immune response-activating signaling pathway - Ontology Report

GO_REF:0000033

NCBI chr11:114,813,605...114,825,197
Ensembl chr11:114,813,607...114,825,212

Cd300ld

CD300 molecule like family member d

involved_in

IBA

GO_REF:0000033

NCBI chr11:114,873,269...114,880,712
Ensembl chr11:114,873,100...114,880,748

Cd300ld2

CD300 molecule like family member D2

involved_in

IBA

GO_REF:0000033

NCBI chr11:114,901,146...114,907,657
Ensembl chr11:114,901,161...114,907,019

Cd300ld3

CD300 molecule like family member D3

involved_in

IBA

GO_REF:0000033

NCBI chr11:114,932,930...114,939,244
Ensembl chr11:114,932,957...114,939,235

Cd300ld4

CD300 molecule like family member D4

involved_in

IBA

GO_REF:0000033

NCBI chr11:114,892,491...114,918,301
Ensembl chr11:114,911,554...114,917,838

Cd300lf

CD300 molecule like family member F

involved_in

IBA

GO_REF:0000033

NCBI chr11:115,007,040...115,024,834
Ensembl chr11:115,007,040...115,024,818

Tmigd3

transmembrane and immunoglobulin domain containing 3

involved_in

IBA

GO_REF:0000033

NCBI chr 3:105,778,174...105,831,360
Ensembl chr 3:105,778,174...105,816,242
Ensembl chr 3:105,778,174...105,816,242
Ensembl chr 3:105,778,174...105,816,242

Zc3h12a

zinc finger CCCH type containing 12A

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 4:125,012,207...125,021,674
Ensembl chr 4:125,012,216...125,021,633

antigen receptor-mediated signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Bcar1

breast cancer anti-estrogen resistance 1

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr 8:112,437,106...112,470,481
Ensembl chr 8:112,437,106...112,470,441

Cd19

CD19 antigen

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr 7:126,007,620...126,016,401
Ensembl chr 7:126,007,622...126,014,061

Lax1

lymphocyte transmembrane adaptor 1

involved_in
acts_upstream_of_or_within

IBA
IMP

(PMID:15843560)

PMID:15843560

GO_REF:0000033

NCBI chr 1:133,606,767...133,620,760
Ensembl chr 1:133,606,829...133,617,846

Sh2b2

SH2B adaptor protein 2

involved_in

IBA

GO_REF:0000033

NCBI chr 5:136,247,003...136,275,446
Ensembl chr 5:136,247,001...136,275,410

B cell receptor apoptotic signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Bax

BCL2-associated X protein

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta

involved_in

IDA

(PMID:23728777)

PMID:23728777

NCBI chr16:55,631,740...55,659,018
Ensembl chr16:55,631,738...55,659,262

B cell receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Abl1

c-abl oncogene 1, non-receptor tyrosine kinase

acts_upstream_of_or_within

IMP

(PMID:11120811), (PMID:19228876)

PMID:11120811 PMID:19228876

NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239

Bcar1

breast cancer anti-estrogen resistance 1

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 8:112,437,106...112,470,481
Ensembl chr 8:112,437,106...112,470,441

Bcl2

B cell leukemia/lymphoma 2

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

Blk

B lymphoid kinase

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr14:63,610,286...63,654,636
Ensembl chr14:63,610,285...63,654,486

Blnk

B cell linker

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr19:40,917,371...40,982,664
Ensembl chr19:40,917,371...40,982,978

Bmx

BMX non-receptor tyrosine kinase

involved_in

IBA

GO_REF:0000033

NCBI chr X:162,975,838...163,041,189
Ensembl chr X:162,975,838...163,041,189

Bruton agammaglobulinemia tyrosine kinase

involved_in

ISO
IBA
IEA

GO_REF:0000033 GO_REF:0000107 GO_REF:0000119

NCBI chr X:133,443,083...133,484,366
Ensembl chr X:133,443,085...133,484,319

Cd19

CD19 antigen

acts_upstream_of_or_within
involved_in

IDA
IMP
IBA

(PMID:9254656)
(PMID:23499492)

PMID:9254656 PMID:23499492

GO_REF:0000033

NCBI chr 7:126,007,620...126,016,401
Ensembl chr 7:126,007,622...126,014,061

Cd38

CD38 antigen

involved_in

ISO
IEA

PMID:1373499 PMID:1439759 PMID:8626447

GO_REF:0000107 GO_REF:0000119

NCBI chr 5:44,026,153...44,069,714
Ensembl chr 5:44,025,895...44,069,717

Cd79a

CD79A antigen (immunoglobulin-associated alpha)

acts_upstream_of_or_within
involved_in

IDA
IBA

(PMID:1373499), (PMID:8626447)
(PMID:1439759), (PMID:8626447)

MGI
GO_Central
UniProt

GO_REF:0000033

NCBI chr 7:24,596,922...24,601,283
Ensembl chr 7:24,596,806...24,601,622

Cd79b

CD79B antigen

acts_upstream_of_or_within
involved_in

IDA
IBA

(PMID:1373499), (PMID:8626447)
(PMID:8626447)

PMID:1373499 PMID:8626447

GO_REF:0000033

NCBI chr11:106,202,167...106,205,388
Ensembl chr11:106,202,167...106,205,588

Ctla4

cytotoxic T-lymphocyte-associated protein 4

involved_in

IBA
ISO

GO_REF:0000033 GO_REF:0000119

NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991

Fcrl5

Fc receptor-like 5

acts_upstream_of

IDA
IGI

(PMID:23509253)

PMID:23509253

NCBI chr 3:87,343,084...87,407,985
Ensembl chr 3:87,343,080...87,407,985

Grb2

growth factor receptor bound protein 2

involved_in

IDA

(PMID:9199344)

PMID:9199344

NCBI chr11:115,534,871...115,599,423
Ensembl chr11:115,534,871...115,599,423

Ifi211

interferon activated gene 211

involved_in

ISO

(PMID:17875758)

PMID:17875758

NCBI chr 1:173,723,907...173,740,650
Ensembl chr 1:173,723,911...173,740,612

Ighe

Immunoglobulin heavy constant epsilon

involved_in

ISO

GO_REF:0000119

NCBI chr12:113,232,883...113,236,868
Ensembl chr12:113,232,880...113,236,868

Ighm

immunoglobulin heavy constant mu

acts_upstream_of_or_within

IDA

(PMID:1373499), (PMID:7499277), (PMID:8626447), (PMID:9254656)

PMID:1373499 PMID:7499277 PMID:8626447 PMID:9254656

NCBI chr12:113,382,446...113,386,350
Ensembl chr12:113,382,178...113,386,350

Itk

IL2 inducible T cell kinase

involved_in

IBA

GO_REF:0000033

NCBI chr11:46,215,975...46,280,342
Ensembl chr11:46,215,977...46,280,342

Klhl6

kelch-like 6

involved_in

IMP

(PMID:16166635)

PMID:16166635

NCBI chr16:19,765,242...19,801,766
Ensembl chr16:19,765,246...19,801,787

Lat2

linker for activation of T cells family, member 2

involved_in

IBA
ISS
ISO

(PMID:12514734)

GO_Central
HGNC-UCL

PMID:12514734

GO_REF:0000033 GO_REF:0000119

NCBI chr 5:134,628,957...134,648,637
Ensembl chr 5:134,628,876...134,643,879

Lck

lymphocyte protein tyrosine kinase

acts_upstream_of_or_within
involved_in

IDA
IBA

(PMID:7499277)

PMID:7499277

GO_REF:0000033

NCBI chr 4:129,442,142...129,467,415
Ensembl chr 4:129,442,137...129,467,434

Lime1

Lck interacting transmembrane adaptor 1

involved_in
acts_upstream_of_or_within

IBA
IDA

(PMID:16249387)

PMID:16249387

GO_REF:0000033

NCBI chr 2:181,023,028...181,025,421
Ensembl chr 2:181,021,871...181,025,421

LYN proto-oncogene, Src family tyrosine kinase

acts_upstream_of_or_within

IDA
IGI

(PMID:7499277)
(PMID:23509253)

PMID:7499277 PMID:23509253

NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122

Mapk1

mitogen-activated protein kinase 1

acts_upstream_of_or_within

IDA

(PMID:9254656)

PMID:9254656

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

Mef2c

myocyte enhancer factor 2C

involved_in

IMP

(PMID:18955699)

PMID:18955699

NCBI chr13:83,652,136...83,815,197
Ensembl chr13:83,652,153...83,815,199

Ms4a1

membrane-spanning 4-domains, subfamily A, member 1

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr19:11,227,043...11,243,513
Ensembl chr19:11,227,039...11,243,605

Nckap1l

NCK associated protein 1 like

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr15:103,362,219...103,411,288
Ensembl chr15:103,362,221...103,407,237

Nfam1

Nfat activating molecule with ITAM motif 1

involved_in
acts_upstream_of_or_within

IBA
IMP
IDA

(PMID:15143214)

GO_Central
HGNC-UCL
MGI

PMID:15143214

GO_REF:0000033

NCBI chr15:82,880,937...82,917,598
Ensembl chr15:82,877,174...82,917,507

Nfatc2

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 2:168,318,330...168,443,900
Ensembl chr 2:168,318,330...168,443,577

Nfkb1

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

involved_in

IDA

(PMID:17367755)

PMID:17367755

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

involved_in

IDA

(PMID:17367755)

PMID:17367755

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta

involved_in

IDA

(PMID:17367755)

PMID:17367755

NCBI chr16:55,631,740...55,659,018
Ensembl chr16:55,631,738...55,659,262

phospholipase C, gamma 2

involved_in

IMP
ISO

(PMID:10925250)

PMID:10925250

GO_REF:0000119

NCBI chr 8:118,225,014...118,361,881
Ensembl chr 8:118,225,030...118,361,881

Plekha1

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 7:130,462,281...130,515,224
Ensembl chr 7:130,467,486...130,515,042

Prkcb

protein kinase C, beta

involved_in

IMP

(PMID:12118249)

PMID:12118249

NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625

protein tyrosine phosphatase, non-receptor type 6

acts_upstream_of_or_within

IMP
IGI

(PMID:9254656)
(PMID:23509253)

PMID:9254656 PMID:23509253

NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677

PMID:7499277 PMID:8692271 PMID:9254656

protein tyrosine phosphatase receptor type C

acts_upstream_of_or_within
involved_in

IMP

(PMID:7499277)
(PMID:8692271)
(PMID:9254656)

MGI
UniProt

NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446

Rftn1

raftlin lipid raft linker 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr17:50,300,287...50,497,525
Ensembl chr17:50,299,285...50,497,702

Sh2b2

SH2B adaptor protein 2

acts_upstream_of_or_within
involved_in

IDA
ISO

(PMID:10872802)

PMID:10872802

GO_REF:0000119

NCBI chr 5:136,247,003...136,275,446
Ensembl chr 5:136,247,001...136,275,410

Sos1

SOS Ras/Rac guanine nucleotide exchange factor 1

involved_in

IGI

(PMID:24043312)

PMID:24043312

NCBI chr17:80,701,181...80,787,882
Ensembl chr17:80,701,180...80,787,882

Syk

spleen tyrosine kinase

acts_upstream_of_or_within
involved_in

IDA
IBA
ISO

(PMID:7499277), (PMID:8626447)
(PMID:9199344)

PMID:7499277 PMID:8626447 PMID:9199344

GO_REF:0000033 GO_REF:0000119

NCBI chr13:52,736,670...52,802,828
Ensembl chr13:52,737,209...52,802,828

Tec

tec protein tyrosine kinase

involved_in

ISO
IBA

GO_REF:0000033 GO_REF:0000119

NCBI chr 5:72,913,061...73,025,997
Ensembl chr 5:72,913,059...73,025,826

Vav3

vav 3 oncogene

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 3:109,247,757...109,593,010
Ensembl chr 3:109,247,969...109,593,014

cell surface pattern recognition receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cd14

CD14 antigen

involved_in

ISO

PMID:12719478 PMID:19358895

GO_REF:0000119

NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851

Clec7a

C-type lectin domain family 7, member a

acts_upstream_of_or_within
involved_in

IDA
ISO

(PMID:12719478)
(PMID:19358895)

MGI
ARUK-UCL

NCBI chr 6:129,438,554...129,449,748
Ensembl chr 6:129,438,554...129,449,742

Fcna

ficolin A

involved_in

ISS

GO_REF:0000024

NCBI chr 2:25,514,677...25,525,448
Ensembl chr 2:25,514,678...25,518,042

Fcnb

ficolin B

involved_in

IEA

GO_REF:0000107

NCBI chr 2:27,966,491...27,974,921
Ensembl chr 2:27,966,390...27,974,897

Ffar2

free fatty acid receptor 2

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr 7:30,517,778...30,523,200
Ensembl chr 7:30,517,773...30,523,200

Lbp

lipopolysaccharide binding protein

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 2:158,148,413...158,174,772
Ensembl chr 2:158,148,413...158,174,772

Mbl2

mannose-binding lectin (protein C) 2

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087

Syk

spleen tyrosine kinase

involved_in

IEA

GO_REF:0000107

NCBI chr13:52,736,670...52,802,828
Ensembl chr13:52,737,209...52,802,828

toll-like receptor 2

acts_upstream_of_or_within

IMP

(PMID:12719478)

PMID:12719478

NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074

cGAS/STING signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

cyclic GMP-AMP synthase

involved_in

ISO
IDA

(PMID:39322678)

PMID:39322678

GO_REF:0000119

NCBI chr 9:78,337,800...78,350,519
Ensembl chr 9:78,337,808...78,350,519

Ddx41

DEAD box helicase 41

involved_in

ISO

(PMID:35613581)

PMID:35613581

NCBI chr13:55,678,223...55,684,471
Ensembl chr13:55,678,223...55,684,471

Sting1

stimulator of interferon response cGAMP interactor 1

involved_in

ISS
IDA
ISO

(PMID:37832545)

PMID:37832545

GO_REF:0000024 GO_REF:0000119

NCBI chr18:35,866,731...35,873,607
Ensembl chr18:35,866,732...35,873,607

complement component C5a signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Blvra

biliverdin reductase A

acts_upstream_of_or_within

IMP

(PMID:30952817)

PMID:30952817

NCBI chr 2:126,912,549...126,939,004
Ensembl chr 2:126,912,585...126,939,004

C5ar1

complement component 5a receptor 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 7:15,980,668...15,993,465
Ensembl chr 7:15,980,668...15,993,465

complement receptor mediated signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Akt1

thymoma viral proto-oncogene 1

involved_in

ISO

(PMID:19162005)

PMID:19162005

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

complement component 3

involved_in

IMP

(PMID:22632727)

PMID:22632727

NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136

C3ar1

complement component 3a receptor 1

involved_in

ISO
IBA
IEA

GO_REF:0000033 GO_REF:0000107 GO_REF:0000119

NCBI chr 6:122,824,099...122,833,116
Ensembl chr 6:122,824,097...122,833,120

C5ar1

complement component 5a receptor 1

involved_in

IBA

GO_REF:0000033

NCBI chr 7:15,980,668...15,993,465
Ensembl chr 7:15,980,668...15,993,465

C5ar2

complement component 5a receptor 2

involved_in

IEA
IBA

GOC
GO_Central

GO_REF:0000033 GO_REF:0000108

NCBI chr 7:15,968,512...15,978,079
Ensembl chr 7:15,968,510...15,978,079

Cmklr1

chemerin chemokine-like receptor 1

involved_in

IBA

GO_REF:0000033

NCBI chr 5:113,750,415...113,792,971
Ensembl chr 5:113,750,415...113,788,487

Cr2

complement receptor 2

involved_in

IEA

GOC

GO_REF:0000108

NCBI chr 1:194,819,120...194,859,096
Ensembl chr 1:194,819,119...194,859,024

Fpr-rs3

formyl peptide receptor, related sequence 3

involved_in

IBA

GO_REF:0000033

NCBI chr17:20,844,108...20,845,139
Ensembl chr17:20,844,108...20,845,139

Fpr-rs4

formyl peptide receptor, related sequence 4

involved_in

IBA

GO_REF:0000033

NCBI chr17:18,241,995...18,242,966
Ensembl chr17:18,241,995...18,242,966

Fpr-rs6

formyl peptide receptor, related sequence 6

involved_in

IBA

GO_REF:0000033

NCBI chr17:20,402,340...20,403,359
Ensembl chr17:20,402,340...20,403,359

Fpr-rs7

formyl peptide receptor, related sequence 7

involved_in

IBA

GO_REF:0000033

NCBI chr17:20,333,472...20,334,488
Ensembl chr17:20,333,472...20,334,488

Fpr1

formyl peptide receptor 1

involved_in

IBA

GO_REF:0000033

NCBI chr17:18,096,733...18,104,201
Ensembl chr17:18,096,733...18,104,202

Fpr2

formyl peptide receptor 2

involved_in

IBA

GO_REF:0000033

NCBI chr17:18,108,086...18,114,214
Ensembl chr17:18,108,086...18,114,214

Fpr3

formyl peptide receptor 3

involved_in

IBA

GO_REF:0000033

NCBI chr17:18,190,720...18,191,939
Ensembl chr17:18,108,114...18,191,939

Gpld1

glycosylphosphatidylinositol specific phospholipase D1

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr13:25,127,135...25,175,919
Ensembl chr13:25,127,135...25,176,484

Gpr33

G protein-coupled receptor 33

involved_in

IBA

GO_REF:0000033

NCBI chr12:52,069,786...52,074,887
Ensembl chr12:52,069,786...52,074,846

Itgam

integrin alpha M

involved_in

IMP

(PMID:22632727)

PMID:22632727

NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663

Rgcc

regulator of cell cycle

involved_in

ISO

(PMID:19162005)

PMID:19162005

NCBI chr14:79,526,190...79,539,075
Ensembl chr14:79,526,196...79,539,085

cytoplasmic pattern recognition receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Alpk1

alpha-kinase 1

involved_in

ISO
IBA
IMP

(PMID:30111836)

PMID:30111836

GO_REF:0000033 GO_REF:0000119

NCBI chr 3:127,460,367...127,574,195
Ensembl chr 3:127,463,959...127,574,176

Becn1

beclin 1, autophagy related

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

cyclic GMP-AMP synthase

involved_in

ISO

GO_REF:0000119

NCBI chr 9:78,337,800...78,350,519
Ensembl chr 9:78,337,808...78,350,519

DEAD box helicase 3, X-linked

involved_in

ISO

(PMID:23478265)

PMID:23478265

NCBI chr X:13,147,261...13,160,222
Ensembl chr X:13,147,209...13,160,291

DExH-box helicase 58

involved_in

ISS
IBA
ISO

GO_REF:0000024 GO_REF:0000033 GO_REF:0000119

NCBI chr11:100,585,710...100,595,165
Ensembl chr11:100,585,710...100,595,097

Ipo5

importin 5

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr14:121,134,271...121,185,451
Ensembl chr14:121,148,636...121,185,411

Irf3

interferon regulatory factor 3

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272

Irf7

interferon regulatory factor 7

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394

Mavs

mitochondrial antiviral signaling protein

involved_in

ISO

GO_REF:0000119

NCBI chr 2:131,075,445...131,089,945
Ensembl chr 2:131,075,983...131,089,945

Rigi

RNA sensor RIG-I

involved_in

ISO
IBA

GO_REF:0000033 GO_REF:0000119

NCBI chr 4:40,203,775...40,239,843
Ensembl chr 4:40,203,773...40,239,828

Sting1

stimulator of interferon response cGAMP interactor 1

involved_in

ISO

GO_REF:0000119

NCBI chr18:35,866,731...35,873,607
Ensembl chr18:35,866,732...35,873,607

Tbk1

TANK-binding kinase 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr10:121,382,360...121,422,699
Ensembl chr10:121,382,360...121,422,692

Tifa

TRAF-interacting protein with forkhead-associated domain

involved_in

IBA
ISS
ISO

GO_REF:0000024 GO_REF:0000033 GO_REF:0000119

NCBI chr 3:127,582,524...127,592,043
Ensembl chr 3:127,583,454...127,625,813

Traf3ip3

TRAF3 interacting protein 3

involved_in

ISO
IBA

GO_REF:0000033 GO_REF:0000119

NCBI chr 1:192,857,812...192,883,854
Ensembl chr 1:192,857,761...192,884,011

Traf6

TNF receptor-associated factor 6

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014

Trim25

tripartite motif-containing 25

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr11:88,890,194...88,911,119
Ensembl chr11:88,890,202...88,911,119

