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ONTOLOGY REPORT - ANNOTATIONS


Term:T cell activation involved in immune response
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Accession:GO:0002286 term browser browse the term
Definition:The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
Synonyms:related_synonym: T cell activation during immune response;   T lymphocyte activation during immune response


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T cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07049134.3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 5:107,355,354...107,357,276 JBrowse link
G Cd74 CD74 molecule IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO (MGI:MGI:5544501|PMID:24310610) RGD PMID:24310610 MGI:MGI:5544501 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO
ISS
(MGI:MGI:4839888|PMID:19845798)
GO_REF:0000024
RGD
UniProt
PMID:19845798 GO_REF:0000024, MGI:MGI:4839888 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Ifna1 interferon, alpha 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:106,951,822...106,952,908
Ensembl chr 5:106,952,082...106,952,792
JBrowse link
G Ifna11 interferon alpha family, gene 11 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:107,504,741...107,505,783
Ensembl chr 5:107,504,879...107,505,454
JBrowse link
G Ifna16l1 interferon, alpha 16-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:107,446,898...107,447,636
Ensembl chr 5:107,447,061...107,447,636
JBrowse link
G Ifna2 interferon alpha 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:107,416,117...107,416,695
Ensembl chr 5:107,416,117...107,416,695
JBrowse link
G Ifna4 interferon, alpha 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:106,922,563...106,923,132
Ensembl chr 5:106,922,563...106,923,132
JBrowse link
G Ifna5 interferon, alpha 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:107,039,347...107,039,925
Ensembl chr 5:107,039,347...107,039,925
JBrowse link
G Ifnb1 interferon beta 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Ifne interferon, epsilon IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:107,232,651...107,235,943
Ensembl chr 5:107,233,230...107,233,799
JBrowse link
G Ifnk interferon kappa IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:50,631,217...50,634,142
Ensembl chr 5:50,631,217...50,634,142
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 ISO (PMID:17294403) RGD PMID:17294403 NCBI chr15:57,170,566...57,277,811
Ensembl chr15:57,221,292...57,277,811
JBrowse link
G LOC100911527 interferon alpha-12-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:87,328,395...87,328,946
Ensembl chr 5:87,354,042...87,354,596
JBrowse link
G LOC100912314 interferon alpha-1-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:107,369,378...107,370,443
Ensembl chr 5:107,504,879...107,505,454
Ensembl chr 5:107,504,879...107,505,454
JBrowse link
G LOC100912356 interferon alpha-1-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:107,387,566...107,388,182
Ensembl chr 5:107,387,613...107,388,182
JBrowse link
G Mdk midkine ISS
ISO
GO_REF:0000024
(MGI:MGI:5897914|PMID:28183532)
UniProt
RGD
PMID:28183532 GO_REF:0000024, MGI:MGI:5897914 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
JBrowse link
G Psen1 presenilin 1 ISO MGI:MGI:109284 (MGI:MGI:3760494|PMID:17698590) RGD PMID:17698590 MGI:MGI:3760494 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
G Psen2 presenilin 2 ISO MGI:MGI:1202717 (MGI:MGI:3760494|PMID:17698590) RGD PMID:17698590 MGI:MGI:3760494 NCBI chr13:98,513,600...98,539,347
Ensembl chr13:98,513,570...98,530,724
JBrowse link
G RGD1560539 similar to interferon alpha 8/6 precursor; IFNa8/6 (B6) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:87,353,750...87,354,699
Ensembl chr 5:87,354,042...87,354,596
JBrowse link
