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Term:Factor XII activation
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Accession:GO:0002542 term browser browse the term
Definition:Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
Synonyms:exact_synonym: Hageman factor activation

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Factor XII activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F12 coagulation factor XII ISO
PMID:18725990 GO_REF:0000107 NCBI chr17:9,736,577...9,744,420
Ensembl chr17:9,736,577...9,744,420
JBrowse link
G Kng2 kininogen 2 IDA RGD PMID:6685967 RGD:11062094 NCBI chr11:81,509,185...81,516,759 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20045
    response to stimulus 10558
      protein activation cascade 14
        kinin cascade 3
          plasma kallikrein-kinin cascade 3
            Factor XII activation 2
Path 2
Term Annotations click to browse term
  biological_process 20045
    metabolic process 12101
      organic substance metabolic process 11622
        macromolecule metabolic process 10033
          protein metabolic process 6073
            cellular protein metabolic process 5398
              regulation of cellular protein metabolic process 2561
                positive regulation of cellular protein metabolic process 1512
                  positive regulation of proteolysis 378
                    positive regulation of protein processing 29
                      Factor XII activation 2
paths to the root