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ONTOLOGY REPORT - ANNOTATIONS


Term:somatic diversification of immune receptors
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Accession:GO:0002200 term browser browse the term
Definition:The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.
Comment:Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification.



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immunoglobulin heavy chain V-D-J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit involved_in TAS (PMID:23531880) MGI PMID:23531880 NCBI chr 6:47,507,208...47,613,843
Ensembl chr 6:47,507,073...47,572,275
JBrowse link
G Polb polymerase (DNA directed), beta acts_upstream_of_or_within IMP (PMID:24388753) MGI PMID:24388753 NCBI chr 8:23,118,135...23,143,482
Ensembl chr 8:23,118,142...23,143,451
JBrowse link
G Yy1 YY1 transcription factor involved_in IMP (PMID:23531880) MGI PMID:23531880 NCBI chr12:108,758,841...108,786,074
Ensembl chr12:108,758,899...108,786,074
JBrowse link
immunoglobulin V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyren cell cycle regulator of NHEJ involved_in IMP (MGI:6202149|PMID:30017584), (MGI:6716972|PMID:31795137) UniProt PMID:30017584 PMID:31795137 MGI:6202149 MGI:6716972 NCBI chr 6:34,848,706...34,855,024
Ensembl chr 6:34,848,706...34,854,995
JBrowse link
G Foxp1 forkhead box P1 acts_upstream_of_or_within IMP (PMID:16819554) MGI PMID:16819554 NCBI chr 6:98,902,303...99,510,587
Ensembl chr 6:98,902,299...99,499,682
JBrowse link
G Lig4 ligase IV, DNA, ATP-dependent involved_in
acts_upstream_of_or_within
IBA
IMP
(PMID:9823897) GO_Central
MGI
PMID:9823897 GO_REF:0000033 NCBI chr 8:10,020,020...10,027,680
Ensembl chr 8:10,019,049...10,027,686
JBrowse link
G Nhej1 non-homologous end joining factor 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:75,006,505...75,101,870
Ensembl chr 1:75,006,298...75,101,844
JBrowse link
G Prkdc protein kinase, DNA activated, catalytic polypeptide acts_upstream_of_or_within
involved_in
IMP
IBA
(PMID:9768755) MGI
GO_Central
PMID:9768755 GO_REF:0000033 NCBI chr16:15,455,698...15,660,103
Ensembl chr16:15,455,730...15,660,099
JBrowse link
G Tcf3 transcription factor 3 acts_upstream_of_or_within
involved_in
IMP
IBA
ISO
(PMID:16428437) MGI
GO_Central
PMID:16428437 GO_REF:0000033 NCBI chr10:80,245,375...80,269,814
Ensembl chr10:80,245,348...80,269,481
JBrowse link
G Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 acts_upstream_of_or_within
involved_in
IMP
IBA
(PMID:9875844) MGI
GO_Central
PMID:9875844 GO_REF:0000033 NCBI chr13:89,997,033...90,237,727
Ensembl chr13:89,922,146...90,237,727
JBrowse link
isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase involved_in
acts_upstream_of_or_within
IMP (MGI:5004983|PMID:21518874)
(PMID:17713479)
UniProt
MGI
PMID:17713479 PMID:21518874 MGI:5004983 NCBI chr 6:122,530,768...122,541,139
Ensembl chr 6:122,530,760...122,541,139
JBrowse link
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of IMP (PMID:25404367) MGI PMID:25404367 NCBI chr11:79,980,205...80,026,623
Ensembl chr11:79,980,226...80,026,620
JBrowse link
G Batf basic leucine zipper transcription factor, ATF-like involved_in IMP (MGI:4456325|PMID:20421391), (MGI:5004732|PMID:21572431) UniProt PMID:20421391 PMID:21572431 MGI:4456325 MGI:5004732 NCBI chr12:85,733,494...85,755,861
Ensembl chr12:85,733,443...85,755,861
JBrowse link
G Cd40lg CD40 ligand involved_in IDA (MGI:3687427|PMID:7529792) UniProt PMID:7529792 MGI:3687427 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402
JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 acts_upstream_of_or_within IMP (PMID:15280420) MGI PMID:15280420 NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449
JBrowse link
