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ONTOLOGY REPORT - ANNOTATIONS

Term:B cell activation involved in immune response
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Accession:GO:0002312 term browser browse the term
Definition:The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
Synonyms:related_synonym: B lymphocyte activation during immune response;   B-cell activation during immune response


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B cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPR183 G protein-coupled receptor 183 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr22:49,332,665...49,347,721
Ensembl chr22:49,333,188...49,347,593 		JBrowse link
G IFNB1 interferon beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:40,668,295...40,668,855
Ensembl chr11:40,668,295...40,668,855 		JBrowse link
B cell proliferation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7671324)
(PMID:8806812)
(PMID:11120811)		 Ensembl
MGI		 PMID:7671324 PMID:8806812 PMID:11120811 GO_REF:0000107 NCBI chr 9:53,118,462...53,262,092
Ensembl chr 9:53,119,641...53,261,307 		JBrowse link
G CD180 CD180 molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10880523) Ensembl
MGI
TreeGrafter		 PMID:10880523 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:52,644,357...52,660,830
Ensembl chr 2:52,645,766...52,660,790 		JBrowse link
G CD19 CD19 molecule involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 6:18,419,092...18,425,524
Ensembl chr 6:18,418,241...18,425,400 		JBrowse link
G GAPT GRB2 binding adaptor protein, transmembrane involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18559951) TreeGrafter
MGI		 PMID:18559951 GO_REF:0000118 NCBI chr 2:45,383,244...45,402,649
Ensembl chr 2:45,397,899...45,398,369 		JBrowse link
G PLCL2 phospholipase C like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14517301) Ensembl
MGI		 PMID:14517301 GO_REF:0000107 NCBI chr23:25,814,392...25,999,666
Ensembl chr23:25,814,862...25,999,749 		JBrowse link
G TLR4 toll like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10880523) Ensembl
MGI		 PMID:10880523 GO_REF:0000107 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165 		JBrowse link
follicular B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IRF8 interferon regulatory factor 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:66,789,264...66,812,477
Ensembl chr 5:66,791,350...66,842,179 		JBrowse link
G PLCG2 phospholipase C gamma 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12928432) Ensembl
MGI		 PMID:12928432 GO_REF:0000107 NCBI chr 5:70,054,683...70,233,459
Ensembl chr 5:70,059,255...70,207,049 		JBrowse link
G SPI1 Spi-1 proto-oncogene involved_in ISO (MGI:6303891|PMID:31000603) ARUK-UCL PMID:31000603 MGI:6303891 NCBI chr18:42,253,849...42,269,497
Ensembl chr18:42,253,811...42,269,727 		JBrowse link
germinal center B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14607964) Ensembl
MGI		 PMID:14607964 GO_REF:0000107 NCBI chr24:32,083,786...32,119,810
Ensembl chr24:32,083,931...32,111,160 		JBrowse link
G CDH17 cadherin 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:38,918,098...38,980,709
Ensembl chr29:38,918,574...38,977,217 		JBrowse link
G IL21 interleukin 21 involved_in ISS UniProt GO_REF:0000024 NCBI chr19:17,641,833...17,651,275
Ensembl chr19:17,641,833...17,651,266 		JBrowse link
G IL6 interleukin 6 involved_in ISO (MGI:5450752|PMID:23045607) UniProt PMID:23045607 MGI:5450752 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G IRF8 interferon regulatory factor 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:66,789,264...66,812,477
Ensembl chr 5:66,791,350...66,842,179 		JBrowse link
G ITFG2 integrin alpha FG-GAP repeat containing 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23997217) Ensembl
MGI		 PMID:23997217 GO_REF:0000107 NCBI chr27:41,933,741...41,944,464
Ensembl chr27:41,934,575...41,944,472 		JBrowse link
G PHF14 PHD finger protein 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:25,907,955...26,089,666
Ensembl chr14:25,914,188...26,125,766 		JBrowse link
G POU2AF1 POU class 2 homeobox associating factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:21,671,000...21,695,757
Ensembl chr 5:21,628,439...21,694,773 		JBrowse link
G SPI1 Spi-1 proto-oncogene involved_in ISO (MGI:6303891|PMID:31000603) ARUK-UCL PMID:31000603 MGI:6303891 NCBI chr18:42,253,849...42,269,497
Ensembl chr18:42,253,811...42,269,727 		JBrowse link
isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17713479) Ensembl
MGI		 PMID:17713479 GO_REF:0000107 NCBI chr27:37,064,107...37,073,791
Ensembl chr27:37,064,080...37,073,789 		JBrowse link
