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ONTOLOGY REPORT - ANNOTATIONS


Term:somatic diversification of immune receptors
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Accession:GO:0002200 term browser browse the term
Definition:The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.
Comment:Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification.



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immunoglobulin heavy chain V-D-J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POLB DNA polymerase beta involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:24388753) Ensembl
MGI
PMID:24388753 GO_REF:0000107 NCBI chr 8:42,338,494...42,371,808
Ensembl chr 8:42,338,454...42,371,808
JBrowse link
G YY1 YY1 transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:100,239,144...100,282,788
Ensembl chr14:100,238,298...100,282,788
JBrowse link
immunoglobulin V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYREN cell cycle regulator of NHEJ involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr 7:135,092,303...135,172,469
Ensembl chr 7:135,092,363...135,170,795
JBrowse link
G FOXP1 forkhead box P1 acts_upstream_of_or_within ISO (PMID:16819554) MGI PMID:16819554 NCBI chr 3:70,954,708...71,583,978
Ensembl chr 3:70,954,693...71,583,978
JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(PMID:9823897) Ensembl
MGI
GO_Central
TreeGrafter
PMID:9823897 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr13:108,207,442...108,218,349
Ensembl chr13:108,207,439...108,218,368
JBrowse link
G NHEJ1 non-homologous end joining factor 1 involved_in IDA (PMID:20558749) UniProt PMID:20558749 NCBI chr 2:219,069,357...219,160,815
Ensembl chr 2:219,069,355...219,160,869
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(PMID:9768755) Ensembl
MGI
GO_Central
PMID:9768755 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178
JBrowse link
G TCF3 transcription factor 3 acts_upstream_of_or_within
involved_in
IDA
IBA
IEA
(PMID:16428437) MGI
GO_Central
TreeGrafter
PMID:16428437 GO_REF:0000033 GO_REF:0000118 NCBI chr19:1,609,292...1,652,615
Ensembl chr19:1,609,291...1,652,615
JBrowse link
G XRCC4 X-ray repair cross complementing 4 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:9875844) GO_Central
MGI
PMID:9875844 GO_REF:0000033 NCBI chr 5:83,077,547...83,374,473
Ensembl chr 5:83,077,498...83,353,787
JBrowse link
isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17713479) Ensembl
MGI
PMID:17713479 GO_REF:0000107 NCBI chr12:8,602,170...8,612,859
Ensembl chr12:8,602,155...8,613,242
JBrowse link
G ATAD5 ATPase family AAA domain containing 5 involved_in
acts_upstream_of
IEA
ISO
(PMID:25404367) Ensembl
MGI
PMID:25404367 GO_REF:0000107 NCBI chr17:30,831,966...30,895,869
Ensembl chr17:30,831,966...30,895,869
JBrowse link
G BATF basic leucine zipper ATF-like transcription factor involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr14:75,522,469...75,546,992
Ensembl chr14:75,522,455...75,546,993
JBrowse link
G CD40LG CD40 ligand involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15280420) Ensembl
MGI
PMID:15280420 GO_REF:0000107 NCBI chr19:45,407,334...45,451,547
Ensembl chr19:45,407,334...45,478,828
JBrowse link
G EXO1 exonuclease 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14716311) Ensembl
MGI
PMID:14716311 GO_REF:0000107 NCBI chr 1:241,847,986...241,889,939
Ensembl chr 1:241,847,967...241,895,148
JBrowse link
G EXOSC3 exosome component 3 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 9:37,779,714...37,785,092
Ensembl chr 9:37,759,234...37,832,117
JBrowse link
G EXOSC6 exosome component 6 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr16:70,246,778...70,251,940
Ensembl chr16:70,246,778...70,251,940
JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within
IEA
ISO
ISS
(PMID:17713479) Ensembl
MGI
UniProt
PMID:17713479 GO_REF:0000024 GO_REF:0000107 NCBI chr13:108,207,442...108,218,349
Ensembl chr13:108,207,439...108,218,368
JBrowse link
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12743174) Ensembl