G Exo1 exonuclease 1 acts_upstream_of_or_within IMP (PMID:14716311) MGI PMID:14716311 NCBI chr 1:175,708,334...175,738,962
Ensembl chr 1:175,708,147...175,741,055
JBrowse link
G Exosc3 exosome component 3 involved_in IMP (MGI:5009766|PMID:21255825) UniProt PMID:21255825 MGI:5009766 NCBI chr 4:45,316,613...45,320,616
Ensembl chr 4:45,316,613...45,342,732
JBrowse link
G Exosc6 exosome component 6 involved_in IMP (MGI:5009766|PMID:21255825) UniProt PMID:21255825 MGI:5009766 NCBI chr 8:111,782,971...111,784,296
Ensembl chr 8:111,782,971...111,784,296
JBrowse link
G Icosl icos ligand involved_in NAS (MGI:2683576|PMID:11343122) UniProt PMID:11343122 MGI:2683576 NCBI chr10:77,904,921...77,915,359
Ensembl chr10:77,905,136...77,919,747
JBrowse link
G Lig4 ligase IV, DNA, ATP-dependent acts_upstream_of_or_within IMP (PMID:17713479) MGI PMID:17713479 NCBI chr 8:10,020,020...10,027,680
Ensembl chr 8:10,019,049...10,027,686
JBrowse link
G Mlh1 mutL homolog 1 acts_upstream_of_or_within IMP (PMID:12743174) MGI PMID:12743174 NCBI chr 9:111,057,296...111,100,854
Ensembl chr 9:111,057,296...111,100,859
JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within IMP (PMID:10430621)
(PMID:12743174)
MGI PMID:10430621 PMID:12743174 NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141
JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within IGI
IMP
(PMID:17015724)
(PMID:16618598)
MGI PMID:16618598 PMID:17015724 NCBI chr17:88,282,478...88,298,320
Ensembl chr17:88,282,490...88,298,320
JBrowse link
G Nbn nibrin involved_in IDA (MGI:3529405|PMID:15668383) UniProt PMID:15668383 MGI:3529405 NCBI chr 4:15,955,388...15,992,589
Ensembl chr 4:15,957,925...15,992,589
JBrowse link
G Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta involved_in IMP (PMID:25124037)
(PMID:31182790)
MGI PMID:25124037 PMID:31182790 NCBI chr16:55,631,740...55,659,018
Ensembl chr16:55,631,738...55,659,262
JBrowse link
G Rnf168 ring finger protein 168 involved_in IMP (MGI:4420833|PMID:20080757) UniProt PMID:20080757 MGI:4420833 NCBI chr16:32,096,279...32,120,260
Ensembl chr16:32,096,277...32,120,252
JBrowse link
G Rnf8 ring finger protein 8 involved_in IMP (MGI:4420833|PMID:20080757) UniProt PMID:20080757 MGI:4420833 NCBI chr17:29,833,763...29,860,638
Ensembl chr17:29,833,764...29,863,965
JBrowse link
G Sanbr SANT and BTB domain regulator of CSR involved_in IDA (MGI:6707280|PMID:33831416) UniProt PMID:33831416 MGI:6707280 NCBI chr11:23,514,949...23,596,409
Ensembl chr11:23,514,961...23,583,631
JBrowse link
G Swap70 SWA-70 protein acts_upstream_of_or_within IDA (PMID:9642267) MGI PMID:9642267 NCBI chr 7:109,820,890...109,882,720
Ensembl chr 7:109,820,918...109,882,713
JBrowse link
G Ung uracil DNA glycosylase acts_upstream_of_or_within IGI (PMID:17015724) MGI PMID:17015724 NCBI chr 5:114,268,427...114,277,382
Ensembl chr 5:114,268,447...114,277,384
JBrowse link
G Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 acts_upstream_of_or_within IMP (PMID:17713479) MGI PMID:17713479 NCBI chr13:89,997,033...90,237,727
Ensembl chr13:89,922,146...90,237,727
JBrowse link
isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr6 C-C motif chemokine receptor 6 involved_in IMP (MGI:5787846|PMID:27174992) UniProt PMID:27174992 MGI:5787846 NCBI chr17:8,454,875...8,477,353
Ensembl chr17:8,454,875...8,475,973
JBrowse link
isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 B cell leukemia/lymphoma 6 acts_upstream_of IMP
IGI
(PMID:10490661) MGI PMID:10490661 NCBI chr16:23,780,058...23,807,602
Ensembl chr16:23,783,802...23,807,602
JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of IMP (PMID:16275384) MGI PMID:16275384 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484
JBrowse link
G Il4 interleukin 4 acts_upstream_of IDA (PMID:14988498) MGI PMID:14988498 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of IGI (PMID:10490661) MGI PMID:10490661 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826
