Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:tolerance induction
go back to main search page
Accession:GO:0002507 term browser browse the term
Definition:A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it.



show annotations for term's descendants           Sort by:
 
tolerance induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 IEP RGD PMID:16555329 RGD:5129541 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 acts_upstream_of_or_within ISO MGI:2136258 (MGI:3576946|PMID:15809349) RGD PMID:15809349 MGI:3576946 NCBI chr 8:114,176,256...114,182,155
Ensembl chr 8:114,176,974...114,178,056
JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO (MGI:3576946|PMID:15809349) RGD PMID:15809349 MGI:3576946 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:18420485), (PMID:20935202) RGD PMID:18420485 PMID:20935202 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
JBrowse link
central tolerance induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxj1 forkhead box J1 involved_in ISO (MGI:3713603|PMID:16339515) RGD PMID:16339515 MGI:3713603 NCBI chr10:101,566,299...101,570,249
Ensembl chr10:101,566,304...101,570,237
JBrowse link
central tolerance induction to self antigen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aire autoimmune regulator involved_in ISO
IBA
(PMID:26084028)
PMID:21873635
RGD PMID:26084028 PMID:21873635 RGD:13792537 NCBI chr20:10,636,058...10,651,060
Ensembl chr20:10,636,123...10,651,060
JBrowse link
natural killer cell tolerance induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO UniProtKB:O00182 (PMID:25578313) RGD PMID:25578313 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137
JBrowse link
G Lgals9 galectin 9 involved_in ISO UniProtKB:Q8TDQ0 (PMID:25578313) RGD PMID:25578313 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 involved_in ISO (PMID:9486650) RGD PMID:9486650 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-S3 RT1 class Ib, locus S3 involved_in ISO (PMID:9486650) RGD PMID:9486650 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
negative regulation of T cell anergy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule IMP RGD PMID:18424705 RGD:4892228 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
negative regulation of tolerance induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdcd1 programmed cell death 1 acts_upstream_of_or_within ISO (MGI:5543330|PMID:23636058) RGD PMID:23636058 MGI:5543330 NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937
JBrowse link
peripheral B cell tolerance induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:24453251) RGD PMID:24453251 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
peripheral T cell tolerance induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aire autoimmune regulator involved_in IBA
ISO
PMID:21873635
(MGI:5562496|PMID:23993652)
RGD PMID:23993652 PMID:21873635 MGI:5562496, RGD:13792537 NCBI chr20:10,636,058...10,651,060
Ensembl chr20:10,636,123...10,651,060
JBrowse link
positive regulation of B cell tolerance induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfbr2 transforming growth factor, beta receptor 2 acts_upstream_of_or_within ISO MGI:2183502|MGI:2386448 (MGI:3686949|PMID:16973387) RGD PMID:16973387 MGI:3686949 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
positive regulation of central B cell tolerance induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxj1 forkhead box J1 involved_in ISO (MGI:3589323|PMID:16002694) RGD PMID:16002694 MGI:3589323 NCBI chr10:101,566,299...101,570,249
Ensembl chr10:101,566,304...101,570,237
JBrowse link
positive regulation of macrophage tolerance induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irak3 interleukin-1 receptor-associated kinase 3 involved_in ISO (MGI:2183694|PMID:12150927) RGD PMID:12150927 MGI:2183694 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
JBrowse link
positive regulation of peripheral T cell tolerance induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:2654936 (MGI:3662775|PMID:16532000) RGD PMID:16532000 MGI:3662775 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
positive regulation of T cell anergy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cblb Cbl proto-oncogene B acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:2180572 (MGI:3038342|PMID:14973438)
GO_REF:0000107
RGD
Ensembl
PMID:14973438 GO_REF:0000107 MGI:3038342 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839
JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex acts_upstream_of_or_within ISO (MGI:3038342|PMID:14973438) RGD PMID:14973438 MGI:3038342 NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022
JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:1857034 (MGI:3692513|PMID:16945588) RGD PMID:16945588 MGI:3692513 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Itch itchy E3 ubiquitin protein ligase acts_upstream_of_or_within ISO MGI:1856404 (MGI:3038342|PMID:14973438) RGD PMID:14973438 MGI:3038342 NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:16493035) RGD PMID:16493035 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
JBrowse link
positive regulation of T cell tolerance induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:1857034 (MGI:3692513|PMID:16945588) RGD PMID:16945588 MGI:3692513 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 acts_upstream_of_or_within ISO (MGI:1277518|PMID:9712583) RGD PMID:9712583 MGI:1277518 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Lilrb2 leukocyte immunoglobulin like receptor B2 involved_in ISO (PMID:20008523), (PMID:20448110) RGD PMID:20008523 PMID:20448110 NCBI chr 1:65,326,832...65,334,683
Ensembl chr 1:65,326,832...65,334,679
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:20448110) RGD PMID:20448110 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 acts_upstream_of_or_within ISO MGI:2183502|MGI:2386448|MGI:2665469 (MGI:3686949|PMID:16973387) RGD PMID:16973387 MGI:3686949 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
positive regulation of tolerance induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lilrb2 leukocyte immunoglobulin like receptor B2 involved_in ISO (PMID:22802125) RGD PMID:22802125 NCBI chr 1:65,326,832...65,334,683
Ensembl chr 1:65,326,832...65,334,679
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:22802125) RGD PMID:22802125 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
positive regulation of tolerance induction to nonself antigen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-A1 RT1 class Ia, locus A1 IMP RGD PMID:16000395 RGD:2313504 NCBI chr20:4,905,309...4,914,593 JBrowse link
