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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell differentiation involved in immune response
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Accession:GO:0002292 term browser browse the term
Definition:The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: T cell development involved in immune response;   T cell differentiation during immune response;   T-lymphocyte differentiation during immune response


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T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLEC4E C-type lectin domain family 4 member E acts_upstream_of_or_within ISO (MGI:5525050|PMID:23602766) MGI PMID:23602766 MGI:5525050 NCBI chr 5:63,219,229...63,228,566 JBrowse link
G FCER1G Fc epsilon receptor Ig acts_upstream_of_or_within
involved_in		 ISO
IBA		 (MGI:5525050|PMID:23602766)
(PMID:21873635)		 MGI
GO_Central		 PMID:21873635 PMID:23602766 MGI:5525050 NCBI chr 4:89,242,467...89,246,344
Ensembl chr 4:89,242,459...89,247,065 		JBrowse link
G SEMA4A semaphorin 4A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:93,865,054...93,892,995
Ensembl chr 4:93,865,055...93,886,371 		JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EOMES eomesodermin involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr13:14,209,590...14,216,184
Ensembl chr13:14,210,083...14,215,797 		JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (MGI:3829555|PMID:17277142) MGI PMID:17277142 MGI:3829555 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752 		JBrowse link
memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TSC1 TSC complex subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5608813|PMID:25271321) Ensembl
Ensembl
MGI		 PMID:25271321 GO_REF:0000107 MGI:5608813 NCBI chr 1:272,636,530...272,685,948
Ensembl chr 1:272,636,532...272,685,952 		JBrowse link
negative regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGL2 fibrinogen like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:6188369|PMID:29341118) Ensembl
Ensembl
MGI		 PMID:29341118 GO_REF:0000107 MGI:6188369 NCBI chr 9:102,869,044...102,875,564
Ensembl chr 9:102,868,836...102,875,577 		JBrowse link
G IL29 interleukin 29 (interferon, lambda 1) involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr17:51,484,658...51,485,233
Ensembl chr17:51,484,658...51,485,233 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL4R interleukin 4 receptor acts_upstream_of_or_within ISO (MGI:3761239|PMID:16424184) MGI PMID:16424184 MGI:3761239 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544 		JBrowse link
G JAK3 Janus kinase 3 involved_in ISO (MGI:3719947|PMID:16020505) BHF-UCL PMID:16020505 MGI:3719947 NCBI chr 2:59,905,901...59,926,504
Ensembl chr 2:59,905,919...59,926,495 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (MGI:4942267|PMID:9670042) BHF-UCL PMID:9670042 MGI:4942267 NCBI chr 9:115,535,185...115,857,457
Ensembl chr 9:115,550,567...115,857,448 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr  X:43,303,777...43,328,164
Ensembl chr  X:43,303,782...43,328,735 		JBrowse link
G IL2 interleukin 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609 		JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:21873635)
(MGI:3817792|PMID:18792410)		 GO_Central
GO_Central
MGI		 PMID:18792410 PMID:21873635 MGI:3817792 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G RC3H1 ring finger and CCCH-type domains 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 9:116,204,807...116,292,455
Ensembl chr 9:116,209,094...116,292,366 		JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 1:263,769,403...263,822,101
Ensembl chr 1:263,772,168...263,822,104 		JBrowse link
G SMAD7 SMAD family member 7 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 1:98,512,800...98,543,924
Ensembl chr 1:98,510,229...98,542,382 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:23,996,415...24,009,353
Ensembl chr12:23,996,415...24,009,355 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5450776|PMID:23034280) Ensembl
Ensembl
MGI		 PMID:23034280 GO_REF:0000107 MGI:5450776 NCBI chr 4:94,780,404...94,796,722
Ensembl chr 4:94,780,401...94,798,588 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:93,541,334...93,551,200
Ensembl chr 6:93,541,334...93,551,195 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOXL3 lysyl oxidase like 3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:68,498,114...68,516,829
