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ONTOLOGY REPORT - ANNOTATIONS


Term:somatic diversification of immune receptors
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Accession:GO:0002200 term browser browse the term
Definition:The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.
Comment:Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification.



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immunoglobulin heavy chain V-D-J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POLB DNA polymerase beta involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5553198|PMID:24388753) Ensembl
MGI
PMID:24388753 GO_REF:0000107 MGI:5553198 NCBI chr17:11,356,130...11,388,122
Ensembl chr17:11,356,129...11,388,821
JBrowse link
G YY1 YY1 transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:121,132,168...121,170,699
Ensembl chr 7:121,131,917...121,170,697
JBrowse link
immunoglobulin V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYREN cell cycle regulator of NHEJ involved_in ISO (MGI:6202149|PMID:30017584), (MGI:6716972|PMID:31795137) UniProt PMID:30017584 PMID:31795137 MGI:6202149 MGI:6716972 NCBI chr18:14,127,724...14,133,486 JBrowse link
G FOXP1 forkhead box P1 acts_upstream_of_or_within ISO (MGI:3662963|PMID:16819554) MGI PMID:16819554 MGI:3662963 NCBI chr13:52,346,844...52,974,358
Ensembl chr13:52,347,849...52,974,261
JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:1312981|PMID:9823897)
GO_Central
MGI
PMID:9823897 PMID:21873635 MGI:1312981 NCBI chr11:75,537,027...75,547,711
Ensembl chr11:75,537,032...75,547,691
JBrowse link
G NHEJ1 non-homologous end joining factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:121,100,624...121,190,086
Ensembl chr15:121,100,611...121,190,062
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:1290043|PMID:9768755)
GO_Central
MGI
PMID:9768755 PMID:21873635 MGI:1290043 NCBI chr 4:79,687,375...79,850,146
Ensembl chr 4:79,687,359...79,847,281
JBrowse link
G TCF3 transcription factor 3 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(PMID:16428437)
(MGI:3615721|PMID:16428437)
GO_Central
MGI
PMID:16428437 PMID:21873635 MGI:3615721 NCBI chr 2:76,859,079...76,906,275
Ensembl chr 2:76,858,786...76,898,351
JBrowse link
isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3761960|PMID:17713479) Ensembl
MGI
PMID:17713479 GO_REF:0000107 MGI:3761960 NCBI chr 5:62,777,236...62,787,342
Ensembl chr 5:62,777,352...62,787,483
JBrowse link
G ATAD5 ATPase family AAA domain containing 5 involved_in
acts_upstream_of
IEA
ISO
(MGI:5763555|PMID:25404367) Ensembl
MGI
PMID:25404367 GO_REF:0000107 MGI:5763555 NCBI chr12:42,874,705...42,920,438
Ensembl chr12:42,874,549...42,920,412
JBrowse link
G BATF basic leucine zipper ATF-like transcription factor involved_in ISO (MGI:4456325|PMID:20421391), (MGI:5004732|PMID:21572431) UniProt PMID:20421391 PMID:21572431 MGI:4456325 MGI:5004732 NCBI chr 7:98,670,211...98,692,230 JBrowse link
G CD40LG CD40 ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:111,778,666...111,788,901
Ensembl chr  X:111,778,493...111,789,711
JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit acts_upstream_of_or_within ISO (MGI:3052883|PMID:15280420) MGI PMID:15280420 MGI:3052883 NCBI chr 6:51,783,537...51,808,898 JBrowse link
G EXO1 exonuclease 1 acts_upstream_of_or_within ISO (MGI:3028407|PMID:14716311) MGI PMID:14716311 MGI:3028407 NCBI chr10:15,317,555...15,360,593
Ensembl chr10:15,317,581...15,359,839
JBrowse link
G EXOSC3 exosome component 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:238,536,341...238,541,756
Ensembl chr 1:238,536,343...238,541,333
JBrowse link
G EXOSC6 exosome component 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:13,295,591...13,296,942
Ensembl chr 6:13,296,055...13,296,873
JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3761960|PMID:17713479) Ensembl
MGI
PMID:17713479 GO_REF:0000107 MGI:3761960 NCBI chr11:75,537,027...75,547,711