JBrowse link
isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hspd1 heat shock protein 1 (chaperonin) involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402
JBrowse link
G Il4 interleukin 4 acts_upstream_of IDA (PMID:14988498) MGI PMID:14988498 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 involved_in IMP (MGI:6214451|PMID:26000965) UniProt PMID:26000965 MGI:6214451 NCBI chr 9:106,347,521...106,354,148
Ensembl chr 9:106,347,521...106,354,148
JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 B cell leukemia/lymphoma 6 acts_upstream_of_or_within IMP
IGI
(PMID:10490661) MGI PMID:10490661 NCBI chr16:23,780,058...23,807,602
Ensembl chr16:23,783,802...23,807,602
JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within IMP (PMID:16275384) MGI PMID:16275384 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484
JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within IMP (PMID:17137798) MGI PMID:17137798 NCBI chr18:38,551,960...38,598,250
Ensembl chr18:38,543,449...38,598,356
JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 involved_in IMP (MGI:3763508|PMID:12496423) BHF-UCL PMID:12496423 MGI:3763508 NCBI chr 1:161,223,009...161,245,777
Ensembl chr 1:161,222,980...161,245,981
JBrowse link
positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exosc3 exosome component 3 acts_upstream_of_or_within IMP (PMID:21255825) MGI PMID:21255825 NCBI chr 4:45,316,613...45,320,616
Ensembl chr 4:45,316,613...45,342,732
JBrowse link
G Exosc6 exosome component 6 acts_upstream_of_or_within IMP (PMID:21255825) MGI PMID:21255825 NCBI chr 8:111,782,971...111,784,296
Ensembl chr 8:111,782,971...111,784,296
JBrowse link
G Hmces 5-hydroxymethylcytosine (hmC) binding, ES cell specific involved_in IDA (MGI:6393148|PMID:31806351) UniProt PMID:31806351 MGI:6393148 NCBI chr 6:87,890,889...87,913,603
Ensembl chr 6:87,890,917...87,913,611
JBrowse link
G Kmt5b lysine methyltransferase 5B involved_in IMP (MGI:6370097|PMID:28114273) UniProt PMID:28114273 MGI:6370097 NCBI chr19:3,816,436...3,868,303
Ensembl chr19:3,817,421...3,868,303
JBrowse link
G Kmt5c lysine methyltransferase 5C involved_in IMP (MGI:6370097|PMID:28114273) UniProt PMID:28114273 MGI:6370097 NCBI chr 7:4,743,091...4,750,513
Ensembl chr 7:4,743,114...4,750,513
JBrowse link
G Mad2l2 MAD2 mitotic arrest deficient-like 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:148,214,615...148,230,161
Ensembl chr 4:148,214,841...148,230,156
JBrowse link
G Paxip1 PAX interacting (with transcription-activation domain) protein 1 involved_in IMP (MGI:4821506|PMID:20671152) UniProt PMID:20671152 MGI:4821506 NCBI chr 5:27,947,044...27,999,326
Ensembl chr 5:27,945,078...27,996,689
JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in IMP (MGI:5468036|PMID:23306439), (MGI:5476381|PMID:23333305), (MGI:5490831|PMID:23333306) UniProt PMID:23306439 PMID:23333305 PMID:23333306 MGI:5468036 MGI:5476381 MGI:5490831 NCBI chr 2:51,962,725...52,016,781
Ensembl chr 2:51,962,844...52,012,395
JBrowse link
G Shld1 shieldin complex subunit 1 involved_in ISO
IBA
MGI
GO_Central
GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 2:132,528,871...132,592,975
Ensembl chr 2:132,528,851...132,592,975
JBrowse link
G Shld2 shieldin complex subunit 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr14:33,958,905...34,032,528
Ensembl chr14:33,958,990...34,032,450
JBrowse link
G Shld3 shieldin complex subunit 3 involved_in ISO
IBA
MGI
GO_Central
GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr13:104,310,228...104,314,967
Ensembl chr13:104,310,230...104,314,947
JBrowse link
G Tfrc transferrin receptor involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612