alpha-beta T cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100909797 RT1 class I histocompatibility antigen, AA alpha chain-like ISO MGI:MGI:3701255 (MGI:MGI:3700871|PMID:16476767) RGD PMID:16476767 MGI:MGI:3700871 NCBI chr20:3,242,236...3,253,995
Ensembl chr20:3,242,470...3,249,189
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:1,814,661...1,833,033
Ensembl chr20:1,814,661...1,818,800
JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin ISO
IBA
(PMID:17566017)
PMID:21873635
(MGI:MGI:4399030|PMID:14605368)
RGD PMID:14605368, PMID:17566017, PMID:21873635 MGI:MGI:4399030, RGD:13792537 NCBI chr 8:127,144,367...127,152,618
Ensembl chr 8:127,144,903...127,151,493
JBrowse link
G Ifng interferon gamma ISO (MGI:MGI:3829555|PMID:17277142) RGD PMID:17277142 MGI:MGI:3829555 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab27a RAB27A, member RAS oncogene family ISO MGI:MGI:1856656 (MGI:MGI:3653524|PMID:11266473) RGD PMID:11266473 MGI:MGI:3653524 NCBI chr 8:79,722,334...79,776,228
Ensembl chr 8:79,722,334...79,776,221
JBrowse link
G Stx11 syntaxin 11 ISO MGI:MGI:5461477 (MGI:MGI:5460953|PMID:23042080), (MGI:MGI:5471188|PMID:23190531) RGD PMID:23042080, PMID:23190531 MGI:MGI:5460953, MGI:MGI:5471188 NCBI chr 1:7,039,160...7,064,870
Ensembl chr 1:7,039,162...7,064,870
JBrowse link
memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tsc1 TSC complex subunit 1 ISO MGI:MGI:2656240 (MGI:MGI:5608813|PMID:25271321) RGD PMID:25271321 MGI:MGI:5608813 NCBI chr 3:7,219,955...7,269,063
Ensembl chr 3:7,237,192...7,265,145
JBrowse link
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 ISO
ISS
(PMID:18424730)
GO_REF:0000024
RGD
UniProt
PMID:18424730 GO_REF:0000024 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
negative regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgl2 fibrinogen-like 2 ISO MGI:MGI:3582343 (MGI:MGI:6188369|PMID:29341118) RGD PMID:29341118 MGI:MGI:6188369 NCBI chr 4:10,323,598...10,329,241
Ensembl chr 4:10,323,607...10,329,241
JBrowse link
G Ifnl1 interferon, lambda 1 ISO (PMID:19346497) RGD PMID:19346497 NCBI chr 1:85,252,103...85,253,635
Ensembl chr 1:85,252,103...85,253,635
JBrowse link
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 ISO (PMID:26492563) RGD PMID:26492563 NCBI chr10:31,561,838...31,590,624
Ensembl chr10:31,561,895...31,588,943
JBrowse link
G Lgals3 galectin 3 ISO (MGI:MGI:4355752|PMID:19706535) RGD PMID:19706535 MGI:MGI:4355752 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4r interleukin 4 receptor ISO MGI:MGI:96109 (MGI:MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:MGI:3761239 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Jak3 Janus kinase 3 ISO
ISS
(MGI:MGI:3719947|PMID:16020505)
GO_REF:0000024
RGD
BHF-UCL
PMID:16020505 GO_REF:0000024, MGI:MGI:3719947 NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668
JBrowse link
G Tnfsf4 TNF superfamily member 4 ISO (MGI:MGI:4942267|PMID:9670042) RGD PMID:9670042 MGI:MGI:4942267 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 ISO (PMID:23169781) RGD PMID:23169781 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Il2 interleukin 2 ISO RNAcentral:URS000039ED8D_10090 (MGI:MGI:5634593|PMID:25642768) RGD PMID:25642768 MGI:MGI:5634593 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 ISO
IBA
(MGI:MGI:3817792|PMID:18792410)
PMID:21873635
RGD PMID:18792410, PMID:21873635 MGI:MGI:3817792, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 ISO (MGI:MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:MGI:6142401 NCBI chr13:78,723,028...78,794,663
Ensembl chr13:78,722,763...78,789,266
JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 ISO (MGI:MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:MGI:6142401 NCBI chr 3:21,621,976...21,676,789
Ensembl chr 3:21,623,041...21,670,014
JBrowse link
G Smad7 SMAD family member 7 IEA
ISO
GO_REF:0000107
(MGI:MGI:5634593|PMID:25642768)
Ensembl
RGD
