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ONTOLOGY REPORT - ANNOTATIONS

Term:mast cell mediated immunity
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Accession:GO:0002448 term browser browse the term
Definition:Any process involved in the carrying out of an immune response by a mast cell.


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mast cell mediated immunity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NDST2 N-deacetylase and N-sulfotransferase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10466726)
(PMID:10466727)		 Ensembl
MGI		 PMID:10466726 PMID:10466727 GO_REF:0000107 NCBI chr 4:24,235,051...24,243,411
Ensembl chr 4:24,231,492...24,243,455 		JBrowse link
G SERPINB9 serpin family B member 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr35:3,186,209...3,200,894
Ensembl chr35:3,190,543...3,199,690 		JBrowse link
G SPON2 spondin 2 acts_upstream_of_or_within ISO (PMID:14691481) MGI PMID:14691481 NCBI chr 3:91,411,245...91,421,245 JBrowse link
histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA3 adenosine A3 receptor acts_upstream_of_or_within ISO (PMID:12817016) MGI PMID:12817016 NCBI chr17:63,895,408...63,898,666
Ensembl chr17:63,895,408...63,898,666 		JBrowse link
G BTK Bruton tyrosine kinase ISO RGD PMID:12220673 RGD:1600535 NCBI chr  X:75,270,952...75,302,663
Ensembl chr  X:75,270,979...75,302,562 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase ISO RGD PMID:16177098 RGD:1578516 NCBI chr29:7,367,617...7,448,862
Ensembl chr29:7,332,684...7,448,507 		JBrowse link
G RAB44 RAB44, member RAS oncogene family involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:32238914) Ensembl
MGI		 PMID:32238914 GO_REF:0000107 NCBI chr12:5,769,056...5,804,963
Ensembl chr12:5,770,882...5,804,949 		JBrowse link
G SLC18A2 solute carrier family 18 member A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:27,731,709...27,809,341
Ensembl chr28:27,731,004...27,767,993 		JBrowse link
G SNAP23 synaptosome associated protein 23 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:9,453,931...9,493,506
Ensembl chr30:9,456,084...9,492,329 		JBrowse link
G YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta ISO RGD PMID:12499633 RGD:1625716 NCBI chr13:2,729,404...2,764,422 JBrowse link
mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2B adenosine A2b receptor acts_upstream_of ISO (PMID:11454903) MGI PMID:11454903 NCBI chr 5:39,884,375...39,908,214 JBrowse link
G ADORA3 adenosine A3 receptor acts_upstream_of ISO (PMID:12817016) MGI PMID:12817016 NCBI chr17:63,895,408...63,898,666
Ensembl chr17:63,895,408...63,898,666 		JBrowse link
G C10orf99 chromosome 10 open reading frame 99 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 4:32,424,531...32,431,812 JBrowse link
G CBL Cbl proto-oncogene ISO RGD PMID:18243321 RGD:11576314 NCBI chr 5:14,600,409...14,676,974
Ensembl chr 5:14,607,013...14,676,956 		JBrowse link
G CD300A CD300a molecule acts_upstream_of ISO (PMID:12874256) MGI PMID:12874256 NCBI chr 9:5,952,428...5,976,328 JBrowse link
G CHGA chromogranin A involved_in ISO (PMID:21214543) UniProt PMID:21214543 NCBI chr 8:1,970,966...1,973,511 JBrowse link
G CLNK cytokine dependent hematopoietic cell linker involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:68,929,239...69,083,777
Ensembl chr 3:68,881,358...69,080,263 		JBrowse link
G FCER1A Fc epsilon receptor Ia involved_in
acts_upstream_of		 ISO (PMID:8551243)
(PMID:9000133)		 UniProt
MGI		 PMID:8551243 PMID:9000133 NCBI chr38:22,683,478...22,688,842
Ensembl chr38:22,683,477...22,690,763 		JBrowse link
