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ONTOLOGY REPORT - ANNOTATIONS

Term:plasma kallikrein-kinin cascade
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Accession:GO:0002353 term browser browse the term
Definition:A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.


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plasma kallikrein-kinin cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F12 coagulation factor XII involved_in ISO (PMID:18725990), (PMID:6793628) RGD PMID:6793628 PMID:18725990 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G Prcp prolylcarboxypeptidase acts_upstream_of_or_within ISO MGI:4123993 (PMID:21297000) RGD PMID:21297000 NCBI chr 1:146,931,487...146,983,891
Ensembl chr 1:146,930,561...146,984,530 		JBrowse link
Factor XII activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F12 coagulation factor XII involved_in ISO
IEA		 (PMID:18725990)
GO_REF:0000107		 RGD
Ensembl		 PMID:18725990 GO_REF:0000107 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G Kng2 kininogen 2 IDA RGD PMID:6685967 RGD:11062094 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    metabolic process 11720
      primary metabolic process 10271
        protein metabolic process 4698
          protein maturation 558
            protein activation cascade 21
              kinin cascade 3
                plasma kallikrein-kinin cascade 3
                  Factor XII activation 2
                  negative regulation of plasma kallikrein-kinin cascade 0
                  positive regulation of plasma kallikrein-kinin cascade 0
                  regulation of plasma kallikrein-kinin cascade + 0
Path 2
Term Annotations click to browse term
  biological_process 20292
    cellular process 18769
      cellular metabolic process 10279
        cellular biosynthetic process 8211
          macromolecule biosynthetic process 7370
            gene expression 6922
              protein maturation 558
                protein activation cascade 21
                  kinin cascade 3
                    plasma kallikrein-kinin cascade 3
                      Factor XII activation 2
                      negative regulation of plasma kallikrein-kinin cascade 0
                      positive regulation of plasma kallikrein-kinin cascade 0
                      regulation of plasma kallikrein-kinin cascade + 0
paths to the root