JBrowse link
G Trp53bp1 transformation related protein 53 binding protein 1 involved_in IMP
ISO
(MGI:3041657|PMID:15077110), (MGI:3046005|PMID:15159415) UniProt
MGI
PMID:15077110 PMID:15159415 GO_REF:0000119 MGI:3041657 MGI:3046005 MGI:4834177 NCBI chr 2:121,025,316...121,126,830
Ensembl chr 2:121,023,762...121,101,888
JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 involved_in IMP (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chr 9:111,057,296...111,100,854
Ensembl chr 9:111,057,296...111,100,859
JBrowse link
G Msh2 mutS homolog 2 involved_in IMP (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141
JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 acts_upstream_of_or_within IMP (PMID:23241889) MGI PMID:23241889 NCBI chr 5:33,974,286...34,055,310
Ensembl chr 5:33,978,069...34,055,319
JBrowse link
G Pms2 PMS1 homolog2, mismatch repair system component involved_in IGI
IMP
(MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chr 5:143,846,379...143,922,538
Ensembl chr 5:143,846,782...143,870,786
Ensembl chr 5:143,846,782...143,870,786
JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within ISO (PMID:14988498) MGI PMID:14988498 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tnfsf13 tumor necrosis factor (ligand) superfamily, member 13 involved_in
acts_upstream_of_or_within
IBA
ISO
IMP
(PMID:14988498) GO_Central
MGI
PMID:14988498 GO_REF:0000033 NCBI chr11:69,573,403...69,576,380
Ensembl chr11:69,573,672...69,576,610
JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcf1 cardiotrophin-like cytokine factor 1 involved_in IDA (MGI:3777853|PMID:12023368) BHF-UCL PMID:12023368 MGI:3777853 NCBI chr19:4,264,479...4,273,548
Ensembl chr19:4,264,292...4,273,544
JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within IDA (PMID:14988498) MGI PMID:14988498 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within IGI (PMID:10490661) MGI PMID:10490661 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826
JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within IMP (PMID:25404367) MGI PMID:25404367 NCBI chr11:79,980,205...80,026,623
Ensembl chr11:79,980,226...80,026,620
JBrowse link
G Cd28 CD28 antigen acts_upstream_of_or_within IMP (PMID:7688139) MGI PMID:7688139 NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518
JBrowse link
G Cd40 CD40 antigen acts_upstream_of_or_within IDA (PMID:12882831) MGI PMID:12882831 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within IDA (PMID:12882831) MGI PMID:12882831 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Il2 interleukin 2 acts_upstream_of_or_within IMP (PMID:1830926) MGI PMID:1830926 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within IDA (PMID:12882831), (PMID:14988498) MGI PMID:12882831 PMID:14988498 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Mlh1 mutL homolog 1 involved_in IMP (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chr 9:111,057,296...111,100,854
Ensembl chr 9:111,057,296...111,100,859
JBrowse link
G Msh2 mutS homolog 2 involved_in IMP (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141
JBrowse link
G Pagr1a PAXIP1 associated glutamate rich protein 1A involved_in IMP (MGI:5752090|PMID:26744420) UniProt PMID:26744420 MGI:5752090 NCBI chr 7:126,614,223...126,616,524
Ensembl chr 7:126,614,205...126,616,524
Ensembl chr 7:126,614,205...126,616,524
JBrowse link
G Paxip1 PAX interacting (with transcription-activation domain) protein 1 involved_in IMP (MGI:5752090|PMID:26744420) UniProt PMID:26744420 MGI:5752090 NCBI chr 5:27,947,044...27,999,326
Ensembl chr 5:27,945,078...27,996,689
JBrowse link
G Pms2 PMS1 homolog2, mismatch repair system component involved_in IMP
IGI
(MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chr 5:143,846,379...143,922,538
