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ONTOLOGY REPORT - ANNOTATIONS


Term:leukocyte activation involved in inflammatory response
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Accession:GO:0002269 term browser browse the term
Definition:A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response.
Synonyms:related_synonym: immune cell activation during inflammatory response;   leukocyte activation during inflammatory response



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leukocyte activation involved in inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO MGI:2385534 (MGI:6407632|PMID:29259245) RGD PMID:29259245 MGI:6407632 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor acts_upstream_of_or_within ISO MGI:104696 (MGI:6478086|PMID:22419116) RGD PMID:22419116 MGI:6478086 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:108005 (MGI:6478086|PMID:22419116)
Ensembl
RGD
PMID:22419116 GO_REF:0000107 MGI:6478086 NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451
JBrowse link
G Traf3ip2 Traf3 interacting protein 2 involved_in ISO MGI:3510784 (MGI:4440789|PMID:20303295) RGD PMID:20303295 MGI:4440789 NCBI chr20:43,011,405...43,054,654
Ensembl chr20:43,011,450...43,054,667
JBrowse link
microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in ISO UniProtKB:P05067 (PMID:15457210)
UniProtKB:P05067 (MGI:5424311|PMID:22406537)
RGD PMID:15457210 PMID:22406537 MGI:5424311 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G App amyloid beta precursor protein involved_in ISO UniProtKB:F1M670 (PMID:18723082)
UniProtKB:Q15109|UniProtKB:Q62151 (PMID:15457210), (PMID:22406537)
RGD PMID:15457210 PMID:18723082 PMID:22406537 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G C1qa complement C1q A chain involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (MGI:3607035|PMID:15269255) RGD PMID:15269255 MGI:3607035 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
JBrowse link
G C5ar1 complement C5a receptor 1 involved_in ISO UniProtKB:P05067 (MGI:4354701|PMID:19561098) RGD PMID:19561098 MGI:4354701 NCBI chr 1:76,948,622...76,959,826 JBrowse link
G Casp1 caspase 1 IMP RGD PMID:15149850 RGD:2315925 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Clu clusterin involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:15857407)
Alzheimers_University_of_Toronto
Ensembl
RGD
PMID:15857407 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Csf1r colony stimulating factor 1 receptor IMP RGD PMID:33841088 RGD:151665762 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 involved_in IDA PMID:11870871 RGD
ARUK-UCL
PMID:20018408 PMID:11870871 RGD:9491804, RGD:4892001 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IMP RGD PMID:24447880 RGD:9491776 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014
JBrowse link
G Ifng interferon gamma involved_in ISO
IGI
ComplexPortal:CPX-1062|UniProtKB:P05067|UniProtKB:P10636|UniProtKB:P49768 (PMID:19808651), (PMID:7715705)
ComplexPortal:CPX-1062|UniProtKB:P05067|UniProtKB:P49768 (MGI:4454469|PMID:20368278), (MGI:5776417|PMID:26227742), (MGI:6305053|PMID:7715705)
PMID:27094552
RGD PMID:7715705 PMID:19808651 PMID:20368278 PMID:26227742 PMID:27094552 MGI:4454469 MGI:5776417 MGI:6305053, RGD:14397550 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO UniProtKB:P05067 (MGI:3697769|PMID:17255335) RGD PMID:17255335 MGI:3697769 NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
JBrowse link
G Ifngr2 interferon gamma receptor 2 involved_in IGI PMID:27094552 ARUK-UCL PMID:27094552 RGD:14397550 NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005
JBrowse link
G Il13 interleukin 13 IMP RGD PMID:19752235 RGD:8549634 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il4 interleukin 4 involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:23786632 PMID:21873635 RGD:8142387, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Itgam integrin subunit alpha M involved_in ISO (MGI:3814938|PMID:18981141) RGD PMID:18981141 MGI:3814938 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Jak2 Janus kinase 2 involved_in ISO UniProtKB:P01580 (MGI:5776417|PMID:26227742) RGD PMID:26227742 MGI:5776417 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit acts_upstream_of_or_within ISO MGI:2445420 (MGI:3772001|PMID:15233917) RGD PMID:15233917 MGI:3772001 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase IMP RGD PMID:28528966 RGD:13781879 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G P2ry1 purinergic receptor P2Y1 NOT|involved_in IMP PMID:11245682 ARUK-UCL PMID:11245682 RGD:13673788 NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457
JBrowse link
G P2ry2 purinergic receptor P2Y2 NOT|involved_in IMP PMID:11245682 ARUK-UCL PMID:11245682 RGD:13673788 NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632
JBrowse link
G Snca synuclein alpha acts_upstream_of_or_within ISO MGI:2389489 (MGI:3664828|PMID:17035541) RGD PMID:17035541 MGI:3664828 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Tlr1 toll-like receptor 1 IDA RGD PMID:16973131 RGD:1643119 NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125
JBrowse link
G Tlr2 toll-like receptor 2 IDA RGD PMID:16973131 RGD:1643119 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr3 toll-like receptor 3 IDA RGD PMID:16973131 RGD:1643119 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tlr4 toll-like receptor 4 IDA RGD PMID:16973131 RGD:1643119 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr6 toll-like receptor 6 IDA RGD PMID:16973131 RGD:1643119 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
JBrowse link
G Tlr9 toll-like receptor 9 IDA RGD PMID:16973131 RGD:1643119 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