Ensembl chr 3:68,498,189...68,520,115 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr12:23,996,415...24,009,353
Ensembl chr12:23,996,415...24,009,355 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) UniProt PMID:24107315 MGI:5551556 NCBI chr 9:115,447,438...115,460,649
Ensembl chr 9:115,448,971...115,459,886 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in ISS
IEA
IBA		 (PMID:21873635) UniProt
Ensembl
GO_Central
UniProt
GO_Central		 PMID:21873635 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:226,414,200...226,431,963
Ensembl chr 1:226,414,307...226,432,287 		JBrowse link
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2450484|PMID:12594267) Ensembl
Ensembl
MGI		 PMID:12594267 GO_REF:0000107 MGI:2450484 NCBI chr13:125,377,247...125,401,328
Ensembl chr13:125,377,248...125,393,330 		JBrowse link
G HLX H2.0 like homeobox involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3761239|PMID:16424184) Ensembl
Ensembl
MGI		 PMID:16424184 GO_REF:0000107 MGI:3761239 NCBI chr10:10,263,441...10,269,882
Ensembl chr10:10,264,244...10,275,855 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:93,777,402...93,925,859
Ensembl chr 3:93,783,964...93,925,865 		JBrowse link
G ZNF397 zinc finger protein 397 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:119,076,683...119,144,643
Ensembl chr 6:119,076,714...119,086,762 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RC3H1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3580753|PMID:15917799) MGI
Ensembl		 PMID:15917799 GO_REF:0000107 MGI:3580753 NCBI chr 9:116,204,807...116,292,455
Ensembl chr 9:116,209,094...116,292,366 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752 		JBrowse link
G LGALS9 galectin 9 involved_in ISO (PMID:20209097) UniProt PMID:20209097 NCBI chr12:44,155,079...44,173,634 JBrowse link
positive regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD46 CD46 molecule, complement regulatory protein involved_in ISO (PMID:12540904) UniProt PMID:12540904 NCBI chr 9:135,025,439...135,078,910 JBrowse link
G IL23A interleukin 23 subunit alpha involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 5:21,732,416...21,733,981
Ensembl chr 5:21,732,165...21,734,267 		JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 involved_in ISS
IEA		 UniProt
Ensembl
UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:57,930,507...57,936,523
Ensembl chr17:57,930,432...57,938,896 		JBrowse link
G SLA-DRA MHC class II DR-alpha involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 7:24,825,037...24,830,650
Ensembl chr 7:24,825,053...24,835,160 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (MGI:3806904|PMID:18713990) BHF-UCL PMID:18713990 MGI:3806904 NCBI chr 9:115,535,185...115,857,457
Ensembl chr 9:115,550,567...115,857,448 		JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in IBA
IEA
ISS		 (PMID:21873635) GO_Central
Ensembl
UniProt
GO_Central
UniProt		 PMID:21873635 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:226,414,200...226,431,963
Ensembl chr 1:226,414,307...226,432,287 		JBrowse link
G CCL19 C-C motif chemokine ligand 19 involved_in ISO (MGI:3576832|PMID:15845453) BHF-UCL PMID:15845453 MGI:3576832 NCBI chr10:32,110,366...32,112,529
Ensembl chr10:32,110,064...32,112,739 		JBrowse link
G HLX H2.0 like homeobox involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3761239|PMID:16424184) Ensembl
Ensembl
MGI		 PMID:16424184 GO_REF:0000107 MGI:3761239 NCBI chr10:10,263,441...10,269,882
Ensembl chr10:10,264,244...10,275,855 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2176424|PMID:11894097) Ensembl
Ensembl
MGI		 PMID:11894097 GO_REF:0000107 MGI:2176424 NCBI chr 4:47,026,558...47,075,133
Ensembl chr 4:47,027,092...47,074,725 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:93,777,402...93,925,859
Ensembl chr 3:93,783,964...93,925,865 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MALT1 MALT1 paracaspase involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 1:162,076,933...162,144,915
Ensembl chr 1:162,076,951...162,144,880 		JBrowse link
G MIR326 microRNA mir-326 acts_upstream_of_or_within ISO (MGI:4436838|PMID:19838199) MGI PMID:19838199 MGI:4436838 NCBI chr 9:9,581,944...9,582,034
Ensembl chr 9:9,581,944...9,582,034 		JBrowse link
G NFKBID NFKB inhibitor delta involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chr 6:45,298,289...45,307,471
Ensembl chr 6:45,296,039...45,306,317 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:157,261,419...157,273,119