Ensembl chr 5:143,846,782...143,870,786
Ensembl chr 5:143,846,782...143,870,786
JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C acts_upstream_of_or_within IMP (PMID:9015183) MGI PMID:9015183 NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446
JBrowse link
G Tbx21 T-box 21 acts_upstream_of_or_within IMP (PMID:12882831) MGI PMID:12882831 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157
JBrowse link
regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplf aprataxin and PNKP like factor acts_upstream_of_or_within IMP (PMID:21211721) MGI PMID:21211721 NCBI chr 6:87,605,407...87,649,244
Ensembl chr 6:87,605,406...87,649,175
JBrowse link
G Mir181b-1 microRNA 181b-1 acts_upstream_of_or_within IDA (PMID:18762567) MGI PMID:18762567 NCBI chr 1:137,894,377...137,894,456
Ensembl chr 1:137,894,377...137,894,456
JBrowse link
G Mir181b-2 microRNA 181b-2 acts_upstream_of_or_within IDA (PMID:18762567) MGI PMID:18762567 NCBI chr 2:38,743,842...38,743,930
Ensembl chr 2:38,743,842...38,743,930
JBrowse link
G Supt6 SPT6, histone chaperone and transcription elongation factor involved_in IMP (MGI:5004983|PMID:21518874) UniProt PMID:21518874 MGI:5004983 NCBI chr11:78,097,575...78,136,798
Ensembl chr11:78,097,572...78,136,813
JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within IMP (PMID:16275384) MGI PMID:16275384 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484
JBrowse link
G Il27ra interleukin 27 receptor, alpha acts_upstream_of_or_within IMP (PMID:11057672) MGI PMID:11057672 NCBI chr 8:84,756,915...84,769,250
Ensembl chr 8:84,756,923...84,769,218
JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within IMP (PMID:17137798) MGI PMID:17137798 NCBI chr18:38,551,960...38,598,250
Ensembl chr18:38,543,449...38,598,356
JBrowse link
G Slc15a4 solute carrier family 15, member 4 involved_in IMP (MGI:5649169|PMID:25310967) UniProt PMID:25310967 MGI:5649169 NCBI chr 5:127,668,795...127,710,356
Ensembl chr 5:127,672,728...127,709,961
JBrowse link
somatic diversification of immune receptors via somatic mutation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase, RNA-specific acts_upstream_of_or_within IDA (PMID:23209284) MGI PMID:23209284 NCBI chr 3:89,622,321...89,660,756
Ensembl chr 3:89,622,329...89,660,753
JBrowse link
somatic diversification of immunoglobulins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 6:122,530,768...122,541,139
Ensembl chr 6:122,530,760...122,541,139
JBrowse link
G Ctnnbl1 catenin, beta like 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:157,579,321...157,733,823
Ensembl chr 2:157,579,321...157,733,534
JBrowse link
G Polb polymerase (DNA directed), beta acts_upstream_of_or_within IMP (PMID:24388753) MGI PMID:24388753 NCBI chr 8:23,118,135...23,143,482
Ensembl chr 8:23,118,142...23,143,451
JBrowse link
somatic diversification of immunoglobulins involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mad2l2 MAD2 mitotic arrest deficient-like 2 involved_in NAS (MGI:6156517|PMID:29656893) ComplexPortal PMID:29656893 MGI:6156517 NCBI chr 4:148,214,615...148,230,161
Ensembl chr 4:148,214,841...148,230,156
JBrowse link
G Shld1 shieldin complex subunit 1 involved_in NAS (MGI:6156517|PMID:29656893) ComplexPortal PMID:29656893 MGI:6156517 NCBI chr 2:132,528,871...132,592,975
Ensembl chr 2:132,528,851...132,592,975
JBrowse link
G Shld2 shieldin complex subunit 2 involved_in NAS (MGI:6156517|PMID:29656893) ComplexPortal PMID:29656893 MGI:6156517 NCBI chr14:33,958,905...34,032,528
Ensembl chr14:33,958,990...34,032,450
JBrowse link
G Shld3 shieldin complex subunit 3 involved_in NAS (MGI:6156517|PMID:29656893) ComplexPortal PMID:29656893 MGI:6156517 NCBI chr13:104,310,228...104,314,967
Ensembl chr13:104,310,230...104,314,947
JBrowse link
