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ONTOLOGY REPORT - ANNOTATIONS


Term:pro-B cell differentiation
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Accession:GO:0002328 term browser browse the term
Definition:The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed.
Synonyms:exact_synonym: pro-B lymphocyte differentiation
 related_synonym: pro-B cell development


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pro-B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt3 Fms related receptor tyrosine kinase 3 acts_upstream_of_or_within
involved_in
ISO MGI:2384051 (MGI:74655|PMID:7621074)
(MGI:4946600|PMID:21228325)
RGD PMID:7621074 PMID:21228325 MGI:4946600 MGI:74655 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
JBrowse link
G Lig4 DNA ligase 4 acts_upstream_of_or_within ISO MGI:1857732 (MGI:1312981|PMID:9823897), (MGI:1860400|PMID:10911993) RGD PMID:9823897 PMID:10911993 MGI:1312981 MGI:1860400 NCBI chr16:85,331,771...85,339,496
Ensembl chr16:85,331,866...85,337,769
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO MGI:2383951 (MGI:1290043|PMID:9768755) RGD PMID:9768755 MGI:1290043 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Sox4 SRY-box transcription factor 4 involved_in ISO (MGI:80229|PMID:8614465) RGD PMID:8614465 MGI:80229 NCBI chr17:37,615,022...37,619,728 JBrowse link
G Xrcc4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO MGI:1926771 (MGI:1913213|PMID:9875844) RGD PMID:9875844 MGI:1913213 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365
JBrowse link
negative regulation of pro-B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hes1 hes family bHLH transcription factor 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:12032823)
UniProt
Ensembl
RGD
PMID:12032823 GO_REF:0000024 GO_REF:0000107 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hes5 hes family bHLH transcription factor 5 involved_in IMP PMID:12032823 UniProt PMID:12032823 RGD:8553570 NCBI chr 5:172,364,421...172,365,188
Ensembl chr 5:172,364,421...172,365,188
JBrowse link
G Notch1 notch receptor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5319620|PMID:12032823)
UniProt
RGD
PMID:12032823 GO_REF:0000024 MGI:5319620 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
positive regulation of pro-B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nudt21 nudix hydrolase 21 involved_in ISS
ISO
GO_REF:0000024
(MGI:6110185|PMID:29249356)
UniProt
RGD
PMID:29249356 GO_REF:0000024 MGI:6110185 NCBI chr19:11,451,366...11,470,637
Ensembl chr19:11,450,760...11,467,644
JBrowse link
regulation of pro-B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07029605.1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 Ensembl chr10:39,850,818...39,870,188 JBrowse link
G Flcn folliculin involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:3774414 (MGI:5444323|PMID:22709692)
UniProt
RGD
PMID:22709692 GO_REF:0000024 MGI:5444323 NCBI chr10:46,153,185...46,172,331
Ensembl chr10:46,153,188...46,172,309
JBrowse link
G Fnip1 folliculin interacting protein 1 acts_upstream_of_or_within ISO MGI:5445116 (MGI:5444323|PMID:22709692) RGD PMID:22709692 MGI:5444323 NCBI chr10:39,786,687...39,870,188 JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO MGI:98355 (MGI:5547878|PMID:24043312) RGD PMID:24043312 MGI:5547878 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996
JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 acts_upstream_of_or_within ISO MGI:98355 (MGI:5547878|PMID:24043312) RGD PMID:24043312 MGI:5547878 NCBI chr 6:91,885,292...92,008,059
Ensembl chr 6:91,883,425...92,007,957
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19610
    cellular process 18463
      cellular developmental process 4463
        cell differentiation 4367
          hematopoietic progenitor cell differentiation 162
            lymphoid progenitor cell differentiation 24
              pro-B cell differentiation 14
                negative regulation of pro-B cell differentiation 3
                positive regulation of pro-B cell differentiation 1
                regulation of pro-B cell differentiation + 9
Path 2
Term Annotations click to browse term
  biological_process 19610
    developmental process 6757
      anatomical structure development 6182
        multicellular organism development 5619
          system development 5290
            animal organ development 4053
              hematopoietic or lymphoid organ development 1028
                hemopoiesis 976
                  hematopoietic progenitor cell differentiation 162
                    lymphoid progenitor cell differentiation 24
                      pro-B cell differentiation 14
                        negative regulation of pro-B cell differentiation 3
                        positive regulation of pro-B cell differentiation 1
                        regulation of pro-B cell differentiation + 9
paths to the root