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ONTOLOGY REPORT - ANNOTATIONS


Term:type II hypersensitivity
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Accession:GO:0002445 term browser browse the term
Definition:An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors.
Synonyms:xref: Wikipedia:Type_II_hypersensitivity


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antibody-dependent cellular cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcgr1a Fc fragment of IgG receptor Ia ISO MGI:2664927|MGI:2679238 (MGI:2664488|PMID:11911824), (MGI:2679189|PMID:11911823) RGD PMID:11911823 PMID:11911824 MGI:2664488 MGI:2679189 NCBI chr 2:198,430,536...198,439,453
Ensembl chr 2:198,430,530...198,458,041
JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa ISO MGI:1861924 (MGI:2683749|PMID:9743367), (MGI:82508|PMID:8769481) RGD PMID:8769481 PMID:9743367 MGI:2683749 MGI:82508 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036
JBrowse link
G Ighg1 immunoglobulin heavy constant gamma 1 ISO (MGI:2683749|PMID:9743367) RGD PMID:9743367 MGI:2683749 NCBI chr 6:139,140,572...139,784,388
Ensembl chr 6:139,140,679...139,142,218
JBrowse link
positive regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-S3 RT1 class Ib, locus S3 involved_in ISO (PMID:30134159) RGD PMID:30134159 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
positive regulation of type IIa hypersensitivity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA
ISO
GO_REF:0000107
MGI:1861799 (MGI:2177393|PMID:11901193)
Ensembl
RGD
PMID:11901193 GO_REF:0000107 MGI:2177393 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig ISO MGI:1857165|MGI:2384004 (MGI:2177393|PMID:11901193), (MGI:2383973|PMID:8976192), (MGI:2664488|PMID:11911824) RGD PMID:8976192 PMID:11901193 PMID:11911824 MGI:2177393 MGI:2383973 MGI:2664488 NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326
JBrowse link
G Fcgr1a Fc fragment of IgG receptor Ia ISO MGI:2664927 (MGI:2664488|PMID:11911824) RGD PMID:11911824 MGI:2664488 NCBI chr 2:198,430,536...198,439,453
Ensembl chr 2:198,430,530...198,458,041
JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa ISO MGI:1861924 (MGI:2664488|PMID:11911824), (MGI:2683747|PMID:9834201) RGD PMID:9834201 PMID:11911824 MGI:2664488 MGI:2683747 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036
JBrowse link
G Ighg1 immunoglobulin heavy constant gamma 1 ISO (MGI:2177393|PMID:11901193), (MGI:2683747|PMID:9834201) RGD PMID:9834201 PMID:11901193 MGI:2177393 MGI:2683747 NCBI chr 6:139,140,572...139,784,388
Ensembl chr 6:139,140,679...139,142,218
JBrowse link
regulation of antibody-dependent cellular cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcgr2a Fc fragment of IgG receptor IIa IMP RGD PMID:16482158 RGD:2293335 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20078
    immune system process 2843
      immune effector process 902
        leukocyte mediated immunity 513
          myeloid leukocyte mediated immunity 125
            type II hypersensitivity 6
              negative regulation of type II hypersensitivity + 0
              positive regulation of type II hypersensitivity + 6
              regulation of type II hypersensitivity + 6
              type IIa hypersensitivity + 6
              type IIb hypersensitivity + 0
Path 2
Term Annotations click to browse term
  biological_process 20078
    response to stimulus 10589
      response to stress 4054
        defense response 1677
          inflammatory response 732
            inflammatory response to antigenic stimulus 85
              acute inflammatory response to antigenic stimulus 36
                hypersensitivity 17
                  type II hypersensitivity 6
                    negative regulation of type II hypersensitivity + 0
                    positive regulation of type II hypersensitivity + 6
                    regulation of type II hypersensitivity + 6
                    type IIa hypersensitivity + 6
                    type IIb hypersensitivity + 0
paths to the root