Ywhae

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr11:75,620,121...75,656,667
Ensembl chr11:75,623,695...75,656,671

endolysosomal toll-like receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Washc4

WASH complex subunit 4

acts_upstream_of_or_within

IMP

(PMID:33749590)

PMID:33749590

NCBI chr10:83,379,073...83,432,350
Ensembl chr10:83,379,616...83,432,337

Fc receptor mediated stimulatory signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Fcer1g

Fc receptor, IgE, high affinity I, gamma polypeptide

involved_in
acts_upstream_of_or_within

IBA
IMP

(PMID:14764707)

PMID:14764707

GO_REF:0000033

NCBI chr 1:171,057,141...171,061,918
Ensembl chr 1:171,057,141...171,061,934

LYN proto-oncogene, Src family tyrosine kinase

involved_in

IBA
IMP

(PMID:16272347)

PMID:16272347

GO_REF:0000033

NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122

Fc-gamma receptor signaling pathway involved in phagocytosis

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Fcer2a

Fc receptor, IgE, low affinity II, alpha polypeptide

involved_in

IEA

GO_REF:0000107

NCBI chr 8:3,730,280...3,744,174
Ensembl chr 8:3,731,737...3,744,175

Ifng

interferon gamma

involved_in

ISO

(PMID:7544003)

PMID:7544003

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

Myo1g

myosin IG

involved_in

IMP

(PMID:23038771)

PMID:23038771

NCBI chr11:6,456,548...6,470,960
Ensembl chr11:6,456,548...6,470,965

Nos2

nitric oxide synthase 2, inducible

involved_in

IEA

GO_REF:0000107

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

immune response-activating cell surface receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Bag6

BCL2-associated athanogene 6

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr17:35,354,132...35,366,297
Ensembl chr17:35,354,154...35,366,298

Mill2

MHC I like leukocyte 2

involved_in

ISO

(PMID:11491531)

PMID:11491531

NCBI chr 7:18,573,878...18,603,621
Ensembl chr 7:18,573,891...18,599,327

Ncr3-ps

natural cytotoxicity triggering receptor 3, pseudogene

involved_in

ISO

GO_REF:0000119

NCBI chr17:35,399,512...35,403,785
Ensembl chr17:35,399,511...35,403,638

inflammasome-mediated signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Elp6

elongator acetyltransferase complex subunit 6

acts_upstream_of_or_within

IMP

(PMID:30097576)

PMID:30097576

NCBI chr 9:110,133,321...110,151,170
Ensembl chr 9:110,134,241...110,151,170

Gm15441

predicted gene 15441

acts_upstream_of_or_within

IDA
IMP

(PMID:33203882)

PMID:33203882

NCBI chr 3:96,463,084...96,474,117
Ensembl chr 3:96,462,168...96,474,162

innate immune response-activating signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

toll-like receptor 4

involved_in

ISO

PMID:19226379

GO_REF:0000096 RGD:2312509

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

MDA-5 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ifih1

interferon induced with helicase C domain 1

involved_in

IBA
ISO
ISS

GO_REF:0000024 GO_REF:0000033 GO_REF:0000119

NCBI chr 2:62,426,137...62,476,599
Ensembl chr 2:62,426,142...62,476,599

Oas3

2'-5' oligoadenylate synthetase 3

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 5:120,891,163...120,915,755
Ensembl chr 5:120,891,163...120,915,726

MyD88-dependent toll-like receptor 4 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Lrrfip2

leucine rich repeat (in FLII) interacting protein 2

acts_upstream_of_or_within

IDA

(PMID:19265123)

PMID:19265123

NCBI chr 9:110,946,614...111,054,736
Ensembl chr 9:110,946,660...111,054,736

MyD88-dependent toll-like receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

high mobility group box 1

involved_in

ISO

(PMID:14660645)

PMID:14660645

NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299

Hspd1

heat shock protein 1 (chaperonin)

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402

myeloid differentiation primary response gene 88

acts_upstream_of_or_within

IMP
IGI

(PMID:14764662)
(PMID:12719478)
(PMID:12872135)

PMID:12719478 PMID:12872135 PMID:14764662

NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477

Reg3g

regenerating islet-derived 3 gamma

involved_in

IMP

(PMID:17635956)

PMID:17635956

NCBI chr 6:78,443,252...78,445,857
Ensembl chr 6:78,443,252...78,445,855

Tlr13

toll-like receptor 13

acts_upstream_of_or_within

IGI

(PMID:21131352)

PMID:21131352

NCBI chr X:105,186,881...105,204,099
Ensembl chr X:105,186,810...105,204,099

toll-like receptor 2

acts_upstream_of_or_within

IGI

(PMID:12719478)

PMID:12719478

NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074

toll-like receptor 4

involved_in

ISO
IBA
IGI

(PMID:20037584)

GO_Central
ARUK-UCL

GO_REF:0000033 GO_REF:0000119

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

toll-like receptor 6

involved_in

ISO
IGI

(PMID:20037584)

GO_Central
ARUK-UCL

GO_REF:0000119

NCBI chr 5:65,109,373...65,128,387
Ensembl chr 5:65,109,374...65,117,440

toll-like receptor 9

involved_in

IPI

(PMID:18820679)

PMID:18820679

NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082

Tnip1

TNFAIP3 interacting protein 1

involved_in

IDA

(PMID:22011580)

PMID:22011580

NCBI chr11:54,801,613...54,853,766
Ensembl chr11:54,801,611...54,853,743

MyD88-independent toll-like receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Lrrfip2

leucine rich repeat (in FLII) interacting protein 2

acts_upstream_of_or_within

IDA

(PMID:19265123)

PMID:19265123

NCBI chr 9:110,946,614...111,054,736
Ensembl chr 9:110,946,660...111,054,736

TIR domain containing adaptor molecule 1

acts_upstream_of_or_within

IMP

(PMID:12855817)
(PMID:12872135)

PMID:12855817 PMID:12872135

NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786

Tnip3

TNFAIP3 interacting protein 3

involved_in

ISO

GO_REF:0000119

NCBI chr 6:65,567,382...65,611,024
NCBI chr 6:65,502,319...65,554,145
Ensembl chr 6:65,502,297...65,611,024

negative regulation of AIM2 inflammasome complex assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ifi203

interferon activated gene 203

involved_in

ISO

GO_REF:0000119

NCBI chr 1:173,747,966...173,770,432
Ensembl chr 1:173,747,973...173,770,238

Ifi203-ps

interferon activated gene 203, pseudogene

involved_in

ISO

GO_REF:0000119

NCBI chr 1:173,602,018...173,630,321
Ensembl chr 1:173,604,095...173,625,836

Ifi204

interferon activated gene 204

involved_in

ISO

(PMID:30104205)

PMID:30104205

NCBI chr 1:173,574,859...173,594,606
Ensembl chr 1:173,574,859...173,594,509

Ifi206

interferon activated gene 206

involved_in

ISO

GO_REF:0000119

NCBI chr 1:173,296,051...173,318,884
Ensembl chr 1:173,296,051...173,318,607

Ifi207

interferon activated gene 207

involved_in

ISO

GO_REF:0000119

NCBI chr 1:173,550,993...173,569,394
Ensembl chr 1:173,550,993...173,569,313

Ifi208

interferon activated gene 208

involved_in

ISO

GO_REF:0000119

NCBI chr 1:173,501,194...173,525,959
Ensembl chr 1:173,501,241...173,525,961

Ifi209

interferon activated gene 209

involved_in

ISO

GO_REF:0000119

NCBI chr 1:173,458,425...173,475,494
Ensembl chr 1:173,458,483...173,475,494

Ifi213

interferon activated gene 213

involved_in

ISO

GO_REF:0000119

NCBI chr 1:173,393,849...173,426,868
Ensembl chr 1:173,393,849...173,426,840

Ifi214

interferon activated gene 214

involved_in

ISO

GO_REF:0000119

NCBI chr 1:173,348,877...173,363,523
Ensembl chr 1:173,347,283...173,363,523

Mndal

myeloid nuclear differentiation antigen like

involved_in

ISO

GO_REF:0000119

NCBI chr 1:173,684,786...173,708,038
Ensembl chr 1:173,676,692...173,708,447

Trim11

tripartite motif-containing 11

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr11:58,865,054...58,882,288
Ensembl chr11:58,868,919...58,882,284

negative regulation of B cell receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cd22

CD22 antigen

involved_in

IBA
ISO
IEA

GO_REF:0000033 GO_REF:0000107 GO_REF:0000119

NCBI chr 7:30,564,829...30,579,767
Ensembl chr 7:30,564,827...30,579,767

Cd300a

CD300A molecule

involved_in

ISO

GO_REF:0000119

NCBI chr11:114,780,006...114,792,772
Ensembl chr11:114,780,867...114,795,480

Cd72

CD72 antigen

involved_in

ISO

(PMID:1711157)

PMID:1711157

NCBI chr 4:43,447,724...43,454,708
Ensembl chr 4:43,446,462...43,454,628

Fcgr2b

Fc receptor, IgG, low affinity IIb

involved_in

ISO

(PMID:24169826)

PMID:24169826

NCBI chr 1:170,786,186...170,804,141
Ensembl chr 1:170,786,186...170,804,116

Fcrl5

Fc receptor-like 5

acts_upstream_of_or_within

IGI
IDA

(PMID:23509253)

PMID:23509253

NCBI chr 3:87,343,084...87,407,985
Ensembl chr 3:87,343,080...87,407,985

Gps2

G protein pathway suppressor 2

involved_in

IMP

(PMID:28039360)

PMID:28039360

NCBI chr11:69,804,805...69,807,882
Ensembl chr11:69,804,714...69,807,417

Lpxn

leupaxin

involved_in

IDA
IBA
ISO

(PMID:17640867)

PMID:17640867

GO_REF:0000033 GO_REF:0000119

NCBI chr19:12,773,251...12,811,177
Ensembl chr19:12,773,557...12,811,171

Mir34a

microRNA 34a

involved_in

ISO

(PMID:30111844)

PMID:30111844

NCBI chr 4:150,152,911...150,153,012
Ensembl chr 4:150,152,911...150,153,012

Plcl2

phospholipase C-like 2

acts_upstream_of_or_within

IMP

(PMID:14517301)

PMID:14517301

NCBI chr17:50,815,893...50,995,522
Ensembl chr17:50,816,431...50,995,512

protein tyrosine phosphatase, non-receptor type 6

involved_in

IEA

GO_REF:0000107

NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677

negative regulation of cGAS/STING signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Aars2

alanyl-tRNA synthetase 2, mitochondrial

involved_in

IDA

(PMID:39322678)

PMID:39322678

NCBI chr17:45,817,473...45,831,769
Ensembl chr17:45,817,767...45,831,769

Akt1

thymoma viral proto-oncogene 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

Aurkb

aurora kinase B

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490

Banf1

BAF nuclear assembly factor 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr19:5,414,661...5,416,904
Ensembl chr19:5,414,666...5,417,196

cyclic GMP-AMP synthase

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 9:78,337,800...78,350,519
Ensembl chr 9:78,337,808...78,350,519

Igtp

interferon gamma induced GTPase

involved_in

ISO

GO_REF:0000119

NCBI chr11:58,090,382...58,098,418
Ensembl chr11:58,090,382...58,098,417

Irgm1

immunity-related GTPase family M member 1

involved_in

ISO

GO_REF:0000119

NCBI chr11:48,756,072...48,762,247
Ensembl chr11:48,752,795...48,762,510

immunity-related GTPase family M member 2

involved_in

ISO

GO_REF:0000119

NCBI chr11:58,105,803...58,113,609
Ensembl chr11:58,090,444...58,113,608

Lyplal1

lysophospholipase-like 1

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr 1:185,819,929...185,849,507
Ensembl chr 1:185,819,928...185,849,507

Parp1

poly (ADP-ribose) polymerase family, member 1

involved_in

ISO

GO_REF:0000119

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

Pcbp2

poly(rC) binding protein 2

involved_in

ISO

GO_REF:0000119

NCBI chr15:102,378,974...102,408,503
Ensembl chr15:102,378,974...102,408,496

Ppp6c

protein phosphatase 6, catalytic subunit

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 2:39,084,381...39,116,361
Ensembl chr 2:39,084,366...39,116,463

Prkdc

protein kinase, DNA activated, catalytic polypeptide

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr16:15,455,698...15,660,103
Ensembl chr16:15,455,730...15,660,099

Smpdl3a

sphingomyelin phosphodiesterase, acid-like 3A

involved_in

IMP

(PMID:37890481)

PMID:37890481

NCBI chr10:57,670,640...57,687,926
Ensembl chr10:57,670,431...57,687,926

Spsb3

splA/ryanodine receptor domain and SOCS box containing 3

involved_in

ISS

GO_REF:0000024

NCBI chr17:25,104,956...25,111,124
Ensembl chr17:25,105,617...25,111,126

Trex1

three prime repair exonuclease 1

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 9:108,887,000...108,888,791
Ensembl chr 9:108,887,001...108,888,802

Zdhhc18

zinc finger, DHHC domain containing 18

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 4:133,331,969...133,360,801
Ensembl chr 4:133,332,610...133,377,465

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Itch

itchy, E3 ubiquitin protein ligase

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 2:154,975,401...155,068,775
Ensembl chr 2:154,975,429...155,068,775

Marchf5

membrane associated ring-CH-type finger 5

involved_in

ISO

(PMID:31881323)

PMID:31881323

NCBI chr19:37,184,939...37,201,856
Ensembl chr19:37,184,942...37,199,550

Rnf39

ring finger protein 39

involved_in

ISO

(PMID:33674311)

PMID:33674311

NCBI chr17:37,253,943...37,258,878
Ensembl chr17:37,253,810...37,258,878

Sec14l1

SEC14-like lipid binding 1

involved_in

ISO

(PMID:23843640)

PMID:23843640

NCBI chr11:117,005,994...117,050,094
Ensembl chr11:117,005,994...117,050,094

Tarbp2

TARBP2, RISC loading complex RNA binding subunit

involved_in

ISO

GO_REF:0000119

NCBI chr15:102,423,327...102,432,112
Ensembl chr15:102,426,627...102,432,111

Tax1bp1

Tax1 (human T cell leukemia virus type I) binding protein 1

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 6:52,690,677...52,743,765
Ensembl chr 6:52,690,714...52,743,765

Tspan6

tetraspanin 6

involved_in

ISO

GO_REF:0000119

NCBI chr X:132,791,817...132,801,957
Ensembl chr X:132,791,817...132,799,178

negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Appl1

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

involved_in

IMP

(PMID:25568335)

PMID:25568335

NCBI chr14:26,640,943...26,692,567
Ensembl chr14:26,640,945...26,693,189

negative regulation of MDA-5 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

C1qbp

complement component 1, q subcomponent binding protein

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr11:70,868,672...70,873,852
Ensembl chr11:70,868,662...70,873,852

DExH-box helicase 58

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr11:100,585,710...100,595,165
Ensembl chr11:100,585,710...100,595,097

Riok3

RIO kinase 3

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr18:12,259,114...12,290,424
Ensembl chr18:12,261,798...12,290,444

Tkfc

triokinase, FMN cyclase

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr19:10,565,153...10,583,257
Ensembl chr19:10,565,155...10,583,018

negative regulation of MyD88-dependent toll-like receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cd300a

CD300A molecule

involved_in

ISO

GO_REF:0000119

NCBI chr11:114,780,006...114,792,772
Ensembl chr11:114,780,867...114,795,480

Cd300lf

CD300 molecule like family member F

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr11:115,007,040...115,024,834
Ensembl chr11:115,007,040...115,024,818

negative regulation of MyD88-independent toll-like receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Sarm1

sterile alpha and HEAT/Armadillo motif containing 1

involved_in

IEA

GO_REF:0000002

NCBI chr11:78,361,099...78,388,642
Ensembl chr11:78,363,156...78,388,580

negative regulation of NLRP3 inflammasome complex assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Abhd17a

abhydrolase domain containing 17A

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr10:80,419,483...80,426,199
Ensembl chr10:80,419,488...80,426,175

Abhd8

abhydrolase domain containing 8

involved_in

ISO

(PMID:39225180)

PMID:39225180

NCBI chr 8:71,909,344...71,917,351
Ensembl chr 8:71,909,349...71,916,299

Cptp

ceramide-1-phosphate transfer protein

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 4:155,949,180...155,953,897
Ensembl chr 4:155,949,180...155,953,897

Csnk1a1

casein kinase 1, alpha 1

involved_in

IDA

(PMID:34615873)

PMID:34615873

NCBI chr18:61,687,307...61,723,391
Ensembl chr18:61,688,345...61,723,132

Fbxl2

F-box and leucine-rich repeat protein 2

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 9:113,787,625...113,855,871
Ensembl chr 9:113,792,705...113,875,259

Hspa8

heat shock protein 8

involved_in

ISO

GO_REF:0000119

NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383

Igtp

interferon gamma induced GTPase

involved_in

ISO

GO_REF:0000119

NCBI chr11:58,090,382...58,098,418
Ensembl chr11:58,090,382...58,098,417

Irgm1

immunity-related GTPase family M member 1

involved_in

IDA
ISO

(PMID:30612879)

PMID:30612879

GO_REF:0000119

NCBI chr11:48,756,072...48,762,247
Ensembl chr11:48,752,795...48,762,510

immunity-related GTPase family M member 2

involved_in

ISO

GO_REF:0000119

NCBI chr11:58,105,803...58,113,609
Ensembl chr11:58,090,444...58,113,608

Lamp2

lysosomal-associated membrane protein 2

involved_in

ISO

GO_REF:0000119

NCBI chr X:37,488,524...37,545,337
Ensembl chr X:37,490,234...37,545,331

Mefv

Mediterranean fever

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr16:3,524,838...3,536,073
Ensembl chr16:3,525,082...3,535,961

mt-Rnr2

16S rRNA, mitochondrial

involved_in

ISO

(PMID:32923762)

PMID:32923762

NCBI chr MT:1,094...2,675
Ensembl chr MT:1,094...2,675

Nlrc3

NLR family, CARD domain containing 3

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr16:3,762,871...3,796,881
Ensembl chr16:3,762,871...3,794,496

Sirt2

sirtuin 2

acts_upstream_of_or_within

IMP

(PMID:23502856)

NCBI chr 7:28,466,192...28,488,086
Ensembl chr 7:28,466,160...28,488,086

triggering receptor expressed on myeloid cells 2

acts_upstream_of_or_within

ISO
IMP

(PMID:29887864)

GO_Central
ARUK-UCL

PMID:29887864

GO_REF:0000119

NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175

Trim30a

tripartite motif-containing 30A

involved_in

IMP

(PMID:21048113)

PMID:21048113

NCBI chr 7:104,058,232...104,114,400
Ensembl chr 7:104,058,232...104,114,400

Trim31

tripartite motif-containing 31

involved_in

IDA
ISO

(PMID:27929086)

PMID:27929086

GO_REF:0000119

NCBI chr17:37,209,022...37,221,109
Ensembl chr17:37,209,010...37,221,106

Trim65

tripartite motif-containing 65

involved_in

ISO

(PMID:34512673)

PMID:34512673

NCBI chr11:116,008,015...116,022,239
Ensembl chr11:116,012,672...116,021,954

Zdhhc12

zinc finger, DHHC domain containing 12

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 2:29,980,956...29,983,647
Ensembl chr 2:29,980,956...29,983,660

negative regulation of non-canonical inflammasome complex assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

immunity-related GTPase family M member 2

involved_in

IDA

(PMID:33124745), (PMID:33124769)

PMID:33124745 PMID:33124769

NCBI chr11:58,105,803...58,113,609
Ensembl chr11:58,090,444...58,113,608

Ogt

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

involved_in

ISS

GO_REF:0000024

NCBI chr X:100,683,617...100,727,957
Ensembl chr X:100,683,666...100,727,957

negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

tumor necrosis factor, alpha-induced protein 3

involved_in

IMP

(PMID:18342009)

PMID:18342009

NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Erbin

Erbb2 interacting protein

involved_in

ISO
IBA
IMP

(PMID:16203728)

