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ONTOLOGY REPORT - ANNOTATIONS


Term:plasma kallikrein-kinin cascade
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Accession:GO:0002353 term browser browse the term
Definition:A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.


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plasma kallikrein-kinin cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F12 coagulation factor XII ISO (PMID:18725990), (PMID:6793628) RGD PMID:6793628, PMID:18725990 NCBI chr17:9,736,577...9,744,420
Ensembl chr17:9,736,577...9,744,420
JBrowse link
G Prcp prolylcarboxypeptidase ISO MGI:4123993 (MGI:5009114|PMID:21297000) RGD PMID:21297000 MGI:5009114 NCBI chr 1:157,701,089...157,750,177
Ensembl chr 1:157,701,089...157,750,169
JBrowse link
Factor XII activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F12 coagulation factor XII ISO
IEA
(PMID:18725990)
GO_REF:0000107
RGD
Ensembl
PMID:18725990 GO_REF:0000107 NCBI chr17:9,736,577...9,744,420
Ensembl chr17:9,736,577...9,744,420
JBrowse link
G Kng2 kininogen 2 IDA RGD PMID:6685967 RGD:11062094 NCBI chr11:81,509,185...81,516,759 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    response to stimulus 10580
      protein activation cascade 14
        kinin cascade 3
          plasma kallikrein-kinin cascade 3
            Factor XII activation 2
            negative regulation of plasma kallikrein-kinin cascade 0
            positive regulation of plasma kallikrein-kinin cascade 0
            regulation of plasma kallikrein-kinin cascade + 0
Path 2
Term Annotations click to browse term
  biological_process 20020
    response to stimulus 10580
      response to stress 4062
        defense response 1682
          inflammatory response 716
            acute inflammatory response 130
              kinin cascade 3
                plasma kallikrein-kinin cascade 3
                  Factor XII activation 2
                  negative regulation of plasma kallikrein-kinin cascade 0
                  positive regulation of plasma kallikrein-kinin cascade 0
                  regulation of plasma kallikrein-kinin cascade + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.