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ONTOLOGY REPORT - ANNOTATIONS

Term:leukocyte activation involved in inflammatory response
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Accession:GO:0002269 term browser browse the term
Definition:A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response.
Synonyms:related_synonym: immune cell activation during inflammatory response;   leukocyte activation during inflammatory response


show annotations for term's descendants           Sort by:
leukocyte activation involved in inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO MGI:2385534 (PMID:29259245) RGD PMID:29259245 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor acts_upstream_of_or_within ISO
IEA 		MGI:104696 (PMID:22419116)
GO_REF:0000107 		RGD
Ensembl		 PMID:22419116 GO_REF:0000107 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta acts_upstream_of_or_within ISO MGI:108005 (PMID:22419116) RGD PMID:22419116 NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451 		JBrowse link
G Traf3ip2 Traf3 interacting protein 2 involved_in ISO MGI:3510784 (PMID:20303295) RGD PMID:20303295 NCBI chr20:44,565,992...44,609,240
Ensembl chr20:43,011,450...43,054,667 		JBrowse link
microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in ISO
IEA 		UniProtKB:P05067 (PMID:15457210)
UniProtKB:P05067 (PMID:22406537)
GO_REF:0000107 		RGD
Ensembl		 PMID:15457210 PMID:22406537 GO_REF:0000107 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G App amyloid beta precursor protein involved_in ISO
IEA 		UniProtKB:Q15109|UniProtKB:Q62151 (PMID:15457210), (PMID:22406537)
GO_REF:0000107
(PMID:18723082) 		RGD
Ensembl		 PMID:15457210 PMID:18723082 PMID:22406537 GO_REF:0000107 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G C1qa complement C1q A chain involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:15269255) RGD PMID:15269255 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C5ar1 complement C5a receptor 1 involved_in ISO UniProtKB:P05067 (PMID:19561098) RGD PMID:19561098 NCBI chr 1:76,948,622...76,959,826 JBrowse link
G Casp1 caspase 1 IMP RGD PMID:15149850 RGD:2315925 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Clu clusterin involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:15857407) 		Alzheimers_University_of_Toronto
Ensembl
RGD		 PMID:15857407 GO_REF:0000024 GO_REF:0000107 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Csf1r colony stimulating factor 1 receptor IMP RGD PMID:33841088 RGD:151665762 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 involved_in IDA PMID:11870871 RGD
ARUK-UCL		 PMID:20018408 PMID:11870871 RGD:9491804, RGD:4892001 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IMP RGD PMID:24447880 RGD:9491776 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Fpr2 formyl peptide receptor 2 involved_in IGI PMID:18723082 ARUK-UCL PMID:18723082 RGD:12910993 NCBI chr 1:58,776,592...58,785,227
Ensembl chr 1:58,776,752...58,786,019 		JBrowse link
G Ifng interferon gamma involved_in ISO
IGI 		ComplexPortal:CPX-1062|UniProtKB:P05067|UniProtKB:P10636|UniProtKB:P49768 (PMID:19808651), (PMID:7715705)
ComplexPortal:CPX-1062|UniProtKB:P05067|UniProtKB:P49768 (PMID:20368278), (PMID:26227742), (PMID:7715705)
PMID:27094552 		RGD PMID:7715705 PMID:19808651 PMID:20368278 PMID:26227742 PMID:27094552 RGD:14397550 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO UniProtKB:P05067 (PMID:17255335) RGD PMID:17255335 NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785 		JBrowse link
G Ifngr2 interferon gamma receptor 2 involved_in IGI PMID:27094552 ARUK-UCL PMID:27094552 RGD:14397550 NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005 		JBrowse link
G Il13 interleukin 13 IMP RGD PMID:19752235 RGD:8549634 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il4 interleukin 4 IDA RGD PMID:23786632 RGD:8142387 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Itgam integrin subunit alpha M involved_in ISO (PMID:18981141) RGD PMID:18981141 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Jak2 Janus kinase 2 involved_in ISO
IEA 		UniProtKB:P01580 (PMID:26227742)
GO_REF:0000107 		RGD
Ensembl		 PMID:26227742 GO_REF:0000107 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit acts_upstream_of_or_within ISO
IEA 		MGI:2445420 (PMID:15233917)
GO_REF:0000107 		RGD
Ensembl		 PMID:15233917 GO_REF:0000107 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 acts_upstream_of_or_within ISO
IEA 		MGI:3720053 (PMID:29540778)
GO_REF:0000107 		RGD
Ensembl		 PMID:29540778 GO_REF:0000107 NCBI chr 4:177,240,692...177,246,548
Ensembl chr 4:175,508,912...175,515,603 		JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase acts_upstream_of_or_within ISO
IEA 		MGI:1934018 (PMID:26607664)
GO_REF:0000107 		RGD
Ensembl		 PMID:26607664 GO_REF:0000107 NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase IMP RGD PMID:28528966 RGD:13781879 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G P2ry1 purinergic receptor P2Y1 NOT|involved_in IMP PMID:11245682 ARUK-UCL PMID:11245682 RGD:13673788 NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457 		JBrowse link
G P2ry2 purinergic receptor P2Y2 NOT|involved_in IMP PMID:11245682 ARUK-UCL PMID:11245682 RGD:13673788 NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632 		JBrowse link
G Snca synuclein alpha acts_upstream_of_or_within ISO
IEA 		MGI:2389489 (PMID:17035541)
GO_REF:0000107 		RGD
Ensembl		 PMID:17035541 GO_REF:0000107 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Tlr1 toll-like receptor 1 IDA RGD PMID:16973131 RGD:1643119 NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125 		JBrowse link
G Tlr2 toll-like receptor 2 IDA RGD PMID:16973131 RGD:1643119 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr3 toll-like receptor 3 IDA RGD PMID:16973131 RGD:1643119 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tlr4 toll-like receptor 4 IDA RGD PMID:16973131 RGD:1643119 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr6 toll-like receptor 6 IDA RGD PMID:16973131 RGD:1643119 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685 		JBrowse link