Ensembl chr13:157,261,418...157,294,478 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) UniProt PMID:26098997 MGI:5689221 NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,242...56,977,234 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL23A interleukin 23 subunit alpha involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr 5:21,732,416...21,733,981
Ensembl chr 5:21,732,165...21,734,267 		JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL18 interleukin 18 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,966...39,873,300 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of_or_within ISO (MGI:3761239|PMID:16424184) MGI PMID:16424184 MGI:3761239 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544 		JBrowse link
G IL6 interleukin 6 acts_upstream_of_or_within ISO (MGI:2450484|PMID:12594267) MGI PMID:12594267 MGI:2450484 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) UniProt PMID:26098997 MGI:5689221 NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,242...56,977,234 		JBrowse link
G PRKCZ protein kinase C zeta involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:64,073,343...64,159,187
Ensembl chr 6:64,068,575...64,163,472 		JBrowse link
G RARA retinoic acid receptor alpha involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr12:22,047,449...22,085,759
Ensembl chr12:22,047,442...22,085,674 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (MGI:4943387|PMID:18354165) BHF-UCL PMID:18354165 MGI:4943387 NCBI chr 9:115,535,185...115,857,457
Ensembl chr 9:115,550,567...115,857,448 		JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYB MYB proto-oncogene, transcription factor involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 1:28,819,500...28,856,222
Ensembl chr 1:28,819,503...28,857,000 		JBrowse link
G SHB SH2 domain containing adaptor protein B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5617929|PMID:24645804) Ensembl
Ensembl
MGI		 PMID:24645804 GO_REF:0000107 MGI:5617929 NCBI chr 1:238,680,804...238,826,424 JBrowse link
regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3051162|PMID:15240675) Ensembl
Ensembl
MGI		 PMID:15240675 GO_REF:0000107 MGI:3051162 NCBI chr13:125,377,247...125,401,328
Ensembl chr13:125,377,248...125,393,330 		JBrowse link
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL27 interleukin 27 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr 3:18,421,962...18,427,916
Ensembl chr 3:18,421,981...18,427,915 		JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL20 C-C motif chemokine ligand 20 NOT|involved_in ISO (MGI:3820359|PMID:19050256) UniProt PMID:19050256 MGI:3820359 NCBI chr15:129,172,743...129,176,069 JBrowse link
G CCR6 C-C motif chemokine receptor 6 NOT|involved_in ISO (MGI:3820359|PMID:19050256) UniProt PMID:19050256 MGI:3820359 NCBI chr 1:2,016,600...2,034,172
Ensembl chr 1:2,018,608...2,019,821 		JBrowse link
regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA3 GATA binding protein 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3817343|PMID:18776904) MGI
Ensembl		 PMID:18776904 GO_REF:0000107 MGI:3817343 NCBI chr10:63,367,684...63,397,977
Ensembl chr10:63,367,660...63,388,859 		JBrowse link
G SLA-DRA MHC class II DR-alpha involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 7:24,825,037...24,830,650
Ensembl chr 7:24,825,053...24,835,160 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3817343|PMID:18776904) MGI
Ensembl		 PMID:18776904 GO_REF:0000107 MGI:3817343 NCBI chr 4:94,780,404...94,796,722
Ensembl chr 4:94,780,401...94,798,588 		JBrowse link
T follicular helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP1 forkhead box P1 involved_in ISO (MGI:5607369|PMID:24859450) UniProt PMID:24859450 MGI:5607369 NCBI chr13:52,346,844...52,974,358
Ensembl chr13:52,347,849...52,974,261 		JBrowse link
G GPR183 G protein-coupled receptor 183 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr11:68,231,851...68,248,627
Ensembl chr11:68,231,851...68,245,751 		JBrowse link
G IL21 interleukin 21 involved_in ISS UniProt
UniProt		 GO_REF:0000024 NCBI chr 8:101,532,742...101,540,712
Ensembl chr 8:101,530,949...101,540,738 		JBrowse link
G IL6 interleukin 6 involved_in ISO (MGI:5450752|PMID:23045607) UniProt PMID:23045607 MGI:5450752 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263 		JBrowse link
G RC3H1 ring finger and CCCH-type domains 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5486592|PMID:23583643) Ensembl