Ensembl chr11:75,537,032...75,547,691
JBrowse link
G MLH1 mutL homolog 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2662086|PMID:12743174) MGI
Ensembl
PMID:12743174 GO_REF:0000107 MGI:2662086 NCBI chr13:21,791,276...21,877,789
Ensembl chr13:21,791,201...21,877,757
JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2662086|PMID:12743174)
(MGI:1342394|PMID:10430621)
Ensembl
MGI
PMID:10430621 PMID:12743174 GO_REF:0000107 MGI:1342394 MGI:2662086 NCBI chr 3:93,082,958...93,163,556
Ensembl chr 3:93,081,219...93,163,628
JBrowse link
G MSH6 mutS homolog 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3723381|PMID:17015724)
(MGI:3641510|PMID:16618598)
Ensembl
MGI
PMID:16618598 PMID:17015724 GO_REF:0000107 MGI:3641510 MGI:3723381 NCBI chr 3:92,792,590...92,814,154
Ensembl chr 3:92,785,664...92,814,128
JBrowse link
G NBN nibrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:46,787,664...46,854,331
Ensembl chr 4:46,787,659...46,903,999
JBrowse link
G RNF168 ring finger protein 168 involved_in ISO (MGI:4420833|PMID:20080757) UniProt PMID:20080757 MGI:4420833 NCBI chr13:133,625,534...133,659,253 JBrowse link
G RNF8 ring finger protein 8 involved_in ISO (MGI:4420833|PMID:20080757) UniProt PMID:20080757 MGI:4420833 NCBI chr 7:32,931,786...32,969,536
Ensembl chr 7:32,931,786...33,063,739
JBrowse link
G SWAP70 switching B cell complex subunit SWAP70 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1270060|PMID:9642267) Ensembl
MGI
PMID:9642267 GO_REF:0000107 MGI:1270060 NCBI chr 2:49,721,120...49,805,262
Ensembl chr 2:49,719,669...49,804,883
JBrowse link
G UNG uracil DNA glycosylase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3723381|PMID:17015724) Ensembl
MGI
PMID:17015724 GO_REF:0000107 MGI:3723381 NCBI chr14:41,746,498...41,757,841
Ensembl chr14:41,746,501...41,757,862
JBrowse link
isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR6 C-C motif chemokine receptor 6 involved_in ISO (MGI:5787846|PMID:27174992) UniProt PMID:27174992 MGI:5787846 NCBI chr 1:2,016,600...2,034,172
Ensembl chr 1:2,018,608...2,019,821
JBrowse link
isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPD1 heat shock protein family D (Hsp60) member 1 involved_in ISO (PMID:16148103) BHF-UCL PMID:16148103 NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,527
JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARP3 poly(ADP-ribose) polymerase family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:34,075,807...34,084,384
Ensembl chr13:34,075,801...34,085,210
JBrowse link
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G THOC1 THO complex 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:106,039,262...106,088,125
Ensembl chr 6:106,040,042...106,088,026
JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1345885|PMID:10490661) Ensembl
MGI
PMID:10490661 GO_REF:0000107 MGI:1345885 NCBI chr13:125,377,247...125,401,328
Ensembl chr13:125,377,248...125,393,330
JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3695768|PMID:16275384) Ensembl
MGI
PMID:16275384 GO_REF:0000107 MGI:3695768 NCBI chr  X:43,303,777...43,328,164
Ensembl chr  X:43,303,782...43,328,735
JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3694584|PMID:17137798) Ensembl
MGI
PMID:17137798 GO_REF:0000107 MGI:3694584 NCBI chr 2:143,688,946...143,734,523
Ensembl chr 2:143,628,784...143,734,525
JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFSF4 TNF superfamily member 4 involved_in ISO (MGI:3763508|PMID:12496423) BHF-UCL PMID:12496423 MGI:3763508 NCBI chr 9:115,535,185...115,857,457
Ensembl chr 9:115,550,567...115,857,448
JBrowse link
positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EXOSC3 exosome component 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5009766|PMID:21255825) Ensembl
MGI
PMID:21255825 GO_REF:0000107 MGI:5009766 NCBI chr 1:238,536,341...238,541,756
Ensembl chr 1:238,536,343...238,541,333
JBrowse link
G EXOSC6 exosome component 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5009766|PMID:21255825) Ensembl