G ATAD5 ATPase family AAA domain containing 5 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:25404367) Ensembl
MGI		 PMID:25404367 GO_REF:0000107 NCBI chr 9:40,869,778...40,917,976
Ensembl chr 9:40,870,924...40,915,629 		JBrowse link
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:48,537,036...48,561,154 JBrowse link
G CD40LG CD40 ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:107,001,421...107,023,007
Ensembl chr  X:107,010,890...107,023,006 		JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15280420) Ensembl
MGI		 PMID:15280420 GO_REF:0000107 NCBI chr 1:110,130,353...110,146,660
Ensembl chr 1:110,130,481...110,146,602 		JBrowse link
G EXO1 exonuclease 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14716311) Ensembl
MGI		 PMID:14716311 GO_REF:0000107 NCBI chr 7:33,237,124...33,268,835
Ensembl chr 7:33,237,593...33,268,254 		JBrowse link
G EXOSC3 exosome component 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:54,072,993...54,079,024
Ensembl chr11:54,073,313...54,078,598 		JBrowse link
G EXOSC6 exosome component 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:76,286,286...76,287,667
Ensembl chr 5:76,286,789...76,287,976 		JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17713479) Ensembl
MGI		 PMID:17713479 GO_REF:0000107 NCBI chr22:56,980,333...56,987,636
Ensembl chr22:56,980,622...56,983,357 		JBrowse link
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12743174) Ensembl
MGI		 PMID:12743174 GO_REF:0000107 NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116 		JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10430621)
(PMID:12743174)		 Ensembl
MGI		 PMID:10430621 PMID:12743174 GO_REF:0000107 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210 		JBrowse link
G MSH6 mutS homolog 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16618598)
(PMID:17015724)		 Ensembl
MGI		 PMID:16618598 PMID:17015724 GO_REF:0000107 NCBI chr10:49,825,330...49,838,036
Ensembl chr10:49,803,898...49,838,028 		JBrowse link
G NBN nibrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:35,416,093...35,477,569
Ensembl chr29:35,416,093...35,477,563 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:8,147,160...8,154,401
Ensembl chr33:8,073,840...8,154,561 		JBrowse link
G RNF168 ring finger protein 168 involved_in ISO (MGI:4420833|PMID:20080757) UniProt PMID:20080757 MGI:4420833 NCBI chr33:29,542,209...29,575,127
Ensembl chr33:29,539,182...29,628,248 		JBrowse link
G RNF8 ring finger protein 8 involved_in ISO (MGI:4420833|PMID:20080757) UniProt PMID:20080757 MGI:4420833 NCBI chr12:6,380,365...6,415,407
Ensembl chr12:6,292,459...6,415,382 		JBrowse link
G SANBR SANT and BTB domain regulator of CSR involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:61,143,971...61,195,058
Ensembl chr10:61,123,655...61,193,241 		JBrowse link
G SWAP70 switching B cell complex subunit SWAP70 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9642267) Ensembl
MGI		 PMID:9642267 GO_REF:0000107 NCBI chr21:32,910,547...32,985,617
Ensembl chr21:32,910,563...32,984,580 		JBrowse link
G UNG uracil DNA glycosylase acts_upstream_of_or_within ISO (PMID:17015724) MGI PMID:17015724 NCBI chr26:17,900,354...17,911,126
Ensembl chr26:17,901,357...17,911,288 		JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO (PMID:17713479) MGI PMID:17713479 NCBI chr 3:24,316,598...24,547,463
Ensembl chr 3:24,269,974...24,533,465 		JBrowse link
isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR6 C-C motif chemokine receptor 6 involved_in ISO (MGI:5787846|PMID:27174992) UniProt PMID:27174992 MGI:5787846 NCBI chr 1:54,932,798...54,960,646
Ensembl chr 1:54,932,690...54,959,740 		JBrowse link
isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of		 IEA
ISO		 (PMID:10490661) Ensembl
MGI		 PMID:10490661 GO_REF:0000107 NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704 		JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:16275384) Ensembl
MGI		 PMID:16275384 GO_REF:0000107 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758 		JBrowse link
G IL4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G RTP2 receptor transporter protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:20,087,395...20,091,248
Ensembl chr34:20,087,226...20,115,428 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:10490661) Ensembl
MGI		 PMID:10490661 GO_REF:0000107 NCBI chr10:1,232,515...1,247,011
Ensembl chr10:1,233,691...1,247,075 		JBrowse link
isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPD1 heat shock protein family D (Hsp60) member 1 involved_in ISO (PMID:16148103) BHF-UCL PMID:16148103 NCBI chr37:7,010,421...7,025,912 JBrowse link
G IL4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