PMID:16203728

GO_REF:0000033 GO_REF:0000119

NCBI chr13:103,955,294...104,057,094
Ensembl chr13:103,955,295...104,057,022

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

involved_in

IMP
ISO

(PMID:23991106)

PMID:23991106

GO_REF:0000119

NCBI chr 3:103,763,891...103,819,568
Ensembl chr 3:103,767,111...103,819,563

tumor necrosis factor, alpha-induced protein 3

involved_in

IDA

(PMID:18342009)

PMID:18342009

NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405

Znrf4

zinc and ring finger 4

involved_in

ISO

GO_REF:0000119

NCBI chr17:56,818,248...56,819,483
Ensembl chr17:56,818,248...56,819,431

negative regulation of RIG-I signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

C1qbp

complement component 1, q subcomponent binding protein

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr11:70,868,672...70,873,852
Ensembl chr11:70,868,662...70,873,852

DExH-box helicase 58

involved_in

IBA
IMP
ISO

(PMID:17475874)

PMID:17475874

GO_REF:0000033 GO_REF:0000119

NCBI chr11:100,585,710...100,595,165
Ensembl chr11:100,585,710...100,595,097

Gpatch3

G patch domain containing 3

involved_in

IBA
ISO
IEA

GO_REF:0000033 GO_REF:0000107 GO_REF:0000119

NCBI chr 4:133,302,056...133,311,553
Ensembl chr 4:133,302,056...133,311,554

Nlrx1

NLR family member X1

acts_upstream_of_or_within

IMP

(PMID:21703540)

PMID:21703540

NCBI chr 9:44,164,010...44,179,896
Ensembl chr 9:44,164,014...44,179,896

Nploc4

NPL4 homolog, ubiquitin recognition factor

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr11:120,270,624...120,328,526
Ensembl chr11:120,271,196...120,328,534

Rnf125

ring finger protein 125

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr18:21,077,672...21,120,416
Ensembl chr18:21,077,682...21,116,919

Sec14l1

SEC14-like lipid binding 1

involved_in

IBA
ISO
ISS

GO_REF:0000024 GO_REF:0000033 GO_REF:0000119

NCBI chr11:117,005,994...117,050,094
Ensembl chr11:117,005,994...117,050,094

Ufd1

ubiquitin recognition factor in ER-associated degradation 1

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr16:18,630,486...18,654,011
Ensembl chr16:18,630,529...18,654,011

negative regulation of T cell receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Btn2a2

butyrophilin, subfamily 2, member A2

acts_upstream_of_or_within

IDA

(PMID:23589618)

PMID:23589618

NCBI chr13:23,661,219...23,673,028
Ensembl chr13:23,661,846...23,673,027

Btnl2

butyrophilin-like 2

acts_upstream_of_or_within

IMP

(PMID:16751379)

PMID:16751379

NCBI chr17:34,573,763...34,588,466
Ensembl chr17:34,573,796...34,588,469

Btrc

beta-transducin repeat containing protein

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr19:45,352,119...45,521,782
Ensembl chr19:45,352,173...45,518,452

Cblb

Casitas B-lineage lymphoma b

acts_upstream_of_or_within

IMP

(PMID:14738763)

PMID:14738763

NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411

Cd160

CD160 antigen

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 3:96,706,079...96,736,667
Ensembl chr 3:96,706,079...96,736,667

Ceacam1

CEA cell adhesion molecule 1

involved_in

ISS

GO_REF:0000024

NCBI chr 7:25,161,127...25,177,072
Ensembl chr 7:25,161,132...25,177,028

Dgkz

diacylglycerol kinase zeta

involved_in

IMP

(PMID:12883552)

PMID:12883552

NCBI chr 2:91,763,167...91,806,788
Ensembl chr 2:91,763,169...91,806,209

Dusp22

dual specificity phosphatase 22

acts_upstream_of_or_within
involved_in

IMP
ISO

(PMID:24714587)

PMID:24714587

GO_REF:0000119

NCBI chr13:30,844,042...30,895,215
Ensembl chr13:30,843,982...30,895,214

Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

involved_in

IBA
ISO

GO_REF:0000033 GO_REF:0000119

NCBI chr11:101,861,967...101,877,839
Ensembl chr11:101,861,969...101,877,839

Elf1

E74 like ETS transcription factor 1

acts_upstream_of_or_within

IGI

(PMID:14738763)

PMID:14738763

NCBI chr14:79,718,619...79,819,916
Ensembl chr14:79,718,634...79,819,934

Ezr

ezrin

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr17:7,005,530...7,050,179
Ensembl chr17:7,005,440...7,050,183

Gbp2b

guanylate binding protein 2b

involved_in

ISO

(PMID:24337748)

PMID:24337748

NCBI chr 3:142,300,577...142,324,940
Ensembl chr 3:142,300,608...142,324,940

Itpripl1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

involved_in

IEA

GO_REF:0000107

NCBI chr 2:126,980,689...126,985,377
Ensembl chr 2:126,980,692...126,985,362

Laptm5

lysosomal-associated protein transmembrane 5

involved_in

IMP

(PMID:18619870)

PMID:18619870

NCBI chr 4:130,640,627...130,663,459
Ensembl chr 4:130,640,436...130,663,452

Lgals3

lectin, galactose binding, soluble 3

involved_in

IMP

(PMID:19706535)

PMID:19706535

NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617

Lilrb4a

leukocyte immunoglobulin-like receptor, subfamily B, member 4A

involved_in

ISO

GO_REF:0000119

NCBI chr10:51,366,999...51,372,709
Ensembl chr10:51,367,052...51,372,707
Ensembl chr10:51,367,052...51,372,707

Lilrb4b

leukocyte immunoglobulin-like receptor, subfamily B, member 4B

involved_in

ISO

GO_REF:0000119

NCBI chr10:51,356,757...51,362,417
Ensembl chr10:51,356,728...51,362,799

Nck1

non-catalytic region of tyrosine kinase adaptor protein 1

involved_in

IEA

GO_REF:0000107

NCBI chr 9:100,376,047...100,428,187
Ensembl chr 9:100,374,346...100,428,187

Pawr

PRKC, apoptosis, WT1, regulator

acts_upstream_of_or_within

IMP

(PMID:12970181)

PMID:12970181

NCBI chr10:108,168,050...108,250,708
Ensembl chr10:108,167,982...108,250,101

Phpt1

phosphohistidine phosphatase 1

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 2:25,463,442...25,465,528
Ensembl chr 2:25,463,442...25,465,236

Prnp

prion protein

involved_in

IMP

(PMID:20145049)

PMID:20145049

NCBI chr 2:131,751,848...131,780,356
Ensembl chr 2:131,751,848...131,780,349

Ptpn2

protein tyrosine phosphatase, non-receptor type 2

involved_in

IMP

(PMID:22080863)

PMID:22080863

NCBI chr18:67,798,571...67,857,697
Ensembl chr18:67,798,581...67,857,665

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr 3:103,763,891...103,819,568
Ensembl chr 3:103,767,111...103,819,563

protein tyrosine phosphatase, non-receptor type 6

acts_upstream_of_or_within

IMP

(PMID:9064344)

PMID:9064344

NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677

Ptprj

protein tyrosine phosphatase receptor type J

involved_in

IDA
ISO

(PMID:12913111)

PMID:12913111

GO_REF:0000119

NCBI chr 2:90,260,100...90,411,102
Ensembl chr 2:90,260,098...90,410,991

Pvrig

poliovirus receptor related immunoglobulin domain containing

involved_in

IBA
ISO

GO_REF:0000033 GO_REF:0000119

NCBI chr 5:138,340,193...138,346,953
Ensembl chr 5:138,340,223...138,341,819

Sh2d1a

SH2 domain containing 1A

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr X:41,591,442...41,610,974
Ensembl chr X:41,591,330...41,618,207

Sla2

Src-like-adaptor 2

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 2:156,716,071...156,729,161
Ensembl chr 2:156,714,377...156,729,112

Thy1

thymus cell antigen 1, theta

involved_in

IDA

(PMID:9285719)

PMID:9285719

NCBI chr 9:43,954,681...43,959,876
Ensembl chr 9:43,954,681...43,959,876

Ubash3a

ubiquitin associated and SH3 domain containing, A

involved_in
acts_upstream_of_or_within

IBA
IGI

(PMID:14738763)

PMID:14738763

GO_REF:0000033

NCBI chr17:31,426,842...31,478,655
Ensembl chr17:31,426,847...31,465,866

negative regulation of toll-like receptor 2 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Acod1

aconitate decarboxylase 1

involved_in

IMP

(PMID:23609450)

PMID:23609450

NCBI chr14:103,284,448...103,294,009
Ensembl chr14:103,284,413...103,294,009

LYN proto-oncogene, Src family tyrosine kinase

involved_in

IMP

(PMID:20385881)

PMID:20385881

NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122

malignant fibrous histiocytoma amplified sequence 1

involved_in

ISO
IMP
ISS

(PMID:26599367)

PMID:26599367

GO_REF:0000024 GO_REF:0000119

NCBI chr 8:36,054,922...36,146,603
Ensembl chr 8:36,054,952...36,146,603

nucleotide-binding oligomerization domain containing 2

acts_upstream_of_or_within

IMP

(PMID:15220916)

PMID:15220916

NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102

toll-like receptor 6

involved_in

ISO

GO_REF:0000119

NCBI chr 5:65,109,373...65,128,387
Ensembl chr 5:65,109,374...65,117,440

triggering receptor expressed on myeloid cells 2

involved_in

IMP

(PMID:31134514)

PMID:31134514

NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175

negative regulation of toll-like receptor 3 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

F2R like trypsin receptor 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr13:95,648,226...95,661,748
Ensembl chr13:95,648,240...95,661,735

Rnf170

ring finger protein 170

involved_in

ISO

GO_REF:0000119

NCBI chr 8:26,609,396...26,633,903
Ensembl chr 8:26,609,396...26,641,818

tumor necrosis factor, alpha-induced protein 3

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405

Ubqln1

ubiquilin 1

involved_in

IMP

(PMID:21695056)

CACAO

PMID:21695056

NCBI chr13:58,323,970...58,363,467
Ensembl chr13:58,323,970...58,363,467

negative regulation of toll-like receptor 4 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Acod1

aconitate decarboxylase 1

involved_in

IDA

(PMID:23609450)

PMID:23609450

NCBI chr14:103,284,448...103,294,009
Ensembl chr14:103,284,413...103,294,009

Bpifb1

BPI fold containing family B, member 1

involved_in

IBA
ISO
IEA

GO_REF:0000033 GO_REF:0000107 GO_REF:0000119

NCBI chr 2:154,032,738...154,062,263
Ensembl chr 2:154,032,738...154,062,289

Dab2ip

disabled 2 interacting protein

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 2:35,448,285...35,621,006
Ensembl chr 2:35,448,278...35,621,006

LYN proto-oncogene, Src family tyrosine kinase

involved_in

IMP

(PMID:20385881)

PMID:20385881

NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122

malignant fibrous histiocytoma amplified sequence 1

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 8:36,054,922...36,146,603
Ensembl chr 8:36,054,952...36,146,603

Mir140

microRNA 140

involved_in

ISO

(PMID:30321456)
(PMID:30233718)

PMID:30233718 PMID:30321456

NCBI chr 8:108,277,876...108,277,945
Ensembl chr 8:108,277,876...108,277,945

Mir149

microRNA 149

involved_in

ISO

(PMID:28260877)

PMID:28260877

NCBI chr 1:92,778,100...92,778,165
Ensembl chr 1:92,778,100...92,778,165

Mir200b

microRNA 200b

involved_in

ISO

(PMID:22522429)

PMID:22522429

NCBI chr 4:156,140,138...156,140,207
Ensembl chr 4:156,140,138...156,140,207

Mir200c

microRNA 200c

involved_in

ISO

(PMID:22522429)

PMID:22522429

NCBI chr 6:124,695,285...124,695,353
Ensembl chr 6:124,695,285...124,695,353

Mir20a

microRNA 20a

involved_in

ISO

(PMID:29653364)

PMID:29653364

NCBI chr14:115,281,589...115,281,695
Ensembl chr14:115,281,589...115,281,695

Mir708

microRNA 708

involved_in

ISO

(PMID:31599428)

PMID:31599428

NCBI chr 7:95,898,631...95,898,739
Ensembl chr 7:95,898,631...95,898,739

Nr1d1

nuclear receptor subfamily 1, group D, member 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr11:98,658,758...98,666,233
Ensembl chr11:98,658,758...98,666,159

Rab7b

RAB7B, member RAS oncogene family

involved_in

IMP

(PMID:17395780)

PMID:17395780

NCBI chr 1:131,616,412...131,646,288
Ensembl chr 1:131,616,433...131,643,177

Sqstm1

sequestosome 1

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654

Tax1bp1

Tax1 (human T cell leukemia virus type I) binding protein 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 6:52,690,677...52,743,765
Ensembl chr 6:52,690,714...52,743,765

TIR domain containing adaptor molecule 2

involved_in

ISO

GO_REF:0000119

NCBI chr18:46,691,298...46,707,600
Ensembl chr18:46,690,358...46,707,600

triggering receptor expressed on myeloid cells 2

involved_in

IDA
IMP

(PMID:29407460)
(PMID:31134514)

PMID:29407460 PMID:31134514

NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175

Trim32

tripartite motif-containing 32

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 4:65,523,223...65,534,477
Ensembl chr 4:65,523,223...65,534,475

negative regulation of toll-like receptor 5 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

tumor necrosis factor, alpha-induced protein 3

involved_in

IDA

(PMID:19912257)

PMID:19912257

NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405

negative regulation of toll-like receptor 6 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Mir210

microRNA 210

involved_in

ISO

(PMID:38742642)

FlyBase

PMID:38742642

NCBI chr 7:140,801,297...140,801,406
Ensembl chr 7:140,801,297...140,801,406

negative regulation of toll-like receptor 9 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Gramd4

GRAM domain containing 4

involved_in

IBA
IMP

(PMID:25917084)

PMID:25917084

GO_REF:0000033

NCBI chr15:85,941,896...86,021,837
Ensembl chr15:85,941,896...86,021,835

Ppt1

palmitoyl-protein thioesterase 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 4:122,729,879...122,752,968
Ensembl chr 4:122,730,035...122,752,968

Ptprs

protein tyrosine phosphatase receptor type S

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr17:56,719,426...56,783,480
Ensembl chr17:56,719,426...56,783,483

Rab7b

RAB7B, member RAS oncogene family

involved_in

IMP

(PMID:19587007)

PMID:19587007

NCBI chr 1:131,616,412...131,646,288
Ensembl chr 1:131,616,433...131,643,177

negative regulation of toll-like receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Arrb2

arrestin, beta 2

involved_in

IMP

(PMID:16378096)

PMID:16378096

NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654

Cactin

cactin, spliceosome C complex subunit

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr10:81,156,937...81,162,085
Ensembl chr10:81,156,937...81,162,076

Gpr108

G protein-coupled receptor 108

involved_in

IBA
IMP

(PMID:30332431)

PMID:30332431

GO_REF:0000033

NCBI chr17:57,541,914...57,555,743
Ensembl chr17:57,541,635...57,555,446

Gps2

G protein pathway suppressor 2

involved_in

IMP

(PMID:28039360)

PMID:28039360

NCBI chr11:69,804,805...69,807,882
Ensembl chr11:69,804,714...69,807,417

Irak3

interleukin-1 receptor-associated kinase 3

involved_in

IMP

(PMID:12150927)

PMID:12150927

NCBI chr10:119,977,553...120,038,035
Ensembl chr10:119,977,553...120,038,035

Irf4

interferon regulatory factor 4

acts_upstream_of_or_within

IMP

(PMID:16236719)

PMID:16236719

NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959

Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

involved_in

IMP

(PMID:23589304)

PMID:23589304

NCBI chr 2:109,747,919...109,844,602
Ensembl chr 2:109,747,992...109,844,602

Lrrc14

leucine rich repeat containing 14

involved_in

ISO
ISS
IBA

GO_REF:0000024 GO_REF:0000033 GO_REF:0000119

NCBI chr15:76,594,820...76,599,297
Ensembl chr15:76,594,823...76,601,899

Mir140

microRNA 140

ISO

PMID:31376096

RGD:329337378

NCBI chr 8:108,277,876...108,277,945
Ensembl chr 8:108,277,876...108,277,945

Mir17

microRNA 17

involved_in

ISO

(PMID:26041742)

PMID:26041742

NCBI chr14:115,281,103...115,281,186
Ensembl chr14:115,281,103...115,281,186

Mir19a

microRNA 19a

involved_in

ISO

(PMID:26041742)

PMID:26041742

NCBI chr14:115,281,432...115,281,513
Ensembl chr14:115,281,432...115,281,513

Nfkbil1

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1

involved_in

IBA
ISS
ISO

GO_REF:0000024 GO_REF:0000033 GO_REF:0000119

NCBI chr17:35,439,151...35,455,457
Ensembl chr17:35,439,151...35,454,768

Nlrp6

NLR family, pyrin domain containing 6

acts_upstream_of_or_within

IMP

(PMID:22763455)

PMID:22763455

NCBI chr 7:140,500,777...140,509,105
Ensembl chr 7:140,500,815...140,509,105

Otud4

OTU domain containing 4

involved_in

ISO
IBA
IDA

(PMID:29395066)

PMID:29395066

GO_REF:0000033 GO_REF:0000119

NCBI chr 8:80,366,305...80,404,384
Ensembl chr 8:80,366,247...80,404,353

Pdpk1

3-phosphoinositide dependent protein kinase 1

involved_in

IMP

(PMID:20584979)

PMID:20584979

NCBI chr17:24,292,654...24,370,957
Ensembl chr17:24,292,654...24,369,898

phosphoinositide-3-kinase adaptor protein 1

involved_in

IMP

(PMID:20728433)

PMID:20728433

NCBI chr19:41,260,980...41,373,541
Ensembl chr19:41,260,816...41,373,541

Ptgs2os

prostaglandin-endoperoxide synthase 2, opposite strand

acts_upstream_of_or_within

IDA
IMP

(PMID:23907535)

PMID:23907535

NCBI chr 1:149,950,624...149,975,625
Ensembl chr 1:149,909,888...149,975,714

Rnf115

ring finger protein 115

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 3:96,634,869...96,698,471
Ensembl chr 3:96,634,980...96,698,954

Smpdl3b

sphingomyelin phosphodiesterase, acid-like 3B

involved_in

IMP

(PMID:26095358)

PMID:26095358

NCBI chr 4:132,460,277...132,484,558
Ensembl chr 4:132,460,277...132,484,563

Trim30a

tripartite motif-containing 30A

involved_in

IMP

(PMID:18345001)

PMID:18345001

NCBI chr 7:104,058,232...104,114,400
Ensembl chr 7:104,058,232...104,114,400

Tyro3

TYRO3 protein tyrosine kinase 3

involved_in

IGI

(PMID:18083102)

PMID:18083102

NCBI chr 2:119,628,123...119,648,585
Ensembl chr 2:119,628,214...119,648,585

Ywhae

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr11:75,620,121...75,656,667
Ensembl chr11:75,623,695...75,656,671

NLRP1 inflammasome complex assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Nlrp1a

NLR family, pyrin domain containing 1A

involved_in

ISO

GO_REF:0000119

NCBI chr11:70,982,023...71,035,780
Ensembl chr11:70,983,062...71,035,530

Nlrp1b

NLR family, pyrin domain containing 1B

involved_in

ISO

GO_REF:0000119

NCBI chr11:71,043,400...71,133,340
Ensembl chr11:71,043,928...71,121,559

NLRP3 inflammasome complex assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Atat1

alpha tubulin acetyltransferase 1

acts_upstream_of

IMP

(PMID:23502856)

NCBI chr17:36,208,487...36,220,971
Ensembl chr17:36,208,487...36,220,967

Gkn2

gastrokine 2

acts_upstream_of_or_within

IMP

(PMID:32226647)

PMID:32226647

NCBI chr 6:87,350,347...87,356,476
Ensembl chr 6:87,350,339...87,356,479

Kcnj8

potassium inwardly-rectifying channel, subfamily J, member 8

acts_upstream_of_or_within

IDA
IMP

(PMID:28928055)

PMID:28928055

NCBI chr 6:142,510,563...142,517,340
Ensembl chr 6:142,510,563...142,517,340

Nlrp3

NLR family, pyrin domain containing 3

acts_upstream_of_or_within
involved_in

IMP
IDA
ISO

(PMID:22753929)
(PMID:23582325), (PMID:26173909), (PMID:27043286), (PMID:28465465), (PMID:28656979), (PMID:28716882), (PMID:28943315), (PMID:30487600), (PMID:34615873), (PMID:34861190)

PMID:22753929 PMID:23582325 PMID:26173909 PMID:27043286 PMID:28465465 More...