somatic hypermutation of immunoglobulin genes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 6:122,530,768...122,541,139
Ensembl chr 6:122,530,760...122,541,139
JBrowse link
G Exo1 exonuclease 1 acts_upstream_of_or_within IMP (PMID:14716311) MGI PMID:14716311 NCBI chr 1:175,708,334...175,738,962
Ensembl chr 1:175,708,147...175,741,055
JBrowse link
G Hmces 5-hydroxymethylcytosine (hmC) binding, ES cell specific involved_in IDA
ISO
(MGI:7279208|PMID:35450882) UniProt
MGI
PMID:35450882 GO_REF:0000119 MGI:4834177 MGI:7279208 NCBI chr 6:87,890,889...87,913,603
Ensembl chr 6:87,890,917...87,913,611
JBrowse link
G Ighd immunoglobulin heavy constant delta acts_upstream_of_or_within IMP (PMID:8418208) MGI PMID:8418208 NCBI chr12:113,371,155...113,379,944
Ensembl chr12:113,370,224...113,379,944
JBrowse link
G Mcm3ap minichromosome maintenance complex component 3 associated protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:76,304,736...76,351,693
Ensembl chr10:76,304,761...76,351,691
JBrowse link
G Mlh1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IBA
IMP
(PMID:10092760), (PMID:10429667) GO_Central
MGI
PMID:10092760 PMID:10429667 GO_REF:0000033 NCBI chr 9:111,057,296...111,100,854
Ensembl chr 9:111,057,296...111,100,859
JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within
NOT|acts_upstream_of_or_within
IMP
IGI
(PMID:9607916)
(PMID:14568978)
(PMID:9607915)
(PMID:9697842), (PMID:9697843)
(PMID:15494304)
MGI PMID:9607915 PMID:9607916 PMID:9697842 PMID:9697843 PMID:14568978 More... NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141
JBrowse link
G Msh3 mutS homolog 3 NOT|acts_upstream_of_or_within IMP (PMID:10662804) MGI PMID:10662804 NCBI chr13:92,348,387...92,491,515
Ensembl chr13:92,348,380...92,491,511
JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within IMP (PMID:10662804), (PMID:15238604), (PMID:17015724)
(PMID:16618598)
MGI PMID:10662804 PMID:15238604 PMID:16618598 PMID:17015724 NCBI chr17:88,282,478...88,298,320
Ensembl chr17:88,282,490...88,298,320
JBrowse link
G Nuggc nuclear GTPase, germinal center associated acts_upstream_of_or_within IMP (PMID:22833677) MGI PMID:22833677 NCBI chr14:65,830,901...65,885,893
Ensembl chr14:65,835,995...65,885,980
JBrowse link
G Pms2 PMS1 homolog2, mismatch repair system component involved_in
acts_upstream_of_or_within
IMP
IBA
(MGI:1261707|PMID:9618520)
(PMID:10429667)
CAFA
MGI
GO_Central
PMID:9618520 PMID:10429667 GO_REF:0000033 MGI:1261707 NCBI chr 5:143,846,379...143,922,538
Ensembl chr 5:143,846,782...143,870,786
Ensembl chr 5:143,846,782...143,870,786
JBrowse link
G Polb polymerase (DNA directed), beta acts_upstream_of_or_within IMP (PMID:24388753) MGI PMID:24388753 NCBI chr 8:23,118,135...23,143,482
Ensembl chr 8:23,118,142...23,143,451
JBrowse link
G Polm polymerase (DNA directed), mu acts_upstream_of_or_within IMP (PMID:15789338) MGI PMID:15789338 NCBI chr11:5,777,860...5,788,831
Ensembl chr11:5,777,860...5,788,016
JBrowse link
G Polq polymerase (DNA directed), theta involved_in IMP (MGI:3603978|PMID:16172387), (MGI:3609287|PMID:16222339), (MGI:3692678|PMID:16890500) UniProt PMID:16172387 PMID:16222339 PMID:16890500 MGI:3603978 MGI:3609287 MGI:3692678 NCBI chr16:36,832,104...36,922,321
Ensembl chr16:36,832,148...36,915,779
JBrowse link
G Samhd1 SAM domain and HD domain, 1 involved_in IMP (MGI:6157199|PMID:29669924) UniProt PMID:29669924 MGI:6157199 NCBI chr 2:156,939,454...156,977,016
Ensembl chr 2:156,939,453...156,977,185
JBrowse link
G Ung uracil DNA glycosylase acts_upstream_of_or_within IGI
IMP
(PMID:15494304)
(PMID:17015724)
MGI PMID:15494304 PMID:17015724 NCBI chr 5:114,268,427...114,277,382
Ensembl chr 5:114,268,447...114,277,384
JBrowse link
somatic recombination of immunoglobulin gene segments term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 acts_upstream_of_or_within IMP (PMID:11828012) MGI PMID:11828012 NCBI chr 9:111,057,296...111,100,854
