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ONTOLOGY REPORT - ANNOTATIONS

Term:T-helper 1 cell lineage commitment
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Accession:GO:0002296 term browser browse the term
Definition:The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis.
Synonyms:exact_synonym: T-helper 1 cell fate commitment;   Th1 cell lineage commitment;   Th1 fate commitment

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T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtor mechanistic target of rapamycin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:158,376...282,310
Ensembl chrNW_004936474:157,590...282,342 		JBrowse link
G Spn sialophorin involved_in ISO (PMID:18036228) UniProt PMID:18036228 NCBI chrNW_004936501:12,773,967...12,776,642 JBrowse link
G Stat6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20706986) Ensembl
MGI		 PMID:20706986 GO_REF:0000107 NCBI chrNW_004936646:1,297,530...1,312,508
Ensembl chrNW_004936646:1,296,290...1,312,157 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,546,405...13,558,635
Ensembl chrNW_004936490:13,546,292...13,558,635 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15969
    immune system process 2209
      T cell selection 54
        positive T cell selection 38
          CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 24
            CD4-positive, alpha-beta T cell lineage commitment 20
              T-helper cell lineage commitment 18
                T-helper 1 cell lineage commitment 4
Path 2
Term Annotations click to browse term
  biological_process 15969
    cellular process 15075
      cellular developmental process 4256
        cell differentiation 4255
          cell development 3054
            hemopoiesis 956
              leukocyte differentiation 607
                mononuclear cell differentiation 491
                  lymphocyte differentiation 402
                    T cell differentiation 299
                      T cell differentiation involved in immune response 80
                        alpha-beta T cell differentiation involved in immune response 73
                          CD4-positive, alpha-beta T cell differentiation involved in immune response 72
                            T-helper cell differentiation 70
                              T-helper cell lineage commitment 18
                                T-helper 1 cell lineage commitment 4
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