GO_REF:0000119

NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782

Pycard

PYD and CARD domain containing

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039

Sirt2

sirtuin 2

acts_upstream_of

IMP

(PMID:23502856)

NCBI chr 7:28,466,192...28,488,086
Ensembl chr 7:28,466,160...28,488,086

NLRP6 inflammasome complex assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Nlrp6

NLR family, pyrin domain containing 6

involved_in

ISO
IDA

(PMID:32424362), (PMID:34678144)

PMID:32424362 PMID:34678144

GO_REF:0000119

NCBI chr 7:140,500,777...140,509,105
Ensembl chr 7:140,500,815...140,509,105

nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Rnf34

ring finger protein 34

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 5:122,988,270...123,007,008
Ensembl chr 5:122,988,111...123,009,354

nucleotide-binding oligomerization domain containing 1 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

acts_upstream_of_or_within

IDA

(PMID:18261938)

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

Nod1

nucleotide-binding oligomerization domain containing 1

involved_in

ISS
ISO
IDA

(PMID:27007849)

PMID:27007849

GO_REF:0000024 GO_REF:0000119

NCBI chr 6:54,900,927...54,949,655
Ensembl chr 6:54,900,934...54,949,597

receptor (TNFRSF)-interacting serine-threonine kinase 2

acts_upstream_of_or_within
involved_in

IMP
ISO

(PMID:11894098)

PMID:11894098

GO_REF:0000119

NCBI chr 4:16,122,740...16,163,674
Ensembl chr 4:16,122,733...16,163,647

toll-like receptor 4

acts_upstream_of

IDA

(PMID:18261938)

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

Xiap

X-linked inhibitor of apoptosis

involved_in

IEA

GO_REF:0000107

NCBI chr X:41,148,483...41,198,541
Ensembl chr X:41,148,556...41,198,533

nucleotide-binding oligomerization domain containing 2 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Igtp

interferon gamma induced GTPase

involved_in

ISO

GO_REF:0000119

NCBI chr11:58,090,382...58,098,418
Ensembl chr11:58,090,382...58,098,417

Inava

innate immunity activator

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 1:136,141,259...136,162,045
Ensembl chr 1:136,141,269...136,162,002

Irf5

interferon regulatory factor 5

involved_in

ISO

(PMID:22412986)

PMID:22412986

NCBI chr 6:29,526,129...29,541,874
Ensembl chr 6:29,526,624...29,541,870

Irgm1

immunity-related GTPase family M member 1

involved_in

ISO

GO_REF:0000119

NCBI chr11:48,756,072...48,762,247
Ensembl chr11:48,752,795...48,762,510

immunity-related GTPase family M member 2

involved_in

ISO

GO_REF:0000119

NCBI chr11:58,105,803...58,113,609
Ensembl chr11:58,090,444...58,113,608

Lacc1

laccase domain containing 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr14:77,261,640...77,274,344
Ensembl chr14:77,261,640...77,274,344

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

acts_upstream_of_or_within

IDA

(PMID:18261938)

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

nucleotide-binding oligomerization domain containing 2

acts_upstream_of_or_within
involved_in

IMP
ISO
IDA
ISS

(PMID:23892723)
(PMID:15692052)
(PMID:27007849)

PMID:15692052 PMID:23892723 PMID:27007849

GO_REF:0000008 GO_REF:0000024 GO_REF:0000119

NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102

Otulin

OTU deubiquitinase with linear linkage specificity

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr15:27,606,005...27,630,793
Ensembl chr15:27,542,721...27,630,779

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

acts_upstream_of_or_within

ISO

GO_REF:0000008

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

receptor (TNFRSF)-interacting serine-threonine kinase 2

acts_upstream_of_or_within
involved_in

IMP
ISS
IDA
ISO

(PMID:11894098)
(PMID:17947236)

PMID:11894098 PMID:17947236

GO_REF:0000024 GO_REF:0000119

NCBI chr 4:16,122,740...16,163,674
Ensembl chr 4:16,122,733...16,163,647

toll-like receptor 4

acts_upstream_of

IDA

(PMID:18261938)

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

Xiap

X-linked inhibitor of apoptosis

involved_in

ISS

GO_REF:0000024

NCBI chr X:41,148,483...41,198,541
Ensembl chr X:41,148,556...41,198,533

pattern recognition receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Aim2

absent in melanoma 2

involved_in

NAS

(PMID:20351693)

PMID:20351693

NCBI chr 1:173,177,105...173,293,606
Ensembl chr 1:173,178,445...173,293,606

Casp1

caspase 1

involved_in

NAS

(PMID:20351693), (PMID:22258606), (PMID:25879281), (PMID:29196474)

PMID:20351693 PMID:22258606 PMID:25879281 PMID:29196474

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

cyclic GMP-AMP synthase

involved_in

ISO

GO_REF:0000119

NCBI chr 9:78,337,800...78,350,519
Ensembl chr 9:78,337,808...78,350,519

Clec4e

C-type lectin domain family 4, member e

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 6:123,258,748...123,266,830
Ensembl chr 6:123,258,748...123,266,829

Inava

innate immunity activator

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 1:136,141,259...136,162,045
Ensembl chr 1:136,141,269...136,162,002

Lacc1

laccase domain containing 1

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr14:77,261,640...77,274,344
Ensembl chr14:77,261,640...77,274,344

Mefv

Mediterranean fever

involved_in

NAS

(PMID:29196474)

PMID:29196474

NCBI chr16:3,524,838...3,536,073
Ensembl chr16:3,525,082...3,535,961

Nlrp1a

NLR family, pyrin domain containing 1A

involved_in

NAS

(PMID:25879281)

PMID:25879281

NCBI chr11:70,982,023...71,035,780
Ensembl chr11:70,983,062...71,035,530

Nlrp3

NLR family, pyrin domain containing 3

involved_in

NAS

(PMID:22258606)

PMID:22258606

NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782

Nod1

nucleotide-binding oligomerization domain containing 1

involved_in

ISO

GO_REF:0000119

NCBI chr 6:54,900,927...54,949,655
Ensembl chr 6:54,900,934...54,949,597

nucleotide-binding oligomerization domain containing 2

involved_in

ISO

GO_REF:0000119

NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102

Pycard

PYD and CARD domain containing

involved_in

NAS

(PMID:20351693), (PMID:22258606), (PMID:29196474)

PMID:20351693 PMID:22258606 PMID:29196474

NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039

Rnf144a

ring finger protein 144A

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr12:26,356,796...26,465,296
Ensembl chr12:26,350,963...26,465,253

Sting1

stimulator of interferon response cGAMP interactor 1

involved_in

ISO

GO_REF:0000119

NCBI chr18:35,866,731...35,873,607
Ensembl chr18:35,866,732...35,873,607

positive regulation of AIM2 inflammasome complex assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Gbp2

guanylate binding protein 2

involved_in

IDA

(PMID:25774715), (PMID:25774716)

PMID:25774715 PMID:25774716

NCBI chr 3:142,326,424...142,343,769
Ensembl chr 3:142,326,363...142,343,769

Gbp5

guanylate binding protein 5

involved_in

IDA

(PMID:25774715), (PMID:25774716)

PMID:25774715 PMID:25774716

NCBI chr 3:142,202,695...142,228,105
Ensembl chr 3:142,199,739...142,228,105

Gm12250

predicted gene 12250

involved_in

IDA

(PMID:27693356), (PMID:30510167)

PMID:27693356 PMID:30510167

NCBI chr11:58,074,669...58,081,024
Ensembl chr11:58,078,565...58,079,838
Ensembl chr11:58,078,565...58,079,838

positive regulation of antigen receptor-mediated signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

protein tyrosine phosphatase receptor type C

involved_in

IMP

(PMID:8692271)

PMID:8692271

NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446

positive regulation of B cell receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cd81

CD81 antigen

involved_in

IMP
ISO

(PMID:23499492)

PMID:23499492

GO_REF:0000119

NCBI chr 7:142,606,487...142,621,667
Ensembl chr 7:142,606,476...142,621,671

Cmtm3

CKLF-like MARVEL transmembrane domain containing 3

acts_upstream_of_or_within

IDA

(PMID:15196959)

PMID:15196959

NCBI chr 8:105,065,993...105,074,304
Ensembl chr 8:105,066,042...105,074,304

Foxp1

forkhead box P1

involved_in

ISO

GO_REF:0000119

NCBI chr 6:98,902,303...99,510,587
Ensembl chr 6:98,902,299...99,499,682

Mir18

microRNA 18

involved_in

ISO

(PMID:24169826)

PMID:24169826

NCBI chr14:115,281,283...115,281,378
Ensembl chr14:115,281,283...115,281,378

Mir19a

microRNA 19a

involved_in

ISO

(PMID:24169826), (PMID:26017478)

PMID:24169826 PMID:26017478

NCBI chr14:115,281,432...115,281,513
Ensembl chr14:115,281,432...115,281,513

Nfam1

Nfat activating molecule with ITAM motif 1

involved_in

IEA

GO_REF:0000002

NCBI chr15:82,880,937...82,917,598
Ensembl chr15:82,877,174...82,917,507

Prkch

protein kinase C, eta

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr12:73,631,570...73,824,959
Ensembl chr12:73,631,570...73,824,959

Slc39a10

solute carrier family 39 (zinc transporter), member 10

acts_upstream_of_or_within

IMP

(PMID:25074919)

PMID:25074919

NCBI chr 1:46,846,704...46,964,952
Ensembl chr 1:46,846,704...46,932,012

Stap1

signal transducing adaptor family member 1

involved_in

IBA
ISO
IEA

GO_REF:0000033 GO_REF:0000107 GO_REF:0000119

NCBI chr 5:86,219,446...86,251,859
Ensembl chr 5:86,219,605...86,253,984

positive regulation of cGAS/STING signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Bruton agammaglobulinemia tyrosine kinase

involved_in

IEA

GO_REF:0000107

NCBI chr X:133,443,083...133,484,366
Ensembl chr X:133,443,085...133,484,319

Map3k7

mitogen-activated protein kinase kinase kinase 7

involved_in

ISO

GO_REF:0000119

NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467

Marchf5

membrane associated ring-CH-type finger 5

involved_in

ISO

(PMID:37916870)

PMID:37916870

NCBI chr19:37,184,939...37,201,856
Ensembl chr19:37,184,942...37,199,550

Rnf39

ring finger protein 39

involved_in

ISO

(PMID:39255680)

PMID:39255680

NCBI chr17:37,253,943...37,258,878
Ensembl chr17:37,253,810...37,258,878

Slc19a1

solute carrier family 19 (folate transporter), member 1

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr10:76,868,103...76,886,266
Ensembl chr10:76,868,075...76,896,836

Tab1

TGF-beta activated kinase 1/MAP3K7 binding protein 1

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr15:80,017,333...80,045,908
Ensembl chr15:80,017,328...80,045,908

Zdhhc9

zinc finger, DHHC domain containing 9

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr X:47,260,844...47,297,792
Ensembl chr X:47,260,846...47,297,755

positive regulation of Fc receptor mediated stimulatory signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cd226

CD226 antigen

involved_in

IBA
IEA
ISO

GO_REF:0000033 GO_REF:0000107 GO_REF:0000119

NCBI chr18:89,195,078...89,290,356
Ensembl chr18:89,195,091...89,290,353

LYN proto-oncogene, Src family tyrosine kinase

involved_in

ISO
IEA

RGD
Ensembl
GO_Central

PMID:16177098

GO_REF:0000096 GO_REF:0000107 RGD:1578516

NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122

protein tyrosine phosphatase receptor type C

involved_in

IGI

(PMID:18249142)

PMID:18249142

NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446

Ptprj

protein tyrosine phosphatase receptor type J

involved_in

IGI

(PMID:18249142)

PMID:18249142

NCBI chr 2:90,260,100...90,411,102
Ensembl chr 2:90,260,098...90,410,991

Rap1a

RAS-related protein 1a

involved_in

ISO

PMID:18832707

GO_REF:0000096 RGD:9835043

NCBI chr 3:105,634,576...105,708,740
Ensembl chr 3:105,634,583...105,708,652

Rapgef1

Rap guanine nucleotide exchange factor (GEF) 1

involved_in

ISO
IEA

RGD
Ensembl
GO_Central

PMID:18832707

GO_REF:0000096 GO_REF:0000107 RGD:9835043

NCBI chr 2:29,509,732...29,630,376
Ensembl chr 2:29,509,732...29,630,990

positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

involved_in

IMP

(PMID:25568335)

PMID:25568335

NCBI chr10:83,435,897...83,484,741
Ensembl chr10:83,435,897...83,484,602

positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Nr4a3

nuclear receptor subfamily 4, group A, member 3

involved_in

IMP

(PMID:24586680)

PMID:24586680

NCBI chr 4:48,045,098...48,086,446
Ensembl chr 4:48,045,153...48,086,447

positive regulation of MDA-5 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ankrd17

ankyrin repeat domain 17

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr 5:90,375,025...90,517,133
Ensembl chr 5:90,375,025...90,514,436

Ddx60

DExD/H box helicase 60

involved_in

ISO

GO_REF:0000119

NCBI chr 8:62,381,155...62,491,278
Ensembl chr 8:62,381,121...62,491,278

DExH-box helicase 58

involved_in

IMP

(PMID:20080593)

PMID:20080593

NCBI chr11:100,585,710...100,595,165
Ensembl chr11:100,585,710...100,595,097

Usp17le

ubiquitin specific peptidase 17-like E

involved_in

ISS

GO_REF:0000024

NCBI chr 7:104,417,168...104,426,677
Ensembl chr 7:104,417,256...104,426,677

positive regulation of MyD88-dependent toll-like receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ccdc134

coiled-coil domain containing 134

involved_in

ISS

GO_REF:0000024

NCBI chr15:82,012,101...82,026,404
Ensembl chr15:82,012,123...82,026,404

positive regulation of NLRP3 inflammasome complex assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Atat1

alpha tubulin acetyltransferase 1

acts_upstream_of_or_within

IMP

(PMID:23502856)

NCBI chr17:36,208,487...36,220,971
Ensembl chr17:36,208,487...36,220,967

Brcc3

BRCA1/BRCA2-containing complex, subunit 3

involved_in

ISO
IDA

(PMID:23246432)

PMID:23246432

GO_REF:0000119

NCBI chr X:74,460,234...74,499,307
Ensembl chr X:74,460,234...74,497,607

Brcc3dc

BRCA1/BRCA2-containing complex, subunit 3, domain containing

involved_in

ISO

GO_REF:0000119

NCBI chr10:108,534,905...108,536,021
Ensembl chr10:108,534,625...108,536,021

Bruton agammaglobulinemia tyrosine kinase

involved_in

IDA
ISO

(PMID:34554188)

PMID:34554188

GO_REF:0000119

NCBI chr X:133,443,083...133,484,366
Ensembl chr X:133,443,085...133,484,319

Casp4

caspase 4, apoptosis-related cysteine peptidase

involved_in

IDA

(PMID:26173909)

PMID:26173909

NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783

Cd36

CD36 molecule

involved_in

IDA

(PMID:23812099)

PMID:23812099

NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799

DEAD box helicase 3, X-linked

involved_in

IDA

(PMID:31511697)

PMID:31511697

NCBI chr X:13,147,261...13,160,222
Ensembl chr X:13,147,209...13,160,291

Dhx33

DEAH-box helicase 33

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr11:70,874,917...70,895,258
Ensembl chr11:70,874,917...70,895,263

Gbp5

guanylate binding protein 5

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 3:142,202,695...142,228,105
Ensembl chr 3:142,199,739...142,228,105

Gm12250

predicted gene 12250

involved_in

IDA

(PMID:30510167), (PMID:34694641)

PMID:30510167 PMID:34694641

NCBI chr11:58,074,669...58,081,024
Ensembl chr11:58,078,565...58,079,838
Ensembl chr11:58,078,565...58,079,838

Lats1

large tumor suppressor

involved_in

IDA

(PMID:39173637)

PMID:39173637

NCBI chr10:7,556,964...7,592,225
Ensembl chr10:7,556,978...7,592,224

Lats2

large tumor suppressor 2

involved_in

IDA

(PMID:39173637)

PMID:39173637

NCBI chr14:57,927,119...57,983,669
Ensembl chr14:57,927,119...57,995,845
Ensembl chr14:57,927,119...57,995,845

Mapk8

mitogen-activated protein kinase 8

involved_in

ISO
IDA

(PMID:28943315)

PMID:28943315

GO_REF:0000119

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

Marchf5

membrane associated ring-CH-type finger 5

involved_in

ISO

(PMID:37575012)

PMID:37575012

NCBI chr19:37,184,939...37,201,856
Ensembl chr19:37,184,942...37,199,550

Mark4

MAP/microtubule affinity regulating kinase 4

involved_in

IDA
ISO

(PMID:28656979)

PMID:28656979

GO_REF:0000119

NCBI chr 7:19,159,027...19,193,255
Ensembl chr 7:19,158,700...19,192,746

Mavs

mitochondrial antiviral signaling protein

involved_in

IDA
ISO

(PMID:23582325)

PMID:23582325

GO_REF:0000119

NCBI chr 2:131,075,445...131,089,945
Ensembl chr 2:131,075,983...131,089,945

Mir21a

microRNA 21a

ISO

PMID:29084974

RGD:41404715

NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984

myeloid differentiation primary response gene 88

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477

Nek7

NIMA (never in mitosis gene a)-related expressed kinase 7

involved_in

IDA
IBA
IMP
ISO

(PMID:26642356)
(PMID:26814970)

PMID:26642356 PMID:26814970

GO_REF:0000033 GO_REF:0000119

NCBI chr 1:138,411,575...138,547,481
Ensembl chr 1:138,410,613...138,547,879

P2rx7

purinergic receptor P2X, ligand-gated ion channel, 7

involved_in

IMP

(PMID:29958799)

PMID:29958799

NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495

phospholipase C, gamma 2

involved_in
acts_upstream_of_or_within

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 8:118,225,014...118,361,881
Ensembl chr 8:118,225,030...118,361,881

Ppp2ca

protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform

involved_in

IMP

(PMID:28465465)

PMID:28465465

NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605

Prkd1

protein kinase D1

involved_in

IDA

(PMID:28716882)

PMID:28716882

NCBI chr12:50,388,009...50,696,075
Ensembl chr12:50,388,014...50,695,881

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

involved_in

IDA
ISO

(PMID:27043286)

PMID:27043286

GO_REF:0000119

NCBI chr 3:103,763,891...103,819,568
Ensembl chr 3:103,767,111...103,819,563

Stmp1

short transmembrane mitochondrial protein 1

involved_in

IMP

(PMID:31836654)

PMID:31836654

NCBI chr 6:35,229,645...35,238,574
Ensembl chr 6:35,229,589...35,240,431

toll-like receptor 4

involved_in

IDA

(PMID:23812099)

PMID:23812099

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

toll-like receptor 6

involved_in

IDA

(PMID:23812099)

PMID:23812099

NCBI chr 5:65,109,373...65,128,387
Ensembl chr 5:65,109,374...65,117,440

Usp50

ubiquitin specific peptidase 50

acts_upstream_of_or_within

IMP
ISO

(PMID:28094437)

PMID:28094437

NCBI chr 2:126,602,970...126,625,380
Ensembl chr 2:126,551,016...126,625,390

Zdhhc1

zinc finger, DHHC domain containing 1

involved_in

IDA

(PMID:39173637)

PMID:39173637

NCBI chr 8:106,199,055...106,223,694
Ensembl chr 8:106,199,055...106,223,534

Zdhhc5

zinc finger, DHHC domain containing 5

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 2:84,518,264...84,545,508
Ensembl chr 2:84,518,314...84,545,524

positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

solute carrier family 15, member 4

involved_in

IMP

(PMID:19570976), (PMID:21277849)

