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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell lineage commitment
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Accession:GO:0002360 term browser browse the term
Definition:The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell.
Synonyms:exact_synonym: T-lymphocyte lineage commitment


show annotations for term's descendants           Sort by:
T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within ISO MGI:2156165 (PMID:8788039) RGD PMID:8788039 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Foxn1 forkhead box N1 involved_in ISO
IEA 		(PMID:24184560)
GO_REF:0000107 		RGD
Ensembl		 PMID:24184560 GO_REF:0000107 NCBI chr10:63,749,461...63,778,468
Ensembl chr10:63,251,400...63,273,710 		JBrowse link
G Il7 interleukin 7 acts_upstream_of_or_within ISO MGI:1857652 (PMID:9252127) RGD PMID:9252127 NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:94,234,766...94,280,075 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO
IEA 		MGI:1857113 (PMID:8788039)
GO_REF:0000107 		RGD
Ensembl		 PMID:8788039 GO_REF:0000107 NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Rag2 recombination activating 2 acts_upstream_of_or_within ISO
IEA 		MGI:1858556 (PMID:8788039)
GO_REF:0000107 		RGD
Ensembl		 PMID:8788039 GO_REF:0000107 NCBI chr 3:108,357,399...108,367,186
Ensembl chr 3:87,902,238...87,911,066 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO
IEA 		MGI:1857590 (PMID:8788039)
GO_REF:0000107 		RGD
Ensembl		 PMID:8788039 GO_REF:0000107 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rhoa ras homolog family member A involved_in ISO (PMID:25398325) RGD PMID:25398325 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO MGI:1857579 (PMID:18228248) RGD PMID:18228248 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO
IEA 		MGI:3664438 (PMID:16501569)
GO_REF:0000107 		RGD
Ensembl		 PMID:16501569 GO_REF:0000107 NCBI chr19:34,487,491...34,547,311
Ensembl chr19:18,314,019...18,373,658 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:17227833)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:17227833 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
CD4-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsl cathepsin L involved_in ISS
ISO 		GO_REF:0000024
(PMID:9545226) 		UniProt
RGD		 PMID:9545226 GO_REF:0000024 NCBI chr17:770,104...776,266
Ensembl chr17:764,309...770,548 		JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in ISO
IEA 		(PMID:18195075)
GO_REF:0000107 		RGD
Ensembl		 PMID:18195075 GO_REF:0000107 NCBI chr 5:24,672,487...24,968,754
Ensembl chr 5:19,874,467...20,171,272 		JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tox thymocyte selection-associated high mobility group box involved_in ISO
IEA 		(PMID:18195075)
GO_REF:0000107 		RGD
Ensembl		 PMID:18195075 GO_REF:0000107 NCBI chr 5:24,672,487...24,968,754
Ensembl chr 5:19,874,467...20,171,272 		JBrowse link
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within ISO MGI:2156165 (PMID:8170972) RGD PMID:8170972 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in ISO
IEA 		(PMID:11850626), (PMID:15078895)
GO_REF:0000107 		RGD
Ensembl		 PMID:11850626 PMID:15078895 GO_REF:0000107 NCBI chr 5:24,672,487...24,968,754
Ensembl chr 5:19,874,467...20,171,272 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 Cd69 molecule involved_in ISO (PMID:24752896) RGD PMID:24752896 NCBI chr 4:164,411,485...164,419,403
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (PMID:20696842) RGD PMID:20696842 NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Lgals1 galectin 1 involved_in ISO
IEA 		(PMID:24752896)
GO_REF:0000107 		RGD
Ensembl		 PMID:24752896 GO_REF:0000107 NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Loxl3 lysyl oxidase-like 3 involved_in ISO (PMID:28065600) RGD PMID:28065600 NCBI chr 4:117,098,358...117,114,673
Ensembl chr 4:115,540,685...115,557,466 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A involved_in ISO
IEA 		(PMID:20696842)
GO_REF:0000107 		RGD
Ensembl		 PMID:20696842 GO_REF:0000107 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO
IEA 		(PMID:21151104)
GO_REF:0000107 		RGD
Ensembl		 PMID:21151104 GO_REF:0000107 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (PMID:24107315) RGD PMID:24107315 NCBI chr13:76,366,790...76,440,673
Ensembl chr13:73,831,252...73,843,169 		JBrowse link
NK T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kctd9 potassium channel tetramerization domain containing 9 acts_upstream_of_or_within ISO (PMID:31024568) RGD PMID:31024568 NCBI chr15:46,117,211...46,145,258