MGI
PMID:21255825 GO_REF:0000107 MGI:5009766 NCBI chr 6:13,295,591...13,296,942
Ensembl chr 6:13,296,055...13,296,873
JBrowse link
G HMCES 5-hydroxymethylcytosine binding, ES cell specific involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:71,732,311...71,752,296
Ensembl chr13:71,732,277...71,753,504
JBrowse link
G KMT5B lysine methyltransferase 5B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:4,710,510...4,768,237
Ensembl chr 2:4,710,769...4,766,005
JBrowse link
G KMT5C lysine methyltransferase 5C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:59,517,058...59,524,551
Ensembl chr 6:59,517,058...59,525,434
JBrowse link
G MAD2L2 mitotic arrest deficient 2 like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:71,773,680...71,779,192
Ensembl chr 6:71,773,681...71,779,183
JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in ISO (MGI:4821506|PMID:20671152) UniProt PMID:20671152 MGI:4821506 NCBI chr18:3,066,853...3,111,239
Ensembl chr18:3,066,847...3,111,239
JBrowse link
G RIF1 replication timing regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:769,518...832,036
Ensembl chr15:774,189...832,010
JBrowse link
G SHLD1 shieldin complex subunit 1 involved_in IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr17:14,610,723...14,706,082
Ensembl chr17:14,601,193...14,707,906
JBrowse link
G SHLD2 shieldin complex subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:88,005,599...88,121,155
Ensembl chr14:88,005,590...88,121,383
JBrowse link
G TFRC transferrin receptor involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr13:133,976,765...133,997,554
Ensembl chr13:133,970,594...134,000,278
JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:127,958,500...128,032,370
Ensembl chr 1:127,958,518...128,028,718
JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:21,791,276...21,877,789
Ensembl chr13:21,791,201...21,877,757
JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:93,082,958...93,163,556
Ensembl chr 3:93,081,219...93,163,628
JBrowse link
G NSD2 nuclear receptor binding SET domain protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5462481|PMID:23241889) Ensembl
MGI
PMID:23241889 GO_REF:0000107 MGI:5462481 NCBI chr 8:938,832...1,018,032
Ensembl chr 8:963,884...1,018,025
JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in ISO (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chr 3:5,118,002...5,145,634
Ensembl chr 3:5,113,230...5,145,634
JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in
acts_upstream_of_or_within
ISS
ISO
(PMID:14988498) AgBase
MGI
PMID:14988498 GO_REF:0000024 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
G TNFSF13 TNF superfamily member 13 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(PMID:14988498)
(MGI:3037416|PMID:14988498)
GO_Central
MGI
PMID:14988498 PMID:21873635 MGI:3037416 NCBI chr12:52,853,646...52,857,033
Ensembl chr12:52,853,665...52,857,033
JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCF1 cardiotrophin like cytokine factor 1 involved_in ISO (MGI:3777853|PMID:12023368) BHF-UCL PMID:12023368 MGI:3777853 NCBI chr 2:5,142,315...5,152,750 JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:3037416|PMID:14988498)
GO_Central
MGI
PMID:14988498 PMID:21873635 MGI:3037416 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
JBrowse link
G STAT6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1345885|PMID:10490661) Ensembl
MGI
PMID:10490661 GO_REF:0000107 MGI:1345885 NCBI chr 5:22,406,356...22,422,412
Ensembl chr 5:22,406,364...22,421,990
JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAD5 ATPase family AAA domain containing 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5763555|PMID:25404367) Ensembl
MGI
PMID:25404367 GO_REF:0000107 MGI:5763555 NCBI chr12:42,874,705...42,920,438
Ensembl chr12:42,874,549...42,920,412
JBrowse link
G CD28 CD28 molecule involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:62368|PMID:7688139) Ensembl
MGI