G FCER1G Fc epsilon receptor Ig acts_upstream_of ISO (PMID:14764707) MGI PMID:14764707 NCBI chr38:21,267,841...21,271,036
Ensembl chr38:21,268,001...21,270,940 		JBrowse link
G GPR15LG G protein-coupled receptor 15 ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:32,426,663...32,432,103 JBrowse link
G GRP gastrin releasing peptide involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000043 GO_REF:0000107 NCBI chr 1:16,974,818...16,987,578
Ensembl chr 1:16,975,113...16,987,531 		JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr13:47,108,442...47,190,935
Ensembl chr13:47,108,504...47,190,029 		JBrowse link
G MILR1 mast cell immunoglobulin like receptor 1 involved_in ISO (MGI:4461821|PMID:20526344) UniProt PMID:20526344 MGI:4461821 NCBI chr 9:12,251,085...12,266,608
Ensembl chr 9:12,251,186...12,266,605 		JBrowse link
G MRGPRX MAS related GPR family member X involved_in ISO (PMID:22069323) UniProt PMID:22069323 NCBI chr21:41,195,255...41,235,734 JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 involved_in ISO (MGI:5586645|PMID:24586680) UniProt PMID:24586680 MGI:5586645 NCBI chr11:56,806,506...56,846,997
Ensembl chr11:56,812,804...56,847,689 		JBrowse link
G PLA2G3 phospholipase A2 group III involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23624557) Ensembl
MGI		 PMID:23624557 GO_REF:0000107 NCBI chr26:24,127,074...24,132,508
Ensembl chr26:24,128,005...24,132,508 		JBrowse link
G PTGDS prostaglandin D2 synthase involved_in IEA UniProt GO_REF:0000043 NCBI chr 9:48,647,334...48,650,608
Ensembl chr 9:48,646,255...48,669,814 		JBrowse link
G RAB44 RAB44, member RAS oncogene family involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:32238914) Ensembl
MGI		 PMID:32238914 GO_REF:0000107 NCBI chr12:5,769,056...5,804,963
Ensembl chr12:5,770,882...5,804,949 		JBrowse link
G RABGEF1 RAB guanine nucleotide exchange factor 1 acts_upstream_of ISO (PMID:15235600) MGI PMID:15235600 NCBI chr 6:1,064,694...1,159,906
Ensembl chr 6:1,064,655...1,179,547 		JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17190838) Ensembl
MGI		 PMID:17190838 GO_REF:0000107 NCBI chr30:5,840,901...5,914,804
Ensembl chr30:5,841,738...5,914,810 		JBrowse link
G SCN11A sodium voltage-gated channel alpha subunit 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,559,804...8,651,448
Ensembl chr23:8,559,952...8,651,500 		JBrowse link
G SYK spleen associated tyrosine kinase involved_in
acts_upstream_of		 IEA
ISO		 (PMID:9000133) Ensembl
MGI		 PMID:9000133 GO_REF:0000107 NCBI chr 1:95,903,501...95,955,577
Ensembl chr 1:95,903,566...95,955,583 		JBrowse link
negative regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD300A CD300a molecule involved_in
acts_upstream_of_or_within		 ISO (PMID:16339535)
(PMID:12874256)		 UniProt
MGI		 PMID:12874256 PMID:16339535 NCBI chr 9:5,952,428...5,976,328 JBrowse link
G CD84 CD84 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:21,702,788...21,727,373
Ensembl chr38:21,702,494...21,759,668 		JBrowse link
G FOXF1 forkhead box F1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18421012) Ensembl
MGI		 PMID:18421012 GO_REF:0000107 NCBI chr 5:66,343,776...66,347,785
Ensembl chr 5:66,345,150...66,347,935 		JBrowse link
G HMOX1 heme oxygenase 1 ISO RGD PMID:17234154 RGD:1601626 NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773 		JBrowse link
G IL13RA2 interleukin 13 receptor subunit alpha 2 acts_upstream_of_or_within ISO (PMID:15944273) MGI PMID:15944273 NCBI chr  X:87,747,373...87,776,797
Ensembl chr  X:87,747,373...87,776,798 		JBrowse link
G LGALS9 galectin 9 involved_in ISO (PMID:24465902) UniProt PMID:24465902 NCBI chr 9:42,154,613...42,170,423