PMID:19570976 PMID:21277849

NCBI chr 5:127,668,795...127,710,356
Ensembl chr 5:127,672,728...127,709,961

Slc46a2

solute carrier family 46, member 2

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 4:59,905,899...59,915,056
Ensembl chr 4:59,905,126...59,915,056

toll-like receptor 4

acts_upstream_of_or_within

IDA

(PMID:18261938)

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Hspa1a

heat shock protein 1A

involved_in

ISO

(PMID:24790089)

PMID:24790089

NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132

Hspa1b

heat shock protein 1B

involved_in

ISO

GO_REF:0000119

NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214

Nagk

N-acetylglucosamine kinase

involved_in

ISO
IDA

(PMID:36002575)

PMID:36002575

GO_REF:0000119

NCBI chr 6:83,770,810...83,779,538
Ensembl chr 6:83,771,964...83,781,000

Peli3

pellino 3

acts_upstream_of_or_within

IMP

(PMID:23892723)

PMID:23892723

NCBI chr19:4,979,745...4,993,155
Ensembl chr19:4,979,745...4,993,155

Slc15a3

solute carrier family 15, member 3

involved_in

IDA

(PMID:24695226)

PMID:24695226

NCBI chr19:10,819,908...10,835,279
Ensembl chr19:10,817,091...10,836,726

solute carrier family 15, member 4

involved_in

IDA

(PMID:24695226)

PMID:24695226

NCBI chr 5:127,668,795...127,710,356
Ensembl chr 5:127,672,728...127,709,961

toll-like receptor 4

acts_upstream_of_or_within

IDA

(PMID:18261938)

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

positive regulation of pattern recognition receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Zdhhc5

zinc finger, DHHC domain containing 5

involved_in

IMP
IBA
ISO

(PMID:31649195)

PMID:31649195

GO_REF:0000033 GO_REF:0000119

NCBI chr 2:84,518,264...84,545,508
Ensembl chr 2:84,518,314...84,545,524

positive regulation of RIG-I signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ankrd17

ankyrin repeat domain 17

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr 5:90,375,025...90,517,133
Ensembl chr 5:90,375,025...90,514,436

Ddx60

DExD/H box helicase 60

involved_in

ISO

GO_REF:0000119

NCBI chr 8:62,381,155...62,491,278
Ensembl chr 8:62,381,121...62,491,278

DExH-box helicase 58

involved_in

IMP

(PMID:20080593)

PMID:20080593

NCBI chr11:100,585,710...100,595,165
Ensembl chr11:100,585,710...100,595,097

Oasl1

2'-5' oligoadenylate synthetase-like 1

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 5:115,061,236...115,075,970
Ensembl chr 5:115,061,299...115,075,974

Pum1

pumilio RNA-binding family member 1

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 4:130,390,509...130,508,875
Ensembl chr 4:130,390,632...130,508,875

Pum2

pumilio RNA-binding family member 2

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr12:8,724,092...8,802,583
Ensembl chr12:8,724,134...8,802,581

Trim15

tripartite motif-containing 15

involved_in

ISO

GO_REF:0000119

NCBI chr17:37,171,582...37,179,066
Ensembl chr17:37,171,583...37,178,102

Usp15

ubiquitin specific peptidase 15

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr10:122,940,911...123,032,924
Ensembl chr10:122,940,911...123,032,900

Usp17le

ubiquitin specific peptidase 17-like E

involved_in

ISS

GO_REF:0000024

NCBI chr 7:104,417,168...104,426,677
Ensembl chr 7:104,417,256...104,426,677

Zc3hav1

zinc finger CCCH type, antiviral 1

involved_in

ISO
TAS

(PMID:21102435)

PMID:21102435

GO_REF:0000119

NCBI chr 6:38,282,221...38,332,859
Ensembl chr 6:38,282,221...38,331,538

Zcchc3

zinc finger, CCHC domain containing 3

involved_in

IBA
ISO
ISS

GO_REF:0000024 GO_REF:0000033 GO_REF:0000119

NCBI chr 2:152,253,875...152,256,711
Ensembl chr 2:152,253,875...152,256,947

positive regulation of T cell receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ada

adenosine deaminase

acts_upstream_of_or_within

IMP

(PMID:11435465)

PMID:11435465

NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159

B cell leukemia/lymphoma 10

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 3:145,630,017...145,640,121
Ensembl chr 3:145,628,559...145,640,111

Card11

caspase recruitment domain family, member 11

involved_in

IMP
IBA
ISO

(PMID:12154356)

PMID:12154356

GO_REF:0000033 GO_REF:0000119

NCBI chr 5:140,858,109...140,986,398
Ensembl chr 5:140,858,745...140,986,337

Ccr7

C-C motif chemokine receptor 7

involved_in

IMP

(PMID:17785582)

PMID:17785582

NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903

Cd226

CD226 antigen

involved_in

IBA
IEA
ISO

GO_REF:0000033 GO_REF:0000107 GO_REF:0000119

NCBI chr18:89,195,078...89,290,356
Ensembl chr18:89,195,091...89,290,353

Cd81

CD81 antigen

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 7:142,606,487...142,621,667
Ensembl chr 7:142,606,476...142,621,671

Cyld

CYLD lysine 63 deubiquitinase

acts_upstream_of_or_within

IMP

(PMID:16501569)

PMID:16501569

NCBI chr 8:89,423,506...89,478,574
Ensembl chr 8:89,423,675...89,478,573

Ikbkg

inhibitor of kappaB kinase gamma

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr X:73,436,883...73,498,013
Ensembl chr X:73,436,896...73,497,460

Kcnn4

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 7:24,069,750...24,084,635
Ensembl chr 7:24,069,688...24,086,115

Lipa

lysosomal acid lipase A

acts_upstream_of_or_within

IMP

(PMID:19179613)

PMID:19179613

NCBI chr19:34,469,716...34,504,874
Ensembl chr19:34,469,718...34,504,874

Nectin2

nectin cell adhesion molecule 2

involved_in

IBA
IEA
ISO

GO_REF:0000033 GO_REF:0000107 GO_REF:0000119

NCBI chr 7:19,450,569...19,483,498
Ensembl chr 7:19,450,569...19,484,408

Prkd2

protein kinase D2

involved_in

IMP

(PMID:20819079)

PMID:20819079

NCBI chr 7:16,576,827...16,604,386
Ensembl chr 7:16,576,827...16,604,389

Rab29

RAB29, member RAS oncogene family

involved_in

ISO

GO_REF:0000119

NCBI chr 1:131,795,004...131,801,003
Ensembl chr 1:131,794,962...131,800,625

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

Rps3

ribosomal protein S3

involved_in

ISO

GO_REF:0000119

NCBI chr 7:99,127,103...99,132,916
Ensembl chr 7:99,127,103...99,132,945

Tespa1

thymocyte expressed, positive selection associated 1

involved_in

IBA
IMP

(PMID:22561606)

PMID:22561606

GO_REF:0000033

NCBI chr10:130,158,696...130,199,338
Ensembl chr10:130,158,739...130,199,980

Trat1

T cell receptor associated transmembrane adaptor 1

involved_in
acts_upstream_of_or_within

IBA
ISO

(PMID:11390434)

PMID:11390434

GO_REF:0000033

NCBI chr16:48,551,137...48,630,883
Ensembl chr16:48,551,137...48,592,384

Ubr2

ubiquitin protein ligase E3 component n-recognin 2

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr17:47,239,217...47,321,812
Ensembl chr17:47,239,221...47,321,482

Usp12

ubiquitin specific peptidase 12

acts_upstream_of_or_within

ISO

(PMID:26811477)

NCBI chr 5:146,671,619...146,731,817
Ensembl chr 5:146,671,619...146,731,816

Usp46

ubiquitin specific peptidase 46

acts_upstream_of_or_within

ISO

(PMID:26811477)

NCBI chr 5:74,159,387...74,229,070
Ensembl chr 5:74,159,114...74,229,092

positive regulation of toll-like receptor 13 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Treml4

triggering receptor expressed on myeloid cells-like 4

involved_in

IMP

(PMID:25848864)

PMID:25848864

NCBI chr17:48,571,229...48,582,635
Ensembl chr17:48,571,323...48,582,388

positive regulation of toll-like receptor 2 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cyba

cytochrome b-245, alpha polypeptide

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669

F2R like trypsin receptor 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr13:95,648,226...95,661,748
Ensembl chr13:95,648,240...95,661,735

high mobility group box 1

involved_in

IDA

(PMID:16267105)

PMID:16267105

NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299

malignant fibrous histiocytoma amplified sequence 1

involved_in

ISO
IMP
ISS

(PMID:26599367)

PMID:26599367

GO_REF:0000024 GO_REF:0000119

NCBI chr 8:36,054,922...36,146,603
Ensembl chr 8:36,054,952...36,146,603

Pja2

praja ring finger ubiquitin ligase 2

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr17:64,588,001...64,638,878
Ensembl chr17:64,588,000...64,638,911

toll-interleukin 1 receptor (TIR) domain-containing adaptor protein

involved_in

ISO
ISS

GO_Central
BHF-UCL

GO_REF:0000024 GO_REF:0000119

NCBI chr 9:35,095,687...35,111,587
Ensembl chr 9:35,095,847...35,111,587

Tlr1

toll-like receptor 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 5:65,082,023...65,090,945
Ensembl chr 5:65,082,022...65,090,906

positive regulation of toll-like receptor 3 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cav1

caveolin 1, caveolae protein

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451

F2R like trypsin receptor 1

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr13:95,648,226...95,661,748
Ensembl chr13:95,648,240...95,661,735

Flot1

flotillin 1

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr17:36,134,243...36,143,674
Ensembl chr17:36,134,122...36,143,683

Peli1

pellino 1

acts_upstream_of_or_within

IMP

(PMID:19734906)

PMID:19734906

NCBI chr11:21,041,283...21,100,327
Ensembl chr11:21,041,291...21,100,323

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

involved_in

ISO
IMP

(PMID:23871208)

GO_REF:0000119

NCBI chr 3:103,763,891...103,819,568
Ensembl chr 3:103,767,111...103,819,563

toll-interleukin 1 receptor (TIR) domain-containing adaptor protein

involved_in

IDA

(PMID:17322885)

PMID:17322885

NCBI chr 9:35,095,687...35,111,587
Ensembl chr 9:35,095,847...35,111,587

Trim3

tripartite motif-containing 3

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 7:105,253,670...105,282,805
Ensembl chr 7:105,253,670...105,282,778

Wdfy1

WD repeat and FYVE domain containing 1

involved_in

IMP
IBA
ISO

(PMID:25736436)

PMID:25736436

GO_REF:0000033 GO_REF:0000119

NCBI chr 1:79,679,979...79,753,764
Ensembl chr 1:79,679,979...79,753,860

positive regulation of toll-like receptor 4 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cd14

CD14 antigen

involved_in

IMP

(PMID:24380872)

PMID:24380872

NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851

F2R like trypsin receptor 1

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr13:95,648,226...95,661,748
Ensembl chr13:95,648,240...95,661,735

high mobility group box 1

involved_in

IDA

(PMID:16267105)

PMID:16267105

NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299

Ifi35

interferon-induced protein 35

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr11:101,339,238...101,349,527
Ensembl chr11:101,339,233...101,349,524

Lbp

lipopolysaccharide binding protein

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 2:158,148,413...158,174,772
Ensembl chr 2:158,148,413...158,174,772

Ltf

lactotransferrin

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 9:110,848,360...110,871,834
Ensembl chr 9:110,848,339...110,871,835

Ninj1

ninjurin 1

involved_in

IDA

(PMID:25860173)

PMID:25860173

NCBI chr13:49,341,005...49,349,727
Ensembl chr13:49,340,961...49,349,720

Nr1h3

nuclear receptor subfamily 1, group H, member 3

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179

Peli1

pellino 1

acts_upstream_of_or_within

IMP

(PMID:19734906)

PMID:19734906

NCBI chr11:21,041,283...21,100,327
Ensembl chr11:21,041,291...21,100,323

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

involved_in

IMP
ISO

(PMID:23871208)

GO_REF:0000119

NCBI chr 3:103,763,891...103,819,568
Ensembl chr 3:103,767,111...103,819,563

TIR domain containing adaptor molecule 2

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr18:46,691,298...46,707,600
Ensembl chr18:46,690,358...46,707,600

toll-interleukin 1 receptor (TIR) domain-containing adaptor protein

involved_in

ISO
ISS

GO_Central
BHF-UCL

GO_REF:0000024 GO_REF:0000119

NCBI chr 9:35,095,687...35,111,587
Ensembl chr 9:35,095,847...35,111,587

Wdfy1

WD repeat and FYVE domain containing 1

involved_in

IMP
IBA
ISO

(PMID:25736436)

PMID:25736436

GO_REF:0000033 GO_REF:0000119

NCBI chr 1:79,679,979...79,753,764
Ensembl chr 1:79,679,979...79,753,860

Znrf1

zinc and ring finger 1

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 8:112,262,652...112,352,352
Ensembl chr 8:112,262,729...112,352,662

positive regulation of toll-like receptor 7 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

D1Pas1

DNA segment, Chr 1, Pasteur Institute 1

involved_in

ISO

GO_REF:0000119

NCBI chr 1:186,699,613...186,702,824
Ensembl chr 1:186,699,613...186,702,824

DEAD box helicase 3, X-linked

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr X:13,147,261...13,160,222
Ensembl chr X:13,147,209...13,160,291

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

involved_in

IMP

(PMID:23871208)

NCBI chr 3:103,763,891...103,819,568
Ensembl chr 3:103,767,111...103,819,563

Rsad2

radical S-adenosyl methionine domain containing 2

involved_in

IMP

(PMID:21435586)

PMID:21435586

NCBI chr12:26,492,742...26,506,451
Ensembl chr12:26,492,745...26,506,451

solute carrier family 15, member 4

involved_in

IMP
ISO

(PMID:21045126), (PMID:25238095)

PMID:21045126 PMID:25238095

GO_REF:0000119

NCBI chr 5:127,668,795...127,710,356
Ensembl chr 5:127,672,728...127,709,961

Tasl

TLR adaptor interacting with endolysosomal SLC15A4

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr X:84,820,445...84,935,105
Ensembl chr X:84,913,960...84,935,105

Treml4

triggering receptor expressed on myeloid cells-like 4

involved_in

ISO
IBA
IMP

(PMID:25848864)

PMID:25848864

GO_REF:0000033 GO_REF:0000119

NCBI chr17:48,571,229...48,582,635
Ensembl chr17:48,571,323...48,582,388

positive regulation of toll-like receptor 8 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

D1Pas1

DNA segment, Chr 1, Pasteur Institute 1

involved_in

ISO

GO_REF:0000119

NCBI chr 1:186,699,613...186,702,824
Ensembl chr 1:186,699,613...186,702,824

DEAD box helicase 3, X-linked

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr X:13,147,261...13,160,222
Ensembl chr X:13,147,209...13,160,291

solute carrier family 15, member 4

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 5:127,668,795...127,710,356
Ensembl chr 5:127,672,728...127,709,961

Tasl

TLR adaptor interacting with endolysosomal SLC15A4

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr X:84,820,445...84,935,105
Ensembl chr X:84,913,960...84,935,105

positive regulation of toll-like receptor 9 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cd300ld3

CD300 molecule like family member D3

acts_upstream_of_or_within

IMP
IDA

(PMID:21940676)

PMID:21940676

NCBI chr11:114,932,930...114,939,244
Ensembl chr11:114,932,957...114,939,235

high mobility group box 1

involved_in

ISS

GO_REF:0000024

NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

involved_in

IMP

(PMID:23871208)

NCBI chr 3:103,763,891...103,819,568
Ensembl chr 3:103,767,111...103,819,563

Rsad2

radical S-adenosyl methionine domain containing 2

involved_in

IMP

(PMID:21435586)

PMID:21435586

NCBI chr12:26,492,742...26,506,451
Ensembl chr12:26,492,745...26,506,451

Rtn4

reticulon 4

involved_in

IMP

(PMID:25917084)

PMID:25917084

NCBI chr11:29,642,898...29,694,414
Ensembl chr11:29,642,947...29,694,331

solute carrier family 15, member 4

involved_in

IMP
ISO

(PMID:21045126), (PMID:21277849), (PMID:25238095)

PMID:21045126 PMID:21277849 PMID:25238095

GO_REF:0000119

NCBI chr 5:127,668,795...127,710,356
Ensembl chr 5:127,672,728...127,709,961

toll-like receptor 9

involved_in

IMP

(PMID:18931679)

PMID:18931679

NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082

Treml4

triggering receptor expressed on myeloid cells-like 4

involved_in

IMP

(PMID:25848864)

PMID:25848864

NCBI chr17:48,571,229...48,582,635
Ensembl chr17:48,571,323...48,582,388

Zdhhc3

zinc finger, DHHC domain containing 3

involved_in

ISO

GO_REF:0000119

NCBI chr 9:122,895,224...122,942,269
Ensembl chr 9:122,895,225...122,942,270

positive regulation of toll-like receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Gdi1

GDP dissociation inhibitor 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr X:73,348,618...73,355,473
Ensembl chr X:73,348,604...73,355,468

Hsp90b1

heat shock protein 90, beta (Grp94), member 1

involved_in

ISO

(PMID:11584270)

PMID:11584270

NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373

Lrch4

leucine-rich repeats and calponin homology (CH) domain containing 4

involved_in

IDA

(PMID:16449650)

PMID:16449650

NCBI chr 5:137,627,385...137,639,361
Ensembl chr 5:137,627,383...137,639,361

phosphoinositide-3-kinase adaptor protein 1

involved_in

IMP

(PMID:20728433)

PMID:20728433

NCBI chr19:41,260,980...41,373,541
Ensembl chr19:41,260,816...41,373,541

regulation of B cell receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cd19

CD19 antigen

involved_in

IMP
ISO
ISS

(PMID:9382888)

PMID:9382888

GO_REF:0000024 GO_REF:0000119

NCBI chr 7:126,007,620...126,016,401
Ensembl chr 7:126,007,622...126,014,061

Fcmr

Fc fragment of IgM receptor

involved_in

IMP

(PMID:28135254)

PMID:28135254

NCBI chr 1:130,793,514...130,808,528
Ensembl chr 1:130,793,406...130,808,528

Gcsam

germinal center associated, signaling and motility

involved_in

IBA
ISO
IEA

GO_REF:0000033 GO_REF:0000107 GO_REF:0000119

NCBI chr16:45,430,803...45,443,230
Ensembl chr16:45,430,743...45,443,230

LYN proto-oncogene, Src family tyrosine kinase

involved_in

IBA
IMP

(PMID:11672542)

PMID:11672542

GO_REF:0000033

NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122

regulation of cytoplasmic pattern recognition receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Mir708

microRNA 708

involved_in

ISO

(PMID:31599428)

PMID:31599428

NCBI chr 7:95,898,631...95,898,739
Ensembl chr 7:95,898,631...95,898,739

regulation of Fc receptor mediated stimulatory signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cd47

CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

involved_in

ISO

GO_REF:0000096

NCBI chr16:49,671,691...49,732,799
Ensembl chr16:49,620,896...49,735,373

Csk

c-src tyrosine kinase

involved_in

ISO
IEA
IBA

RGD
GO_Central
Ensembl

PMID:9325302

GO_REF:0000033 GO_REF:0000096 GO_REF:0000107 RGD:2303720

NCBI chr 9:57,533,929...57,560,758
Ensembl chr 9:57,533,929...57,560,914

Fcgr3

Fc receptor, IgG, low affinity III

ISO

PMID:16482158 PMID:22184119

RGD:11041001 RGD:2293335

NCBI chr 1:170,878,738...170,893,477
Ensembl chr 1:170,878,743...170,892,504

Plscr1

phospholipid scramblase 1

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000096

NCBI chr 9:92,132,265...92,154,034
Ensembl chr 9:92,131,803...92,154,331

Plscr2

phospholipid scramblase 2

involved_in

ISO

GO_REF:0000096

NCBI chr 9:92,157,655...92,179,805
Ensembl chr 9:92,157,655...92,179,805

Pten

phosphatase and tensin homolog

involved_in

ISO

negative regulation

PMID:18056380

GO_REF:0000096 RGD:2292524

NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560

Rabgef1

RAB guanine nucleotide exchange factor (GEF) 1

acts_upstream_of_or_within

IMP
IDA

(PMID:15235600)
(PMID:17341663)