Ensembl
MGI		 PMID:23583643 GO_REF:0000107 MGI:5486592 NCBI chr 9:116,204,807...116,292,455
Ensembl chr 9:116,209,094...116,292,366 		JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5486592|PMID:23583643) Ensembl
Ensembl
MGI		 PMID:23583643 GO_REF:0000107 MGI:5486592 NCBI chr 1:263,769,403...263,822,101
Ensembl chr 1:263,772,168...263,822,104 		JBrowse link
T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRACR2A calcium release activated channel regulator 2A involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 5:66,574,758...66,650,447
Ensembl chr 5:66,443,491...66,661,654 		JBrowse link
G HLX H2.0 like homeobox acts_upstream_of
involved_in		 ISO
IEA		 (MGI:3761239|PMID:16424184) MGI
Ensembl		 PMID:16424184 GO_REF:0000107 MGI:3761239 NCBI chr10:10,263,441...10,269,882
Ensembl chr10:10,264,244...10,275,855 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:15944249) UniProt PMID:15944249 NCBI chr11:7,195,556...7,321,071 JBrowse link
G IL18R1 interleukin 18 receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2136797|PMID:10227969) Ensembl
MGI		 PMID:10227969 GO_REF:0000107 MGI:2136797 NCBI chr 3:51,803,383...51,844,758
Ensembl chr 3:51,803,404...51,902,079 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:51,868,549...51,902,454
Ensembl chr 3:51,803,165...51,951,383 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of ISO (MGI:3761239|PMID:16424184) MGI PMID:16424184 MGI:3761239 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544 		JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 8:113,824,511...113,944,078
Ensembl chr 8:113,824,547...113,944,078 		JBrowse link
G RELB RELB proto-oncogene, NF-kB subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3621346|PMID:16081776) Ensembl
Ensembl
MGI		 PMID:16081776 GO_REF:0000107 MGI:3621346 NCBI chr 6:51,444,670...51,480,350
Ensembl chr 6:51,444,636...51,480,320 		JBrowse link
G SEMA4A semaphorin 4A involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 4:93,865,054...93,892,995
Ensembl chr 4:93,865,055...93,886,371 		JBrowse link
G TMEM98 transmembrane protein 98 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr12:42,087,691...42,101,152
Ensembl chr12:42,083,553...42,100,494 		JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL4 interleukin 4 acts_upstream_of_or_within ISO (MGI:4838368|PMID:20706986) MGI PMID:20706986 MGI:4838368 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G MTOR mechanistic target of rapamycin kinase involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888 		JBrowse link
G SPN sialophorin involved_in ISO (PMID:18036228) UniProt PMID:18036228 NCBI chr 3:17,978,731...17,982,222 JBrowse link
G STAT6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:4838368|PMID:20706986) Ensembl
Ensembl
MGI		 PMID:20706986 GO_REF:0000107 MGI:4838368 NCBI chr 5:22,406,356...22,422,412
Ensembl chr 5:22,406,364...22,421,990 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr12:23,996,415...24,009,353
Ensembl chr12:23,996,415...24,009,355 		JBrowse link
T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:98,670,211...98,692,230 JBrowse link
G ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr14:110,827,833...110,877,972
Ensembl chr14:110,827,914...110,882,575 		JBrowse link
G RORA RAR related orphan receptor A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:110,719,004...111,482,807
Ensembl chr 1:110,719,190...111,477,703 		JBrowse link
G RORC RAR related orphan receptor C involved_in
acts_upstream_of_or_within		 ISO (MGI:3692468|PMID:16990136), (MGI:3772713|PMID:18164222)
(MGI:3817792|PMID:18792410)		 GO_Central
MGI		 PMID:16990136 PMID:18164222 PMID:18792410 MGI:3692468 MGI:3772713 MGI:3817792 NCBI chr 4:97,374,672...97,399,017
Ensembl chr 4:97,375,136...97,400,231 		JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:98,670,211...98,692,230 JBrowse link
G IL-6 interleukin-6 involved_in ISS
IEA		 UniProt
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000024
G IL6 interleukin 6 involved_in ISS
IEA		 UniProt
UniProt
InterPro
InterPro		 GO_REF:0000002 GO_REF:0000024 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263 		JBrowse link
G IL6R interleukin 6 receptor involved_in ISS UniProt
UniProt		 GO_REF:0000024 NCBI chr 4:95,322,426...95,381,393
Ensembl chr 4:95,322,426...95,381,282 		JBrowse link
G IRF4 interferon regulatory factor 4 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 7:133,358...149,609
