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ONTOLOGY REPORT - ANNOTATIONS

Term:germinal center B cell differentiation
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Accession:GO:0002314 term browser browse the term
Definition:The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: germinal center B lymphocyte differentiation
 related_synonym: germinal center B cell development


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germinal center B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14607964) Ensembl
MGI		 PMID:14607964 GO_REF:0000107 NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868 		JBrowse link
G CDH17 cadherin 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:90,750,904...90,818,629
Ensembl chr 8:92,696,182...92,760,732 		JBrowse link
G IL21 interleukin 21 involved_in ISO (MGI:5450752|PMID:23045607) UniProt PMID:23045607 MGI:5450752 NCBI chr 4:114,795,979...114,806,936
Ensembl chr 4:125,943,495...125,951,915 		JBrowse link
G IL6 interleukin 6 involved_in ISO (MGI:5450752|PMID:23045607) UniProt PMID:23045607 MGI:5450752 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IRF8 interferon regulatory factor 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:66,568,370...66,591,949
Ensembl chr16:85,905,334...85,929,073 		JBrowse link
G ITFG2 integrin alpha FG-GAP repeat containing 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23997217) Ensembl
MGI		 PMID:23997217 GO_REF:0000107 NCBI chr12:2,933,227...2,980,509
Ensembl chr12:2,865,297...2,877,555 		JBrowse link
G PHF14 PHD finger protein 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:11,608,934...11,822,039
Ensembl chr 7:10,972,503...11,169,377 		JBrowse link
G POU2AF1 POU class 2 homeobox associating factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:106,231,870...106,258,822
Ensembl chr11:110,078,850...110,103,996 		JBrowse link
G SPI1 Spi-1 proto-oncogene involved_in ISO (MGI:6303891|PMID:31000603) ARUK-UCL PMID:31000603 MGI:6303891 NCBI chr11:47,301,245...47,326,891
Ensembl chr11:47,853,991...47,880,259 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    immune system process 2406
      leukocyte activation 979
        lymphocyte activation 795
          B cell activation 275
            B cell activation involved in immune response 94
              mature B cell differentiation involved in immune response 33
                germinal center B cell differentiation 9
Path 2
Term Annotations click to browse term
  biological_process 16440
    cellular process 15499
      cellular developmental process 4402
        cell differentiation 4401
          cell development 3136
            hemopoiesis 998
              leukocyte differentiation 639
                mononuclear cell differentiation 518
                  lymphocyte differentiation 421
                    B cell differentiation 143
                      mature B cell differentiation 42
                        mature B cell differentiation involved in immune response 33
                          germinal center B cell differentiation 9
paths to the root