PMID:15235600 PMID:17341663

NCBI chr 5:130,200,644...130,243,178
Ensembl chr 5:130,200,639...130,243,183

regulation of MyD88-dependent toll-like receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Irf1

interferon regulatory factor 1

involved_in

IMP

(PMID:17018642)

PMID:17018642

NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200

Irf7

interferon regulatory factor 7

involved_in

IMP

(PMID:15800576)

PMID:15800576

NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394

regulation of MyD88-independent toll-like receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Irf7

interferon regulatory factor 7

involved_in

IMP

(PMID:15800576)

PMID:15800576

NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394

regulation of NLRP3 inflammasome complex assembly

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Eif2ak2

eukaryotic translation initiation factor 2-alpha kinase 2

involved_in

IMP

(PMID:22801494)

PMID:22801494

NCBI chr17:79,157,933...79,190,001
Ensembl chr17:79,159,993...79,190,002

Kcnk13

potassium channel, subfamily K, member 13

involved_in

IMP

(PMID:35353387)

PMID:35353387

NCBI chr12:99,928,132...100,028,941
Ensembl chr12:99,930,758...100,028,941

regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Slc15a2

solute carrier family 15 (H+/peptide transporter), member 2

involved_in

IMP

(PMID:29784761)

PMID:29784761

NCBI chr16:36,570,523...36,605,506
Ensembl chr16:36,570,539...36,605,324

solute carrier family 15, member 4

involved_in

IMP

(PMID:29784761)

PMID:29784761

NCBI chr 5:127,668,795...127,710,356
Ensembl chr 5:127,672,728...127,709,961

regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Peli3

pellino 3

acts_upstream_of_or_within

IMP

(PMID:23892723)

PMID:23892723

NCBI chr19:4,979,745...4,993,155
Ensembl chr19:4,979,745...4,993,155

regulation of RIG-I signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Nop53

NOP53 ribosome biogenesis factor

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 7:15,671,760...15,680,033
Ensembl chr 7:15,670,108...15,679,999

regulation of T cell receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

B cell leukemia/lymphoma 10

acts_upstream_of_or_within

IMP

(PMID:14614861)

PMID:14614861

NCBI chr 3:145,630,017...145,640,121
Ensembl chr 3:145,628,559...145,640,111

Cblb

Casitas B-lineage lymphoma b

acts_upstream_of_or_within

ISO

(PMID:26811477)

NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411

Cd300a

CD300A molecule

involved_in

ISO

GO_REF:0000119

NCBI chr11:114,780,006...114,792,772
Ensembl chr11:114,780,867...114,795,480

Cyld

CYLD lysine 63 deubiquitinase

acts_upstream_of_or_within

ISO

(PMID:26811477)

NCBI chr 8:89,423,506...89,478,574
Ensembl chr 8:89,423,675...89,478,573

Lck

lymphocyte protein tyrosine kinase

acts_upstream_of_or_within

IDA

(PMID:14752163)

PMID:14752163

NCBI chr 4:129,442,142...129,467,415
Ensembl chr 4:129,442,137...129,467,434

Malt1

MALT1 paracaspase

acts_upstream_of_or_within

IMP

(PMID:14614861)

PMID:14614861

NCBI chr18:65,564,010...65,612,138
Ensembl chr18:65,564,009...65,612,138

protein tyrosine phosphatase receptor type C

involved_in

IGI

(PMID:15661907)

PMID:15661907

NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446

Rc3h1

RING CCCH (C3H) domains 1

involved_in

IMP

(PMID:15917799)

PMID:15917799

NCBI chr 1:160,733,981...160,802,546
Ensembl chr 1:160,733,988...160,802,548

Tespa1

thymocyte expressed, positive selection associated 1

acts_upstream_of

IMP
IDA

(PMID:28598420)

PMID:28598420

NCBI chr10:130,158,696...130,199,338
Ensembl chr10:130,158,739...130,199,980

Usp9x

ubiquitin specific peptidase 9, X chromosome

acts_upstream_of_or_within

ISO

(PMID:26811477)

NCBI chr X:12,937,221...13,039,567
Ensembl chr X:12,937,737...13,039,567

regulation of toll-like receptor 3 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Flot2

flotillin 2

NOT|involved_in

ISO

(PMID:25204797)

PMID:25204797

NCBI chr11:77,928,757...77,951,260
Ensembl chr11:77,928,757...77,951,260

Hcfc2

host cell factor C2

acts_upstream_of_or_within

IMP

(PMID:28970238)

NCBI chr10:82,534,841...82,631,699
Ensembl chr10:82,531,994...82,578,262

Src

Rous sarcoma oncogene

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782

regulation of toll-like receptor 4 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Appl1

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

involved_in

IMP

(PMID:27219021)

PMID:27219021

NCBI chr14:26,640,943...26,692,567
Ensembl chr14:26,640,945...26,693,189

Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

involved_in

IMP

(PMID:27219021)

PMID:27219021

NCBI chr10:83,435,897...83,484,741
Ensembl chr10:83,435,897...83,484,602

Arf6

ARF GTPase 6

involved_in

NAS

(PMID:16751103)

PMID:16751103

NCBI chr12:69,418,924...69,422,754
Ensembl chr12:69,418,924...69,420,557

Flot1

flotillin 1

NOT|involved_in

ISO

(PMID:25204797)

PMID:25204797

NCBI chr17:36,134,243...36,143,674
Ensembl chr17:36,134,122...36,143,683

Pik3r1

phosphoinositide-3-kinase regulatory subunit 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725

regulation of toll-like receptor 6 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

triggering receptor expressed on myeloid cells 2

involved_in

IMP

(PMID:31134514)

PMID:31134514

NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175

regulation of toll-like receptor 9 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

toll-like receptor 9

involved_in

ISO

GO_REF:0000119

NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082

regulation of toll-like receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

App

amyloid beta precursor protein

involved_in

ISO

GO_REF:0000119

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

Cd36

CD36 molecule

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799

Esr1

estrogen receptor 1 (alpha)

acts_upstream_of_or_within

IMP

(PMID:22659029)

PMID:22659029

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

Gfi1

growth factor independent 1 transcription repressor

involved_in

ISO

GO_REF:0000119

NCBI chr 5:107,864,521...107,873,671
Ensembl chr 5:107,864,523...107,873,902

malignant fibrous histiocytoma amplified sequence 1

involved_in

IMP

(PMID:20616063)

PMID:20616063

NCBI chr 8:36,054,922...36,146,603
Ensembl chr 8:36,054,952...36,146,603

Mir146

microRNA 146

involved_in

ISO

(PMID:16885212)

PMID:16885212

NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288

S100a8

S100 calcium binding protein A8 (calgranulin A)

involved_in

NAS

(PMID:22489132), (PMID:25597447)

PMID:22489132 PMID:25597447

NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342

S100a9

S100 calcium binding protein A9 (calgranulin B)

involved_in

NAS

(PMID:23123827), (PMID:25597447)

PMID:23123827 PMID:25597447

NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028

Tasl

TLR adaptor interacting with endolysosomal SLC15A4

involved_in

IEA

GO_REF:0000002

NCBI chr X:84,820,445...84,935,105
Ensembl chr X:84,913,960...84,935,105

RIG-I signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Clpb

ClpB caseinolytic peptidase B

involved_in

ISO

GO_REF:0000119

NCBI chr 7:101,312,958...101,444,667
Ensembl chr 7:101,312,840...101,444,713

Lsm14a

LSM14A mRNA processing body assembly factor

acts_upstream_of_or_within

IGI

(PMID:22745163)

PMID:22745163

NCBI chr 7:34,043,569...34,089,134
Ensembl chr 7:34,044,071...34,092,740

Mavs

mitochondrial antiviral signaling protein

acts_upstream_of_or_within

IGI

(PMID:22745163)

PMID:22745163

NCBI chr 2:131,075,445...131,089,945
Ensembl chr 2:131,075,983...131,089,945

Oas3

2'-5' oligoadenylate synthetase 3

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 5:120,891,163...120,915,755
Ensembl chr 5:120,891,163...120,915,726

Phb1

prohibitin 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr11:95,557,783...95,571,599
Ensembl chr11:95,557,783...95,571,599

Phb2

prohibitin 2

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 6:124,689,252...124,693,908
Ensembl chr 6:124,689,299...124,693,913

Rigi

RNA sensor RIG-I

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr 4:40,203,775...40,239,843
Ensembl chr 4:40,203,773...40,239,828

Rnf135

ring finger protein 135

involved_in

ISO
IGI
IMP

(PMID:21147464)
(PMID:21147464), (PMID:28469175)

PMID:21147464 PMID:28469175

GO_REF:0000119

NCBI chr11:80,074,652...80,090,581
Ensembl chr11:80,074,677...80,090,583

Trim25

tripartite motif-containing 25

NOT|involved_in

ISO

(PMID:31006531)

PMID:31006531

NCBI chr11:88,890,194...88,911,119
Ensembl chr11:88,890,202...88,911,119

stimulatory C-type lectin receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Clec4n

C-type lectin domain family 4, member n

involved_in

IMP

(PMID:22041900)

PMID:22041900

NCBI chr 6:123,206,802...123,223,983
Ensembl chr 6:123,206,802...123,223,980

Clec7a

C-type lectin domain family 7, member a

involved_in

IDA

(PMID:19136564)

PMID:19136564

NCBI chr 6:129,438,554...129,449,748
Ensembl chr 6:129,438,554...129,449,742

Klrc1

killer cell lectin-like receptor subfamily C, member 1

involved_in

IBA

GO_REF:0000033

NCBI chr 6:129,642,978...129,659,815
Ensembl chr 6:129,642,978...129,655,936

Klrc2

killer cell lectin-like receptor subfamily C, member 2

involved_in

IBA

GO_REF:0000033

NCBI chr 6:129,626,565...129,637,700
Ensembl chr 6:129,624,459...129,637,652

Klrc3

killer cell lectin-like receptor subfamily C, member 3

involved_in

IBA

GO_REF:0000033

NCBI chr 6:129,613,226...129,620,474
Ensembl chr 6:129,616,027...129,620,300

Klrd1

killer cell lectin-like receptor, subfamily D, member 1

involved_in

ISO
IBA
ISS

GO_REF:0000024 GO_REF:0000033 GO_REF:0000119

NCBI chr 6:129,565,055...129,575,738
Ensembl chr 6:129,568,745...129,575,738

Klre1

killer cell lectin-like receptor family E member 1

acts_upstream_of_or_within
involved_in

IDA
IBA

(PMID:14707119)

PMID:14707119

GO_REF:0000033

NCBI chr 6:129,536,329...129,562,790
Ensembl chr 6:129,554,868...129,562,790

Klri1

killer cell lectin-like receptor family I member 1

involved_in

IBA

GO_REF:0000033

NCBI chr 6:129,673,001...129,697,605
Ensembl chr 6:129,674,181...129,694,095

Klri2

killer cell lectin-like receptor family I member 2

involved_in

IBA

GO_REF:0000033

NCBI chr 6:129,706,004...129,717,447
Ensembl chr 6:129,706,004...129,717,447

Klrk1

killer cell lectin-like receptor subfamily K, member 1

acts_upstream_of_or_within

IMP

(PMID:12645935)

PMID:12645935

NCBI chr 6:129,587,286...129,600,863
Ensembl chr 6:129,587,286...129,600,827

phospholipase C, gamma 2

involved_in

IMP

(PMID:19136564), (PMID:22041900)

PMID:19136564 PMID:22041900

NCBI chr 8:118,225,014...118,361,881
Ensembl chr 8:118,225,030...118,361,881

Syk

spleen tyrosine kinase

involved_in

IMP

(PMID:19136564)

PMID:19136564

NCBI chr13:52,736,670...52,802,828
Ensembl chr13:52,737,209...52,802,828

Tyrobp

TYRO protein tyrosine kinase binding protein

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr 7:30,113,207...30,117,007
Ensembl chr 7:30,113,185...30,117,010

stimulatory killer cell immunoglobulin-like receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Tyrobp

TYRO protein tyrosine kinase binding protein

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr 7:30,113,207...30,117,007
Ensembl chr 7:30,113,185...30,117,010

T cell receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Abl1

c-abl oncogene 1, non-receptor tyrosine kinase

acts_upstream_of_or_within

IDA

(PMID:18305217)

PMID:18305217

NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239

Ada

adenosine deaminase

acts_upstream_of

IMP

(PMID:11435465)

PMID:11435465

NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159

B cell leukemia/lymphoma 10

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr 3:145,630,017...145,640,121
Ensembl chr 3:145,628,559...145,640,111

Bcl2a1d

B cell leukemia/lymphoma 2 related protein A1d

acts_upstream_of_or_within

IDA

(PMID:15728238)

PMID:15728238

NCBI chr 9:88,605,341...88,613,903
Ensembl chr 9:88,605,338...88,613,967

Braf

Braf transforming gene

acts_upstream_of_or_within

IDA

(PMID:18228248)

PMID:18228248

NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397

Bruton agammaglobulinemia tyrosine kinase

involved_in

IBA

GO_REF:0000033

NCBI chr X:133,443,083...133,484,366
Ensembl chr X:133,443,085...133,484,319

Btn1a1

butyrophilin, subfamily 1, member A1

involved_in

IBA

GO_REF:0000033

NCBI chr13:23,641,154...23,650,084
Ensembl chr13:23,641,162...23,650,071

Btn2a2

butyrophilin, subfamily 2, member A2

involved_in

IBA

GO_REF:0000033

NCBI chr13:23,661,219...23,673,028
Ensembl chr13:23,661,846...23,673,027

Btnl1

butyrophilin-like 1

involved_in

IBA

GO_REF:0000033

NCBI chr17:34,596,097...34,605,136
Ensembl chr17:34,596,106...34,605,002

Btnl10

butyrophilin-like 10

involved_in

IBA

GO_REF:0000033

NCBI chr11:58,808,703...58,817,791
Ensembl chr11:58,808,734...58,817,984

Btnl12

butyrophilin-like 12

involved_in

IBA

GO_REF:0000033

NCBI chr16:37,671,268...37,681,552
Ensembl chr16:37,671,275...37,681,508

Btnl2

butyrophilin-like 2

involved_in

IBA

GO_REF:0000033

NCBI chr17:34,573,763...34,588,466
Ensembl chr17:34,573,796...34,588,469

Btnl4

butyrophilin-like 4

involved_in

IBA

GO_REF:0000033

NCBI chr17:34,687,320...34,696,402
Ensembl chr17:34,685,536...34,696,292

Btnl6

butyrophilin-like 6

involved_in

IBA

GO_REF:0000033

NCBI chr17:34,726,844...34,737,750
Ensembl chr17:34,726,778...34,736,326

Btnl9

butyrophilin-like 9

involved_in

IBA

GO_REF:0000033

NCBI chr11:49,059,152...49,077,916
Ensembl chr11:49,056,412...49,077,986

Cacnb3

calcium channel, voltage-dependent, beta 3 subunit

acts_upstream_of_or_within

IMP

(PMID:17028169)

PMID:17028169

NCBI chr15:98,526,317...98,542,410
Ensembl chr15:98,528,721...98,542,410

Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

acts_upstream_of_or_within

IMP

(PMID:17028169)

PMID:17028169

NCBI chr 2:52,318,332...52,566,816
Ensembl chr 2:52,318,337...52,566,843

Carmil2

capping protein regulator and myosin 1 linker 2

acts_upstream_of_or_within

IMP

(PMID:23793062)

PMID:23793062

NCBI chr 8:106,412,642...106,424,827
Ensembl chr 8:106,412,906...106,424,819

Cblb

Casitas B-lineage lymphoma b

acts_upstream_of_or_within

IMP

(PMID:12697763)

PMID:12697763

NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411

Cd247

CD247 antigen

acts_upstream_of_or_within
involved_in

IDA
IBA
ISO

(PMID:11435465)

PMID:11435465

GO_REF:0000033 GO_REF:0000119

NCBI chr 1:165,607,514...165,698,722
Ensembl chr 1:165,616,250...165,704,846

Cd276

CD276 antigen

involved_in

IBA

GO_REF:0000033

NCBI chr 9:58,431,581...58,463,437
Ensembl chr 9:58,431,581...58,462,720

Cd28

CD28 antigen

acts_upstream_of_or_within
involved_in

IMP
IBA

(PMID:23793062)

PMID:23793062

GO_REF:0000033

NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518

Cd2ap

CD2-associated protein

acts_upstream_of_or_within

IMP

(PMID:14512504)

PMID:10485657 PMID:38614099

PMID:14512504

NCBI chr17:43,059,857...43,187,593
Ensembl chr17:43,103,842...43,187,556

Cd3e

CD3 antigen, epsilon polypeptide

acts_upstream_of_or_within
involved_in

IDA
ISO

(PMID:10485657)
(PMID:38614099)

MGI
UniProt

NCBI chr 9:44,910,033...44,920,961
Ensembl chr 9:44,910,038...44,920,925

Cd8a

CD8 subunit alpha

involved_in

ISO
ISS

GO_Central
ComplexPortal

GO_REF:0000114 GO_REF:0000119

NCBI chr 6:71,350,411...71,356,155
Ensembl chr 6:71,350,411...71,356,157

Cd8b1

CD8 subunit beta 1

involved_in

ISO

GO_REF:0000114

NCBI chr 6:71,299,772...71,314,476
Ensembl chr 6:71,299,772...71,314,478

Clec2i

C-type lectin domain family 2, member i

acts_upstream_of_or_within

IMP

(PMID:16143319)

PMID:16143319

NCBI chr 6:128,864,550...128,875,131
Ensembl chr 6:128,864,551...128,875,130

Crkl

v-crk avian sarcoma virus CT10 oncogene homolog-like

acts_upstream_of_or_within

IDA

(PMID:18305217)

PMID:18305217

NCBI chr16:17,269,849...17,305,304
Ensembl chr16:17,269,851...17,305,298

Ctla4

cytotoxic T-lymphocyte-associated protein 4

involved_in

IBA

GO_REF:0000033

NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991

Dennd1b

DENN domain containing 1B

involved_in

IMP
IBA
ISO

(PMID:26774822)

PMID:26774822

GO_REF:0000033 GO_REF:0000119

NCBI chr 1:138,891,447...139,103,781
Ensembl chr 1:138,891,173...139,106,698

Eif2b1

eukaryotic translation initiation factor 2B, subunit alpha

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr 5:124,708,277...124,717,194
Ensembl chr 5:124,708,276...124,717,194

Eif2b2

eukaryotic translation initiation factor 2B, subunit 2 beta

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr12:85,266,255...85,273,402
Ensembl chr12:85,266,255...85,273,402

Eif2b3

eukaryotic translation initiation factor 2B, subunit 3

involved_in

ISO

GO_REF:0000119

NCBI chr 4:116,876,559...116,944,049
Ensembl chr 4:116,876,599...116,944,503

Eif2b4

eukaryotic translation initiation factor 2B, subunit 4 delta

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 5:31,344,902...31,350,483
Ensembl chr 5:31,344,902...31,350,774

Eif2b5

eukaryotic translation initiation factor 2B, subunit 5 epsilon

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr16:20,317,544...20,328,073
Ensembl chr16:20,317,567...20,328,073

Ermap

erythroblast membrane-associated protein

involved_in

IBA

GO_REF:0000033

NCBI chr 4:119,032,654...119,047,210
Ensembl chr 4:119,032,654...119,047,208

Fcho1

FCH domain only 1

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr 8:72,161,031...72,181,980
Ensembl chr 8:72,161,031...72,178,360

Fosl2

fos-like antigen 2

acts_upstream_of_or_within

IDA
IMP

(PMID:32610127)

PMID:32610127

NCBI chr 5:32,292,599...32,315,184
Ensembl chr 5:32,293,145...32,315,186

Foxp3

forkhead box P3

acts_upstream_of_or_within

IMP

(PMID:10072494), (PMID:11265635)