Ensembl chr 9:42,154,702...42,170,391 		JBrowse link
G RABGEF1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO (PMID:15235600) MGI PMID:15235600 NCBI chr 6:1,064,694...1,159,906
Ensembl chr 6:1,064,655...1,179,547 		JBrowse link
positive regulation of histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPPA natriuretic peptide A involved_in ISO PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
G PLA2G3 phospholipase A2 group III involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:24,127,074...24,132,508
Ensembl chr26:24,128,005...24,132,508 		JBrowse link
G SNX4 sorting nexin 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:28,413,586...28,468,546
Ensembl chr33:28,419,128...28,469,488 		JBrowse link
G VAMP7 vesicle associated membrane protein 7 involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chr  X:123,717,524...123,783,781
Ensembl chr  X:123,717,446...123,783,014 		JBrowse link
G VAMP8 vesicle associated membrane protein 8 involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chr17:39,497,628...39,501,734
Ensembl chr17:39,497,785...39,501,739 		JBrowse link
positive regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2B adenosine A2b receptor acts_upstream_of_or_within ISO (PMID:11454903) MGI PMID:11454903 NCBI chr 5:39,884,375...39,908,214 JBrowse link
G ADORA3 adenosine A3 receptor acts_upstream_of_or_within ISO (PMID:12817016) MGI PMID:12817016 NCBI chr17:63,895,408...63,898,666
Ensembl chr17:63,895,408...63,898,666 		JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 ISO RGD PMID:18209484 RGD:5130941 NCBI chr 9:9,708,696...9,763,281
Ensembl chr 9:9,714,204...9,763,402 		JBrowse link
G FCER1A Fc epsilon receptor Ia acts_upstream_of_or_within ISO (PMID:9000133) MGI PMID:9000133 NCBI chr38:22,683,478...22,688,842
Ensembl chr38:22,683,477...22,690,763 		JBrowse link
G FCER1G Fc epsilon receptor Ig acts_upstream_of_or_within ISO (PMID:14764707) MGI PMID:14764707 NCBI chr38:21,267,841...21,271,036
Ensembl chr38:21,268,001...21,270,940 		JBrowse link
G FGR FGR proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:72,678,858...72,692,417
Ensembl chr 2:72,680,675...72,690,251 		JBrowse link
G GATA1 GATA binding protein 1 ISO RGD PMID:22390417 RGD:9587812 NCBI chr  X:41,991,321...41,998,319
Ensembl chr  X:41,971,582...41,998,303 		JBrowse link
G GATA2 GATA binding protein 2 ISO RGD PMID:22390417 RGD:9587812 NCBI chr20:2,472,251...2,488,380
Ensembl chr20:2,473,912...2,480,991 		JBrowse link
G IL13 interleukin 13 acts_upstream_of_or_within ISO (PMID:15944273) MGI PMID:15944273 NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388 		JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15944273) TreeGrafter
MGI		 PMID:15944273 GO_REF:0000118 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of_or_within ISO (PMID:15944273) MGI PMID:15944273 NCBI chr 6:19,254,183...19,280,973
Ensembl chr 6:19,254,487...19,389,291 		JBrowse link
G MS4A2 membrane spanning 4-domains A2 ISO RGD PMID:16177098 RGD:1578516 NCBI chr21:50,439,133...50,456,785
Ensembl chr21:50,450,024...50,456,785 		JBrowse link
G NARS2 asparaginyl-tRNA synthetase 2, mitochondrial involved_in ISO (MGI:2137187|PMID:11449275) UniProt PMID:11449275 MGI:2137187 NCBI chr21:20,277,707...20,413,624
Ensembl chr21:20,277,507...20,606,736 		JBrowse link
G NPPC natriuretic peptide C involved_in ISO PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chr25:43,714,545...43,718,969
Ensembl chr25:43,717,939...43,718,996 		JBrowse link
G PLD2 phospholipase D2 ISO RGD PMID:16861349 RGD:2299903 NCBI chr 5:31,755,881...31,767,131
