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ONTOLOGY REPORT - ANNOTATIONS

Term:germinal center B cell differentiation
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Accession:GO:0002314 term browser browse the term
Definition:The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: germinal center B lymphocyte differentiation
 related_synonym: germinal center B cell development


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germinal center B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:1857117|MGI:2683027 (PMID:14607964) 		Ensembl
RGD		 PMID:14607964 GO_REF:0000107 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:172,818,176...172,842,293 		JBrowse link
G Cdh17 cadherin 17 involved_in IEA
ISO 		GO_REF:0000107
(PMID:15688343) 		Ensembl
RGD		 PMID:15688343 GO_REF:0000107 NCBI chr 5:30,024,544...30,112,226
Ensembl chr 5:30,060,090...30,112,226 		JBrowse link
G Il21 interleukin 21 involved_in ISS
ISO 		GO_REF:0000024
(PMID:23045607) 		UniProt
RGD		 PMID:23045607 GO_REF:0000024 NCBI chr 2:122,045,240...122,055,142
Ensembl chr 2:122,045,240...122,055,142 		JBrowse link
G Il6 interleukin 6 involved_in ISS
ISO 		GO_REF:0000024
(PMID:23045607) 		UniProt
RGD		 PMID:23045607 GO_REF:0000024 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Irf8 interferon regulatory factor 8 involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:P17433 (PMID:31000603) 		Ensembl
RGD		 PMID:31000603 GO_REF:0000107 NCBI chr19:65,699,284...65,721,066
Ensembl chr19:65,699,284...65,721,062 		JBrowse link
G Itfg2 integrin alpha FG-GAP repeat containing 2 acts_upstream_of_or_within ISO MGI:4235940 (PMID:23997217) RGD PMID:23997217 NCBI chr 4:163,371,125...163,384,676
Ensembl chr 4:163,338,702...163,384,367 		JBrowse link
G Phf14 PHD finger protein 14 involved_in IEA
ISO 		GO_REF:0000107
(PMID:33035772) 		Ensembl
RGD		 PMID:33035772 GO_REF:0000107 NCBI chr 4:40,975,897...41,162,043
Ensembl chr 4:40,975,439...41,162,043 		JBrowse link
G Pou2af1 POU class 2 homeobox associating factor 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:23045607) 		Ensembl
RGD		 PMID:23045607 GO_REF:0000107 NCBI chr 8:60,418,173...60,445,176
Ensembl chr 8:60,436,844...60,445,176 		JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:P23611 (PMID:31000603) 		Ensembl
RGD		 PMID:31000603 GO_REF:0000107 NCBI chr 3:97,529,509...97,548,204
Ensembl chr 3:97,527,572...97,549,540 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    immune system process 2920
      leukocyte activation 1068
        lymphocyte activation 867
          B cell activation 307
            B cell activation involved in immune response 107
              mature B cell differentiation involved in immune response 36
                germinal center B cell differentiation 9
Path 2
Term Annotations click to browse term
  biological_process 19315
    cellular process 18484
      cellular developmental process 4933
        cell differentiation 4932
          cell development 3418
            hemopoiesis 1096
              leukocyte differentiation 699
                mononuclear cell differentiation 559
                  lymphocyte differentiation 454
                    B cell differentiation 158
                      mature B cell differentiation 44
                        mature B cell differentiation involved in immune response 36
                          germinal center B cell differentiation 9
paths to the root