MGI
PMID:12743174 GO_REF:0000107 NCBI chr 3:36,993,466...37,050,846
Ensembl chr 3:36,993,226...37,050,896
JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
IEA
ISO
ISS
(PMID:10430621)
(PMID:12743174)
Ensembl
MGI
BHF-UCL
PMID:10430621 PMID:12743174 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:47,403,067...47,709,830
Ensembl chr 2:47,403,067...47,663,146
JBrowse link
G MSH6 mutS homolog 6 involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
(PMID:16618598)
(PMID:17015724)
BHF-UCL
MGI
Ensembl
PMID:16618598 PMID:17015724 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:47,783,145...47,810,101
Ensembl chr 2:47,695,530...47,810,063
JBrowse link
G NBN nibrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:89,933,331...89,984,667
Ensembl chr 8:89,924,515...90,003,228
JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:101,827,990...101,861,022
Ensembl chr 3:101,827,991...101,861,022
JBrowse link
G RNF168 ring finger protein 168 involved_in ISS UniProt GO_REF:0000024 NCBI chr 3:196,468,783...196,503,768
Ensembl chr 3:196,468,783...196,503,768
JBrowse link
G RNF8 ring finger protein 8 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 6:37,353,983...37,394,734
Ensembl chr 6:37,353,979...37,394,734
JBrowse link
G SANBR SANT and BTB domain regulator of CSR involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 2:61,065,871...61,138,032
Ensembl chr 2:61,065,871...61,138,034
JBrowse link
G SWAP70 switching B cell complex subunit SWAP70 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9642267) Ensembl
MGI
PMID:9642267 GO_REF:0000107 NCBI chr11:9,664,077...9,752,993
Ensembl chr11:9,664,077...9,752,993
JBrowse link
G UNG uracil DNA glycosylase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17015724) Ensembl
MGI
PMID:17015724 GO_REF:0000107 NCBI chr12:109,097,597...109,110,992
Ensembl chr12:109,097,597...109,126,725
JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO (PMID:17713479) MGI PMID:17713479 NCBI chr 5:83,077,547...83,374,473
Ensembl chr 5:83,077,498...83,353,787
JBrowse link
isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR6 C-C motif chemokine receptor 6 involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr 6:167,111,795...167,139,141
Ensembl chr 6:167,111,807...167,139,141
JBrowse link
isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of
IEA
ISO
(PMID:10490661) Ensembl
MGI
PMID:10490661 GO_REF:0000107 NCBI chr 3:187,721,377...187,745,468
Ensembl chr 3:187,721,377...187,745,725
JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of
IEA
ISO
(PMID:16275384) Ensembl
MGI
PMID:16275384 GO_REF:0000107 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,438...49,264,800
JBrowse link
G IL4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G STAT6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of
IEA
ISO
(PMID:10490661) Ensembl
MGI
PMID:10490661 GO_REF:0000107 NCBI chr12:57,095,408...57,111,362
Ensembl chr12:57,095,408...57,132,139
JBrowse link
isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPD1 heat shock protein family D (Hsp60) member 1 involved_in IDA (PMID:16148103) BHF-UCL PMID:16148103 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G IL4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARP3 poly(ADP-ribose) polymerase family member 3 involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr 3:51,942,363...51,948,867
Ensembl chr 3:51,942,345...51,948,867
JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10490661) Ensembl
MGI
PMID:10490661 GO_REF:0000107 NCBI chr 3:187,721,377...187,745,468
Ensembl chr 3:187,721,377...187,745,725
JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16275384) Ensembl
MGI
PMID:16275384 GO_REF:0000107 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,438...49,264,800
JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17137798) Ensembl
MGI
PMID:17137798 GO_REF:0000107 NCBI chr 5:142,108,779...142,154,440
Ensembl chr 5:142,108,779...142,154,440
JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFSF4 TNF superfamily member 4 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 1:173,172,870...173,450,733
Ensembl chr 1:173,183,731...173,207,331
JBrowse link
positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EXOSC3 exosome component 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:21255825) Ensembl
MGI
PMID:21255825 GO_REF:0000107 NCBI chr 9:37,779,714...37,785,092
Ensembl chr 9:37,759,234...37,832,117
JBrowse link
G EXOSC6 exosome component 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:21255825) Ensembl
MGI
PMID:21255825 GO_REF:0000107 NCBI chr16:70,246,778...70,251,940
Ensembl chr16:70,246,778...70,251,940
JBrowse link
G HMCES 5-hydroxymethylcytosine binding, ES cell specific involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 3:129,278,832...129,306,186
Ensembl chr 3:129,278,828...129,306,186
JBrowse link
G KMT5B lysine methyltransferase 5B involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr11:68,154,863...68,213,648
Ensembl chr11:68,154,863...68,213,852
JBrowse link
G KMT5C lysine methyltransferase 5C involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr19:55,339,876...55,348,121
Ensembl chr19:55,339,853...55,348,121
JBrowse link
G MAD2L2 mitotic arrest deficient 2 like 2 involved_in IDA (PMID:29656893) UniProt PMID:29656893 NCBI chr 1:11,674,480...11,691,830
Ensembl chr 1:11,658,918...11,691,811
JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 7:154,943,690...155,003,411
Ensembl chr 7:154,943,687...155,003,124
JBrowse link
G RIF1 replication timing regulatory factor 1 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 2:151,409,902...151,534,435
Ensembl chr 2:151,409,883...151,508,013
JBrowse link
G SHLD1 shieldin complex subunit 1 involved_in IDA
IBA
(PMID:29656893) UniProt
GO_Central
PMID:29656893 GO_REF:0000033 NCBI chr20:5,750,193...5,864,395
Ensembl chr20:5,750,393...5,864,395
JBrowse link
G SHLD2 shieldin complex subunit 2 involved_in IDA (PMID:29656893) UniProt PMID:29656893 NCBI chr10:87,094,473...87,191,465
Ensembl chr10:87,094,161...87,191,465
JBrowse link
G SHLD3 shieldin complex subunit 3 involved_in IDA
IBA
(PMID:29656893) UniProt
GO_Central
PMID:29656893 GO_REF:0000033 NCBI chr 5:65,625,027...65,630,928
Ensembl chr 5:65,625,027...65,630,928
JBrowse link
G TFRC transferrin receptor involved_in IDA (PMID:26642240) UniProt PMID:26642240 NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153
JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IDA
IMP
IEA
(PMID:23345425)
(PMID:23760478)
UniProt
Ensembl
PMID:23345425 PMID:23760478 GO_REF:0000107 NCBI chr15:43,403,061...43,510,640
Ensembl chr15:43,403,061...43,510,728
JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:36,993,466...37,050,846
Ensembl chr 3:36,993,226...37,050,896
JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:47,403,067...47,709,830
Ensembl chr 2:47,403,067...47,663,146
JBrowse link
G NSD2 nuclear receptor binding SET domain protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23241889) Ensembl
MGI
PMID:23241889 GO_REF:0000107 NCBI chr 4:1,871,393...1,982,192
Ensembl chr 4:1,871,393...1,982,207
JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:5,970,925...6,009,106
Ensembl chr 7:5,970,925...6,009,130
JBrowse link
G TGFB1 transforming growth factor beta 1 acts_upstream_of_or_within IDA (PMID:14988498) MGI PMID:14988498 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNFSF12 TNF superfamily member 12 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:7,549,058...7,557,881
Ensembl chr17:7,548,508...7,557,890
JBrowse link
G TNFSF13 TNF superfamily member 13 acts_upstream_of_or_within
involved_in
IDA
IBA
IEA
(PMID:14988498) MGI
GO_Central
TreeGrafter
PMID:14988498 GO_REF:0000033 GO_REF:0000118 NCBI chr17:7,558,282...7,561,601
Ensembl chr17:7,558,292...7,561,608
JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCF1 cardiotrophin like cytokine factor 1 involved_in IEA
ISS
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr11:67,364,168...67,374,177
Ensembl chr11:67,364,168...67,374,177
JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
(PMID:14988498) UniProt
MGI
TreeGrafter
PMID:14988498 GO_REF:0000024 GO_REF:0000118 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G STAT6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10490661) Ensembl
MGI
PMID:10490661 GO_REF:0000107 NCBI chr12:57,095,408...57,111,362
Ensembl chr12:57,095,408...57,132,139
JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAD5 ATPase family AAA domain containing 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:25404367) Ensembl
MGI
PMID:25404367 GO_REF:0000107 NCBI chr17:30,831,966...30,895,869
Ensembl chr17:30,831,966...30,895,869
JBrowse link
G CD28 CD28 molecule involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:7688139) Ensembl
MGI
PMID:7688139 GO_REF:0000107 NCBI chr 2:203,706,482...203,738,912
Ensembl chr 2:203,706,475...203,738,912
JBrowse link
G CD40 CD40 molecule involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12882831) Ensembl
MGI
TreeGrafter
PMID:12882831 GO_REF:0000107 GO_REF:0000118 NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863
JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (PMID:12882831) MGI PMID:12882831 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL2 interleukin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:1830926) Ensembl
MGI
PMID:1830926 GO_REF:0000107 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
(PMID:12882831), (PMID:14988498) UniProt
MGI
TreeGrafter
PMID:12882831 PMID:14988498 GO_REF:0000024 GO_REF:0000118 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G MLH1 mutL homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:36,993,466...37,050,846
Ensembl chr 3:36,993,226...37,050,896
JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:47,403,067...47,709,830
Ensembl chr 2:47,403,067...47,663,146
JBrowse link
G PAGR1 PAXIP1 associated glutamate rich protein 1 involved_in ISO (MGI:5752090|PMID:26744420) UniProt PMID:26744420 MGI:5752090 NCBI chr16:29,816,152...29,822,489
Ensembl chr16:29,816,152...29,822,489
JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:154,943,690...155,003,411
Ensembl chr 7:154,943,687...155,003,124
JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:5,970,925...6,009,106
Ensembl chr 7:5,970,925...6,009,130
JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9015183) Ensembl
MGI
PMID:9015183 GO_REF:0000107 NCBI chr 1:198,638,713...198,757,476
Ensembl chr 1:198,638,457...198,757,476
JBrowse link
G TBX21 T-box transcription factor 21 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12882831) Ensembl
MGI
PMID:12882831 GO_REF:0000107 NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122
JBrowse link
regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLF aprataxin and PNKP like factor involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:21211721) Ensembl
MGI
PMID:21211721 GO_REF:0000107 NCBI chr 2:68,467,585...68,580,162
Ensembl chr 2:68,467,572...68,655,862
JBrowse link
G IL10 interleukin 10 involved_in NAS (PMID:8228801) UniProt PMID:8228801 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL4 interleukin 4 involved_in TAS (PMID:11418631) UniProt PMID:11418631 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G MIR181B1 microRNA 181b-1 acts_upstream_of_or_within ISO (PMID:18762567) MGI PMID:18762567 NCBI chr 1:198,858,873...198,858,982
Ensembl chr 1:198,858,873...198,858,982
JBrowse link
G MIR181B2 microRNA 181b-2 acts_upstream_of_or_within ISO (PMID:18762567) MGI PMID:18762567 NCBI chr 9:124,693,710...124,693,798
Ensembl chr 9:124,693,710...124,693,798
JBrowse link
G SUPT6H SPT6 homolog, histone chaperone and transcription elongation factor involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr17:28,662,205...28,702,679
Ensembl chr17:28,662,198...28,702,679
JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16275384) Ensembl
MGI
PMID:16275384 GO_REF:0000107 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,438...49,264,800
JBrowse link