Ensembl chr 9:111,057,296...111,100,859
JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within IGI
IMP
(PMID:15494304)
(PMID:14563316), (PMID:15955838)
(PMID:11828012)
(PMID:14568978)
MGI PMID:11828012 PMID:14563316 PMID:14568978 PMID:15494304 PMID:15955838 NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141
JBrowse link
G Msh3 mutS homolog 3 involved_in
acts_upstream_of_or_within
IBA
IMP
(PMID:15238604) GO_Central
MGI
PMID:15238604 GO_REF:0000033 NCBI chr13:92,348,387...92,491,515
Ensembl chr13:92,348,380...92,491,511
JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within IMP (PMID:15238604) MGI PMID:15238604 NCBI chr17:88,282,478...88,298,320
Ensembl chr17:88,282,490...88,298,320
JBrowse link
G Pms2 PMS1 homolog2, mismatch repair system component acts_upstream_of_or_within IMP (PMID:11828012) MGI PMID:11828012 NCBI chr 5:143,846,379...143,922,538
Ensembl chr 5:143,846,782...143,870,786
Ensembl chr 5:143,846,782...143,870,786
JBrowse link
G Ung uracil DNA glycosylase acts_upstream_of_or_within IMP
IGI
(PMID:15494304) MGI PMID:15494304 NCBI chr 5:114,268,427...114,277,382
Ensembl chr 5:114,268,447...114,277,384
JBrowse link
somatic recombination of immunoglobulin genes involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 acts_upstream_of_or_within IGI (PMID:12743174) MGI PMID:12743174 NCBI chr 9:111,057,296...111,100,854
Ensembl chr 9:111,057,296...111,100,859
JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within
involved_in
IGI
IBA
(PMID:12743174) MGI
GO_Central
PMID:12743174 GO_REF:0000033 NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141
JBrowse link
T cell receptor V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl11b B cell leukemia/lymphoma 11B acts_upstream_of_or_within IMP (PMID:12717433) MGI PMID:12717433 NCBI chr12:107,876,662...107,970,404
Ensembl chr12:107,876,662...107,969,861
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 acts_upstream_of_or_within IGI (PMID:9462507) MGI PMID:9462507 NCBI chr 3:130,903,972...131,018,006
Ensembl chr 3:130,904,120...131,018,005
JBrowse link
G Lig4 ligase IV, DNA, ATP-dependent acts_upstream_of_or_within IMP (PMID:10911993) MGI PMID:10911993 NCBI chr 8:10,020,020...10,027,680
Ensembl chr 8:10,019,049...10,027,686
JBrowse link
G Prkdc protein kinase, DNA activated, catalytic polypeptide acts_upstream_of_or_within IMP (PMID:9768755) MGI PMID:9768755 NCBI chr16:15,455,698...15,660,103
Ensembl chr16:15,455,730...15,660,099
JBrowse link
G Tcf7 transcription factor 7, T cell specific acts_upstream_of_or_within IGI (PMID:9462507) MGI PMID:9462507 NCBI chr11:52,137,347...52,174,211
Ensembl chr11:52,143,198...52,174,158
JBrowse link
V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ataxia telangiectasia mutated acts_upstream_of_or_within IGI (PMID:23836881) MGI PMID:23836881 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
JBrowse link
G Dcaf1 DDB1 and CUL4 associated factor 1 involved_in IMP (MGI:5314150|PMID:22157821) UniProt PMID:22157821 MGI:5314150 NCBI chr 9:106,691,354...106,758,191
Ensembl chr 9:106,699,073...106,758,191
JBrowse link
G Dclre1c DNA cross-link repair 1C acts_upstream_of_or_within IMP (PMID:23836881) MGI PMID:23836881 NCBI chr 2:3,425,112...3,475,248
Ensembl chr 2:3,425,168...3,465,167
JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
JBrowse link
G Lig1 ligase I, DNA, ATP-dependent NOT|involved_in ISO (PMID:9809069) UniProt PMID:9809069 NCBI chr 7:13,011,101...13,045,351
Ensembl chr 7:13,011,239...13,045,350
JBrowse link
G Lig3 ligase III, DNA, ATP-dependent NOT|involved_in ISO (PMID:9809069) UniProt PMID:9809069 NCBI chr11:82,671,977...82,695,100
Ensembl chr11:82,671,934...82,695,100