positive regulation of tolerance induction to self antigen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfbr2 transforming growth factor, beta receptor 2 acts_upstream_of_or_within ISO MGI:2183502|MGI:2386448 (MGI:3686949|PMID:16973387) RGD PMID:16973387 MGI:3686949 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
positive regulation of tolerance induction to tumor cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule involved_in ISO (PMID:28813410), (PMID:28813417) RGD PMID:28813410 PMID:28813417 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
regulation of T cell anergy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 involved_in ISO (MGI:3710039|PMID:17377532) RGD PMID:17377532 MGI:3710039 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:5013552|PMID:21498666)
Ensembl
RGD
PMID:21498666 GO_REF:0000107 MGI:5013552 NCBI chr13:22,308,532...22,530,978
Ensembl chr13:22,308,548...22,530,977
JBrowse link
G RT1-A1 RT1 class Ia, locus A1 involved_in ISO (PMID:20008523) RGD PMID:20008523 NCBI chr20:4,905,309...4,914,593 JBrowse link
G Runx1 RUNX family transcription factor 1 involved_in ISO (MGI:3710039|PMID:17377532) RGD PMID:17377532 MGI:3710039 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
JBrowse link
regulation of T cell tolerance induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2ra interleukin 2 receptor subunit alpha involved_in ISO (PMID:23416241) RGD PMID:23416241 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
JBrowse link
regulation of tolerance induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:18631454)
(MGI:3803065|PMID:18631454)
RGD PMID:18631454 MGI:3803065 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 acts_upstream_of_or_within ISO MGI:3530008 (MGI:3529633|PMID:15670816) RGD PMID:15670816 MGI:3529633 NCBI chr 3:44,680,229...44,720,172
Ensembl chr 3:44,681,632...44,720,168
JBrowse link
regulation of tolerance induction dependent upon immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (MGI:2679123|PMID:14556006) RGD PMID:14556006 MGI:2679123 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137
JBrowse link
T cell anergy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cblb Cbl proto-oncogene B acts_upstream_of
involved_in
ISO
IEA
MGI:2180572 (MGI:3038342|PMID:14973438)
GO_REF:0000107
RGD
Ensembl
PMID:14973438 GO_REF:0000107 MGI:3038342 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839
JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex acts_upstream_of ISO (MGI:3038342|PMID:14973438) RGD PMID:14973438 MGI:3038342 NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022
JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of ISO MGI:1857034 (MGI:3692513|PMID:16945588) RGD PMID:16945588 MGI:3692513 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Itch itchy E3 ubiquitin protein ligase acts_upstream_of ISO MGI:1856404 (MGI:3038342|PMID:14973438) RGD PMID:14973438 MGI:3038342 NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543
JBrowse link
T cell tolerance induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of ISO MGI:1857034 (MGI:3692513|PMID:16945588) RGD PMID:16945588 MGI:3692513 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Icos inducible T-cell co-stimulator involved_in IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:16220623 PMID:21873635 RGD:1624271, RGD:13792537 NCBI chr 9:62,368,075...62,406,900
Ensembl chr 9:62,383,832...62,405,672
JBrowse link
G RT1-A1 RT1 class Ia, locus A1 IMP RGD PMID:16000395 RGD:2313504 NCBI chr20:4,905,309...4,914,593 JBrowse link
tolerance induction to lipopolysaccharide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 involved_in ISO (PMID:23609450)
(MGI:5490396|PMID:23609450)
RGD PMID:23609450 MGI:5490396 NCBI chr15:79,871,819...79,881,101
Ensembl chr15:79,871,827...79,880,529
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO (PMID:21220427) RGD PMID:21220427 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
tolerance induction to nonself antigen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3ar1 complement C3a receptor 1 IMP RGD PMID:12514742 RGD:5129547 NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701
JBrowse link
tolerance induction to self antigen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blk BLK proto-oncogene, Src family tyrosine kinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031
JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:2654936 (MGI:3574163|PMID:15780990) RGD PMID:15780990 MGI:3574163 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:894972|PMID:9252121)
PMID:21873635
UniProt
RGD
PMID:9252121 PMID:21873635 GO_REF:0000024 MGI:894972, RGD:13792537 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within ISO MGI:3719583 (MGI:3718815|PMID:17481928) RGD PMID:17481928 MGI:3718815 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Xkr8 XK related 8 acts_upstream_of_or_within ISO MGI:5528895 (MGI:6120635|PMID:29440417) RGD PMID:29440417 MGI:6120635 NCBI chr 5:144,938,061...144,945,195
Ensembl chr 5:144,938,064...144,945,195
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20099
    immune system process 2563
      tolerance induction 35
        B cell tolerance induction + 3
        T cell tolerance induction + 16
        central tolerance induction + 2
        lymphocyte anergy + 9
        macrophage tolerance induction + 1
        natural killer cell tolerance induction + 4
        negative regulation of tolerance induction + 2
        positive regulation of tolerance induction + 13
        regulation of tolerance induction + 21
        tolerance induction dependent upon immune response + 7
        tolerance induction to lipopolysaccharide 2
        tolerance induction to self antigen + 7
Path 2
Term Annotations click to browse term
  biological_process 20099
    developmental process 7010
      anatomical structure development 6447
        multicellular organism development 5225
          system development 4486
            immune system development 233
              tolerance induction 35
                B cell tolerance induction + 3
                T cell tolerance induction + 16
                central tolerance induction + 2
                lymphocyte anergy + 9
                macrophage tolerance induction + 1
                natural killer cell tolerance induction + 4
                negative regulation of tolerance induction + 2
                positive regulation of tolerance induction + 13
                regulation of tolerance induction + 21
                tolerance induction dependent upon immune response + 7
                tolerance induction to lipopolysaccharide 2
                tolerance induction to self antigen + 7
paths to the root