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ONTOLOGY REPORT - ANNOTATIONS


Term:platelet degranulation
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Accession:GO:0002576 term browser browse the term
Definition:The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
Synonyms:exact_synonym: platelet exocytosis


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platelet degranulation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LYN LYN proto-oncogene, Src family tyrosine kinase ISO (MGI:MGI:5298337|PMID:20189992) UniProtKB PMID:20189992 MGI:MGI:5298337 NCBI chr 8:52,318,497...52,455,741
Ensembl chr 8:49,755,708...49,825,287
JBrowse link
G PLEK pleckstrin ISO (PMID:7559487) BHF-UCL PMID:7559487 NCBI chr2A:68,414,281...68,446,647
Ensembl chr2A:69,537,983...69,570,393
JBrowse link
G STXBP1 syntaxin binding protein 1 ISO (PMID:12773094) UniProtKB PMID:12773094 NCBI chr 9:98,731,527...98,811,608
Ensembl chr 9:127,434,080...127,486,152
JBrowse link
protein secretion by platelet term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DMTN dematin actin binding protein ISO (MGI:MGI:5465511|PMID:23060452) UniProtKB PMID:23060452 MGI:MGI:5465511 NCBI chr 8:21,293,759...21,327,600
Ensembl chr 8:18,251,886...18,266,229
JBrowse link
G PLEK pleckstrin ISO (MGI:MGI:3844782|PMID:19190246) BHF-UCL PMID:19190246 MGI:MGI:3844782 NCBI chr2A:68,414,281...68,446,647
Ensembl chr2A:69,537,983...69,570,393
JBrowse link
serotonin secretion by platelet term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FCER1G Fc fragment of IgE receptor Ig ISO (MGI:MGI:87668|PMID:9171347) UniProtKB PMID:9171347 MGI:MGI:87668 NCBI chr 1:136,627,672...136,631,696 JBrowse link
G P2RX1 purinergic receptor P2X 1 ISO (MGI:MGI:2671726|PMID:12913094) MGI PMID:12913094 MGI:MGI:2671726 NCBI chr17:3,944,636...3,965,260
Ensembl chr17:3,935,982...3,956,595
JBrowse link
G SYK spleen associated tyrosine kinase ISO (MGI:MGI:87668|PMID:9171347) UniProtKB PMID:9171347 MGI:MGI:87668 NCBI chr 9:61,859,767...61,956,619
Ensembl chr 9:89,959,599...90,056,101
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12524
    cellular process 11624
      cellular localization 2330
        establishment of localization in cell 1654
          platelet degranulation 7
            histamine secretion by platelet 0
            protein secretion by platelet 2
            serotonin secretion by platelet 3
Path 2
Term Annotations click to browse term
  biological_process 12524
    localization 4924
      establishment of localization 3533
        transport 3389
          export from cell 929
            secretion by cell 885
              exocytosis 312
                regulated exocytosis 234
                  platelet degranulation 7
                    histamine secretion by platelet 0
                    protein secretion by platelet 2
                    serotonin secretion by platelet 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.