PMID:25642768 GO_REF:0000107, MGI:MGI:5634593 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Tbx21 T-box transcription factor 21 ISO (MGI:MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:MGI:4868293 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B ISO MGI:MGI:3530739 (MGI:MGI:5450776|PMID:23034280) RGD PMID:23034280 MGI:MGI:5450776 NCBI chr 2:188,704,989...188,719,674
Ensembl chr 2:188,704,687...188,718,704
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A ISS
ISO
GO_REF:0000024
(MGI:MGI:6142401|PMID:25282160)
UniProt
RGD
PMID:25282160 GO_REF:0000024, MGI:MGI:6142401 NCBI chr 5:143,111,342...143,120,131
Ensembl chr 5:143,111,074...143,120,165
JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase-like 3 ISO (MGI:MGI:5825383|PMID:28065600) RGD PMID:28065600 MGI:MGI:5825383 NCBI chr 4:113,866,782...113,883,713
Ensembl chr 4:113,866,804...113,883,477
JBrowse link
G Tbx21 T-box transcription factor 21 ISO (MGI:MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:MGI:4868293 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
JBrowse link
G Tnfsf18 TNF superfamily member 18 ISO (MGI:MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:MGI:5551556 NCBI chr13:79,378,412...79,388,687
Ensembl chr13:79,378,733...79,388,498
JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 ISO
IBA
ISS
(PMID:17008549)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:17008549, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Bcl6 BCL6, transcription repressor ISO MGI:MGI:96559 (MGI:MGI:2450484|PMID:12594267) RGD PMID:12594267 MGI:MGI:2450484 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Hlx H2.0-like homeobox ISO MGI:MGI:105367|MGI:MGI:2182089 (MGI:MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:MGI:3761239 NCBI chr13:102,637,967...102,643,376
Ensembl chr13:102,637,769...102,643,223
JBrowse link
G Socs5 suppressor of cytokine signaling 5 ISO (MGI:MGI:3687909|PMID:12242343) RGD PMID:12242343 MGI:MGI:3687909 NCBI chr 6:10,671,311...10,705,610
Ensembl chr 6:10,674,371...10,704,977
JBrowse link
G Zfp35 zinc finger protein 35 ISO MGI:MGI:4398896 (MGI:MGI:4366385|PMID:19783676) RGD PMID:19783676 MGI:MGI:4366385 NCBI chr18:15,883,182...15,898,803
Ensembl chr18:15,883,182...15,898,821
JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rc3h1 ring finger and CCCH-type domains 1 ISO MGI:MGI:3581675 (MGI:MGI:3580753|PMID:15917799) RGD PMID:15917799 MGI:MGI:3580753 NCBI chr13:78,723,028...78,794,663
Ensembl chr13:78,722,763...78,789,266
JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma ISO (PMID:20209097) RGD PMID:20209097 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Lgals9 galectin 9 ISO (PMID:20209097) RGD PMID:20209097 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
positive regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule ISO (PMID:12540904) RGD PMID:12540904 NCBI chr13:113,786,525...113,818,741
Ensembl chr13:113,787,349...113,817,995
JBrowse link
G Il23a interleukin 23 subunit alpha ISO (MGI:MGI:3027369|PMID:14688363) RGD PMID:14688363 MGI:MGI:3027369 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 ISS
ISO
GO_REF:0000024
(MGI:MGI:6119963|PMID:29230018)
UniProt
RGD
PMID:29230018 GO_REF:0000024, MGI:MGI:6119963 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Tnfsf4 TNF superfamily member 4 ISO (MGI:MGI:3806904|PMID:18713990) RGD PMID:18713990 MGI:MGI:3806904 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 Cd81 molecule ISS
ISO
IEA
GO_REF:0000024
(MGI:MGI:1926561|PMID:11046035)
(PMID:8766544)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:8766544, PMID:11046035 GO_REF:0000024, GO_REF:0000107, MGI:MGI:1926561 NCBI chr 1:216,237,663...216,253,460
Ensembl chr 1:216,237,697...216,253,311
JBrowse link
G Lgals9 galectin 9 ISO (PMID:16116184) RGD PMID:16116184 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G RT1-DMb RT1 class II, locus DMb ISO (PMID:8139689) RGD PMID:8139689 NCBI chr20:3,945,383...3,952,838
Ensembl chr20:5,227,045...5,234,290
JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 ISO
IBA
ISS
