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ONTOLOGY REPORT - ANNOTATIONS


Term:somatic diversification of immune receptors via somatic mutation
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Accession:GO:0002566 term browser browse the term
Definition:The process in which immune receptor genes are diversified through somatic mutation.



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somatic diversification of immune receptors via somatic mutation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase, RNA-specific involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:5469797|PMID:23209284)
Ensembl
RGD
PMID:23209284 GO_REF:0000107 MGI:5469797 NCBI chr 2:175,138,391...175,178,280
Ensembl chr 2:175,138,403...175,178,282
JBrowse link
somatic hypermutation of immunoglobulin genes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase involved_in ISO (PMID:21518874) RGD PMID:21518874 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972
JBrowse link
G Exo1 exonuclease 1 acts_upstream_of_or_within ISO MGI:2653925 (MGI:3028407|PMID:14716311) RGD PMID:14716311 MGI:3028407 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
JBrowse link
G Mcm3ap minichromosome maintenance complex component 3 associated protein involved_in ISO (PMID:23652018) RGD PMID:23652018 NCBI chr20:12,127,570...12,165,165
Ensembl chr20:12,127,570...12,165,165
JBrowse link
G Mlh1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
PMID:21873635
MGI:1857946 (MGI:1332749|PMID:10092760), (MGI:3691360|PMID:10429667)
GO_REF:0000107
RGD
Ensembl
PMID:10092760 PMID:10429667 PMID:21873635 GO_REF:0000107 MGI:1332749 MGI:3691360, RGD:13792537 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
G Msh2 mutS homolog 2 involved_in
NOT|acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1858055 (MGI:1261398|PMID:9607915)
MGI:109352|MGI:1857940|MGI:1858055|MGI:2680817 (MGI:1275866|PMID:9697842), (MGI:1275867|PMID:9697843), (MGI:2679186|PMID:14568978), (MGI:3513244|PMID:15494304), (MGI:3641481|PMID:9607916)
Ensembl
RGD
PMID:9607915 PMID:9607916 PMID:9697842 PMID:9697843 PMID:14568978 More... GO_REF:0000107 MGI:1261398 MGI:1275866 MGI:1275867 MGI:2679186 MGI:3513244 MGI:3641481 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Msh3 mutS homolog 3 NOT|acts_upstream_of_or_within ISO MGI:1858056 (MGI:1353126|PMID:10662804) RGD PMID:10662804 MGI:1353126 NCBI chr 2:23,444,326...23,585,777 JBrowse link
G Msh6 mutS homolog 6 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1858014|MGI:3653701 (MGI:1353126|PMID:10662804), (MGI:3046392|PMID:15238604), (MGI:3641510|PMID:16618598), (MGI:3723381|PMID:17015724)
RGD PMID:10662804 PMID:15238604 PMID:16618598 PMID:17015724 PMID:21873635 MGI:1353126 MGI:3046392 MGI:3641510 MGI:3723381, RGD:13792537 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
JBrowse link
G Nuggc nuclear GTPase, germinal center associated acts_upstream_of_or_within ISO MGI:5449552 (MGI:5448793|PMID:22833677) RGD PMID:22833677 MGI:5448793 NCBI chr15:39,821,851...39,866,122
Ensembl chr15:39,821,855...39,866,122
JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:1261707|PMID:9618520)
MGI:1857947 (MGI:3691360|PMID:10429667)
RGD PMID:9618520 PMID:10429667 PMID:21873635 MGI:1261707 MGI:3691360, RGD:13792537 NCBI chr12:10,676,819...10,701,161
Ensembl chr12:10,676,764...10,701,066
JBrowse link
G Polb DNA polymerase beta acts_upstream_of_or_within ISO MGI:5427084 (MGI:5553198|PMID:24388753) RGD PMID:24388753 MGI:5553198 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812
JBrowse link
G Polm DNA polymerase mu acts_upstream_of_or_within ISO MGI:2179233 (MGI:3576407|PMID:15789338) RGD PMID:15789338 MGI:3576407 NCBI chr14:80,707,075...80,716,677
Ensembl chr14:80,706,345...80,717,086
JBrowse link
G Polq DNA polymerase theta involved_in ISO (MGI:3603978|PMID:16172387), (MGI:3609287|PMID:16222339), (MGI:3692678|PMID:16890500) RGD PMID:16172387 PMID:16222339 PMID:16890500 MGI:3603978 MGI:3609287 MGI:3692678 NCBI chr11:63,673,796...63,775,905
Ensembl chr11:63,673,816...63,775,878
JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 involved_in ISO (MGI:6157199|PMID:29669924) RGD PMID:29669924 MGI:6157199 NCBI chr 3:145,761,549...145,794,420
Ensembl chr 3:145,761,558...145,794,386
JBrowse link
G Ung uracil-DNA glycosylase acts_upstream_of_or_within ISO MGI:101816|MGI:2182610 (MGI:3513244|PMID:15494304), (MGI:3723381|PMID:17015724) RGD PMID:15494304 PMID:17015724 MGI:3513244 MGI:3723381 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19541
    immune system process 2852
      somatic diversification of immune receptors 85
        somatic diversification of immune receptors via somatic mutation 15
          somatic hypermutation of immunoglobulin genes + 14
Path 2
Term Annotations click to browse term
  biological_process 19541
    developmental process 6920
      anatomical structure development 6337
        multicellular organism development 5765
          system development 5408
            immune system development 1108
              somatic diversification of immune receptors 85
                somatic diversification of immune receptors via somatic mutation 15
                  somatic hypermutation of immunoglobulin genes + 14
paths to the root