PMID:10072494 PMID:11265635

NCBI chr X:7,445,915...7,461,482
Ensembl chr X:7,439,883...7,461,484

Fyb1

FYN binding protein 1

involved_in

IBA

GO_REF:0000033

NCBI chr15:6,552,280...6,695,089
Ensembl chr15:6,552,334...6,692,794

Fyb2

FYN binding protein 2

involved_in

IBA
ISO
ISS

GO_REF:0000024 GO_REF:0000033 GO_REF:0000119

NCBI chr 4:104,692,431...104,874,061
Ensembl chr 4:104,770,653...104,874,060

Fyn

Fyn proto-oncogene

involved_in

IBA
ISO
IEA

GO_REF:0000033 GO_REF:0000107 GO_REF:0000119

NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377

Gata3

GATA binding protein 3

involved_in

IDA

(PMID:20696860)

PMID:20696860

NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845

H2-Ab1

histocompatibility 2, class II antigen A, beta 1

involved_in

ISO

(PMID:32341563)

PMID:32341563

NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393

H2-Eb1

histocompatibility 2, class II antigen E beta

involved_in

ISO

(PMID:32341563)

PMID:32341563

NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648

H2-Q1

histocompatibility 2, Q region locus 1

involved_in

ISO

(PMID:10435578)

PMID:10435578

NCBI chr17:35,539,503...35,547,118
Ensembl chr17:35,539,381...35,544,075

Hras

Harvey rat sarcoma virus oncogene

acts_upstream_of_or_within

IMP

(PMID:21444916)

PMID:21444916

NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918

Icosl

icos ligand

involved_in

IBA

GO_REF:0000033

NCBI chr10:77,904,921...77,915,359
Ensembl chr10:77,905,136...77,919,747

Ifng

interferon gamma

acts_upstream_of_or_within

IDA

(PMID:21444916)

PMID:21444916

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

Itk

IL2 inducible T cell kinase

involved_in

IBA
IMP

(PMID:10213685)

PMID:10213685

GO_REF:0000033

NCBI chr11:46,215,975...46,280,342
Ensembl chr11:46,215,977...46,280,342

Khdrbs1

KH domain containing, RNA binding, signal transduction associated 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 4:129,596,143...129,637,402
Ensembl chr 4:129,596,957...129,636,096

Lat

linker for activation of T cells

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 7:125,962,999...125,968,877
Ensembl chr 7:125,962,996...125,968,742

Lck

lymphocyte protein tyrosine kinase

involved_in

ISO

GO_REF:0000119

NCBI chr 4:129,442,142...129,467,415
Ensembl chr 4:129,442,137...129,467,434

Lcp2

lymphocyte cytosolic protein 2

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr11:33,996,928...34,042,281
Ensembl chr11:33,996,920...34,042,295

Lime1

Lck interacting transmembrane adaptor 1

involved_in

IEA

GO_REF:0000002

NCBI chr 2:181,023,028...181,025,421
Ensembl chr 2:181,021,871...181,025,421

Malt1

MALT1 paracaspase

involved_in

IDA
IBA
ISO

(PMID:25282160)

GO_REF:0000033 GO_REF:0000119

NCBI chr18:65,564,010...65,612,138
Ensembl chr18:65,564,009...65,612,138

Mapk1

mitogen-activated protein kinase 1

acts_upstream_of_or_within

IDA

(PMID:9064344)

PMID:9064344

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

Mog

myelin oligodendrocyte glycoprotein

involved_in

IBA

GO_REF:0000033

NCBI chr17:37,321,632...37,334,290
Ensembl chr17:37,321,635...37,334,290

Nfkbid

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta

involved_in

IMP

(PMID:25282160)

NCBI chr 7:30,121,156...30,128,173
Ensembl chr 7:30,121,157...30,128,171

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta

involved_in

IMP

(PMID:25282160)

NCBI chr16:55,631,740...55,659,018
Ensembl chr16:55,631,738...55,659,262

Nras

neuroblastoma ras oncogene

acts_upstream_of_or_within

IMP

(PMID:21444916)

PMID:21444916

NCBI chr 3:102,965,643...102,975,230
Ensembl chr 3:102,965,601...102,975,230

Pde4b

phosphodiesterase 4B, cAMP specific

involved_in

ISO

GO_REF:0000119

NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456

Pde4d

phosphodiesterase 4D, cAMP specific

involved_in

ISO

GO_REF:0000119

NCBI chr13:108,790,711...110,092,503
Ensembl chr13:108,586,482...110,089,995

Plcg1

phospholipase C, gamma 1

acts_upstream_of_or_within

IDA

(PMID:15728238)

PMID:15728238

NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680

phospholipase C, gamma 2

acts_upstream_of_or_within

IDA

(PMID:15728238)

PMID:15728238

NCBI chr 8:118,225,014...118,361,881
Ensembl chr 8:118,225,030...118,361,881

Pram1

PML-RAR alpha-regulated adaptor molecule 1

involved_in

IBA

GO_REF:0000033

NCBI chr17:33,857,030...33,864,680
Ensembl chr17:33,857,030...33,864,680

Prkd2

protein kinase D2

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 7:16,576,827...16,604,386
Ensembl chr 7:16,576,827...16,604,389

Psen1

presenilin 1

acts_upstream_of_or_within

IGI

(PMID:17698590)

PMID:17698590

NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973

Psen2

presenilin 2

acts_upstream_of_or_within

IGI

(PMID:17698590)

PMID:17698590

NCBI chr 1:180,054,569...180,091,030
Ensembl chr 1:180,054,569...180,091,003

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

acts_upstream_of_or_within
involved_in

IMP
IBA

(PMID:14752163)

PMID:14752163

GO_REF:0000033

NCBI chr 3:103,763,891...103,819,568
Ensembl chr 3:103,767,111...103,819,563

protein tyrosine phosphatase, non-receptor type 6

acts_upstream_of

IMP

(PMID:9064344)

PMID:9064344

NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677

GO_Central
ARUK-UCL
UniProt

protein tyrosine phosphatase receptor type C

involved_in

ISO
IGI
ISS

(PMID:12496963)

PMID:12496963

GO_REF:0000024 GO_REF:0000096 GO_REF:0000119

NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446

Rbck1

RanBP-type and C3HC4-type zinc finger containing 1

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 2:152,158,254...152,174,592
Ensembl chr 2:152,158,254...152,174,573

Rc3h1

RING CCCH (C3H) domains 1

involved_in

IMP

(PMID:25282160)

NCBI chr 1:160,733,981...160,802,546
Ensembl chr 1:160,733,988...160,802,548

Rc3h2

ring finger and CCCH-type zinc finger domains 2

involved_in

IMP

(PMID:25282160)

NCBI chr 2:37,260,078...37,313,007
Ensembl chr 2:37,260,081...37,312,915

Rftn1

raftlin lipid raft linker 1

involved_in

IMP

(PMID:19414744)

PMID:19414744

NCBI chr17:50,300,287...50,497,525
Ensembl chr17:50,299,285...50,497,702

PMID:11894098 PMID:21469090

receptor (TNFRSF)-interacting serine-threonine kinase 2

acts_upstream_of_or_within
involved_in

IMP

(PMID:11894098)
(PMID:21469090)

MGI
UniProt

NCBI chr 4:16,122,740...16,163,674
Ensembl chr 4:16,122,733...16,163,647

Rnf31

ring finger protein 31

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr14:55,829,199...55,841,131
Ensembl chr14:55,829,165...55,841,150

Shb

src homology 2 domain-containing transforming protein B

acts_upstream_of_or_within

IMP

(PMID:24645804)

PMID:24645804

NCBI chr 4:45,423,278...45,530,804
Ensembl chr 4:45,423,278...45,532,470

Siva1

SIVA1, apoptosis-inducing factor

involved_in

ISO

(PMID:16491128)

HGNC-UCL

PMID:16491128

NCBI chr12:112,611,262...112,615,586
Ensembl chr12:112,611,113...112,615,583

Skap1

src family associated phosphoprotein 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr11:96,355,396...96,650,448
Ensembl chr11:96,355,419...96,649,956

Skint1

selection and upkeep of intraepithelial T cells 1

involved_in

IBA

GO_REF:0000033

NCBI chr 4:111,863,466...111,886,735
Ensembl chr 4:111,863,466...111,886,735

Skint10

selection and upkeep of intraepithelial T cells 10

involved_in

IBA

GO_REF:0000033

NCBI chr 4:112,568,027...112,632,058
Ensembl chr 4:112,568,344...112,632,063

Skint11

selection and upkeep of intraepithelial T cells 11

involved_in

IBA

GO_REF:0000033

NCBI chr 4:114,020,581...114,102,225
Ensembl chr 4:114,020,581...114,102,225

Skint2

selection and upkeep of intraepithelial T cells 2

involved_in

IBA

GO_REF:0000033

NCBI chr 4:112,470,917...112,509,447
Ensembl chr 4:112,414,391...112,509,445

Skint3

selection and upkeep of intraepithelial T cells 3

involved_in

IBA

GO_REF:0000033

NCBI chr 4:112,089,442...112,157,665
Ensembl chr 4:112,089,442...112,157,665

Skint4

selection and upkeep of intraepithelial T cells 4

involved_in

IBA

GO_REF:0000033

NCBI chr 4:111,929,213...112,025,273
Ensembl chr 4:111,929,213...112,025,273

Skint5

selection and upkeep of intraepithelial T cells 5

involved_in

IBA

GO_REF:0000033

NCBI chr 4:113,335,088...113,856,700
Ensembl chr 4:113,335,088...113,856,700

Skint6

selection and upkeep of intraepithelial T cells 6

involved_in

IBA

GO_REF:0000033

NCBI chr 4:112,661,813...113,144,170
Ensembl chr 4:112,661,813...113,144,170

Skint7

selection and upkeep of intraepithelial T cells 7

involved_in

IBA

GO_REF:0000033

NCBI chr 4:111,830,121...111,845,457
Ensembl chr 4:111,830,120...111,845,420

Skint8

selection and upkeep of intraepithelial T cells 8

involved_in

IBA

GO_REF:0000033

NCBI chr 4:111,776,643...111,807,558
Ensembl chr 4:111,776,589...111,807,555

Skint9

selection and upkeep of intraepithelial T cells 9

involved_in

IBA

GO_REF:0000033

NCBI chr 4:112,243,166...112,291,182
Ensembl chr 4:112,243,166...112,291,182

Slc39a6

solute carrier family 39 (metal ion transporter), member 6

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr18:24,712,938...24,736,874
Ensembl chr18:24,712,938...24,736,874

Spn

sialophorin

involved_in

ISO

PMID:12496963

PMID:12496963

RGD:1358565

NCBI chr 7:126,731,404...126,743,785
Ensembl chr 7:126,731,404...126,736,995

Sppl3

signal peptide peptidase 3

involved_in

ISO
IDA

(PMID:25384971)

PMID:25384971

GO_REF:0000119

NCBI chr 5:115,149,204...115,236,849
Ensembl chr 5:115,149,196...115,236,849

Stk11

serine/threonine kinase 11

acts_upstream_of_or_within

IGI
IMP

(PMID:21487392)

PMID:21487392

NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516

Stoml2

stomatin (Epb7.2)-like 2

acts_upstream_of_or_within

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 4:43,027,690...43,031,402
Ensembl chr 4:43,027,690...43,031,710

Tcrb

T cell receptor beta chain

acts_upstream_of_or_within

IDA

(PMID:9208839)

PMID:9208839

NCBI chr 6:40,868,230...41,535,305

Tec

tec protein tyrosine kinase

involved_in

IBA

GO_REF:0000033

NCBI chr 5:72,913,061...73,025,997
Ensembl chr 5:72,913,059...73,025,826

Themis

thymocyte selection associated

involved_in

IMP
IBA

(PMID:19597498), (PMID:19597499)

PMID:19597498 PMID:19597499

GO_REF:0000033

NCBI chr10:28,544,356...28,759,816
Ensembl chr10:28,544,356...28,759,814

Themis2

thymocyte selection associated family member 2

acts_upstream_of_or_within
involved_in

IMP
IBA

(PMID:22732588)

PMID:22732588

GO_REF:0000033

NCBI chr 4:132,509,148...132,523,675
Ensembl chr 4:132,509,154...132,523,698

Themis3

thymocyte selection associated family member 3

involved_in

IBA

GO_REF:0000033

NCBI chr17:66,861,519...66,901,642
Ensembl chr17:66,861,500...66,901,616

Thy1

thymus cell antigen 1, theta

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000096

NCBI chr 9:43,954,681...43,959,876
Ensembl chr 9:43,954,681...43,959,876

Tnfrsf21

tumor necrosis factor receptor superfamily, member 21

involved_in

IMP

(PMID:11485735)

PMID:11485735

NCBI chr17:43,327,446...43,400,079
Ensembl chr17:43,327,446...43,400,080

Traf6

TNF receptor-associated factor 6

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014

Trav7-2

T cell receptor alpha variable 7-2

acts_upstream_of_or_within

IDA

(PMID:28561797)

PMID:28561797

NCBI chr14:53,628,090...53,628,593
Ensembl chr14:53,628,092...53,628,599

Txk

TXK tyrosine kinase

involved_in

IBA
IMP

(PMID:10213685)

PMID:10213685

GO_REF:0000033

NCBI chr 5:72,853,321...72,910,337
Ensembl chr 5:72,853,321...72,910,120

Ube2n

ubiquitin-conjugating enzyme E2N

involved_in

ISO
ISS

(PMID:15125833)

GO_Central
HGNC-UCL

PMID:15125833

GO_REF:0000119

NCBI chr10:95,351,024...95,381,520
Ensembl chr10:95,351,007...95,381,519

Vtcn1

V-set domain containing T cell activation inhibitor 1

involved_in

IBA

GO_REF:0000033

NCBI chr 3:100,732,775...100,805,555
Ensembl chr 3:100,732,775...100,804,238

Wnk1

WNK lysine deficient protein kinase 1

involved_in

IMP

(PMID:27400149)

PMID:27400149

NCBI chr 6:119,900,930...120,015,659
Ensembl chr 6:119,900,930...120,015,633

Zap70

zeta-chain (TCR) associated protein kinase

acts_upstream_of_or_within
involved_in

IMP
ISO

(PMID:9208839)

PMID:9208839

GO_REF:0000119

NCBI chr 1:36,800,912...36,821,899
Ensembl chr 1:36,800,879...36,821,899

Zc3h12a

zinc finger CCCH type containing 12A

involved_in

IDA
IMP

(PMID:23185455)
(PMID:25282160)

PMID:23185455 PMID:25282160

NCBI chr 4:125,012,207...125,021,674
Ensembl chr 4:125,012,216...125,021,633

Zfp683

zinc finger protein 683

involved_in

ISO

GO_REF:0000119

NCBI chr 4:133,778,506...133,786,252
Ensembl chr 4:133,781,149...133,786,307

TIRAP-dependent toll-like receptor 4 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

toll-interleukin 1 receptor (TIR) domain-containing adaptor protein

involved_in

ISO

GO_REF:0000119

NCBI chr 9:35,095,687...35,111,587
Ensembl chr 9:35,095,847...35,111,587

toll-like receptor 13 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Tlr13

toll-like receptor 13

involved_in

IDA

(PMID:22821982), (PMID:22896636)

PMID:22821982 PMID:22896636

NCBI chr X:105,186,881...105,204,099
Ensembl chr X:105,186,810...105,204,099

toll-like receptor 2 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

high mobility group box 1

involved_in

ISO

(PMID:14660645)

PMID:14660645

NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299

Irak1

interleukin-1 receptor-associated kinase 1

acts_upstream_of_or_within
involved_in

IDA
IBA
ISO

(PMID:10549626)

PMID:10549626

GO_REF:0000033 GO_REF:0000119

NCBI chr X:73,057,520...73,067,527
Ensembl chr X:73,057,520...73,067,524

Lgals9

lectin, galactose binding, soluble 9

NOT|involved_in

ISO

(PMID:16116184)

PMID:16116184

NCBI chr11:78,853,805...78,875,750
Ensembl chr11:78,853,800...78,875,772

nucleotide-binding oligomerization domain containing 2

acts_upstream_of

IMP

(PMID:15220916)

PMID:15220916

NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102

phosphoinositide-3-kinase adaptor protein 1

involved_in

IMP

(PMID:22187460)

PMID:22187460

NCBI chr19:41,260,980...41,373,541
Ensembl chr19:41,260,816...41,373,541

receptor (TNFRSF)-interacting serine-threonine kinase 2

acts_upstream_of_or_within

ISO

GO_REF:0000008

NCBI chr 4:16,122,740...16,163,674
Ensembl chr 4:16,122,733...16,163,647

toll-like receptor 2

involved_in

ISO

GO_REF:0000119

NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074

Tnip2

TNFAIP3 interacting protein 2

involved_in

IBA
IMP

(PMID:16633345)

PMID:16633345

GO_REF:0000033

NCBI chr 5:34,653,440...34,671,323
Ensembl chr 5:34,653,431...34,671,335

toll-like receptor 3 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cd86

CD86 antigen

involved_in

IMP

(PMID:25158758)

PMID:25158758

NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443

Colec12

collectin sub-family member 12

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr18:9,707,648...9,877,995
Ensembl chr18:9,707,595...9,882,644

Havcr2

hepatitis A virus cellular receptor 2

involved_in

IMP

(PMID:22842346)

PMID:22842346

NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082

Irf1

interferon regulatory factor 1

acts_upstream_of_or_within

ISO

(PMID:28970238)

NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200

Irf2

interferon regulatory factor 2

acts_upstream_of_or_within

ISO

(PMID:28970238)

NCBI chr 8:47,192,751...47,300,493
Ensembl chr 8:47,192,767...47,300,493

Lgals9

lectin, galactose binding, soluble 9

involved_in

ISO

PMID:25158758

PMID:25158758

RGD:10054077

NCBI chr11:78,853,805...78,875,750
Ensembl chr11:78,853,800...78,875,772

Oas1a

2'-5' oligoadenylate synthetase 1A

involved_in

ISO

GO_REF:0000119

NCBI chr 5:121,034,319...121,045,588
Ensembl chr 5:121,034,319...121,045,584

Oas1b

2'-5' oligoadenylate synthetase 1B

involved_in

ISO

GO_REF:0000119

NCBI chr 5:120,950,700...120,962,228
Ensembl chr 5:120,950,700...120,962,228

Oas1c

2'-5' oligoadenylate synthetase 1C

involved_in

ISO

GO_REF:0000119

NCBI chr 5:120,938,259...120,950,605
Ensembl chr 5:120,938,259...120,950,579

Oas1d

2'-5' oligoadenylate synthetase 1D

involved_in

ISO

GO_REF:0000119

NCBI chr 5:121,052,881...121,059,711
Ensembl chr 5:121,052,599...121,059,715

Oas1e

2'-5' oligoadenylate synthetase 1E

involved_in

ISO

GO_REF:0000119

NCBI chr 5:120,924,377...120,933,595
Ensembl chr 5:120,924,291...120,933,595

Oas1f

2'-5' oligoadenylate synthetase 1F

involved_in

ISO

GO_REF:0000119

NCBI chr 5:120,985,432...120,996,049
Ensembl chr 5:120,985,432...120,996,049

Oas1g

2'-5' oligoadenylate synthetase 1G

involved_in

ISO

GO_REF:0000119

NCBI chr 5:121,014,205...121,025,676
Ensembl chr 5:121,014,205...121,025,676

Oas1h

2'-5' oligoadenylate synthetase 1H

involved_in

ISO

GO_REF:0000119

NCBI chr 5:120,999,485...121,011,569
Ensembl chr 5:120,999,484...121,011,569

Rftn1

raftlin lipid raft linker 1

acts_upstream_of_or_within

ISO

(PMID:21266579)

PMID:21266579

NCBI chr17:50,300,287...50,497,525
Ensembl chr17:50,299,285...50,497,702

Rnf170

ring finger protein 170

acts_upstream_of_or_within

IMP

(PMID:31076723)

PMID:31076723

NCBI chr 8:26,609,396...26,633,903
Ensembl chr 8:26,609,396...26,641,818

Scara3

scavenger receptor class A, member 3

NOT|involved_in

ISO

(PMID:25204797)

PMID:25204797

NCBI chr14:66,156,844...66,191,427
Ensembl chr14:66,156,843...66,191,384

SLP adaptor and CSK interacting membrane protein

involved_in

IMP

(PMID:28098138)

NCBI chr11:70,681,758...70,703,387
Ensembl chr11:70,681,758...70,703,412

TIR domain containing adaptor molecule 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786