JBrowse link
G Tnf tumor necrosis factor involved_in ISO (MGI:6274957|PMID:22950459) RGD PMID:22950459 MGI:6274957 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO ComplexPortal:CPX-1120|UniProtKB:P10636 (MGI:5906931|PMID:28802038), (MGI:6095556|PMID:29073081), (MGI:6150565|PMID:29518356), (MGI:6294162|PMID:28592261), (MGI:6695683|PMID:29663649) RGD PMID:28592261 PMID:28802038 PMID:29073081 PMID:29518356 PMID:29663649 MGI:5906931 MGI:6095556 MGI:6150565 MGI:6294162 MGI:6695683 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP RGD PMID:19385063 RGD:2316194 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
microglial cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cx3cr1 C-X3-C motif chemokine receptor 1 acts_upstream_of_or_within
involved_in
ISO
ISS
MGI:2670351 (MGI:3639805|PMID:16732273)
GO_REF:0000024
RGD
UniProt
PMID:16732273 GO_REF:0000024 MGI:3639805 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014
JBrowse link
G Grn granulin precursor involved_in ISS
ISO
GO_REF:0000024
(MGI:4421471|PMID:20026663)
UniProt
RGD
PMID:20026663 GO_REF:0000024 MGI:4421471 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
JBrowse link
G Il33 interleukin 33 involved_in IEA
ISO
GO_REF:0000107
(MGI:5008219|PMID:21349253)
Ensembl
RGD
PMID:21349253 GO_REF:0000107 MGI:5008219 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6201658|PMID:30232263) RGD PMID:30232263 MGI:6201658 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in IBA
ISO
PMID:21873635
(MGI:5638298|PMID:25690660)
RGD PMID:25690660 PMID:21873635 MGI:5638298, RGD:13792537 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848
JBrowse link
negative regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cst7 cystatin F involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:5910746 (MGI:5904382|PMID:28251676)
RGD PMID:28251676 PMID:21873635 MGI:5904382, RGD:13792537 NCBI chr 3:139,396,830...139,405,557
Ensembl chr 3:139,396,850...139,405,557
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 involved_in IDA PMID:19627440 ARUK-UCL PMID:19627440 RGD:13673772 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Grn granulin precursor involved_in ISS
ISO
GO_REF:0000024
(MGI:5440302|PMID:23041626)
UniProt
RGD
PMID:23041626 GO_REF:0000024 MGI:5440302 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
JBrowse link
G Ldlr low density lipoprotein receptor involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (MGI:4415751|PMID:20005821) RGD PMID:20005821 MGI:4415751 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:6283959|PMID:30792350)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:30792350 GO_REF:0000024 GO_REF:0000107 MGI:6283959 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO RNAcentral:URS000024A59E_10090 (MGI:6270781|PMID:30412727) RGD PMID:30412727 MGI:6270781 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Syt11 synaptotagmin 11 involved_in ISS
ISO
GO_REF:0000024
(MGI:5913303|PMID:28686317)
UniProt
RGD
PMID:28686317 GO_REF:0000024 MGI:5913303 NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964
JBrowse link
G Tafa3 TAFA chemokine like family member 3 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:5621218|PMID:25595455)
RGD PMID:25595455 PMID:21873635 MGI:5621218, RGD:13792537 NCBI chr 2:192,264,153...192,280,356
Ensembl chr 2:192,267,093...192,274,019
JBrowse link
positive regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsc cathepsin C acts_upstream_of_or_within ISO (MGI:5904382|PMID:28251676) RGD PMID:28251676 MGI:5904382 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 IMP RGD PMID:22302802 RGD:13462052 NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in IEA
ISO
GO_REF:0000107
(MGI:6201889|PMID:25049354)
Ensembl
RGD
PMID:25049354 GO_REF:0000107 MGI:6201889 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520
JBrowse link
G Stap1 signal transducing adaptor family member 1 involved_in ISO (MGI:3831067|PMID:19100238) RGD PMID:19100238 MGI:3831067 NCBI chr14:21,950,466...21,981,395
Ensembl chr14:21,952,496...21,981,245
JBrowse link
G Tafa3 TAFA chemokine like family member 3 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:5621218|PMID:25595455)
RGD PMID:25595455 PMID:21873635 MGI:5621218, RGD:13792537 NCBI chr 2:192,264,153...192,280,356
Ensembl chr 2:192,267,093...192,274,019
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IBA
ISO
PMID:21873635
(MGI:5606096|PMID:24990881), (MGI:6284411|PMID:29752066), (MGI:6304666|PMID:25631124), (MGI:6313424|PMID:30617257), (MGI:6391511|PMID:31370707)
(PMID:24990881)
RGD PMID:24990881 PMID:25631124 PMID:29752066 PMID:30617257 PMID:31370707 More... MGI:5606096 MGI:6284411 MGI:6304666 MGI:6313424 MGI:6391511, RGD:13792537 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
G Ttbk1 tau tubulin kinase 1 involved_in ISO (PMID:19118186) RGD PMID:19118186 NCBI chr 9:14,493,166...14,538,372
Ensembl chr 9:14,493,389...14,535,774
JBrowse link
regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP RGD PMID:28007901 RGD:12879399 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:6158194|PMID:29662056)
UniProt
RGD
PMID:29662056 GO_REF:0000024 MGI:6158194 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18737
    immune system process 2730
      leukocyte activation 1025
        leukocyte activation involved in inflammatory response 50
          microglial cell activation + 46
Path 2
Term Annotations click to browse term
  biological_process 18737
    response to stimulus 10209
      response to stress 4153
        defense response 1728
          inflammatory response 815
            leukocyte activation involved in inflammatory response 50
              microglial cell activation + 46
paths to the root