PMID:7688139 GO_REF:0000107 MGI:62368 NCBI chr15:107,128,103...107,155,431
Ensembl chr15:107,128,208...107,162,943
JBrowse link
G CD40 CD40 molecule involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:2670820|PMID:12882831)
GO_Central
MGI
PMID:12882831 PMID:21873635 MGI:2670820 NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528
JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (MGI:2670820|PMID:12882831) MGI PMID:12882831 MGI:2670820 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G IL2 interleukin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:87443|PMID:1830926) Ensembl
MGI
PMID:1830926 GO_REF:0000107 MGI:87443 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609
JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:2670820|PMID:12882831), (MGI:3037416|PMID:14988498)
GO_Central
MGI
PMID:12882831 PMID:14988498 PMID:21873635 MGI:2670820 MGI:3037416 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
JBrowse link
G MLH1 mutL homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:21,791,276...21,877,789
Ensembl chr13:21,791,201...21,877,757
JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:93,082,958...93,163,556
Ensembl chr 3:93,081,219...93,163,628
JBrowse link
G PAGR1 PAXIP1 associated glutamate rich protein 1 involved_in ISO (MGI:5752090|PMID:26744420) UniProt PMID:26744420 MGI:5752090 NCBI chr 3:18,052,679...18,056,920 JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:3,066,853...3,111,239
Ensembl chr18:3,066,847...3,111,239
JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in ISO (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chr 3:5,118,002...5,145,634
Ensembl chr 3:5,113,230...5,145,634
JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:85031|PMID:9015183) Ensembl
MGI
PMID:9015183 GO_REF:0000107 MGI:85031 NCBI chr10:21,482,984...21,601,627
Ensembl chr10:21,466,373...21,764,560
JBrowse link
G TBX21 T-box transcription factor 21 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2670820|PMID:12882831) Ensembl
MGI
PMID:12882831 GO_REF:0000107 MGI:2670820 NCBI chr12:23,996,415...24,009,353
Ensembl chr12:23,996,415...24,009,355
JBrowse link
regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLF aprataxin and PNKP like factor acts_upstream_of_or_within ISO (MGI:4887518|PMID:21211721) MGI PMID:21211721 MGI:4887518 NCBI chr 3:73,752,115...73,831,158
Ensembl chr 3:73,752,106...73,831,075
JBrowse link
G MIR181B-1 microRNA mir-181b-1 acts_upstream_of_or_within ISO (MGI:3817382|PMID:18762567) MGI PMID:18762567 MGI:3817382 NCBI chr10:21,696,492...21,696,571
Ensembl chr10:21,696,492...21,696,571
JBrowse link
G MIR181B-2 microRNA mir-181b-2 acts_upstream_of_or_within ISO (MGI:3817382|PMID:18762567) MGI PMID:18762567 MGI:3817382 NCBI chr 1:265,499,111...265,499,196
Ensembl chr 1:265,499,108...265,499,196
JBrowse link
G SUPT6H SPT6 homolog, histone chaperone and transcription elongation factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:44,916,716...44,940,732
Ensembl chr12:44,906,858...44,952,427
JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3695768|PMID:16275384) Ensembl
MGI
PMID:16275384 GO_REF:0000107 MGI:3695768 NCBI chr  X:43,303,777...43,328,164
Ensembl chr  X:43,303,782...43,328,735
JBrowse link
G IL27RA interleukin 27 receptor subunit alpha involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1926579|PMID:11057672) Ensembl
MGI
PMID:11057672 GO_REF:0000107 MGI:1926579 NCBI chr 2:65,127,278...65,149,665
Ensembl chr 2:65,127,278...65,149,764
JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3694584|PMID:17137798) Ensembl
MGI
PMID:17137798 GO_REF:0000107 MGI:3694584 NCBI chr 2:143,688,946...143,734,523
Ensembl chr 2:143,628,784...143,734,525
JBrowse link
G SLC15A4 solute carrier family 15 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:26,122,362...26,154,414
Ensembl chr14:26,122,363...26,154,786
JBrowse link