Ensembl chr15:41,942,381...41,969,862 		JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in ISO
IEA 		(PMID:18195075)
GO_REF:0000107 		RGD
Ensembl		 PMID:18195075 GO_REF:0000107 NCBI chr 5:24,672,487...24,968,754
Ensembl chr 5:19,874,467...20,171,272 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:28262505)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:28262505 GO_REF:0000024 GO_REF:0000107 NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,151...4,735,388 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (PMID:28262505) RGD PMID:28262505 NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,216,446...11,295,539 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:28262505) RGD PMID:28262505 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IBA
ISO
IEA 		GO_REF:0000033
(PMID:19501566)
GO_REF:0000107 		GO_Central
RGD
Ensembl		 PMID:19501566 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:721,809...723,923 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:36171294)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:36171294 GO_REF:0000024 GO_REF:0000107 NCBI chr11:84,612,943...84,690,025
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 acts_upstream_of_or_within ISO MGI:103034 (PMID:20706986) RGD PMID:20706986 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in IEA
ISO 		GO_REF:0000107
(PMID:26410627) 		Ensembl
RGD		 PMID:26410627 GO_REF:0000107 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Spn sialophorin involved_in ISO
ISS 		(PMID:18036228)
GO_REF:0000024 		RGD
UniProt		 PMID:18036228 GO_REF:0000024 NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:181,746,429...181,759,628 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO MGI:96556 (PMID:20706986) RGD PMID:20706986 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO
IEA 		(PMID:10761931)
GO_REF:0000107 		RGD
Ensembl		 PMID:10761931 GO_REF:0000107 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:19578362), (PMID:22983707) 		UniProt
Ensembl
RGD		 PMID:19578362 PMID:22983707 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:111,084,717...111,107,052
Ensembl chr 6:105,353,715...105,376,051 		JBrowse link
G Il6 interleukin 6 involved_in ISS
ISO 		GO_REF:0000024
(PMID:16990136), (PMID:27893700) 		UniProt
RGD		 PMID:16990136 PMID:27893700 GO_REF:0000024 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor involved_in ISS
ISO 		GO_REF:0000024
(PMID:27893700) 		UniProt
RGD		 PMID:27893700 GO_REF:0000024 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Irf4 interferon regulatory factor 4 involved_in ISO
IEA 		(PMID:22983707)
GO_REF:0000107 		RGD
Ensembl		 PMID:22983707 GO_REF:0000107 NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,721,811...33,740,070 		JBrowse link
G Ly9 lymphocyte antigen 9 involved_in ISO
IEA 		(PMID:22184727)
GO_REF:0000107 		RGD
Ensembl		 PMID:22184727 GO_REF:0000107 NCBI chr13:86,610,762...86,633,314
Ensembl chr13:84,079,458...84,100,823 		JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO MGI:2386448|MGI:5752247 (PMID:25470037) RGD PMID:25470037 NCBI chr  X:17,296,750...17,331,257
Ensembl chr  X:14,626,164...14,659,573 		JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (PMID:22184727) RGD PMID:22184727 NCBI chr13:86,916,956...86,937,697
Ensembl chr13:84,383,742...84,405,300 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:28065600)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:28065600 GO_REF:0000024 GO_REF:0000107 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    developmental process 7160
      cellular developmental process 4838
        cell fate commitment 295
          T cell lineage commitment 37
            CD4-positive or CD8-positive, alpha-beta T cell lineage commitment + 30
            alpha-beta T cell lineage commitment + 29
            gamma-delta T cell lineage commitment 0
Path 2
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      cellular developmental process 4838
        cell differentiation 4837
          cell development 3352
            hemopoiesis 1084
              leukocyte differentiation 690
                mononuclear cell differentiation 556
                  lymphocyte differentiation 455
                    T cell differentiation 337
                      T cell lineage commitment 37
                        CD4-positive or CD8-positive, alpha-beta T cell lineage commitment + 30
                        alpha-beta T cell lineage commitment + 29
                        gamma-delta T cell lineage commitment 0
paths to the root