Ensembl chr 5:31,756,433...31,767,066 		JBrowse link
G SPHK2 sphingosine kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:107,681,425...107,689,790
Ensembl chr 1:107,680,599...107,689,707 		JBrowse link
G STXBP1 syntaxin binding protein 1 ISO RGD PMID:23487749 RGD:12904029 NCBI chr 9:55,690,939...55,768,008
Ensembl chr 9:55,678,264...55,727,680 		JBrowse link
G STXBP2 syntaxin binding protein 2 ISO RGD PMID:23487749 RGD:12904029 NCBI chr20:52,413,174...52,421,525
Ensembl chr20:52,413,191...52,421,517 		JBrowse link
G SYK spleen associated tyrosine kinase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9000133) RGD
MGI
TreeGrafter
Ensembl		 PMID:9000133 PMID:16861349 GO_REF:0000107 GO_REF:0000118 RGD:2299903 NCBI chr 1:95,903,501...95,955,577
Ensembl chr 1:95,903,566...95,955,583 		JBrowse link
regulation of histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNX6 sorting nexin 6 NOT|involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chr 8:13,460,676...13,520,282
Ensembl chr 8:13,460,947...13,520,423 		JBrowse link
G VAMP2 vesicle associated membrane protein 2 NOT|involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chr 5:32,975,372...32,977,967 JBrowse link
G VAMP3 vesicle associated membrane protein 3 NOT|involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chr 5:61,430,711...61,440,626
Ensembl chr 5:61,430,740...61,439,063 		JBrowse link
regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADGRE2 adhesion G protein-coupled receptor E2 involved_in ISO (PMID:26841242) UniProt PMID:26841242 NCBI chr20:47,929,357...47,968,525
Ensembl chr20:47,873,897...47,968,525 		JBrowse link
G FER FER tyrosine kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:2,863,804...3,295,999
Ensembl chr 3:2,867,726...3,295,999 		JBrowse link
G FERRY3 FERRY endosomal RAB5 effector complex subunit 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr27:40,341,944...40,388,424
Ensembl chr27:40,343,672...40,388,031 		JBrowse link
G FES FES proto-oncogene, tyrosine kinase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:53,346,975...53,356,547
Ensembl chr 3:53,347,012...53,356,516 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr29:7,367,617...7,448,862
Ensembl chr29:7,332,684...7,448,507 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:38,426,464...38,506,520
Ensembl chr 6:38,431,600...38,499,295 		JBrowse link
G RAC2 Rac family small GTPase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:27,295,597...27,311,864
Ensembl chr10:27,295,640...27,311,397 		JBrowse link
G STXBP2 syntaxin binding protein 2 ISO RGD PMID:12482918 RGD:2312429 NCBI chr20:52,413,174...52,421,525
Ensembl chr20:52,413,191...52,421,517 		JBrowse link
G UNC13D unc-13 homolog D involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:4,753,300...4,766,751
Ensembl chr 9:4,753,166...4,766,756 		JBrowse link
serotonin secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD300A CD300a molecule acts_upstream_of_or_within ISO (PMID:12874256) MGI PMID:12874256 NCBI chr 9:5,952,428...5,976,328 JBrowse link
G SLC18A2 solute carrier family 18 member A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:27,731,709...27,809,341
Ensembl chr28:27,731,004...27,767,993 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17878
    immune system process 2491
      immune effector process 650
        leukocyte mediated immunity 400
          myeloid leukocyte mediated immunity 123
            mast cell mediated immunity 63
              mast cell degranulation + 60
              type I hypersensitivity mediated by mast cells 0
paths to the root