Ensembl chr 7:133,364...149,609 		JBrowse link
G LY9 lymphocyte antigen 9 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 4:89,701,806...89,728,848
Ensembl chr 4:89,701,357...89,729,878 		JBrowse link
G OTUD5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO (MGI:5621075|PMID:25470037) MGI PMID:25470037 MGI:5621075 NCBI chr  X:43,001,491...43,029,471
Ensembl chr  X:43,000,227...43,029,465 		JBrowse link
G SLAMF6 SLAM family member 6 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 4:89,980,592...90,004,222
Ensembl chr 4:89,980,786...90,003,647 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 involved_in IEA
ISS		 Ensembl
Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,993 		JBrowse link
T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:98,670,211...98,692,230 JBrowse link
G BCL3 BCL3 transcription coactivator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3621346|PMID:16081776) Ensembl
Ensembl
MGI		 PMID:16081776 GO_REF:0000107 MGI:3621346 NCBI chr 6:51,256,033...51,264,923
Ensembl chr 6:51,256,033...51,265,355 		JBrowse link
G BCL6 BCL6 transcription repressor acts_upstream_of
involved_in		 ISO
IEA		 (MGI:2450484|PMID:12594267) MGI
Ensembl		 PMID:12594267 GO_REF:0000107 MGI:2450484 NCBI chr13:125,377,247...125,401,328
Ensembl chr13:125,377,248...125,393,330 		JBrowse link
G GATA3 GATA binding protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:4838368|PMID:20706986) Ensembl
Ensembl
MGI		 PMID:20706986 GO_REF:0000107 MGI:4838368 NCBI chr10:63,367,684...63,397,977
Ensembl chr10:63,367,660...63,388,859 		JBrowse link
G HLX H2.0 like homeobox acts_upstream_of
involved_in		 ISO
IEA		 (MGI:3761239|PMID:16424184) MGI
Ensembl		 PMID:16424184 GO_REF:0000107 MGI:3761239 NCBI chr10:10,263,441...10,269,882
Ensembl chr10:10,264,244...10,275,855 		JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:21873635)
(MGI:4838368|PMID:20706986)		 GO_Central
GO_Central
MGI		 PMID:20706986 PMID:21873635 MGI:4838368 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of ISO (MGI:3761239|PMID:16424184) MGI PMID:16424184 MGI:3761239 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544 		JBrowse link
G IL6 interleukin 6 acts_upstream_of ISO (MGI:2450484|PMID:12594267) MGI PMID:12594267 MGI:2450484 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263 		JBrowse link
T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha acts_upstream_of_or_within ISO (MGI:61362|PMID:8434133) MGI PMID:8434133 MGI:61362 NCBI chr  X:61,972,544...62,110,058
Ensembl chr  X:61,972,874...62,110,058 		JBrowse link
G IL12B interleukin 12B involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,147,247...64,158,952 		JBrowse link
G PTGER4 prostaglandin E receptor 4 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr16:25,670,832...25,686,556
Ensembl chr16:25,670,862...25,686,552 		JBrowse link
G RORC RAR related orphan receptor C involved_in ISO (MGI:2686818|PMID:14691482) UniProt PMID:14691482 MGI:2686818 NCBI chr 4:97,374,672...97,399,017
Ensembl chr 4:97,375,136...97,400,231 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17268
    immune system process 2488
      leukocyte activation 993
        lymphocyte activation 815
          lymphocyte differentiation 449
            T cell differentiation 311
              T cell differentiation involved in immune response 77
                alpha-beta T cell differentiation involved in immune response + 70
                gamma-delta T cell differentiation involved in immune response 0
                memory T cell differentiation + 9
Path 2
Term Annotations click to browse term
  biological_process 17268
    developmental process 6613
      anatomical structure development 6166
        multicellular organism development 5265
          system development 4811
            immune system development 1114
              hematopoietic or lymphoid organ development 1047
                hemopoiesis 998
                  leukocyte differentiation 642
                    mononuclear cell differentiation 502
                      lymphocyte differentiation 449
                        T cell differentiation 311
                          T cell differentiation involved in immune response 77
                            alpha-beta T cell differentiation involved in immune response + 70
                            gamma-delta T cell differentiation involved in immune response 0
                            memory T cell differentiation + 9
paths to the root