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ONTOLOGY REPORT - ANNOTATIONS


Term:natural killer cell mediated cytotoxicity directed against tumor cell target
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Accession:GO:0002420 term browser browse the term
Definition:The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
Comment:Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
Synonyms:exact_synonym: NK cell mediated cytotoxicity directed against tumor cell target



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natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkg7 natural killer cell granule protein 7 involved_in ISO (MGI:6506882|PMID:32839608) RGD PMID:32839608 MGI:6506882 NCBI chr 1:93,844,748...93,845,975
Ensembl chr 1:93,844,902...93,845,983
JBrowse link
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO
ISS
(PMID:23696226)
(MGI:5512785|PMID:23696226)
GO_REF:0000024
RGD
UniProt
PMID:23696226 GO_REF:0000024 MGI:5512785 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (MGI:5437532|PMID:22842346) RGD PMID:22842346 MGI:5437532 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137
JBrowse link
G Klre1 killer cell lectin-like receptor, family E, member 1 IDA RGD PMID:12782717 RGD:1299590 NCBI chr 4:163,032,938...163,041,641
Ensembl chr 4:163,033,563...163,041,638
JBrowse link
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd226 CD226 molecule involved_in IBA
ISO
PMID:21873635
(PMID:12913096)
RGD PMID:12913096 PMID:21873635 RGD:13792537 NCBI chr18:82,449,924...82,545,107
Ensembl chr18:82,450,568...82,543,051
JBrowse link
G Crtam cytotoxic and regulatory T cell molecule involved_in IBA
ISO
PMID:21873635
(PMID:15811952)
(MGI:3689781|PMID:15811952)
RGD PMID:15811952 PMID:21873635 MGI:3689781, RGD:13792537 NCBI chr 8:41,340,117...41,377,343
Ensembl chr 8:41,340,837...41,377,343
JBrowse link
G Il12a interleukin 12A involved_in ISO (PMID:7903063) RGD PMID:7903063 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:7903063) RGD PMID:7903063 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Klrk1 killer cell lectin like receptor K1 IMP RGD PMID:16323246 RGD:9685180 NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in IBA
ISO
PMID:21873635
(PMID:12913096)
RGD PMID:12913096 PMID:21873635 RGD:13792537 NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360
JBrowse link
G Pvr PVR cell adhesion molecule involved_in ISO (PMID:12913096) RGD PMID:12913096 NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715
JBrowse link
G Rrlt similar to retinoic acid early transcript 1L IMP RGD PMID:16323246 RGD:9685180 NCBI chr 1:1,397,219...1,437,802
Ensembl chr 1:1,397,230...1,402,656
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20050
    immune system process 2566
      immune response 1697
        immune response to tumor cell 32
          natural killer cell mediated immune response to tumor cell 13
            natural killer cell mediated cytotoxicity directed against tumor cell target 12
              negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target 3
              positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target 8
              regulation of natural killer cell mediated cytotoxicity directed against tumor cell target + 11
Path 2
Term Annotations click to browse term
  biological_process 20050
    response to stimulus 10559
      response to external stimulus 3284
        response to external biotic stimulus 1764
          response to other organism 1760
            defense response to other organism 1211
              innate immune response 896
                natural killer cell mediated immunity 86
                  natural killer cell mediated cytotoxicity 83
                    natural killer cell mediated cytotoxicity directed against tumor cell target 12
                      negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target 3
                      positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target 8
                      regulation of natural killer cell mediated cytotoxicity directed against tumor cell target + 11
paths to the root