somatic diversification of immune receptors via somatic mutation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAR adenosine deaminase RNA specific involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5469797|PMID:23209284) Ensembl
MGI
PMID:23209284 GO_REF:0000107 MGI:5469797 NCBI chr 4:95,154,230...95,197,308
Ensembl chr 4:95,154,358...95,197,305
JBrowse link
somatic diversification of immunoglobulins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase involved_in ISO (PMID:18722174) UniProt PMID:18722174 NCBI chr 5:62,777,236...62,787,342
Ensembl chr 5:62,777,352...62,787,483
JBrowse link
G CTNNBL1 catenin beta like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:40,809,932...40,948,844
Ensembl chr17:40,774,719...40,948,945
JBrowse link
G POLB DNA polymerase beta acts_upstream_of_or_within ISO (MGI:5553198|PMID:24388753) MGI PMID:24388753 MGI:5553198 NCBI chr17:11,356,130...11,388,122
Ensembl chr17:11,356,129...11,388,821
JBrowse link
somatic hypermutation of immunoglobulin genes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:62,777,236...62,787,342
Ensembl chr 5:62,777,352...62,787,483
JBrowse link
G EXO1 exonuclease 1 acts_upstream_of_or_within ISO (MGI:3028407|PMID:14716311) MGI PMID:14716311 MGI:3028407 NCBI chr10:15,317,555...15,360,593
Ensembl chr10:15,317,581...15,359,839
JBrowse link
G MCM3AP minichromosome maintenance complex component 3 associated protein involved_in IEA Ensembl GO_REF:0000107
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:1332749|PMID:10092760), (MGI:3691360|PMID:10429667)
GO_Central
MGI
PMID:10092760 PMID:10429667 PMID:21873635 MGI:1332749 MGI:3691360 NCBI chr13:21,791,276...21,877,789
Ensembl chr13:21,791,201...21,877,757
JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
NOT|acts_upstream_of_or_within
IEA
ISO
(MGI:1275866|PMID:9697842), (MGI:1275867|PMID:9697843)
(MGI:1261398|PMID:9607915)
(MGI:3641481|PMID:9607916)
(MGI:2679186|PMID:14568978)
(MGI:3513244|PMID:15494304)
Ensembl
MGI
PMID:9607915 PMID:9607916 PMID:9697842 PMID:9697843 PMID:14568978 More... GO_REF:0000107 MGI:1261398 MGI:1275866 MGI:1275867 MGI:2679186 MGI:3513244 MGI:3641481 NCBI chr 3:93,082,958...93,163,556
Ensembl chr 3:93,081,219...93,163,628
JBrowse link
G MSH3 mutS homolog 3 NOT|acts_upstream_of_or_within ISO (MGI:1353126|PMID:10662804) MGI PMID:10662804 MGI:1353126 NCBI chr 2:89,255,647...89,456,102
Ensembl chr 2:89,250,189...89,453,936
JBrowse link
G MSH6 mutS homolog 6 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:3641510|PMID:16618598)
(MGI:1353126|PMID:10662804), (MGI:3046392|PMID:15238604), (MGI:3723381|PMID:17015724)
GO_Central
MGI
PMID:10662804 PMID:15238604 PMID:16618598 PMID:17015724 PMID:21873635 MGI:1353126 MGI:3046392 MGI:3641510 MGI:3723381 NCBI chr 3:92,792,590...92,814,154
Ensembl chr 3:92,785,664...92,814,128
JBrowse link
G NUGGC nuclear GTPase, germinal center associated acts_upstream_of_or_within ISO (MGI:5448793|PMID:22833677) MGI PMID:22833677 MGI:5448793 NCBI chr14:11,775,684...11,826,162
Ensembl chr14:11,775,704...11,826,096
JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:3691360|PMID:10429667)
GO_Central
MGI
PMID:10429667 PMID:21873635 MGI:3691360 NCBI chr 3:5,118,002...5,145,634
Ensembl chr 3:5,113,230...5,145,634
JBrowse link
G POLB DNA polymerase beta involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5553198|PMID:24388753) Ensembl
MGI
PMID:24388753 GO_REF:0000107 MGI:5553198 NCBI chr17:11,356,130...11,388,122
Ensembl chr17:11,356,129...11,388,821
JBrowse link
G POLM DNA polymerase mu acts_upstream_of_or_within ISO (MGI:3576407|PMID:15789338) MGI PMID:15789338 MGI:3576407 NCBI chr18:51,077,845...51,091,354
Ensembl chr18:51,079,344...51,088,784
JBrowse link
G POLQ DNA polymerase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:138,962,634...139,108,499
Ensembl chr13:138,978,463...139,108,502
JBrowse link
G SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:40,117,348...40,171,935
Ensembl chr17:40,112,978...40,171,895
JBrowse link
G UNG uracil DNA glycosylase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3723381|PMID:17015724)
