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ONTOLOGY REPORT - ANNOTATIONS

Term:chronic inflammatory response
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Accession:GO:0002544 term browser browse the term
Definition:Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response.


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chronic inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDNF brain derived neurotrophic factor ISO RGD PMID:20223282 RGD:4891140 NCBI chr21:48,191,580...48,243,699
Ensembl chr21:48,192,670...48,204,480 		JBrowse link
G CAMP cathelicidin antimicrobial peptide involved_in ISO (PMID:9182550) UniProt PMID:9182550 NCBI chr20:40,790,823...40,792,781
Ensembl chr20:40,790,811...40,792,794 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO RGD PMID:15104336 RGD:11526143 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO RGD PMID:17164972 RGD:2307142 NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852 		JBrowse link
G GJA1 gap junction protein alpha 1 ISO RGD PMID:23165424 RGD:7207259 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:8,147,160...8,154,401
Ensembl chr33:8,073,840...8,154,561 		JBrowse link
G PTGES prostaglandin E synthase ISO RGD PMID:12707354 RGD:2300108 NCBI chr 9:54,071,472...54,082,232
Ensembl chr 9:54,071,472...54,082,232 		JBrowse link
G S100A8 S100 calcium binding protein A8 ISO RGD PMID:8343166 RGD:633930 NCBI chr 7:43,540,667...43,541,604
Ensembl chr 7:43,501,989...43,541,604 		JBrowse link
G S100A9 S100 calcium binding protein A9 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:8343166 GO_REF:0000118 RGD:633930 NCBI chr 7:43,566,993...43,570,074 JBrowse link
G SCN11A sodium voltage-gated channel alpha subunit 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,559,804...8,651,448
Ensembl chr23:8,559,952...8,651,500 		JBrowse link
G SPN sialophorin ISO RGD PMID:10486239 RGD:2303982 NCBI chr 6:17,770,303...17,774,946 JBrowse link
G THBS1 thrombospondin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:6,770,212...6,786,875
Ensembl chr30:6,769,470...6,784,915 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 ISO RGD PMID:10706728 RGD:2313132 NCBI chr 6:49,341,669...49,359,841
Ensembl chr 6:49,342,151...49,359,933 		JBrowse link
G VNN1 vanin 1 involved_in ISO (MGI:3029614|PMID:14966568) BHF-UCL PMID:14966568 MGI:3029614 NCBI chr 1:25,678,039...25,704,579
Ensembl chr 1:25,678,042...25,696,807 		JBrowse link
chronic inflammatory response to antigenic stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHCY adenosylhomocysteinase ISO RGD PMID:11123369 RGD:1598898 NCBI chr24:23,410,553...23,423,494
Ensembl chr24:23,411,140...23,419,767 		JBrowse link
G IL10 interleukin 10 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:12452830) Ensembl
MGI		 PMID:12452830 GO_REF:0000107 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057 		JBrowse link
G IL1B interleukin 1 beta ISO RGD PMID:15050649 RGD:1626679 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO RGD PMID:15050649 RGD:1626679 NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329 		JBrowse link
G TNF tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
granuloma formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEBPB CCAAT enhancer binding protein beta involved_in ISO (MGI:4360613|PMID:17911624) UniProt PMID:17911624 MGI:4360613 NCBI chr24:36,661,294...36,663,162
Ensembl chr24:36,661,616...36,662,656 		JBrowse link
G UNC13D unc-13 homolog D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17420270) Ensembl
MGI		 PMID:17420270 GO_REF:0000107 NCBI chr 9:4,753,300...4,766,751
Ensembl chr 9:4,753,166...4,766,756 		JBrowse link
negative regulation of chronic inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 acts_upstream_of_or_within ISO (PMID:25447050) MGI PMID:25447050 NCBI chr30:16,954,020...17,056,728
Ensembl chr30:16,957,215...16,988,353 		JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16769892)
(PMID:16275384)		 Ensembl
MGI		 PMID:16275384 PMID:16769892 GO_REF:0000107 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758 		JBrowse link
G IL4 interleukin 4 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:16869003 GO_REF:0000118 RGD:2317300 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:30,247,432...30,262,992
Ensembl chr 1:30,251,059...30,261,001 		JBrowse link
negative regulation of chronic inflammatory response to antigenic stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12452830) Ensembl
MGI		 PMID:12452830 GO_REF:0000107 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057 		JBrowse link
negative regulation of chronic inflammatory response to non-antigenic stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:24447880 RGD:9491776 NCBI chr23:8,937,069...8,954,738
Ensembl chr23:8,938,906...8,952,808 		JBrowse link
positive regulation of chronic inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDO1 indoleamine 2,3-dioxygenase 1 acts_upstream_of_or_within ISO (PMID:18436652) MGI PMID:18436652 NCBI chr16:25,391,759...25,407,161
Ensembl chr16:25,391,754...25,407,048 		JBrowse link
G PDE5A phosphodiesterase 5A ISO RGD PMID:19129291 RGD:2314463 NCBI chr32:38,272,573...38,407,517
Ensembl chr32:38,244,338...38,407,522 		JBrowse link
positive regulation of chronic inflammatory response to antigenic stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LTA lymphotoxin alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9834074) Ensembl
MGI		 PMID:9834074 GO_REF:0000107 NCBI chr12:1,070,608...1,073,053
Ensembl chr12:1,071,192...1,073,067 		JBrowse link
G TNF tumor necrosis factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9834074) Ensembl
MGI		 PMID:9834074 GO_REF:0000107 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
positive regulation of chronic inflammatory response to non-antigenic stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2B adenosine A2b receptor acts_upstream_of_or_within ISO (PMID:16841096) MGI PMID:16841096 NCBI chr 5:39,884,375...39,908,214 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17878
    response to stimulus 9437
      response to stress 4062
        defense response 1746
          inflammatory response 818
            chronic inflammatory response 30
              chronic inflammatory response to antigenic stimulus + 6
              chronic inflammatory response to non-antigenic stimulus + 2
              granuloma formation + 2
              negative regulation of chronic inflammatory response + 6
              positive regulation of chronic inflammatory response + 5
              regulation of chronic inflammatory response + 11
paths to the root