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ONTOLOGY REPORT - ANNOTATIONS


Term:Fc receptor mediated stimulatory signaling pathway
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Accession:GO:0002431 term browser browse the term
Definition:A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.
Synonyms:exact_synonym: Fc receptor mediated stimulatory signalling pathway



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Fc receptor mediated stimulatory signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blk BLK proto-oncogene, Src family tyrosine kinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3029067|PMID:14764707)
RGD PMID:14764707 PMID:21873635 MGI:3029067, RGD:13792537 NCBI chr13:83,649,447...83,654,215
Ensembl chr13:83,649,449...83,671,443
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in IBA
ISO
ISS
PMID:21873635
(MGI:3703139|PMID:16272347)
GO_REF:0000024
RGD
UniProt
PMID:16272347 PMID:21873635 GO_REF:0000024 MGI:3703139, RGD:13792537 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
Fc-gamma receptor signaling pathway involved in phagocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcgr2b Fc fragment of IgG receptor IIb involved_in ISO (PMID:2142460) RGD PMID:2142460 NCBI chr13:83,191,253...83,207,776
Ensembl chr13:83,193,163...83,207,778
JBrowse link
G Myo1g myosin IG involved_in ISO (MGI:5586792|PMID:23038771) RGD PMID:23038771 MGI:5586792 NCBI chr14:81,386,701...81,401,843
Ensembl chr14:81,386,701...81,401,843
JBrowse link
negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (MGI:6271154|PMID:25568335) RGD PMID:25568335 MGI:6271154 NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692
JBrowse link
G Cd47 Cd47 molecule involved_in IMP PMID:21401967 ARUK-UCL PMID:21401967 RGD:13792533 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
JBrowse link
positive regulation of Fc receptor mediated stimulatory signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07032888.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Cd226 CD226 molecule involved_in ISO
IBA
(PMID:16831868)
PMID:21873635
RGD PMID:16831868 PMID:21873635 RGD:13792537 NCBI chr18:82,449,924...82,545,107
Ensembl chr18:82,450,568...82,543,051
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase IMP RGD PMID:16177098 RGD:1578516 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in ISO (MGI:6271154|PMID:25568335) RGD PMID:25568335 MGI:6271154 NCBI chr 7:20,135,248...20,184,757
Ensembl chr 7:20,135,375...20,184,754
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C involved_in ISO UniProtKB:Q64455 (MGI:3774343|PMID:18249142) RGD PMID:18249142 MGI:3774343 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO UniProtKB:P06800 (MGI:3774343|PMID:18249142) RGD PMID:18249142 MGI:3774343 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family IMP RGD PMID:18832707 RGD:9835043 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 IMP RGD PMID:18832707 RGD:9835043 NCBI chr 3:12,898,349...13,016,234
Ensembl chr 3:12,898,266...13,013,984
JBrowse link
positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:5586645|PMID:24586680)
UniProt
RGD
PMID:24586680 GO_REF:0000024 MGI:5586645 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
JBrowse link
regulation of Fc receptor mediated stimulatory signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csk C-terminal Src kinase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:9325302 PMID:21873635 RGD:2303720, RGD:13792537 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292
JBrowse link
G Plscr1 phospholipid scramblase 1 involved_in IMP PMID:18579528 UniProt PMID:18579528 RGD:2303650 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692
JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO (MGI:3050742|PMID:15235600), (MGI:3834538|PMID:17341663) RGD PMID:15235600 PMID:17341663 MGI:3050742 MGI:3834538 NCBI chr12:26,459,190...26,503,790
Ensembl chr12:26,460,175...26,503,744
JBrowse link
regulation of Fc-gamma receptor signaling pathway involved in phagocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcgr2a Fc fragment of IgG receptor IIa IMP RGD PMID:22184119 PMID:16482158 RGD:11041001, RGD:2293335 NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19390
    immune system process 2787
      activation of immune response 397
        immune response-activating signal transduction 316
          immune response-activating cell surface receptor signaling pathway 315
            Fc receptor mediated stimulatory signaling pathway 19
              Fc-gamma receptor signaling pathway involved in phagocytosis + 10
              positive regulation of Fc receptor mediated stimulatory signaling pathway + 8
              positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway 1
              regulation of Fc receptor mediated stimulatory signaling pathway + 14
Path 2
Term Annotations click to browse term
  biological_process 19390
    biological regulation 13476
      regulation of biological process 12735
        positive regulation of biological process 6556
          positive regulation of immune system process 986
            positive regulation of immune response 619
              activation of immune response 397
                immune response-activating signal transduction 316
                  immune response-activating cell surface receptor signaling pathway 315
                    Fc receptor mediated stimulatory signaling pathway 19
                      Fc-gamma receptor signaling pathway involved in phagocytosis + 10
                      positive regulation of Fc receptor mediated stimulatory signaling pathway + 8
                      positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway 1
                      regulation of Fc receptor mediated stimulatory signaling pathway + 14
paths to the root