...120,166,089
JBrowse link
G Hoxa7 homeobox A7 involved_in ISO (PMID:14704364) RGD PMID:14704364 NCBI chr 4:81,315,730...81,317,629
Ensembl chr 4:81,314,625...81,317,659
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2386884 (MGI:1266928|PMID:9620849)
Ensembl
RGD
PMID:9620849 GO_REF:0000107 MGI:1266928 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor involved_in ISO
ISS
(PMID:9924025)
GO_REF:0000024
RGD
UniProt
PMID:9924025 GO_REF:0000024 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Zbtb46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within ISO MGI:5320483 (MGI:5320487|PMID:22615127) RGD PMID:22615127 MGI:5320487 NCBI chr 3:168,497,294...168,567,799
Ensembl chr 3:168,499,583...168,568,782
JBrowse link
negative regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2386884 (MGI:1266928|PMID:9620849)
Ensembl
RGD
PMID:9620849 GO_REF:0000107 MGI:1266928 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
JBrowse link
G Trib1 tribbles pseudokinase 1 involved_in ISO (MGI:5488531|PMID:23515163) RGD PMID:23515163 MGI:5488531 NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731
JBrowse link
negative regulation of osteoclast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cldn18 claudin 18 acts_upstream_of_or_within ISO MGI:5007067 (MGI:5489769|PMID:22437732) RGD PMID:22437732 MGI:5489769 NCBI chr 8:100,246,499...100,265,797
Ensembl chr 8:100,247,633...100,273,351
JBrowse link
G Fbn1 fibrillin 1 involved_in ISO (PMID:24039232)
(MGI:5795811|PMID:24039232)
RGD PMID:24039232 MGI:5795811 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 involved_in ISO (PMID:29149593)
(MGI:6106664|PMID:29149593)
RGD PMID:29149593 MGI:6106664 NCBI chr 2:170,150,552...170,310,698
Ensembl chr 2:170,149,694...170,309,941
JBrowse link
G Tjp2 tight junction protein 2 acts_upstream_of_or_within ISO (MGI:5489769|PMID:22437732) RGD PMID:22437732 MGI:5489769 NCBI chr 1:221,709,745...221,838,383
Ensembl chr 1:221,709,745...221,838,295
JBrowse link
negative regulation of osteoclast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha involved_in ISO (PMID:10822112) RGD PMID:10822112 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 involved_in ISO
ISS
(PMID:21403648)
GO_REF:0000024
RGD
UniProt
PMID:21403648 GO_REF:0000024 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO (MGI:5691608|PMID:25490771) RGD PMID:25490771 MGI:5691608 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Clec2d C-type lectin domain family 2, member D acts_upstream_of_or_within ISO (MGI:2446956|PMID:12374791) RGD PMID:12374791 MGI:2446956 NCBI chr 4:162,216,052...162,239,530
Ensembl chr 4:162,216,572...162,239,527
JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2148567|MGI:3041864 (MGI:3578468|PMID:15866165)
Ensembl
RGD
PMID:15866165 GO_REF:0000107 MGI:3578468 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Fbn1 fibrillin 1 involved_in ISO (PMID:24039232)
(MGI:5795811|PMID:24039232)
RGD PMID:24039232 MGI:5795811 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fstl3 follistatin like 3 involved_in ISO (PMID:15574124) RGD PMID:15574124 NCBI chr 7:9,924,670...9,929,195
Ensembl chr 7:9,923,576...9,939,639
JBrowse link
G Gpr137 G protein-coupled receptor 137 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:204,129,636...204,132,622
Ensembl chr 1:204,129,636...204,133,082
JBrowse link
G Gpr137b G protein-coupled receptor 137B involved_in IBA
ISO
PMID:21873635
(MGI:6362357|PMID:31173907)
RGD PMID:31173907 PMID:21873635 MGI:6362357, RGD:13792537 NCBI chr17:86,003,630...86,041,841
Ensembl chr17:85,966,921...86,041,835
JBrowse link
G Gpr55 G protein-coupled receptor 55 involved_in ISO (PMID:19805329) RGD PMID:19805329 NCBI chr 9:86,584,906...86,640,601
Ensembl chr 9:86,590,885...86,640,613
JBrowse link
G Ifnb1 interferon beta 1 acts_upstream_of_or_within ISO (MGI:3836131|PMID:17442941) RGD PMID:17442941 MGI:3836131 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (MGI:3836131|PMID:17442941) RGD PMID:17442941 MGI:3836131 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (MGI:2675763|PMID:12941478), (MGI:3836131|PMID:17442941) RGD PMID:12941478 PMID:17442941 MGI:2675763 MGI:3836131 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Inpp4b inositol polyphosphate-4-phosphatase type II B acts_upstream_of_or_within ISO MGI:102469|MGI:1100089 (MGI:5295788|PMID:21982707) RGD PMID:21982707 MGI:5295788 NCBI chr19:25,920,189...26,670,085
