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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:MyD88-dependent toll-like receptor signaling pathway
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Accession:GO:0002755 term browser browse the term
Definition:A toll-like receptor signaling pathway in which the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.
Synonyms:exact_synonym: MyD88-dependent TLR signaling pathway;   MyD88-dependent toll-like receptor signalling pathway


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MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:14660645) UniProt PMID:14660645 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 acts_upstream_of_or_within IMP
IGI		 (PMID:14764662)
(PMID:12719478)
(PMID:12872135)		 MGI PMID:12719478 PMID:12872135 PMID:14764662 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477 		JBrowse link
G Reg3g regenerating islet-derived 3 gamma involved_in IMP (MGI:3760234|PMID:17635956) UniProt PMID:17635956 MGI:3760234 NCBI chr 6:78,443,252...78,445,857
Ensembl chr 6:78,443,252...78,445,855 		JBrowse link
G Tlr13 toll-like receptor 13 acts_upstream_of_or_within IGI (PMID:21131352) MGI PMID:21131352 NCBI chr  X:105,186,881...105,204,099
Ensembl chr  X:105,186,810...105,204,099 		JBrowse link
G Tlr2 toll-like receptor 2 acts_upstream_of_or_within IGI (PMID:12719478) MGI PMID:12719478 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in IGI
IBA
ISO		 (MGI:4438693|PMID:20037584) ARUK-UCL
GO_Central
MGI		 PMID:20037584 GO_REF:0000033 GO_REF:0000119 MGI:4438693 MGI:4834177 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tlr6 toll-like receptor 6 involved_in IGI
ISO		 (MGI:4438693|PMID:20037584) ARUK-UCL
MGI		 PMID:20037584 GO_REF:0000119 MGI:4438693 MGI:4834177 NCBI chr 5:65,109,373...65,128,387
Ensembl chr 5:65,109,374...65,117,440 		JBrowse link
G Tlr9 toll-like receptor 9 involved_in IPI (MGI:3826712|PMID:18820679) UniProt PMID:18820679 MGI:3826712 NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082 		JBrowse link
G Tnip1 TNFAIP3 interacting protein 1 involved_in IDA (MGI:5305352|PMID:22011580) UniProt PMID:22011580 MGI:5305352 NCBI chr11:54,801,613...54,853,766
Ensembl chr11:54,801,611...54,853,743 		JBrowse link
MyD88-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrfip2 leucine rich repeat (in FLII) interacting protein 2 acts_upstream_of_or_within IDA (PMID:19265123) MGI PMID:19265123 NCBI chr 9:110,946,614...111,054,736
Ensembl chr 9:110,946,660...111,054,736 		JBrowse link
negative regulation of MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a CD300A molecule involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:114,780,006...114,792,772
Ensembl chr11:114,780,867...114,795,480 		JBrowse link
G Cd300lf CD300 molecule like family member F involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:115,007,040...115,024,834
Ensembl chr11:115,007,040...115,024,818 		JBrowse link
regulation of MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf1 interferon regulatory factor 1 involved_in IMP (MGI:3691368|PMID:17018642) UniProt PMID:17018642 MGI:3691368 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200 		JBrowse link
G Irf7 interferon regulatory factor 7 involved_in IMP (MGI:3575992|PMID:15800576) UniProt PMID:15800576 MGI:3575992 NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    immune system process 3142
      activation of immune response 604
        activation of innate immune response 332
          innate immune response-activating signaling pathway 295
            pattern recognition receptor signaling pathway 284
              toll-like receptor signaling pathway 79
                MyD88-dependent toll-like receptor signaling pathway 15
                  MyD88-dependent toll-like receptor 2 signaling pathway 0
                  MyD88-dependent toll-like receptor 4 signaling pathway 1
                  negative regulation of MyD88-dependent toll-like receptor signaling pathway 2
                  positive regulation of MyD88-dependent toll-like receptor signaling pathway 0
                  regulation of MyD88-dependent toll-like receptor signaling pathway + 4
Path 2
Term Annotations click to browse term
  biological_process 28573
    response to stimulus 10772
      response to biotic stimulus 2060
        response to external biotic stimulus 2016
          response to other organism 2013
            defense response to other organism 1411
              defense response to symbiont 1281
                innate immune response 1078
                  regulation of innate immune response 501
                    positive regulation of innate immune response 409
                      activation of innate immune response 332
                        innate immune response-activating signaling pathway 295
                          pattern recognition receptor signaling pathway 284
                            toll-like receptor signaling pathway 79
                              MyD88-dependent toll-like receptor signaling pathway 15
                                MyD88-dependent toll-like receptor 2 signaling pathway 0
                                MyD88-dependent toll-like receptor 4 signaling pathway 1
                                negative regulation of MyD88-dependent toll-like receptor signaling pathway 2
                                positive regulation of MyD88-dependent toll-like receptor signaling pathway 0
                                regulation of MyD88-dependent toll-like receptor signaling pathway + 4
paths to the root