(MGI:3513244|PMID:15494304)
Ensembl
MGI
PMID:15494304 PMID:17015724 GO_REF:0000107 MGI:3513244 MGI:3723381 NCBI chr14:41,746,498...41,757,841
Ensembl chr14:41,746,501...41,757,862
JBrowse link
somatic recombination of immunoglobulin gene segments term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 acts_upstream_of_or_within ISO (MGI:3722579|PMID:11828012) MGI PMID:11828012 MGI:3722579 NCBI chr13:21,791,276...21,877,789
Ensembl chr13:21,791,201...21,877,757
JBrowse link
G MSH2 mutS homolog 2 acts_upstream_of_or_within ISO (MGI:3513244|PMID:15494304)
(MGI:3722579|PMID:11828012)
(MGI:2679186|PMID:14568978)
(MGI:3581477|PMID:15955838), (MGI:3582380|PMID:14563316)
MGI PMID:11828012 PMID:14563316 PMID:14568978 PMID:15494304 PMID:15955838 MGI:2679186 MGI:3513244 MGI:3581477 MGI:3582380 MGI:3722579 NCBI chr 3:93,082,958...93,163,556
Ensembl chr 3:93,081,219...93,163,628
JBrowse link
G MSH3 mutS homolog 3 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:3046392|PMID:15238604)
GO_Central
MGI
PMID:15238604 PMID:21873635 MGI:3046392 NCBI chr 2:89,255,647...89,456,102
Ensembl chr 2:89,250,189...89,453,936
JBrowse link
G MSH6 mutS homolog 6 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:3046392|PMID:15238604)
GO_Central
MGI
PMID:15238604 PMID:21873635 MGI:3046392 NCBI chr 3:92,792,590...92,814,154
Ensembl chr 3:92,785,664...92,814,128
JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component acts_upstream_of_or_within ISO (MGI:3722579|PMID:11828012) MGI PMID:11828012 MGI:3722579 NCBI chr 3:5,118,002...5,145,634
Ensembl chr 3:5,113,230...5,145,634
JBrowse link
G UNG uracil DNA glycosylase acts_upstream_of_or_within ISO (MGI:3513244|PMID:15494304) MGI PMID:15494304 MGI:3513244 NCBI chr14:41,746,498...41,757,841
Ensembl chr14:41,746,501...41,757,862
JBrowse link
somatic recombination of immunoglobulin genes involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 acts_upstream_of_or_within ISO (MGI:2662086|PMID:12743174) MGI PMID:12743174 MGI:2662086 NCBI chr13:21,791,276...21,877,789
Ensembl chr13:21,791,201...21,877,757
JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:2662086|PMID:12743174)
GO_Central
MGI
PMID:12743174 PMID:21873635 MGI:2662086 NCBI chr 3:93,082,958...93,163,556
Ensembl chr 3:93,081,219...93,163,628
JBrowse link
T cell receptor V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL11B BAF chromatin remodeling complex subunit BCL11B involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2662810|PMID:12717433) Ensembl
MGI
PMID:12717433 GO_REF:0000107 MGI:2662810 NCBI chr 7:120,205,008...120,295,737
Ensembl chr 7:120,205,008...120,295,815
JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3640275|PMID:9462507) Ensembl
MGI
PMID:9462507 GO_REF:0000107 MGI:3640275 NCBI chr 8:113,824,511...113,944,078
Ensembl chr 8:113,824,547...113,944,078
JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1860400|PMID:10911993) Ensembl
MGI
PMID:10911993 GO_REF:0000107 MGI:1860400 NCBI chr11:75,537,027...75,547,711
Ensembl chr11:75,537,032...75,547,691
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1290043|PMID:9768755) Ensembl
MGI
PMID:9768755 GO_REF:0000107 MGI:1290043 NCBI chr 4:79,687,375...79,850,146
Ensembl chr 4:79,687,359...79,847,281
JBrowse link
G TCF7 transcription factor 7 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3640275|PMID:9462507) InterPro
MGI
PMID:9462507 GO_REF:0000002 MGI:3640275 NCBI chr 2:136,422,740...136,456,323
Ensembl chr 2:136,422,712...136,458,037
JBrowse link
V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5543316|PMID:23836881) Ensembl
MGI
PMID:23836881 GO_REF:0000107 MGI:5543316 NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,658...36,759,554
JBrowse link
G DCAF1 DDB1 and CUL4 associated factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:33,670,976...33,750,872
Ensembl chr13:33,670,974...33,750,734
JBrowse link