marginal zone B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL3 BCL3 transcription coactivator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9009202) Ensembl
MGI		 PMID:9009202 GO_REF:0000107 NCBI chr 1:110,620,850...110,628,830
Ensembl chr 1:110,620,827...110,654,771 		JBrowse link
G CDH17 cadherin 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:38,918,098...38,980,709
Ensembl chr29:38,918,574...38,977,217 		JBrowse link
G DLL1 delta like canonical Notch ligand 1 involved_in ISO (MGI:3044313|PMID:15146182), (MGI:3838059|PMID:19217325) UniProt PMID:15146182 PMID:19217325 MGI:3044313 MGI:3838059 NCBI chr12:72,265,078...72,272,347
Ensembl chr12:72,265,682...72,272,348 		JBrowse link
G DOCK10 dedicator of cytokinesis 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:37,962,666...38,161,396
Ensembl chr25:37,963,297...38,161,305 		JBrowse link
G DOCK11 dedicator of cytokinesis 11 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:90,752,726...90,892,931
Ensembl chr  X:90,716,197...90,892,062 		JBrowse link
G LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:14,631,638...14,640,147
Ensembl chr 6:14,632,691...14,635,485 		JBrowse link
G MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:27,082,616...27,098,994
Ensembl chr10:27,082,789...27,098,617 		JBrowse link
G NOTCH2 notch receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:56,854,825...57,020,157
Ensembl chr17:56,860,429...57,020,857 		JBrowse link
G PTK2B protein tyrosine kinase 2 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:30,137,546...30,264,221
Ensembl chr25:30,138,209...30,264,133 		JBrowse link
mature B cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C9H17orf99 chromosome 9 C17orf99 homolog involved_in ISO (MGI:6103709|PMID:28978694) UniProt PMID:28978694 MGI:6103709 NCBI chr 9:2,977,401...2,987,450
Ensembl chr 9:2,976,893...2,987,564 		JBrowse link
G GPR183 G protein-coupled receptor 183 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:49,332,665...49,347,721
Ensembl chr22:49,333,188...49,347,593 		JBrowse link
G RAG2 recombination activating 2 ISO RGD PMID:30206106 RGD:38508903 NCBI chr18:31,614,143...31,621,489
Ensembl chr18:31,618,481...31,620,064 		JBrowse link
memory B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:29,853,182...29,949,004
Ensembl chr13:29,846,834...29,872,918 		JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARP3 poly(ADP-ribose) polymerase family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:37,767,336...37,774,269
Ensembl chr20:37,767,505...37,773,770 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10490661) Ensembl
MGI		 PMID:10490661 GO_REF:0000107 NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704 		JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16275384) Ensembl
MGI		 PMID:16275384 GO_REF:0000107 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758 		JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17137798) Ensembl
MGI		 PMID:17137798 GO_REF:0000107 NCBI chr 2:36,978,148...37,065,247
Ensembl chr 2:36,961,024...37,064,303 		JBrowse link
G RTP2 receptor transporter protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:20,087,395...20,091,248
Ensembl chr34:20,087,226...20,115,428 		JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15240705) Ensembl
MGI		 PMID:15240705 GO_REF:0000107 NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704 		JBrowse link
G LOC490269 complement receptor type 2 acts_upstream_of ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 7:6,456,238...6,480,672 JBrowse link
G RTP2 receptor transporter protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:20,087,395...20,091,248
Ensembl chr34:20,087,226...20,115,428 		JBrowse link
plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of		 IEA
ISO		 (PMID:15240705) Ensembl
MGI		 PMID:15240705 GO_REF:0000107 NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704 		JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO (PMID:29259245) MGI PMID:29259245 NCBI chr 1:251,985...322,081
Ensembl chr 1:252,103...322,718 		JBrowse link
G LGALS1 galectin 1 acts_upstream_of_or_within ISO (PMID:21753146) MGI PMID:21753146 NCBI chr10:26,932,351...26,935,580
Ensembl chr10:26,932,301...26,935,646 		JBrowse link
G LGALS8 galectin 8 acts_upstream_of_or_within ISO (PMID:21753146) MGI PMID:21753146 NCBI chr 4:3,548,066...3,581,382
Ensembl chr 4:3,533,200...3,567,311 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:8,147,160...8,154,401
Ensembl chr33:8,073,840...8,154,561 		JBrowse link
G NKX2-3 NK2 homeobox 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10926756) Ensembl
MGI		 PMID:10926756 GO_REF:0000107 NCBI chr28:12,466,319...12,469,467
Ensembl chr28:12,466,368...12,469,473 		JBrowse link
