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ONTOLOGY REPORT - ANNOTATIONS


Term:T cell lineage commitment
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Accession:GO:0002360 term browser browse the term
Definition:The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell.
Synonyms:exact_synonym: T-lymphocyte lineage commitment



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T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within ISO MGI:2156165 (MGI:78866|PMID:8788039) RGD PMID:8788039 MGI:78866 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Foxn1 forkhead box N1 involved_in ISO (MGI:5554515|PMID:24184560) RGD PMID:24184560 MGI:5554515 NCBI chr10:63,251,400...63,273,710
Ensembl chr10:63,251,400...63,273,710
JBrowse link
G Il7 interleukin 7 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857652 (MGI:894974|PMID:9252127)
Ensembl
RGD
PMID:9252127 GO_REF:0000107 MGI:894974 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO MGI:1857113 (MGI:78866|PMID:8788039) RGD PMID:8788039 MGI:78866 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Rag2 recombination activating 2 acts_upstream_of_or_within ISO MGI:1858556 (MGI:78866|PMID:8788039) RGD PMID:8788039 MGI:78866 NCBI chr 3:87,902,373...87,910,227
Ensembl chr 3:87,902,238...87,911,066
JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:1857590 (MGI:78866|PMID:8788039)
GO_REF:0000107
RGD
Ensembl
PMID:8788039 GO_REF:0000107 MGI:78866 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rhoa ras homolog family member A involved_in ISO (MGI:5640904|PMID:25398325) RGD PMID:25398325 MGI:5640904 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO MGI:1857579 (MGI:3773982|PMID:18228248) RGD PMID:18228248 MGI:3773982 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO MGI:3664438 (MGI:3656194|PMID:16501569) RGD PMID:16501569 MGI:3656194 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:3834308|PMID:17227833)
(PMID:17227833)
UniProt
Ensembl
RGD
PMID:17227833 GO_REF:0000024 GO_REF:0000107 MGI:3834308 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
CD4-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsl cathepsin L involved_in ISS
ISO
GO_REF:0000024
(MGI:2655909|PMID:9545226)
UniProt
RGD
PMID:9545226 GO_REF:0000024 MGI:2655909 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in ISO (MGI:3773459|PMID:18195075) RGD PMID:18195075 MGI:3773459 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272
JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tox thymocyte selection-associated high mobility group box involved_in ISO (MGI:3773459|PMID:18195075) RGD PMID:18195075 MGI:3773459 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272
JBrowse link
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:2156165 (MGI:2156164|PMID:8170972)
GO_REF:0000107
RGD
Ensembl
PMID:8170972 GO_REF:0000107 MGI:2156164 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in ISO (MGI:2159528|PMID:11850626), (MGI:3045816|PMID:15078895) RGD PMID:11850626 PMID:15078895 MGI:2159528 MGI:3045816 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272
JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase-like 3 involved_in ISO (MGI:5825383|PMID:28065600)
(PMID:28065600)
RGD PMID:28065600 MGI:5825383 NCBI chr 4:115,540,640...115,556,958
Ensembl chr 4:115,540,685...115,557,466
JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:4868293 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:5551556 NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169
JBrowse link
NK T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tox thymocyte selection-associated high mobility group box involved_in ISO (MGI:3773459|PMID:18195075) RGD PMID:18195075 MGI:3773459 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272
JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:28262505)
(MGI:6106706|PMID:28262505)
UniProt
RGD
PMID:28262505 GO_REF:0000024 MGI:6106706 NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388
JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (MGI:6106706|PMID:28262505) RGD PMID:28262505 MGI:6106706 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:28262505) RGD PMID:28262505 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO
IBA
(MGI:3851279|PMID:19501566)
GO_REF:0000033
RGD
GO_Central
PMID:19501566 GO_REF:0000033 MGI:3851279 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 acts_upstream_of_or_within ISO MGI:103034 (MGI:4838368|PMID:20706986) RGD PMID:20706986 MGI:4838368 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO
IEA
(MGI:5788050|PMID:26410627)
GO_REF:0000107
RGD
Ensembl
PMID:26410627 GO_REF:0000107 MGI:5788050 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Spn sialophorin involved_in ISO
ISS
(PMID:18036228)
GO_REF:0000024
RGD
UniProt
PMID:18036228 GO_REF:0000024 NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628
JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO MGI:96556 (MGI:4838368|PMID:20706986) RGD PMID:20706986 MGI:4838368 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:1354779|PMID:10761931) RGD PMID:10761931 MGI:1354779 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
ISO
GO_REF:0000024
(MGI:3851267|PMID:19578362), (MGI:5448096|PMID:22983707)
UniProt
RGD
PMID:19578362 PMID:22983707 GO_REF:0000024 MGI:3851267 MGI:5448096 NCBI chr 6:105,353,715...105,376,051
Ensembl chr 6:105,353,715...105,376,051
JBrowse link
G Il6 interleukin 6 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:3692468|PMID:16990136), (MGI:6142555|PMID:27893700)
GO_REF:0000002
UniProt
RGD
InterPro
PMID:16990136 PMID:27893700 GO_REF:0000002 GO_REF:0000024 MGI:3692468 MGI:6142555 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:6142555|PMID:27893700)
UniProt
Ensembl
RGD
PMID:27893700 GO_REF:0000024 GO_REF:0000107 MGI:6142555 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Irf4 interferon regulatory factor 4 involved_in ISO (MGI:5448096|PMID:22983707) RGD PMID:22983707 MGI:5448096 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
JBrowse link
G Ly9 lymphocyte antigen 9 involved_in ISO (PMID:22184727) RGD PMID:22184727 NCBI chr13:84,079,345...84,100,783
Ensembl chr13:84,079,458...84,100,823
JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO MGI:2386448|MGI:5752247 (MGI:5621075|PMID:25470037) RGD PMID:25470037 MGI:5621075 NCBI chr  X:14,626,173...14,659,331
Ensembl chr  X:14,626,164...14,659,573
JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO
IBA
(PMID:22184727)
GO_REF:0000033
RGD
GO_Central
PMID:22184727 GO_REF:0000033 NCBI chr13:84,384,561...84,405,300
Ensembl chr13:84,383,742...84,405,300
JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5825383|PMID:28065600)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:28065600 GO_REF:0000024 GO_REF:0000107 MGI:5825383 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20295
    developmental process 7050
      cellular developmental process 4751
        cell fate commitment 294
          T cell lineage commitment 31
            CD4-positive or CD8-positive, alpha-beta T cell lineage commitment + 25
            alpha-beta T cell lineage commitment + 23
            gamma-delta T cell lineage commitment 0
Path 2
Term Annotations click to browse term
  biological_process 20295
    cellular process 18772
      cellular developmental process 4751
        cell differentiation 4750
          cell development 3306
            hemopoiesis 1062
              leukocyte differentiation 674
                mononuclear cell differentiation 544
                  lymphocyte differentiation 447
                    T cell differentiation 323
                      T cell lineage commitment 31
                        CD4-positive or CD8-positive, alpha-beta T cell lineage commitment + 25
                        alpha-beta T cell lineage commitment + 23
                        gamma-delta T cell lineage commitment 0
paths to the root