JBrowse link
G Lig4 ligase IV, DNA, ATP-dependent involved_in
acts_upstream_of_or_within
ISO
IDA
IMP
(PMID:15194694)
(PMID:10716994)
MGI PMID:10716994 PMID:15194694 GO_REF:0000119 MGI:4834177 NCBI chr 8:10,020,020...10,027,680
Ensembl chr 8:10,019,049...10,027,686
JBrowse link
G Prkdc protein kinase, DNA activated, catalytic polypeptide acts_upstream_of_or_within IGI (PMID:23836881) MGI PMID:23836881 NCBI chr16:15,455,698...15,660,103
Ensembl chr16:15,455,730...15,660,099
JBrowse link
G Rag1 recombination activating 1 involved_in
acts_upstream_of_or_within
IMP
IGI
IBA
ISO
(MGI:4441018|PMID:20122409), (MGI:4441148|PMID:10601033), (MGI:50458|PMID:1547488), (MGI:64624|PMID:8284210)
(PMID:2360047)
UniProt
MGI
GO_Central
PMID:1547488 PMID:2360047 PMID:8284210 PMID:10601033 PMID:20122409 GO_REF:0000033 GO_REF:0000119 MGI:4441018 MGI:4441148 MGI:4834177 MGI:50458 MGI:64624 NCBI chr 2:101,468,597...101,479,877
Ensembl chr 2:101,468,627...101,479,846
JBrowse link
G Rag2 recombination activating gene 2 involved_in
acts_upstream_of_or_within
IMP
IGI
IBA
(MGI:4441252|PMID:18033247), (MGI:50458|PMID:1547488)
(PMID:2360047)
UniProt
MGI
GO_Central
PMID:1547488 PMID:2360047 PMID:18033247 GO_REF:0000033 MGI:4441252 MGI:50458 NCBI chr 2:101,455,057...101,462,873
Ensembl chr 2:101,455,063...101,462,874
JBrowse link
G Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 acts_upstream_of_or_within IMP (PMID:10716994) MGI PMID:10716994 NCBI chr13:89,997,033...90,237,727
Ensembl chr13:89,922,146...90,237,727
JBrowse link
G Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 acts_upstream_of_or_within IMP (PMID:10716994) MGI PMID:10716994 NCBI chr15:81,868,805...81,924,286
Ensembl chr15:81,872,036...81,924,286
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    immune system process 3142
      somatic diversification of immune receptors 88
        somatic diversification of DSCAM-based immune receptors 0
        somatic diversification of FREP-based immune receptors 0
        somatic diversification of T cell receptor genes + 5
        somatic diversification of immune receptors by N region addition + 0
        somatic diversification of immune receptors via alternate splicing + 0
        somatic diversification of immune receptors via gene conversion + 0
        somatic diversification of immune receptors via germline recombination within a single locus + 80
        somatic diversification of immune receptors via somatic mutation + 17
        somatic diversification of immunoglobulins + 75
        somatic diversification of variable lymphocyte receptors of jawless fish 0
Path 2
Term Annotations click to browse term
  biological_process 28573
    developmental process 7369
      anatomical structure development 6841
        multicellular organism development 5433
          system development 4660
            immune system development 244
              somatic diversification of immune receptors 88
                somatic diversification of DSCAM-based immune receptors 0
                somatic diversification of FREP-based immune receptors 0
                somatic diversification of T cell receptor genes + 5
                somatic diversification of immune receptors by N region addition + 0
                somatic diversification of immune receptors via alternate splicing + 0
                somatic diversification of immune receptors via gene conversion + 0
                somatic diversification of immune receptors via germline recombination within a single locus + 80
                somatic diversification of immune receptors via somatic mutation + 17
                somatic diversification of immunoglobulins + 75
                somatic diversification of variable lymphocyte receptors of jawless fish 0
paths to the root