(PMID:17008549)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:17008549, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 ISO (MGI:MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:MGI:3576832 NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017
JBrowse link
G Hlx H2.0-like homeobox ISO MGI:MGI:105367|MGI:MGI:2182089 (MGI:MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:MGI:3761239 NCBI chr13:102,637,967...102,643,376
Ensembl chr13:102,637,769...102,643,223
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 ISO MGI:MGI:2446070 (MGI:MGI:2176424|PMID:11894097) RGD PMID:11894097 MGI:MGI:2176424 NCBI chr 5:29,838,713...29,870,390
Ensembl chr 5:29,838,747...29,870,735
JBrowse link
G Socs5 suppressor of cytokine signaling 5 ISO (MGI:MGI:3687909|PMID:12242343) RGD PMID:12242343 MGI:MGI:3687909 NCBI chr 6:10,671,311...10,705,610
Ensembl chr 6:10,674,371...10,704,977
JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase ISO (MGI:MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:MGI:6142401 NCBI chr18:61,108,712...61,162,446
Ensembl chr18:61,109,069...61,162,445
JBrowse link
G Mir326 microRNA 326 ISO (MGI:MGI:4436838|PMID:19838199) RGD PMID:19838199 MGI:MGI:4436838 NCBI chr 1:164,518,401...164,518,495
Ensembl chr 1:164,518,401...164,518,495
JBrowse link
G Nfkbid NFKB inhibitor delta ISO (MGI:MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:MGI:6142401 NCBI chr 1:88,883,816...88,892,543
Ensembl chr 1:88,885,937...88,892,615
JBrowse link
G Nfkbiz NFKB inhibitor zeta ISO (MGI:MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:MGI:6142401 NCBI chr11:47,243,342...47,271,487
Ensembl chr11:47,243,342...47,271,487
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO (MGI:MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:MGI:5689221 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il23a interleukin 23 subunit alpha ISO
IBA
(MGI:MGI:3851279|PMID:19501566)
PMID:21873635
RGD PMID:19501566, PMID:21873635 MGI:MGI:3851279, RGD:13792537 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 ISO
IEA
(MGI:MGI:3608083|PMID:12829194)
GO_REF:0000107
RGD
Ensembl
PMID:12829194 GO_REF:0000107, MGI:MGI:3608083 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il4r interleukin 4 receptor ISO MGI:MGI:96109 (MGI:MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:MGI:3761239 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il6 interleukin 6 ISO (MGI:MGI:2450484|PMID:12594267) RGD PMID:12594267 MGI:MGI:2450484 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO (MGI:MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:MGI:5689221 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Prkcz protein kinase C, zeta ISO
ISS
(MGI:MGI:3584076|PMID:15987782)
GO_REF:0000024
RGD
UniProt
PMID:15987782 GO_REF:0000024, MGI:MGI:3584076 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Rara retinoic acid receptor, alpha ISO (PMID:18416830) RGD PMID:18416830 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Tnfsf4 TNF superfamily member 4 ISO (MGI:MGI:4943387|PMID:18354165) RGD PMID:18354165 MGI:MGI:4943387 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myb MYB proto-oncogene, transcription factor ISO (PMID:20484083) RGD PMID:20484083 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Shb SH2 domain containing adaptor protein B ISO MGI:MGI:3721903 (MGI:MGI:5617929|PMID:24645804) RGD PMID:24645804 MGI:MGI:5617929 NCBI chr 5:60,970,650...61,077,881
Ensembl chr 5:60,971,257...61,077,627
JBrowse link
regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor ISO MGI:MGI:2158436 (MGI:MGI:3051162|PMID:15240675) RGD PMID:15240675 MGI:MGI:3051162 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il27 interleukin 27 ISO
IBA
(PMID:12734330)
PMID:21873635
RGD PMID:12734330, PMID:21873635 RGD:13792537 NCBI chr 1:198,003,615...198,010,112
Ensembl chr 1:198,003,683...198,008,893
JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 NOT ISO (MGI:MGI:3820359|PMID:19050256) RGD PMID:19050256 MGI:MGI:3820359 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 NOT ISO (MGI:MGI:3820359|PMID:19050256) RGD PMID:19050256 MGI:MGI:3820359 NCBI chr 1:53,063,380...53,087,519
Ensembl chr 1:53,065,025...53,087,474
JBrowse link
G Mir301a microRNA 301a ISO (MGI:MGI:5426073|PMID:22517757) RGD PMID:22517757 MGI:MGI:5426073 NCBI chr10:74,417,746...74,417,845
Ensembl chr10:74,417,746...74,417,845
JBrowse link
regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il12rb2 interleukin 12 receptor subunit beta 2 NAS RGD PMID:10651948 RGD:1331512 NCBI chr 4:98,049,195...98,141,562
Ensembl chr 4:98,052,842...98,141,482
JBrowse link
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein ISO (MGI:MGI:3714085|PMID:17403904) RGD PMID:17403904 MGI:MGI:3714085 NCBI chr17:90,098,953...90,149,192
Ensembl chr17:90,099,025...90,149,894
JBrowse link
G Fgl2 fibrinogen-like 2 ISO MGI:MGI:3582343 (MGI:MGI:6188369|PMID:29341118) RGD PMID:29341118 MGI:MGI:6188369 NCBI chr 4:10,323,598...10,329,241
Ensembl chr 4:10,323,607...10,329,241
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO (PMID:2477710) RGD PMID:2477710 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Itgal integrin subunit alpha L ISO (PMID:2477710) RGD PMID:2477710 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec4d C-type lectin domain family 4, member D ISO (MGI:MGI:5525050|PMID:23602766) RGD PMID:23602766 MGI:MGI:5525050 NCBI chr 4:156,253,084...156,264,766
Ensembl chr 4:156,253,079...156,264,769
JBrowse link
G Clec4e C-type lectin domain family 4, member E ISO
IEA
MGI:MGI:5013826 (MGI:MGI:5525050|PMID:23602766)
GO_REF:0000107
RGD
Ensembl
PMID:23602766 GO_REF:0000107, MGI:MGI:5525050 NCBI chr 4:156,271,087...156,276,243
Ensembl chr 4:156,270,920...156,276,304
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig ISO
IBA
MGI:MGI:2384004 (MGI:MGI:5525050|PMID:23602766)
PMID:21873635
RGD PMID:23602766, PMID:21873635 MGI:MGI:5525050, RGD:13792537 NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326
JBrowse link
G Sema4a semaphorin 4A ISO (MGI:MGI:3574161|PMID:15780988) RGD PMID:15780988 MGI:MGI:3574161 NCBI chr 2:187,799,568...187,823,014
Ensembl chr 2:187,799,568...187,822,997
JBrowse link
T cell proliferation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule IEP RGD PMID:20500684 RGD:4892204 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G LOC100911372 40S ribosomal protein S6-like IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 5:105,209,844...105,212,791
Ensembl chr 5:105,209,846...105,212,173
JBrowse link
G Rps6 ribosomal protein S6 ISO
IEA
MGI:MGI:2387471|MGI:MGI:98834 (MGI:MGI:3610868|PMID:16357222)
GO_REF:0000107
RGD
Ensembl
PMID:16357222 GO_REF:0000107, MGI:MGI:3610868 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Slc11a1 solute carrier family 11 member 1 ISO
IEA
MGI:MGI:1857755 (MGI:MGI:86848|PMID:9176118)
GO_REF:0000107
RGD
Ensembl
PMID:9176118 GO_REF:0000107, MGI:MGI:86848 NCBI chr 9:81,655,590...81,666,697
Ensembl chr 9:81,655,629...81,666,706
JBrowse link
G Tnfsf18 TNF superfamily member 18 ISO
IBA
(MGI:MGI:2682525|PMID:14608036)
PMID:21873635
RGD PMID:14608036, PMID:21873635 MGI:MGI:2682525, RGD:13792537 NCBI chr13:79,378,412...79,388,687
Ensembl chr13:79,378,733...79,388,498
JBrowse link
G Tp53 tumor protein p53 ISO MGI:MGI:98159 (MGI:MGI:3610868|PMID:16357222) RGD PMID:16357222 MGI:MGI:3610868 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
T follicular helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp1 forkhead box P1 ISO (MGI:MGI:5607369|PMID:24859450) RGD PMID:24859450 MGI:MGI:5607369 NCBI chr 4:131,362,178...131,963,466
Ensembl chr 4:131,366,744...131,694,755
JBrowse link
G Gpr183 G protein-coupled receptor 183 ISO
ISS
(MGI:MGI:5787848|PMID:27147029)
GO_REF:0000024
RGD
UniProt
PMID:27147029 GO_REF:0000024, MGI:MGI:5787848 NCBI chr15:108,364,701...108,376,221
Ensembl chr15:108,364,701...108,376,221
JBrowse link