Ensembl chr19:25,925,358...26,280,634
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2386884 (MGI:2386137|PMID:12161749)
Ensembl
RGD
PMID:12161749 GO_REF:0000107 MGI:2386137 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:18802077) RGD PMID:18802077 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
JBrowse link
G Lrrc17 leucine rich repeat containing 17 involved_in ISO (MGI:3850892|PMID:19336404) RGD PMID:19336404 MGI:3850892 NCBI chr 4:13,501,428...13,531,845
Ensembl chr 4:13,501,436...13,531,845
JBrowse link
G Mafb MAF bZIP transcription factor B involved_in ISS
ISO
GO_REF:0000024
(MGI:3849531|PMID:19440205)
UniProt
RGD
PMID:19440205 GO_REF:0000024 MGI:3849531 NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031
JBrowse link
G Nf1 neurofibromin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1100089|MGI:1339753|MGI:97583 (MGI:3689489|PMID:17053831)
Ensembl
RGD
PMID:17053831 GO_REF:0000107 MGI:3689489 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 acts_upstream_of_or_within ISO (MGI:3836131|PMID:17442941) RGD PMID:17442941 MGI:3836131 NCBI chr 2:184,232,546...184,241,455
Ensembl chr 2:184,232,571...184,241,480
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:97306 (MGI:3689489|PMID:17053831)
Ensembl
RGD
PMID:17053831 GO_REF:0000107 MGI:3689489 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pirb paired Ig-like receptor B involved_in ISO (PMID:18802077) RGD PMID:18802077
G Sfrp1 secreted frizzled-related protein 1 acts_upstream_of_or_within
involved_in
IMP
ISO
IEA
MGI:3045799 (MGI:3040721|PMID:14976225)
GO_REF:0000107
RGD
Ensembl
PMID:14976225 PMID:17540629 GO_REF:0000107 MGI:3040721, RGD:4107086 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286
JBrowse link
G Tcta T-cell leukemia translocation altered involved_in ISO (PMID:19560569) RGD PMID:19560569 NCBI chr 8:108,988,588...108,992,324
Ensembl chr 8:108,988,590...108,991,564
JBrowse link
G Tmem178a transmembrane protein 178A involved_in ISS
ISO
IEA
IBA
GO_REF:0000024
(MGI:5706679|PMID:26644563)
GO_REF:0000107
PMID:21873635
UniProt
RGD
Ensembl
PMID:26644563 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5706679, RGD:13792537 NCBI chr 6:14,004,629...14,063,677
Ensembl chr 6:14,004,630...14,063,549
JBrowse link
G Tob2 transducer of ERBB2, 2 acts_upstream_of_or_within ISO MGI:3789484 (MGI:3785228|PMID:18358842) RGD PMID:18358842 MGI:3785228 NCBI chr 7:113,362,703...113,371,423
Ensembl chr 7:113,361,148...113,372,688
JBrowse link
G Ubash3b ubiquitin associated and SH3 domain containing, B acts_upstream_of_or_within ISO (MGI:5619442|PMID:23149425) RGD PMID:23149425 MGI:5619442 NCBI chr 8:41,385,419...41,532,248
Ensembl chr 8:41,388,341...41,532,201
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19391
    cellular process 18252
      negative regulation of cellular process 5066
        negative regulation of cell differentiation 738
          negative regulation of myeloid cell differentiation 92
            negative regulation of myeloid leukocyte differentiation 50
              negative regulation of granulocyte differentiation + 10
              negative regulation of macrophage differentiation + 6
              negative regulation of mast cell differentiation 1
              negative regulation of monocyte differentiation 7
              negative regulation of osteoclast differentiation + 30
Path 2
Term Annotations click to browse term
  biological_process 19391
    developmental process 6775
      anatomical structure development 6201
        multicellular organism development 5638
          system development 5307
            immune system development 1096
              hematopoietic or lymphoid organ development 1029
                hemopoiesis 977
                  leukocyte differentiation 611
                    myeloid leukocyte differentiation 235
                      regulation of myeloid leukocyte differentiation 133
                        negative regulation of myeloid leukocyte differentiation 50
                          negative regulation of granulocyte differentiation + 10
                          negative regulation of macrophage differentiation + 6
                          negative regulation of mast cell differentiation 1
                          negative regulation of monocyte differentiation 7
                          negative regulation of osteoclast differentiation + 30
paths to the root