Tlr3

toll-like receptor 3

acts_upstream_of_or_within
involved_in

ISO

(PMID:28970238)

GO_REF:0000119

NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117

Tnf

tumor necrosis factor

involved_in

IEA
ISO

GO_REF:0000096 GO_REF:0000107

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

Tnip2

TNFAIP3 interacting protein 2

involved_in

IBA
IMP

(PMID:16633345)

PMID:16633345

GO_REF:0000033

NCBI chr 5:34,653,440...34,671,323
Ensembl chr 5:34,653,431...34,671,335

unc-93 homolog B1, TLR signaling regulator

involved_in

IMP
IBA
ISO

(PMID:16415873)

PMID:16415873

GO_REF:0000033 GO_REF:0000119

NCBI chr19:3,985,222...3,999,340
Ensembl chr19:3,985,186...3,999,340

toll-like receptor 4 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cd14

CD14 antigen

involved_in

IBA
IEA
ISO

GO_REF:0000033 GO_REF:0000107 GO_REF:0000119

NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851

Chuk

conserved helix-loop-helix ubiquitous kinase

involved_in

ISO

GO_REF:0000119

NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919

Ecsit

ECSIT signalling integrator

involved_in

ISO

GO_REF:0000119

NCBI chr 9:21,982,731...21,997,648
Ensembl chr 9:21,983,542...21,996,734

high mobility group box 1

involved_in

ISO

(PMID:14660645)

PMID:14660645

NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299

Irak1

interleukin-1 receptor-associated kinase 1

acts_upstream_of_or_within
involved_in

IDA
IBA

(PMID:10549626)

PMID:10549626

GO_REF:0000033

NCBI chr X:73,057,520...73,067,527
Ensembl chr X:73,057,520...73,067,524

Irak2

interleukin-1 receptor-associated kinase 2

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 6:113,615,428...113,671,987
Ensembl chr 6:113,615,428...113,671,987

Irf3

interferon regulatory factor 3

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272

Letmd1

LETM1 domain containing 1

acts_upstream_of_or_within

IMP

(PMID:31980577)

PMID:31980577

NCBI chr15:100,360,302...100,377,133
Ensembl chr15:100,366,904...100,377,045

Lgals9

lectin, galactose binding, soluble 9

NOT|involved_in

ISO

(PMID:16116184)

PMID:16116184

NCBI chr11:78,853,805...78,875,750
Ensembl chr11:78,853,800...78,875,772

Ly96

lymphocyte antigen 96

involved_in

IBA
IMP

(PMID:24380872)

PMID:24380872

GO_REF:0000033

NCBI chr 1:16,758,680...16,779,829
Ensembl chr 1:16,758,275...16,779,835

LYN proto-oncogene, Src family tyrosine kinase

involved_in

IMP

(PMID:28098138)

NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122

Map3k7

mitogen-activated protein kinase kinase kinase 7

involved_in

ISO

GO_REF:0000119

NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467

myeloid differentiation primary response gene 88

involved_in

IBA
ISO
IEA

GO_REF:0000033 GO_REF:0000107 GO_REF:0000119

NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477

Naglu

alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)

acts_upstream_of_or_within

IMP

(PMID:29624734)

PMID:29624734

NCBI chr11:100,960,918...100,968,483
Ensembl chr11:100,960,838...100,968,498

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

acts_upstream_of_or_within
involved_in

IDA
ISO

(PMID:18261938)

GO_REF:0000119

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

Nmi

N-myc (and STAT) interactor

involved_in

IDA

(PMID:29038465)

PMID:29038465

NCBI chr 2:51,838,517...51,863,241
Ensembl chr 2:51,838,499...51,863,506

Oas1a

2'-5' oligoadenylate synthetase 1A

involved_in

ISO

GO_REF:0000119

NCBI chr 5:121,034,319...121,045,588
Ensembl chr 5:121,034,319...121,045,584

Oas1b

2'-5' oligoadenylate synthetase 1B

involved_in

ISO

GO_REF:0000119

NCBI chr 5:120,950,700...120,962,228
Ensembl chr 5:120,950,700...120,962,228

Oas1c

2'-5' oligoadenylate synthetase 1C

involved_in

ISO

GO_REF:0000119

NCBI chr 5:120,938,259...120,950,605
Ensembl chr 5:120,938,259...120,950,579

Oas1d

2'-5' oligoadenylate synthetase 1D

involved_in

ISO

GO_REF:0000119

NCBI chr 5:121,052,881...121,059,711
Ensembl chr 5:121,052,599...121,059,715

Oas1e

2'-5' oligoadenylate synthetase 1E

involved_in

ISO

GO_REF:0000119

NCBI chr 5:120,924,377...120,933,595
Ensembl chr 5:120,924,291...120,933,595

Oas1f

2'-5' oligoadenylate synthetase 1F

involved_in

ISO

GO_REF:0000119

NCBI chr 5:120,985,432...120,996,049
Ensembl chr 5:120,985,432...120,996,049

Oas1g

2'-5' oligoadenylate synthetase 1G

involved_in

ISO

GO_REF:0000119

NCBI chr 5:121,014,205...121,025,676
Ensembl chr 5:121,014,205...121,025,676

Oas1h

2'-5' oligoadenylate synthetase 1H

involved_in

ISO

GO_REF:0000119

NCBI chr 5:120,999,485...121,011,569
Ensembl chr 5:120,999,484...121,011,569

phosphoinositide-3-kinase adaptor protein 1

involved_in

IMP

(PMID:22187458), (PMID:22187460)

PMID:22187458 PMID:22187460

NCBI chr19:41,260,980...41,373,541
Ensembl chr19:41,260,816...41,373,541

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

receptor (TNFRSF)-interacting serine-threonine kinase 2

acts_upstream_of_or_within

IMP

(PMID:11894098)

PMID:11894098

NCBI chr 4:16,122,740...16,163,674
Ensembl chr 4:16,122,733...16,163,647

S100a14

S100 calcium binding protein A14

involved_in

IBA
IEA
ISO

GO_REF:0000033 GO_REF:0000107 GO_REF:0000119

NCBI chr 3:90,434,156...90,436,144
Ensembl chr 3:90,434,163...90,436,144

SLP adaptor and CSK interacting membrane protein

involved_in

IMP

(PMID:28098138)

NCBI chr11:70,681,758...70,703,387
Ensembl chr11:70,681,758...70,703,412

Tbk1

TANK-binding kinase 1

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr10:121,382,360...121,422,699
Ensembl chr10:121,382,360...121,422,692

TIR domain containing adaptor molecule 1

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786

TIR domain containing adaptor molecule 2

involved_in

ISO

GO_REF:0000119

NCBI chr18:46,691,298...46,707,600
Ensembl chr18:46,690,358...46,707,600

toll-interleukin 1 receptor (TIR) domain-containing adaptor protein

involved_in

IMP
IBA
ISO

(PMID:11526399)
(PMID:11544529)

PMID:11526399 PMID:11544529

GO_REF:0000033 GO_REF:0000119

NCBI chr 9:35,095,687...35,111,587
Ensembl chr 9:35,095,847...35,111,587

PMID:25549946 PMID:28098138

toll-like receptor 4

acts_upstream_of_or_within
involved_in

IDA
IBA
ISO

(PMID:25549946)
(PMID:28098138)

MGI
GO_Central
UniProt

GO_REF:0000033 GO_REF:0000119

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

Tmem126a

transmembrane protein 126A

acts_upstream_of_or_within

IMP

(PMID:25549946)

PMID:25549946

NCBI chr 7:90,099,908...90,106,411
Ensembl chr 7:90,099,908...90,106,437

Tnip3

TNFAIP3 interacting protein 3

involved_in

ISO

GO_REF:0000119

NCBI chr 6:65,567,382...65,611,024
NCBI chr 6:65,502,319...65,554,145
Ensembl chr 6:65,502,297...65,611,024

Traf3

TNF receptor-associated factor 3

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr12:111,132,799...111,233,589
Ensembl chr12:111,132,804...111,233,587

Traf6

TNF receptor-associated factor 6

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014

Tril

TLR4 interactor with leucine-rich repeats

involved_in

IBA
IEA
ISO

GO_REF:0000033 GO_REF:0000107 GO_REF:0000119

NCBI chr 6:53,792,453...53,797,810
Ensembl chr 6:53,792,453...53,797,815

toll-like receptor 5 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

myeloid differentiation primary response gene 88

involved_in

IEA

GO_REF:0000107

NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477

toll-interleukin 1 receptor (TIR) domain-containing adaptor protein

NOT|involved_in

IMP

(PMID:12447442)

PMID:12447442

NCBI chr 9:35,095,687...35,111,587
Ensembl chr 9:35,095,847...35,111,587

Tlr5

toll-like receptor 5

involved_in

ISO

GO_REF:0000119

NCBI chr 1:182,782,317...182,804,010
Ensembl chr 1:182,782,353...182,804,010

toll-like receptor 7 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Havcr2

hepatitis A virus cellular receptor 2

involved_in

IMP

(PMID:22842346)

PMID:22842346

NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082

phosphoinositide-3-kinase adaptor protein 1

involved_in

IMP

(PMID:22187458)

PMID:22187458

NCBI chr19:41,260,980...41,373,541
Ensembl chr19:41,260,816...41,373,541

SLP adaptor and CSK interacting membrane protein

involved_in

IMP

(PMID:28098138)

NCBI chr11:70,681,758...70,703,387
Ensembl chr11:70,681,758...70,703,412

Tlr7

toll-like receptor 7

involved_in

IBA
IMP

(PMID:14976261)

PMID:14976261

GO_REF:0000033

NCBI chr X:166,086,376...166,113,570
Ensembl chr X:166,087,925...166,113,554

unc-93 homolog B1, TLR signaling regulator

involved_in

IMP
IBA
ISO

(PMID:16415873)

PMID:16415873

GO_REF:0000033 GO_REF:0000119

NCBI chr19:3,985,222...3,999,340
Ensembl chr19:3,985,186...3,999,340

toll-like receptor 8 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

myeloid differentiation primary response gene 88

involved_in

ISS
ISO

GO_REF:0000024 GO_REF:0000119

NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477

Tlr7

toll-like receptor 7

involved_in

IDA

(PMID:12032557)

PMID:12032557

NCBI chr X:166,086,376...166,113,570
Ensembl chr X:166,087,925...166,113,554

Tlr8

toll-like receptor 8

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr X:166,024,119...166,047,325
Ensembl chr X:166,025,692...166,047,325

toll-like receptor 9 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cd300ld3

CD300 molecule like family member D3

acts_upstream_of

IMP
IDA

(PMID:21940676)

PMID:21940676

NCBI chr11:114,932,930...114,939,244
Ensembl chr11:114,932,957...114,939,235

Epg5

ectopic P-granules 5 autophagy tethering factor

acts_upstream_of_positive_effect

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr18:77,981,618...78,080,539
Ensembl chr18:77,981,680...78,078,228

Havcr2

hepatitis A virus cellular receptor 2

involved_in

IMP

(PMID:22842346)

PMID:22842346

NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082

Nr1h4

nuclear receptor subfamily 1, group H, member 4

involved_in

IMP

(PMID:23372731)

PMID:23372731

NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447

phosphoinositide-3-kinase adaptor protein 1

involved_in

IMP

(PMID:22187458), (PMID:22187460)

PMID:22187458 PMID:22187460

NCBI chr19:41,260,980...41,373,541
Ensembl chr19:41,260,816...41,373,541

toll-like receptor 9

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082

Tnip2

TNFAIP3 interacting protein 2

involved_in

IMP

(PMID:16633345)

PMID:16633345

NCBI chr 5:34,653,440...34,671,323
Ensembl chr 5:34,653,431...34,671,335

unc-93 homolog B1, TLR signaling regulator

involved_in

ISO
IBA
IDA
IMP

(PMID:38169466)
(PMID:16415873)

PMID:16415873 PMID:38169466

GO_REF:0000033 GO_REF:0000119

NCBI chr19:3,985,222...3,999,340
Ensembl chr19:3,985,186...3,999,340

toll-like receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ap3b1

adaptor-related protein complex 3, beta 1 subunit

acts_upstream_of_or_within

IMP

(PMID:20847273)

PMID:20847273

NCBI chr13:94,492,332...94,702,838
Ensembl chr13:94,495,468...94,702,825

B cell leukemia/lymphoma 10

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr 3:145,630,017...145,640,121
Ensembl chr 3:145,628,559...145,640,111

Cd86

CD86 antigen

acts_upstream_of_or_within

IDA

(PMID:19734906)

PMID:19734906

NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443

Fosl1

fos-like antigen 1

acts_upstream_of_or_within

IMP

(PMID:30990796)

PMID:30990796

NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974

Irak3

interleukin-1 receptor-associated kinase 3

ISO

PMID:27832756

RGD:34888235

NCBI chr10:119,977,553...120,038,035
Ensembl chr10:119,977,553...120,038,035

Lrrc19

leucine rich repeat containing 19

acts_upstream_of_or_within
involved_in

IDA
IBA

(PMID:19679103)

PMID:19679103

GO_REF:0000033

NCBI chr 4:94,523,958...94,538,381
Ensembl chr 4:94,524,890...94,538,381

Ly96

lymphocyte antigen 96

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr 1:16,758,680...16,779,829
Ensembl chr 1:16,758,275...16,779,835

Mapkapk2

MAP kinase-activated protein kinase 2

involved_in

IBA
IMP

(PMID:17906627)

PMID:17906627

GO_REF:0000033

NCBI chr 1:130,981,437...131,025,580
Ensembl chr 1:130,981,437...131,025,563

Mapkapk3

mitogen-activated protein kinase-activated protein kinase 3

involved_in

IBA
IMP

(PMID:17906627)

PMID:17906627

GO_REF:0000033

NCBI chr 9:107,132,125...107,167,082
Ensembl chr 9:107,132,126...107,167,076

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta

involved_in

IMP
IDA

(PMID:25124037)
(PMID:23728777)

PMID:23728777 PMID:25124037

NCBI chr16:55,631,740...55,659,018
Ensembl chr16:55,631,738...55,659,262

phospholipase C, gamma 2

involved_in

IMP

(PMID:19136564)

PMID:19136564

NCBI chr 8:118,225,014...118,361,881
Ensembl chr 8:118,225,030...118,361,881

Ptgs2os

prostaglandin-endoperoxide synthase 2, opposite strand

acts_upstream_of

IDA
IMP

(PMID:23907535)

PMID:23907535

NCBI chr 1:149,950,624...149,975,625
Ensembl chr 1:149,909,888...149,975,714

Rps6ka3

ribosomal protein S6 kinase polypeptide 3

involved_in

IMP

(PMID:17906627)

PMID:17906627

NCBI chr X:158,038,652...158,151,240
Ensembl chr X:157,993,303...158,151,240

TIR domain containing adaptor molecule 1

involved_in

ISO

GO_REF:0000119

NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786

Tifab

TRAF-interacting protein with forkhead-associated domain, family member B

acts_upstream_of_negative_effect

IMP

(PMID:26458771)

PMID:26458771

NCBI chr13:56,318,917...56,326,816
Ensembl chr13:56,321,517...56,326,698

Tlr1

toll-like receptor 1

involved_in

ISO
IBA
IEA

RGD
GO_Central
Ensembl

GO_REF:0000033 GO_REF:0000096 GO_REF:0000107 GO_REF:0000119 RGD:1643119

NCBI chr 5:65,082,023...65,090,945
Ensembl chr 5:65,082,022...65,090,906

Tlr11

toll-like receptor 11

involved_in

IBA

GO_REF:0000033

NCBI chr14:50,595,371...50,601,120
Ensembl chr14:50,595,371...50,601,120

Tlr12

toll-like receptor 12

involved_in

IBA

GO_REF:0000033

NCBI chr 4:128,509,239...128,512,412
Ensembl chr 4:128,509,236...128,512,412

Tlr13

toll-like receptor 13

involved_in

IBA

GO_REF:0000033

NCBI chr X:105,186,881...105,204,099
Ensembl chr X:105,186,810...105,204,099

toll-like receptor 2

involved_in

ISO
IBA

PMID:16973131 PMID:18353287

GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:1643119 RGD:5684896

NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074

Tlr3

toll-like receptor 3

involved_in

ISO
IBA
IEA

RGD
GO_Central
Ensembl

GO_REF:0000033 GO_REF:0000096 GO_REF:0000107 GO_REF:0000119 RGD:1643119

NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117

toll-like receptor 4

involved_in

ISO

GO_REF:0000096 GO_REF:0000119 RGD:1643119

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

Tlr5

toll-like receptor 5

involved_in

IEA
IBA

InterPro
GO_Central

GO_REF:0000002 GO_REF:0000033

NCBI chr 1:182,782,317...182,804,010
Ensembl chr 1:182,782,353...182,804,010

toll-like receptor 6

involved_in

ISO
IBA

PMID:16973131 PMID:18353287

GO_REF:0000033 GO_REF:0000096 RGD:1643119 RGD:5684896

NCBI chr 5:65,109,373...65,128,387
Ensembl chr 5:65,109,374...65,117,440

Tlr7

toll-like receptor 7

involved_in

IBA

GO_REF:0000033

NCBI chr X:166,086,376...166,113,570
Ensembl chr X:166,087,925...166,113,554

Tlr8

toll-like receptor 8

involved_in

IBA

GO_REF:0000033

NCBI chr X:166,024,119...166,047,325
Ensembl chr X:166,025,692...166,047,325

toll-like receptor 9

involved_in

ISO
IBA

GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:1643119

NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082

Traf3

TNF receptor-associated factor 3

involved_in

IMP

(PMID:16306937)

PMID:16306937

NCBI chr12:111,132,799...111,233,589
Ensembl chr12:111,132,804...111,233,587

unc-93 homolog B1, TLR signaling regulator

acts_upstream_of_or_within

IMP

(PMID:16415873)

PMID:16415873

NCBI chr19:3,985,222...3,999,340
Ensembl chr19:3,985,186...3,999,340

toll-like receptor TLR1:TLR2 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

SLP adaptor and CSK interacting membrane protein

involved_in

IMP

(PMID:28098138)

NCBI chr11:70,681,758...70,703,387
Ensembl chr11:70,681,758...70,703,412

toll-like receptor TLR6:TLR2 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

myeloid differentiation primary response gene 88

involved_in

IEA

GO_REF:0000107

NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

involved_in

IEA

GO_REF:0000107

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

toll-like receptor 2

involved_in

ISO

GO_REF:0000119

NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074

toll-like receptor 6

involved_in

ISO

GO_REF:0000119

NCBI chr 5:65,109,373...65,128,387
Ensembl chr 5:65,109,374...65,117,440

TRAM-dependent toll-like receptor 4 signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Prkce

protein kinase C, epsilon

involved_in

IMP

(PMID:16757566)

PMID:16757566

NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347

Rab11fip2

RAB11 family interacting protein 2 (class I)

involved_in

ISO
IEA

GO_REF:0000107 GO_REF:0000119

NCBI chr19:59,881,934...59,933,086
Ensembl chr19:59,891,316...59,932,086

TIR domain containing adaptor molecule 2

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr18:46,691,298...46,707,600
Ensembl chr18:46,690,358...46,707,600

TRIF-dependent toll-like receptor signaling pathway

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cd274

CD274 antigen

involved_in

IEA
ISO

GO_REF:0000107 GO_REF:0000119

NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495

Cd300lf

CD300 molecule like family member F

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr11:115,007,040...115,024,834
Ensembl chr11:115,007,040...115,024,818

Irf3

interferon regulatory factor 3

involved_in

ISO
ISS

GO_REF:0000024 GO_REF:0000119

NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272

ParkinsonsUK-UCL
GO_Central

TIR domain containing adaptor molecule 1

involved_in

IMP
IBA
ISO

(PMID:17658277)

PMID:17658277

GO_REF:0000033 GO_REF:0000119

NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786

TIR domain containing adaptor molecule 2

involved_in

IEA
IBA

InterPro
GO_Central

GO_REF:0000002 GO_REF:0000033

NCBI chr18:46,691,298...46,707,600
Ensembl chr18:46,690,358...46,707,600

toll-like receptor 4

involved_in

IGI

(PMID:20037584)

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

toll-like receptor 6

involved_in

IGI

(PMID:20037584)