G Tlr9 toll-like receptor 9 IDA RGD PMID:16973131 RGD:1643119 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:22950459) RGD PMID:22950459 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO ComplexPortal:CPX-1120|UniProtKB:P10636 (PMID:28592261), (PMID:28802038), (PMID:29073081), (PMID:29518356), (PMID:29663649) RGD PMID:28592261 PMID:28802038 PMID:29073081 PMID:29518356 PMID:29663649 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP RGD PMID:19385063 RGD:2316194 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
microglial cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cx3cr1 C-X3-C motif chemokine receptor 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:16732273) 		UniProt
RGD		 PMID:16732273 GO_REF:0000024 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Grn granulin precursor involved_in ISS
ISO 		GO_REF:0000024
(PMID:20026663) 		UniProt
RGD		 PMID:20026663 GO_REF:0000024 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Il33 interleukin 33 involved_in ISO (PMID:21349253) RGD PMID:21349253 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:30232263) RGD PMID:30232263 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in IBA
ISO 		GO_REF:0000033
(PMID:25690660) 		GO_Central
RGD		 PMID:25690660 GO_REF:0000033 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848 		JBrowse link
negative regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cst7 cystatin F involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
MGI:5910746 (PMID:28251676) 		GO_Central
RGD		 PMID:28251676 GO_REF:0000033 NCBI chr 3:139,396,830...139,405,557
Ensembl chr 3:139,396,850...139,405,557 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 involved_in IDA PMID:19627440 ARUK-UCL PMID:19627440 RGD:13673772 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Grn granulin precursor involved_in ISS
ISO 		GO_REF:0000024
(PMID:23041626) 		UniProt
RGD		 PMID:23041626 GO_REF:0000024 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:P05067|UniProtKB:P49768 (PMID:20005821) 		Ensembl
RGD		 PMID:20005821 GO_REF:0000107 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:30792350)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:30792350 GO_REF:0000024 GO_REF:0000107 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO RNAcentral:URS000024A59E_10090 (PMID:30412727) RGD PMID:30412727 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Syt11 synaptotagmin 11 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:28686317)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:28686317 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964 		JBrowse link
G Tafa3 TAFA chemokine like family member 3 involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
(PMID:25595455) 		GO_Central
RGD		 PMID:25595455 GO_REF:0000033 NCBI chr 2:192,264,153...192,280,356
Ensembl chr 2:192,267,093...192,274,019 		JBrowse link
positive regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsc cathepsin C acts_upstream_of_or_within ISO
IEA 		(PMID:28251676)
GO_REF:0000107 		RGD
Ensembl		 PMID:28251676 GO_REF:0000107 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 IMP RGD PMID:21750563 RGD:329955444 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 IMP RGD PMID:22302802 RGD:13462052 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Mmp8 matrix metallopeptidase 8 acts_upstream_of ISO
IEA 		(PMID:25049354)
GO_REF:0000107 		RGD
Ensembl		 PMID:25049354 GO_REF:0000107 NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520 		JBrowse link
G Stap1 signal transducing adaptor family member 1 involved_in ISO (PMID:19100238) RGD PMID:19100238 NCBI chr14:21,950,466...21,981,395
Ensembl chr14:21,952,496...21,981,245 		JBrowse link
G Tafa3 TAFA chemokine like family member 3 involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
(PMID:25595455) 		GO_Central
RGD		 PMID:25595455 GO_REF:0000033 NCBI chr 2:192,264,153...192,280,356
Ensembl chr 2:192,267,093...192,274,019 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO
IBA
IEA 		(PMID:24990881)
GO_REF:0000033
(PMID:24990881), (PMID:25631124), (PMID:29752066), (PMID:30617257), (PMID:31370707)
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:24990881 PMID:25631124 PMID:29752066 PMID:30617257 PMID:31370707 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Ttbk1 tau tubulin kinase 1 involved_in ISO
IEA 		(PMID:19118186)
GO_REF:0000107 		RGD
Ensembl		 PMID:19118186 GO_REF:0000107 NCBI chr 9:14,493,166...14,538,372
Ensembl chr 9:14,493,389...14,535,774 		JBrowse link
regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP RGD PMID:28007901 RGD:12879399 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Calhm2 calcium homeostasis modulator family member 2 involved_in ISS
ISO 		GO_REF:0000024
(PMID:34433553) 		UniProt
RGD		 PMID:34433553 GO_REF:0000024 NCBI chr 1:246,022,324...246,028,050
Ensembl chr 1:246,022,324...246,028,218 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 IMP rat gene in mouse model RGD PMID:17473852 RGD:5688754 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:29662056) 		UniProt
RGD		 PMID:29662056 GO_REF:0000024 NCBI chr10:102,257,413...102,263,086
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    immune system process 3133
      leukocyte activation 1084
        leukocyte activation involved in inflammatory response 56
          microglial cell activation + 52
Path 2
Term Annotations click to browse term
  biological_process 20543
    response to stimulus 11082
      response to stress 4353
        defense response 1954
          inflammatory response 902
            leukocyte activation involved in inflammatory response 56
              microglial cell activation + 52
paths to the root