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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
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Accession:GO:0002291 term browser browse the term
Definition:The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response.
Synonyms:exact_synonym: T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell


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T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein acts_upstream_of_or_within ISO (MGI:3714085|PMID:17403904) RGD PMID:17403904 MGI:3714085 NCBI chr17:84,941,404...85,033,020
Ensembl chr17:84,982,243...85,033,010 		JBrowse link
G Fgl2 fibrinogen-like 2 acts_upstream_of_or_within ISO MGI:3582343 (MGI:6188369|PMID:29341118) RGD PMID:29341118 MGI:6188369 NCBI chr 4:13,710,566...13,716,207
Ensembl chr 4:13,710,575...13,716,207 		JBrowse link
G Icam1 intercellular adhesion molecule 1 involved_in ISO (PMID:2477710) RGD PMID:2477710 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Itgal integrin subunit alpha L involved_in ISO (PMID:2477710) RGD PMID:2477710 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732 		JBrowse link
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:26492563) RGD PMID:26492563 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Lgals3 galectin 3 involved_in ISO (MGI:4355752|PMID:19706535) RGD PMID:19706535 MGI:4355752 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 Cd81 molecule involved_in ISS
ISO		 GO_REF:0000024
(MGI:1926561|PMID:11046035)
(PMID:8766544)		 UniProt
RGD		 PMID:8766544 PMID:11046035 GO_REF:0000024 MGI:1926561 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:16116184) RGD PMID:16116184 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G RT1-DMb RT1 class II, locus DMb involved_in ISO (PMID:8139689) RGD PMID:8139689 NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    immune system process 2730
      leukocyte activation 1025
        leukocyte activation involved in immune response 301
          lymphocyte activation involved in immune response 206
            T cell activation involved in immune response 110
              T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 9
                negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 2
                positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 3
                regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 5
Path 2
Term Annotations click to browse term
  biological_process 18734
    cellular process 17431
      cell activation 1172
        cell activation involved in immune response 305
          leukocyte activation involved in immune response 301
            lymphocyte activation involved in immune response 206
              T cell activation involved in immune response 110
                T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 9
                  negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 2
                  positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 3
                  regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 5
paths to the root