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ONTOLOGY REPORT - ANNOTATIONS

Term:germinal center formation
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Accession:GO:0002467 term browser browse the term
Definition:The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.


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germinal center formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of IMP (PMID:14607964) MGI PMID:14607964 NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159 		JBrowse link
G Adam17 a disintegrin and metallopeptidase domain 17 involved_in IMP (MGI:3828349|PMID:17371977) BHF-UCL PMID:17371977 MGI:3828349 NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633 		JBrowse link
G Bcl3 B cell leukemia/lymphoma 3 acts_upstream_of_or_within IMP (PMID:9009202)
(PMID:10586052), (PMID:9133427)		 MGI PMID:9009202 PMID:9133427 PMID:10586052 NCBI chr 7:19,542,387...19,556,691
Ensembl chr 7:19,542,387...19,556,695 		JBrowse link
G Bcl6 B cell leukemia/lymphoma 6 acts_upstream_of_or_within IMP (PMID:12354385), (PMID:9236196)
(PMID:9171827)
(PMID:9110977)		 MGI PMID:9110977 PMID:9171827 PMID:9236196 PMID:12354385 NCBI chr16:23,780,058...23,807,602
Ensembl chr16:23,783,802...23,807,602 		JBrowse link
G Klhl6 kelch-like 6 involved_in IMP (MGI:3603885|PMID:16166635) UniProt PMID:16166635 MGI:3603885 NCBI chr16:19,765,242...19,801,766
Ensembl chr16:19,765,246...19,801,787 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in IMP (MGI:3829850|PMID:18955699) UniProt PMID:18955699 MGI:3829850 NCBI chr13:83,652,136...83,815,197
Ensembl chr13:83,652,153...83,815,199 		JBrowse link
G Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 acts_upstream_of_or_within IMP (PMID:10586052) MGI PMID:10586052 NCBI chr19:46,285,478...46,300,839
Ensembl chr19:46,292,759...46,300,824 		JBrowse link
G Tnfrsf13c tumor necrosis factor receptor superfamily, member 13c acts_upstream_of IMP (PMID:14557413) MGI PMID:14557413 NCBI chr15:82,105,943...82,108,581
Ensembl chr15:82,105,944...82,108,570 		JBrowse link
G Tnfsf13 tumor necrosis factor (ligand) superfamily, member 13 acts_upstream_of IMP (PMID:14988498) MGI PMID:14988498 NCBI chr11:69,573,403...69,576,380
Ensembl chr11:69,573,672...69,576,610 		JBrowse link
G Tnfsf13b tumor necrosis factor (ligand) superfamily, member 13b acts_upstream_of IMP (PMID:14557413) MGI PMID:14557413 NCBI chr 8:10,056,637...10,086,000
Ensembl chr 8:10,056,467...10,089,072 		JBrowse link
G Unc13d unc-13 homolog D acts_upstream_of_or_within IMP (PMID:17420270) MGI PMID:17420270 NCBI chr11:115,952,921...115,969,321
Ensembl chr11:115,952,921...115,968,787 		JBrowse link
negative regulation of germinal center formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxj1 forkhead box J1 involved_in IMP (MGI:3589323|PMID:16002694) BHF-UCL PMID:16002694 MGI:3589323 NCBI chr11:116,221,530...116,226,331
Ensembl chr11:116,221,530...116,226,225 		JBrowse link
G Rc3h1 RING CCCH (C3H) domains 1 involved_in IMP (MGI:5284769|PMID:18172933) BHF-UCL PMID:18172933 MGI:5284769 NCBI chr 1:160,733,981...160,802,546
Ensembl chr 1:160,733,988...160,802,548 		JBrowse link
positive regulation of germinal center formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within IMP (PMID:14607964) MGI PMID:14607964 NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159 		JBrowse link
G H2-DMa histocompatibility 2, class II, locus DMa involved_in IMP (MGI:2153656|PMID:11714799) BHF-UCL PMID:11714799 MGI:2153656 NCBI chr17:34,338,667...34,358,075
Ensembl chr17:34,338,515...34,358,075 		JBrowse link
G Tnfrsf13c tumor necrosis factor receptor superfamily, member 13c acts_upstream_of_or_within IMP (PMID:14557413) MGI PMID:14557413 NCBI chr15:82,105,943...82,108,581
Ensembl chr15:82,105,944...82,108,570 		JBrowse link
G Tnfsf13 tumor necrosis factor (ligand) superfamily, member 13 acts_upstream_of_or_within IMP (PMID:14988498) MGI PMID:14988498 NCBI chr11:69,573,403...69,576,380
Ensembl chr11:69,573,672...69,576,610 		JBrowse link
G Tnfsf13b tumor necrosis factor (ligand) superfamily, member 13b acts_upstream_of_or_within IMP (PMID:14557413) MGI PMID:14557413 NCBI chr 8:10,056,637...10,086,000
Ensembl chr 8:10,056,467...10,089,072 		JBrowse link
regulation of germinal center formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mef2c myocyte enhancer factor 2C involved_in IMP (MGI:3795835|PMID:18438409) UniProt PMID:18438409 MGI:3795835 NCBI chr13:83,652,136...83,815,197
Ensembl chr13:83,652,153...83,815,199 		JBrowse link
G Pkn1 protein kinase N1 acts_upstream_of_or_within IMP (PMID:23223530) MGI PMID:23223530 NCBI chr 8:84,393,162...84,425,819
Ensembl chr 8:84,393,165...84,425,808 		JBrowse link
G Rc3h1 RING CCCH (C3H) domains 1 involved_in IMP (MGI:3580753|PMID:15917799), (MGI:3838060|PMID:19217324) BHF-UCL PMID:15917799 PMID:19217324 MGI:3580753 MGI:3838060 NCBI chr 1:160,733,981...160,802,546
Ensembl chr 1:160,733,988...160,802,548 		JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 involved_in IMP (MGI:4946158|PMID:21088135) BHF-UCL PMID:21088135 MGI:4946158 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    developmental process 7369
      anatomical structure formation involved in morphogenesis 1422
        germinal center formation 16
          negative regulation of germinal center formation 2
          positive regulation of germinal center formation 5
          regulation of germinal center formation + 10
Path 2
Term Annotations click to browse term
  biological_process 28573
    immune system process 3142
      immune response 2180
        adaptive immune response 643
          adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 496
            germinal center formation 16
              negative regulation of germinal center formation 2
              positive regulation of germinal center formation 5
              regulation of germinal center formation + 10
paths to the root