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ONTOLOGY REPORT - ANNOTATIONS

Term:CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
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Accession:GO:0002361 term browser browse the term
Definition:The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation
 related_synonym: CD4-positive, CD25-positive, alpha-beta regulatory T cell development


show annotations for term's descendants           Sort by:
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:16301745), (PMID:18573908)
(PMID:16275384)		 Ensembl
MGI		 PMID:16275384 PMID:16301745 PMID:18573908 GO_REF:0000107 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758 		JBrowse link
G FUT7 fucosyltransferase 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18573908) Ensembl
MGI		 PMID:18573908 GO_REF:0000107 NCBI chr 9:48,604,879...48,609,292
Ensembl chr 9:48,606,435...48,609,303 		JBrowse link
G IL2RG interleukin 2 receptor subunit gamma acts_upstream_of ISO (PMID:16227984) MGI PMID:16227984 NCBI chr  X:55,480,846...55,488,485
Ensembl chr  X:55,481,092...55,484,751 		JBrowse link
G NCOR1 nuclear receptor corepressor 1 acts_upstream_of_or_within ISO (PMID:11030619) MGI PMID:11030619 NCBI chr 5:39,687,530...39,837,003
Ensembl chr 5:39,687,543...39,836,464 		JBrowse link
G PLA2G2D phospholipase A2 group IID involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19564598) Ensembl
MGI		 PMID:19564598 GO_REF:0000107 NCBI chr 2:78,739,826...78,745,839
Ensembl chr 2:78,739,769...78,745,920 		JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TOX thymocyte selection associated high mobility group box involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:9,542,471...9,841,759
Ensembl chr29:9,544,561...9,842,034 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DLA-DRA MHC class II DR alpha chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,133,026...2,137,825
Ensembl chr12:2,132,499...2,168,975 		JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12612578)
(PMID:16275384)
(PMID:16301745), (PMID:18573908)		 Ensembl
MGI		 PMID:12612578 PMID:16275384 PMID:16301745 PMID:18573908 GO_REF:0000107 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758 		JBrowse link
G HLA-DRB1 MHC class II DLA DRB1 beta chain involved_in ISO (PMID:28467828) UniProt PMID:28467828 NCBI chr12:2,151,409...2,164,564 JBrowse link
G IL2RG interleukin 2 receptor subunit gamma acts_upstream_of_or_within ISO (PMID:16227984) MGI PMID:16227984 NCBI chr  X:55,480,846...55,488,485
Ensembl chr  X:55,481,092...55,484,751 		JBrowse link
G KLHL25 kelch like family member 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:49,339,576...49,375,473
Ensembl chr 3:49,348,982...49,351,663 		JBrowse link
G LOC100687459 GTPase IMAP family member 5 ISO RGD PMID:15778366 RGD:2303772 NCBI chr16:14,887,308...14,895,522 JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
G LGALS9 galectin 9 involved_in ISO (PMID:20209097) UniProt PMID:20209097 NCBI chr 9:42,154,613...42,170,423
Ensembl chr 9:42,154,702...42,170,391 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    immune system process 2495
      leukocyte activation 1025
        lymphocyte activation 833
          lymphocyte differentiation 453
            T cell differentiation 324
              regulatory T cell differentiation 49
                CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation 12
                  CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response + 2
                  CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment 1
                  negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 0
                  positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 8
                  regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 8
Path 2
Term Annotations click to browse term
  biological_process 17917
    developmental process 6831
      cellular developmental process 4594
        cell differentiation 4593
          cell development 3258
            hemopoiesis 1053
              leukocyte differentiation 673
                mononuclear cell differentiation 551
                  lymphocyte differentiation 453
                    T cell differentiation 324
                      alpha-beta T cell differentiation 141
                        CD4-positive, alpha-beta T cell differentiation 102
                          CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation 12
                            CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response + 2
                            CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment 1
                            negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 0
                            positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 8
                            regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 8
paths to the root