G RTP2 receptor transporter protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:20,087,395...20,091,248
Ensembl chr34:20,087,226...20,115,428 		JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFSF4 TNF superfamily member 4 involved_in ISO (MGI:3763508|PMID:12496423) BHF-UCL PMID:12496423 MGI:3763508 NCBI chr 7:25,883,297...25,909,608
Ensembl chr 7:25,883,251...25,906,892 		JBrowse link
positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EXOSC3 exosome component 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21255825) Ensembl
MGI		 PMID:21255825 GO_REF:0000107 NCBI chr11:54,072,993...54,079,024
Ensembl chr11:54,073,313...54,078,598 		JBrowse link
G EXOSC6 exosome component 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21255825) Ensembl
MGI		 PMID:21255825 GO_REF:0000107 NCBI chr 5:76,286,286...76,287,667
Ensembl chr 5:76,286,789...76,287,976 		JBrowse link
G HMCES 5-hydroxymethylcytosine binding, ES cell specific involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:2,808,687...2,831,123
Ensembl chr20:2,808,689...2,830,462 		JBrowse link
G KMT5B lysine methyltransferase 5B involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:49,655,783...49,691,899
Ensembl chr18:49,637,610...49,827,034 		JBrowse link
G KMT5C lysine methyltransferase 5C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:102,334,687...102,342,090
Ensembl chr 1:102,333,543...102,342,118 		JBrowse link
G MAD2L2 mitotic arrest deficient 2 like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:84,539,724...84,549,402
Ensembl chr 2:84,545,226...84,549,356 		JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:18,066,289...18,116,007
Ensembl chr16:18,066,246...18,112,506 		JBrowse link
G RIF1 replication timing regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:52,661,278...52,711,969
Ensembl chr19:52,661,155...52,709,279 		JBrowse link
G SHLD1 shieldin complex subunit 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr24:15,957,863...16,037,336
Ensembl chr24:15,957,852...16,038,008 		JBrowse link
G SHLD2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chr 4:34,665,111...34,740,645
Ensembl chr 4:34,688,245...34,763,705 		JBrowse link
G SHLD3 shieldin complex subunit 3 involved_in IEA TreeGrafter GO_REF:0000118
G TFRC transferrin receptor involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr33:29,206,024...29,237,221
Ensembl chr33:29,208,609...29,238,242 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:10,263,650...10,362,646
Ensembl chr30:10,263,650...10,336,134 		JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B9D2 B9 domain containing 2 acts_upstream_of_or_within ISO (PMID:14988498) MGI PMID:14988498 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G MLH1 mutL homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116 		JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210 		JBrowse link
G NSD2 nuclear receptor binding SET domain protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23241889) Ensembl
MGI		 PMID:23241889 GO_REF:0000107 NCBI chr 3:62,164,888...62,228,006
Ensembl chr 3:62,167,939...62,228,035 		JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:11,411,062...11,438,767
Ensembl chr 6:11,349,453...11,438,940 		JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in ISS
IEA		 AgBase
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:112,629,476...112,643,885
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:32,473,543...32,481,596
Ensembl chr 5:32,473,083...32,481,121 		JBrowse link
G TNFSF13 TNF superfamily member 13 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14988498) MGI
TreeGrafter
Ensembl		 PMID:14988498 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:32,482,723...32,484,790
Ensembl chr 5:32,482,723...32,484,789 		JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCF1 cardiotrophin like cytokine factor 1 involved_in ISO (MGI:3777853|PMID:12023368) BHF-UCL PMID:12023368 MGI:3777853 NCBI chr18:50,084,120...50,093,825
Ensembl chr18:50,083,915...50,102,651 		JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 ISS
ISO		 (PMID:14988498) UniProt
MGI		 PMID:14988498 GO_REF:0000024 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10490661) Ensembl
MGI		 PMID:10490661 GO_REF:0000107 NCBI chr10:1,232,515...1,247,011
Ensembl chr10:1,233,691...1,247,075 		JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAD5 ATPase family AAA domain containing 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25404367) Ensembl
MGI		 PMID:25404367 GO_REF:0000107 NCBI chr 9:40,869,778...40,917,976
Ensembl chr 9:40,870,924...40,915,629 		JBrowse link
G CD28 CD28 molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7688139) Ensembl