G Il21 interleukin 21 ISS
ISO
GO_REF:0000024
(MGI:MGI:5450752|PMID:23045607)
UniProt
RGD
PMID:23045607 GO_REF:0000024, MGI:MGI:5450752 NCBI chr 2:123,965,021...123,972,356
Ensembl chr 2:123,965,021...123,972,356
JBrowse link
G Il6 interleukin 6 ISS
ISO
GO_REF:0000024
(MGI:MGI:5450752|PMID:23045607)
UniProt
RGD
PMID:23045607 GO_REF:0000024, MGI:MGI:5450752 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 ISO MGI:MGI:2442789 (MGI:MGI:5486592|PMID:23583643) RGD PMID:23583643 MGI:MGI:5486592 NCBI chr13:78,723,028...78,794,663
Ensembl chr13:78,722,763...78,789,266
JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 ISO MGI:MGI:2685397 (MGI:MGI:5486592|PMID:23583643) RGD PMID:23583643 MGI:MGI:5486592 NCBI chr 3:21,621,976...21,676,789
Ensembl chr 3:21,623,041...21,670,014
JBrowse link
T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb1 high mobility group box 1 ISO (PMID:15944249) RGD PMID:15944249 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Il18r1 interleukin 18 receptor 1 ISO MGI:MGI:2136765 (MGI:MGI:2136797|PMID:10227969) RGD PMID:10227969 MGI:MGI:2136797 NCBI chr 9:47,184,404...47,217,403
Ensembl chr 9:47,185,443...47,219,175
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 IEA
ISO
GO_REF:0000107
(MGI:MGI:4834989|PMID:18579517)
Ensembl
RGD
PMID:18579517 GO_REF:0000107, MGI:MGI:4834989 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit ISO MGI:MGI:2179545 (MGI:MGI:3621346|PMID:16081776) RGD PMID:16081776 MGI:MGI:3621346 NCBI chr 1:80,517,081...80,545,019
Ensembl chr 1:80,517,411...80,544,825
JBrowse link
G Sema4a semaphorin 4A ISO (MGI:MGI:3574161|PMID:15780988) RGD PMID:15780988 MGI:MGI:3574161 NCBI chr 2:187,799,568...187,823,014
Ensembl chr 2:187,799,568...187,822,997
JBrowse link
G Tmem98 transmembrane protein 98 ISS
ISO
GO_REF:0000024
(MGI:MGI:6294180|PMID:25946230)
UniProt
RGD
PMID:25946230 GO_REF:0000024, MGI:MGI:6294180 NCBI chr10:68,173,380...68,184,289
Ensembl chr10:68,173,369...68,184,320
JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 ISO MGI:MGI:103034 (MGI:MGI:4838368|PMID:20706986) RGD PMID:20706986 MGI:MGI:4838368 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO (MGI:MGI:5788050|PMID:26410627) RGD PMID:26410627 MGI:MGI:5788050 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Spn sialophorin ISS
ISO
GO_REF:0000024
(PMID:18036228)
UniProt
RGD
PMID:18036228 GO_REF:0000024 NCBI chr 1:198,572,999...198,585,664
Ensembl chr 1:198,572,999...198,577,226
JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO MGI:MGI:96556 (MGI:MGI:4838368|PMID:20706986) RGD PMID:20706986 MGI:MGI:4838368 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor ISS
ISO
GO_REF:0000024
(MGI:MGI:4456325|PMID:20421391), (MGI:MGI:5004732|PMID:21572431)
UniProt
RGD
PMID:20421391, PMID:21572431 GO_REF:0000024, MGI:MGI:4456325, MGI:MGI:5004732 NCBI chr 6:109,562,415...109,584,541
Ensembl chr 6:109,562,587...109,584,545
JBrowse link
G Rora RAR-related orphan receptor A ISO (MGI:MGI:3772713|PMID:18164222) RGD PMID:18164222 MGI:MGI:3772713 NCBI chr 8:75,515,886...75,616,477
Ensembl chr 8:75,516,904...75,607,212
JBrowse link
G Rorc RAR-related orphan receptor C ISO (MGI:MGI:3692468|PMID:16990136), (MGI:MGI:3772713|PMID:18164222), (MGI:MGI:3817792|PMID:18792410) RGD PMID:16990136, PMID:18164222, PMID:18792410 MGI:MGI:3692468, MGI:MGI:3772713, MGI:MGI:3817792 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor ISS
ISO
GO_REF:0000024
(MGI:MGI:3851267|PMID:19578362), (MGI:MGI:5448096|PMID:22983707)
UniProt
RGD
PMID:19578362, PMID:22983707 GO_REF:0000024, MGI:MGI:3851267, MGI:MGI:5448096 NCBI chr 6:109,562,415...109,584,541
Ensembl chr 6:109,562,587...109,584,545
JBrowse link
G Il6 interleukin 6 ISS
ISO
GO_REF:0000024
(MGI:MGI:3692468|PMID:16990136), (MGI:MGI:6142555|PMID:27893700)
UniProt
RGD
PMID:16990136, PMID:27893700 GO_REF:0000024, MGI:MGI:3692468, MGI:MGI:6142555 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:MGI:6142555|PMID:27893700)
