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ONTOLOGY REPORT - ANNOTATIONS


Term:platelet degranulation
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Accession:GO:0002576 term browser browse the term
Definition:The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
Synonyms:exact_synonym: platelet exocytosis


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platelet degranulation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blk B lymphoid kinase IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr14:63,372,837...63,417,187
Ensembl chr14:63,372,836...63,417,037
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase IMP
IBA
(MGI:MGI:5298337|PMID:20189992)
(MGI:MGI:6201960|PMID:21873635)
UniProtKB
GO_Central
PMID:20189992, PMID:21873635 MGI:MGI:5298337, MGI:MGI:6201960 NCBI chr 4:3,678,068...3,791,612
Ensembl chr 4:3,678,115...3,813,122
JBrowse link
G Plek pleckstrin ISO (PMID:7559487) BHF-UCL PMID:7559487 NCBI chr11:16,971,206...17,008,718
Ensembl chr11:16,971,206...17,052,381
JBrowse link
G Stxbp1 syntaxin binding protein 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:32,787,607...32,847,237
Ensembl chr 2:32,787,602...32,847,245
JBrowse link
protein secretion by platelet term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmtn dematin actin binding protein IMP (MGI:MGI:5465511|PMID:23060452) UniProtKB PMID:23060452 MGI:MGI:5465511 NCBI chr14:70,602,184...70,636,048
Ensembl chr14:70,601,263...70,636,048
JBrowse link
G Plek pleckstrin IMP (MGI:MGI:3844782|PMID:19190246) BHF-UCL PMID:19190246 MGI:MGI:3844782 NCBI chr11:16,971,206...17,008,718
Ensembl chr11:16,971,206...17,052,381
JBrowse link
serotonin secretion by platelet term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide IMP (MGI:MGI:87668|PMID:9171347) UniProtKB PMID:9171347 MGI:MGI:87668 NCBI chr 1:171,229,572...171,234,349
Ensembl chr 1:171,229,572...171,234,365
JBrowse link
G P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 IMP (MGI:MGI:2671726|PMID:12913094) MGI PMID:12913094 MGI:MGI:2671726 NCBI chr11:72,999,056...73,015,200
Ensembl chr11:72,999,103...73,015,200
JBrowse link
G Syk spleen tyrosine kinase IMP (MGI:MGI:87668|PMID:9171347) UniProtKB PMID:9171347 MGI:MGI:87668 NCBI chr13:52,582,610...52,648,792
Ensembl chr13:52,583,173...52,648,792
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23369
    cellular process 17359
      cellular localization 2837
        establishment of localization in cell 2090
          platelet degranulation 8
            histamine secretion by platelet 0
            protein secretion by platelet 2
            serotonin secretion by platelet 3
Path 2
Term Annotations click to browse term
  biological_process 23369
    localization 6240
      establishment of localization 4707
        transport 4565
          export from cell 1051
            secretion by cell 1001
              exocytosis 403
                regulated exocytosis 273
                  platelet degranulation 8
                    histamine secretion by platelet 0
                    protein secretion by platelet 2
                    serotonin secretion by platelet 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.