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ONTOLOGY REPORT - ANNOTATIONS

Term:B cell affinity maturation
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Accession:GO:0002344 term browser browse the term
Definition:The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.
Synonyms:exact_synonym: B-lymphocyte affinity maturation


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B cell affinity maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btk Bruton agammaglobulinemia tyrosine kinase acts_upstream_of_or_within IMP (PMID:7680896) MGI PMID:7680896 NCBI chr  X:133,443,083...133,484,366
Ensembl chr  X:133,443,085...133,484,319 		JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 involved_in IDA (MGI:4943414|PMID:1378867) BHF-UCL PMID:1378867 MGI:4943414 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393 		JBrowse link
G Ighm immunoglobulin heavy constant mu acts_upstream_of_or_within IMP (PMID:9707605) MGI PMID:9707605 NCBI chr12:113,382,446...113,386,350
Ensembl chr12:113,382,178...113,386,350 		JBrowse link
G Traf3ip2 TRAF3 interacting protein 2 involved_in IMP (PMID:20543113) MGI PMID:20543113 NCBI chr10:39,488,930...39,531,303
Ensembl chr10:39,488,930...39,531,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    immune system process 3142
      B cell selection 6
        peripheral B cell selection 4
          B cell affinity maturation 4
            somatic hypermutation of immunoglobulin genes involved in immune response 0
Path 2
Term Annotations click to browse term
  biological_process 28573
    cellular process 17545
      cellular developmental process 5063
        cell differentiation 5062
          cell development 3447
            hemopoiesis 1161
              leukocyte differentiation 751
                mononuclear cell differentiation 607
                  lymphocyte differentiation 503
                    B cell differentiation 184
                      B cell selection 6
                        peripheral B cell selection 4
                          B cell affinity maturation 4
                            somatic hypermutation of immunoglobulin genes involved in immune response 0
paths to the root