UniProt
Ensembl
RGD
PMID:27893700 GO_REF:0000024, GO_REF:0000107, MGI:MGI:6142555 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Irf4 interferon regulatory factor 4 ISO (MGI:MGI:5448096|PMID:22983707) RGD PMID:22983707 MGI:MGI:5448096 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117
JBrowse link
G Ly9 lymphocyte antigen 9 ISO (PMID:22184727) RGD PMID:22184727 NCBI chr13:90,002,779...90,022,346
Ensembl chr13:90,002,783...90,022,269
JBrowse link
G Otud5 OTU deubiquitinase 5 ISO MGI:MGI:2386448|MGI:MGI:5752247 (MGI:MGI:5621075|PMID:25470037) RGD PMID:25470037 MGI:MGI:5621075 NCBI chr  X:15,471,212...15,504,372
Ensembl chr  X:15,471,211...15,504,165
JBrowse link
G Slamf6 SLAM family member 6 ISO (PMID:22184727) RGD PMID:22184727 NCBI chr13:90,300,160...90,321,781
Ensembl chr13:90,301,006...90,322,457
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO
ISS
(MGI:MGI:5825383|PMID:28065600)
GO_REF:0000024
RGD
UniProt
PMID:28065600 GO_REF:0000024, MGI:MGI:5825383 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor ISS
ISO
GO_REF:0000024
(MGI:MGI:4456325|PMID:20421391), (MGI:MGI:5004732|PMID:21572431)
UniProt
RGD
PMID:20421391, PMID:21572431 GO_REF:0000024, MGI:MGI:4456325, MGI:MGI:5004732 NCBI chr 6:109,562,415...109,584,541
Ensembl chr 6:109,562,587...109,584,545
JBrowse link
G Bcl3 BCL3, transcription coactivator ISO MGI:MGI:2158443 (MGI:MGI:3621346|PMID:16081776) RGD PMID:16081776 MGI:MGI:3621346 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Gata3 GATA binding protein 3 ISO (MGI:MGI:4838368|PMID:20706986) RGD PMID:20706986 MGI:MGI:4838368 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Il4 interleukin 4 ISO
IBA
(MGI:MGI:4838368|PMID:20706986)
PMID:21873635
RGD PMID:20706986, PMID:21873635 MGI:MGI:4838368, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha ISO MGI:MGI:1856466 (MGI:MGI:61362|PMID:8434133) RGD PMID:8434133 MGI:MGI:61362 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Il12b interleukin 12B ISO (PMID:1673147) RGD PMID:1673147 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Ptger4 prostaglandin E receptor 4 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:4353445|PMID:19465928)
Ensembl
UniProt
RGD
PMID:19465928 GO_REF:0000024, GO_REF:0000107, MGI:MGI:4353445 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Rorc RAR-related orphan receptor C ISO (MGI:MGI:2686818|PMID:14691482) RGD PMID:14691482 MGI:MGI:2686818 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    immune system process 2843
      leukocyte activation 1060
        leukocyte activation involved in immune response 294
          lymphocyte activation involved in immune response 200
            T cell activation involved in immune response 113
              T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 9
              T cell differentiation involved in immune response + 75
              T cell proliferation involved in immune response + 6
              alpha-beta T cell activation involved in immune response + 69
              cytotoxic T cell degranulation + 3
              gamma-delta T cell activation involved in immune response + 0
Path 2
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cell activation 1199
        cell activation involved in immune response 299
          leukocyte activation involved in immune response 294
            lymphocyte activation involved in immune response 200
              T cell activation involved in immune response 113
                T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 9
                T cell differentiation involved in immune response + 75
                T cell proliferation involved in immune response + 6
                alpha-beta T cell activation involved in immune response + 69
                cytotoxic T cell degranulation + 3
                gamma-delta T cell activation involved in immune response + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.