MGI		 PMID:7688139 GO_REF:0000107 NCBI chr37:12,503,849...12,536,362
Ensembl chr37:12,503,811...12,532,854 		JBrowse link
G CD40 CD40 molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12882831) TreeGrafter
MGI		 PMID:12882831 GO_REF:0000118 NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301 		JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (PMID:12882831) MGI PMID:12882831 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
G IL2 interleukin 2 acts_upstream_of_or_within ISO (PMID:1830926) MGI PMID:1830926 NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394 		JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 ISS
ISO		 (PMID:12882831), (PMID:14988498) UniProt
MGI		 PMID:12882831 PMID:14988498 GO_REF:0000024 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G MLH1 mutL homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116 		JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210 		JBrowse link
G PAGR1 PAXIP1 associated glutamate rich protein 1 involved_in ISO (MGI:5752090|PMID:26744420) UniProt PMID:26744420 MGI:5752090 NCBI chr 6:17,876,740...17,879,546 JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:18,066,289...18,116,007
Ensembl chr16:18,066,246...18,112,506 		JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:11,411,062...11,438,767
Ensembl chr 6:11,349,453...11,438,940 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9015183) Ensembl
MGI		 PMID:9015183 GO_REF:0000107 NCBI chr 7:4,155,876...4,282,151
Ensembl chr 7:4,137,728...4,282,124 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12882831) Ensembl
MGI		 PMID:12882831 GO_REF:0000107 NCBI chr 9:24,077,752...24,086,560
Ensembl chr 9:24,077,761...24,086,261 		JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:22962438) ARUK-UCL
Ensembl		 PMID:22962438 GO_REF:0000107 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057 		JBrowse link
G IL2 interleukin 2 acts_upstream_of ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394 		JBrowse link
G XBP1 X-box binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:22,162,675...22,168,149
Ensembl chr26:22,163,222...22,168,105 		JBrowse link
regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLF aprataxin and PNKP like factor acts_upstream_of_or_within ISO (PMID:21211721) MGI PMID:21211721 NCBI chr10:67,454,500...67,522,659
Ensembl chr10:67,454,356...67,521,761 		JBrowse link
G MIR181B-2 microRNA mir-181b-2 acts_upstream_of_or_within ISO (PMID:18762567) MGI PMID:18762567 NCBI chr 9:58,301,314...58,301,373
Ensembl chr 9:58,301,300...58,301,388 		JBrowse link
G MIR181D microRNA mir-181d acts_upstream_of_or_within ISO (PMID:18762567) MGI PMID:18762567 NCBI chr20:48,593,158...48,593,221 JBrowse link
G SUPT6H SPT6 homolog, histone chaperone and transcription elongation factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:42,859,154...42,896,044
Ensembl chr 9:42,859,361...42,904,487 		JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16275384) Ensembl
MGI		 PMID:16275384 GO_REF:0000107 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758 		JBrowse link
G IL27RA interleukin 27 receptor subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11057672) Ensembl
MGI		 PMID:11057672 GO_REF:0000107 NCBI chr20:48,456,766...48,475,414
Ensembl chr20:48,457,134...48,472,450 		JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17137798) Ensembl
MGI		 PMID:17137798 GO_REF:0000107 NCBI chr 2:36,978,148...37,065,247
Ensembl chr 2:36,961,024...37,064,303 		JBrowse link
G SLC15A4 solute carrier family 15 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:2,803,798...2,832,057
Ensembl chr26:2,802,724...2,831,530 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    immune system process 2495
      leukocyte activation 1025
        leukocyte activation involved in immune response 321
          lymphocyte activation involved in immune response 224
            B cell activation involved in immune response 97
              B cell proliferation involved in immune response 6
              isotype switching + 61
              mature B cell differentiation involved in immune response + 33
Path 2
Term Annotations click to browse term
  biological_process 17917
    cellular process 16926
      cell activation 1172
        cell activation involved in immune response 325
          leukocyte activation involved in immune response 321
            lymphocyte activation involved in immune response 224
              B cell activation involved in immune response 97
                B cell proliferation involved in immune response 6
                isotype switching + 61
                mature B cell differentiation involved in immune response + 33
paths to the root