G DCLRE1C DNA cross-link repair 1C involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5543316|PMID:23836881) Ensembl
MGI
PMID:23836881 GO_REF:0000107 MGI:5543316 NCBI chr10:46,820,016...46,863,848
Ensembl chr10:46,820,051...46,868,030
JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:9166431) UniProt PMID:9166431 NCBI chr11:7,195,556...7,321,071 JBrowse link
G LIG1 DNA ligase 1 NOT|involved_in ISO (PMID:9809069) UniProt PMID:9809069 NCBI chr 6:53,620,483...53,660,020
Ensembl chr 6:53,620,483...53,686,562
JBrowse link
G LIG3 DNA ligase 3 NOT|involved_in ISO (PMID:9809069) UniProt PMID:9809069 NCBI chr12:40,153,105...40,205,077
Ensembl chr12:40,147,681...40,183,622
JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within
ISO (PMID:9809069)
(MGI:3641390|PMID:10716994)
(MGI:3052572|PMID:15194694)
UniProt
MGI
PMID:9809069 PMID:10716994 PMID:15194694 MGI:3052572 MGI:3641390 NCBI chr11:75,537,027...75,547,711
Ensembl chr11:75,537,032...75,547,691
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO (MGI:5543316|PMID:23836881) MGI PMID:23836881 MGI:5543316 NCBI chr 4:79,687,375...79,850,146
Ensembl chr 4:79,687,359...79,847,281
JBrowse link
G RAG1 recombination activating 1 involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
ISS
(PMID:21873635)
(MGI:59028|PMID:2360047)
GO_Central
MGI
UniProt
PMID:2360047 PMID:21873635 GO_REF:0000024 GO_REF:0000104 MGI:59028 NCBI chr 2:24,565,447...24,573,853
Ensembl chr 2:24,565,449...24,602,590
JBrowse link
G RAG2 recombination activating 2 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:59028|PMID:2360047)
GO_Central
MGI
PMID:2360047 PMID:21873635 MGI:59028 NCBI chr 2:24,547,605...24,553,944
Ensembl chr 2:24,546,958...24,558,430
JBrowse link
G XRCC6 X-ray repair cross complementing 6 acts_upstream_of_or_within ISO (MGI:3641390|PMID:10716994) MGI PMID:10716994 MGI:3641390 NCBI chr 5:6,903,496...6,929,162
Ensembl chr 5:6,903,496...6,929,083
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16673
    immune system process 2354
      somatic diversification of immune receptors 82
        somatic diversification of DSCAM-based immune receptors 0
        somatic diversification of FREP-based immune receptors 0
        somatic diversification of T cell receptor genes + 5
        somatic diversification of immune receptors by N region addition + 0
        somatic diversification of immune receptors via alternate splicing + 0
        somatic diversification of immune receptors via gene conversion + 0
        somatic diversification of immune receptors via germline recombination within a single locus + 75
        somatic diversification of immune receptors via somatic mutation + 15
        somatic diversification of immunoglobulins + 69
        somatic diversification of variable lymphocyte receptors of jawless fish 0
Path 2
Term Annotations click to browse term
  biological_process 16673
    developmental process 6389
      anatomical structure development 5903
        multicellular organism development 5369
          system development 5035
            immune system development 1057
              somatic diversification of immune receptors 82
                somatic diversification of DSCAM-based immune receptors 0
                somatic diversification of FREP-based immune receptors 0
                somatic diversification of T cell receptor genes + 5
                somatic diversification of immune receptors by N region addition + 0
                somatic diversification of immune receptors via alternate splicing + 0
                somatic diversification of immune receptors via gene conversion + 0
                somatic diversification of immune receptors via germline recombination within a single locus + 75
                somatic diversification of immune receptors via somatic mutation + 15
                somatic diversification of immunoglobulins + 69
                somatic diversification of variable lymphocyte receptors of jawless fish 0
paths to the root