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ONTOLOGY REPORT - ANNOTATIONS


Term:Fc receptor mediated stimulatory signaling pathway
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Accession:GO:0002431 term browser browse the term
Definition:A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.
Synonyms:exact_synonym: Fc receptor mediated stimulatory signalling pathway


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Fc receptor mediated stimulatory signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcer1g Fc fragment of IgE receptor Ig acts_upstream_of_or_within ISO (MGI:3029067|PMID:14764707) MGI PMID:14764707 MGI:3029067 NCBI chrNW_004936903:514,278...517,975 JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (MGI:3703139|PMID:16272347) UniProt PMID:16272347 MGI:3703139 NCBI chrNW_004936496:2,578,598...2,698,165 JBrowse link
Fc-gamma receptor signaling pathway involved in phagocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcgr2b Fc fragment of IgG receptor IIb involved_in ISO (PMID:2142460) ARUK-UCL PMID:2142460 NCBI chrNW_004937131:80,014...96,114 JBrowse link
G Myo1g myosin IG involved_in ISO (MGI:5586792|PMID:23038771) UniProt PMID:23038771 MGI:5586792 NCBI chrNW_004936478:19,788,032...19,802,546 JBrowse link
negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (MGI:6271154|PMID:25568335) UniProt PMID:25568335 MGI:6271154 NCBI chrNW_004936473:7,580,495...7,647,471 JBrowse link
G LOC101967799 leukocyte surface antigen CD47 involved_in ISO PMID:21401967 ARUK-UCL PMID:21401967 RGD:13792533 NCBI chrNW_004936645:1,363,406...1,408,624 JBrowse link
positive regulation of Fc receptor mediated stimulatory signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lyn LYN proto-oncogene, Src family tyrosine kinase ISO RGD PMID:16177098 RGD:1578516 NCBI chrNW_004936496:2,578,598...2,698,165 JBrowse link
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in ISO (MGI:6271154|PMID:25568335) UniProt PMID:25568335 MGI:6271154 NCBI chrNW_004936492:9,477,483...9,526,692 JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C involved_in ISO (MGI:3774343|PMID:18249142) ARUK-UCL PMID:18249142 MGI:3774343 NCBI chrNW_004936567:5,266,653...5,378,464 JBrowse link
G Ptprj protein tyrosine phosphatase receptor type J involved_in ISO (MGI:3774343|PMID:18249142) ARUK-UCL PMID:18249142 MGI:3774343 NCBI chrNW_004936562:1,161,764...1,234,800 JBrowse link
G Rap1a RAP1A, member of RAS oncogene family ISO RGD PMID:18832707 RGD:9835043 NCBI chrNW_004936690:275,840...363,752 JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO RGD PMID:18832707 RGD:9835043 NCBI chrNW_004936487:18,305,537...18,411,170 JBrowse link
positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr4a3 nuclear receptor subfamily 4 group A member 3 involved_in ISO (MGI:5586645|PMID:24586680) UniProt PMID:24586680 MGI:5586645 NCBI chrNW_004936524:8,252,321...8,290,747 JBrowse link
regulation of Fc receptor mediated stimulatory signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csk C-terminal Src kinase ISO RGD PMID:9325302 RGD:2303720 NCBI chrNW_004936471:33,757,778...33,777,871 JBrowse link
G Plscr1 phospholipid scramblase 1 involved_in ISO PMID:18579528 UniProt PMID:18579528 RGD:2303650 NCBI chrNW_004936519:8,759,702...8,790,823 JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO (MGI:3834538|PMID:17341663)
(MGI:3050742|PMID:15235600)
MGI PMID:15235600 PMID:17341663 MGI:3050742 MGI:3834538 NCBI chrNW_004936543:7,405,070...7,447,940 JBrowse link
regulation of Fc-gamma receptor signaling pathway involved in phagocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcgr2a Fc fragment of IgG receptor IIa ISO RGD PMID:16482158 PMID:22184119 RGD:11041001 RGD:2293335 NCBI chrNW_004937131:15,542...22,099 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12173
    immune system process 1972
      activation of immune response 217
        immune response-activating signal transduction 161
          immune response-activating cell surface receptor signaling pathway 160
            Fc receptor mediated stimulatory signaling pathway 16
              Fc-gamma receptor signaling pathway involved in phagocytosis + 10
              positive regulation of Fc receptor mediated stimulatory signaling pathway + 6
              positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway 1
              regulation of Fc receptor mediated stimulatory signaling pathway + 12
Path 2
Term Annotations click to browse term
  biological_process 12173
    biological regulation 8886
      regulation of biological process 8417
        positive regulation of biological process 5487
          positive regulation of immune system process 729
            positive regulation of immune response 409
              activation of immune response 217
                immune response-activating signal transduction 161
                  immune response-activating cell surface receptor signaling pathway 160
                    Fc receptor mediated stimulatory signaling pathway 16
                      Fc-gamma receptor signaling pathway involved in phagocytosis + 10
                      positive regulation of Fc receptor mediated stimulatory signaling pathway + 6
                      positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway 1
                      regulation of Fc receptor mediated stimulatory signaling pathway + 12
paths to the root