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ONTOLOGY REPORT - ANNOTATIONS

Term:pre-B cell differentiation
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Accession:GO:0002329 term browser browse the term
Definition:The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: pre-B lymphocyte differentiation
 related_synonym: pre-B cell development


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pre-B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp11c ATPase phospholipid transporting 11C involved_in ISO (MGI:5002406|PMID:21423173) RGD PMID:21423173 MGI:5002406 NCBI chr  X:138,564,459...138,752,116
Ensembl chr  X:138,565,836...138,751,204 		JBrowse link
G Cd24 CD24 molecule acts_upstream_of_or_within ISO MGI:2179996 (PMID:7795661), (PMID:9028339) RGD PMID:7795661 PMID:9028339 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Foxp1 forkhead box P1 acts_upstream_of_or_within ISO MGI:3711150 (PMID:16819554) RGD PMID:16819554 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G Lrrc8a leucine rich repeat containing 8 VRAC subunit A involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 3:13,509,577...13,537,174
Ensembl chr 3:13,510,513...13,536,202 		JBrowse link
G Mir17 microRNA 17 acts_upstream_of_or_within ISO MGI:2676844|MGI:2676872|MGI:3618743|MGI:3629917|MGI:3629918 (PMID:18329372) RGD PMID:18329372 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir18a microRNA 18a acts_upstream_of_or_within ISO MGI:2676872|MGI:3618743|MGI:3619065|MGI:3629917|MGI:3629918 (PMID:18329372) RGD PMID:18329372 NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860 		JBrowse link
G Mir19a microRNA 19a acts_upstream_of_or_within ISO MGI:2676844|MGI:2676872|MGI:3619065|MGI:3629917|MGI:3629918 (PMID:18329372) RGD PMID:18329372 NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993 		JBrowse link
G Mir19b1 microRNA 19b-1 acts_upstream_of_or_within ISO MGI:2676844|MGI:2676872|MGI:3618743|MGI:3619065|MGI:3629918 (PMID:18329372) RGD PMID:18329372 NCBI chr15:92,181,214...92,181,300
Ensembl chr15:92,181,214...92,181,300 		JBrowse link
G Mir20a microRNA 20a acts_upstream_of_or_within ISO MGI:2676844|MGI:3618743|MGI:3619065|MGI:3629917|MGI:3629918 (PMID:18329372) RGD PMID:18329372 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir92a1 microRNA 92a-1 acts_upstream_of_or_within ISO MGI:2676844|MGI:2676872|MGI:3618743|MGI:3619065|MGI:3629917 (PMID:18329372) RGD PMID:18329372 NCBI chr15:92,181,336...92,181,413
Ensembl chr15:92,181,336...92,181,413 		JBrowse link
negative regulation of pre-B cell receptor expression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (MGI:5444793|PMID:22949502) RGD PMID:22949502 MGI:5444793 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807 		JBrowse link
pre-B cell allelic exclusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase involved_in ISO (MGI:3848557|PMID:19448632) RGD PMID:19448632 MGI:3848557 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Rag1 recombination activating 1 involved_in ISO
IBA		 (MGI:3848557|PMID:19448632)
GO_REF:0000033		 RGD
GO_Central		 PMID:19448632 GO_REF:0000033 MGI:3848557 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rag2 recombination activating 2 involved_in ISO (MGI:3848557|PMID:19448632) RGD PMID:19448632 MGI:3848557 NCBI chr 3:87,902,373...87,910,227
Ensembl chr 3:87,902,238...87,911,066 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    immune system process 2852
      leukocyte activation 1048
        lymphocyte activation 853
          lymphocyte differentiation 450
            B cell differentiation 162
              immature B cell differentiation 24
                pre-B cell differentiation 14
                  pre-B cell allelic exclusion 3
                  pre-B cell receptor expression + 1
Path 2
Term Annotations click to browse term
  biological_process 20115
    developmental process 7009
      cellular developmental process 4729
        cell differentiation 4728
          cell development 3296
            hemopoiesis 1071
              leukocyte differentiation 681
                mononuclear cell differentiation 547
                  lymphocyte differentiation 450
                    B cell differentiation 162
                      immature B cell differentiation 24
                        pre-B cell differentiation 14
                          pre-B cell allelic exclusion 3
                          pre-B cell receptor expression + 1
paths to the root