G IL27RA interleukin 27 receptor subunit alpha involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:11057672) Ensembl
MGI
PMID:11057672 GO_REF:0000107 NCBI chr19:14,031,762...14,053,218
Ensembl chr19:14,031,762...14,053,218
JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17137798) Ensembl
MGI
PMID:17137798 GO_REF:0000107 NCBI chr 5:142,108,779...142,154,440
Ensembl chr 5:142,108,779...142,154,440
JBrowse link
G SLC15A4 solute carrier family 15 member 4 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr12:128,793,194...128,823,958
Ensembl chr12:128,793,194...128,823,958
JBrowse link
somatic diversification of immune receptors via somatic mutation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAR adenosine deaminase RNA specific involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23209284) Ensembl
MGI
PMID:23209284 GO_REF:0000107 NCBI chr 1:154,582,057...154,627,997
Ensembl chr 1:154,581,695...154,628,013
JBrowse link
somatic diversification of immunoglobulins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase involved_in IDA (PMID:18722174) UniProt PMID:18722174 NCBI chr12:8,602,170...8,612,859
Ensembl chr12:8,602,155...8,613,242
JBrowse link
G CTNNBL1 catenin beta like 1 involved_in IMP (PMID:18722174) UniProt PMID:18722174 NCBI chr20:37,694,030...37,872,118
Ensembl chr20:37,694,030...37,872,129
JBrowse link
G POLB DNA polymerase beta involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:24388753) Ensembl
MGI
PMID:24388753 GO_REF:0000107 NCBI chr 8:42,338,494...42,371,808
Ensembl chr 8:42,338,454...42,371,808
JBrowse link
somatic diversification of immunoglobulins involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAD2L2 mitotic arrest deficient 2 like 2 involved_in NAS (PMID:29656893) ComplexPortal PMID:29656893 NCBI chr 1:11,674,480...11,691,830
Ensembl chr 1:11,658,918...11,691,811
JBrowse link
G SHLD1 shieldin complex subunit 1 involved_in NAS (PMID:29656893) ComplexPortal PMID:29656893 NCBI chr20:5,750,193...5,864,395
Ensembl chr20:5,750,393...5,864,395
JBrowse link
G SHLD2 shieldin complex subunit 2 involved_in NAS (PMID:29656893) ComplexPortal PMID:29656893 NCBI chr10:87,094,473...87,191,465
Ensembl chr10:87,094,161...87,191,465
JBrowse link
G SHLD3 shieldin complex subunit 3 involved_in NAS (PMID:29656893) ComplexPortal PMID:29656893 NCBI chr 5:65,625,027...65,630,928
Ensembl chr 5:65,625,027...65,630,928
JBrowse link
somatic hypermutation of immunoglobulin genes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase involved_in IMP (PMID:21518874) UniProt PMID:21518874 NCBI chr12:8,602,170...8,612,859
Ensembl chr12:8,602,155...8,613,242
JBrowse link
G EXO1 exonuclease 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14716311) Ensembl
MGI
PMID:14716311 GO_REF:0000107 NCBI chr 1:241,847,986...241,889,939
Ensembl chr 1:241,847,967...241,895,148
JBrowse link
G HMCES 5-hydroxymethylcytosine binding, ES cell specific involved_in IDA
IEA
(PMID:35450882) UniProt
Ensembl
PMID:35450882 GO_REF:0000107 NCBI chr 3:129,278,832...129,306,186
Ensembl chr 3:129,278,828...129,306,186
JBrowse link
G IGHD immunoglobulin heavy constant delta acts_upstream_of_or_within ISO (PMID:8418208) MGI PMID:8418208 NCBI chr14:105,838,401...105,845,677
Ensembl chr14:105,836,765...105,845,677
JBrowse link
G MCM3AP minichromosome maintenance complex component 3 associated protein involved_in IDA (PMID:23652018) UniProt PMID:23652018 NCBI chr21:46,235,133...46,286,265
Ensembl chr21:46,235,133...46,286,297
JBrowse link
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(PMID:10092760), (PMID:10429667) Ensembl
MGI
GO_Central
TreeGrafter
PMID:10092760 PMID:10429667 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:36,993,466...37,050,846
Ensembl chr 3:36,993,226...37,050,896
JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
NOT|acts_upstream_of_or_within
IEA
ISO
(PMID:9697842), (PMID:9697843)
(PMID:14568978)
(PMID:9607915)
(PMID:9607916)
(PMID:15494304)
Ensembl
MGI
PMID:9607915 PMID:9607916 PMID:9697842 PMID:9697843 PMID:14568978 More... GO_REF:0000107 NCBI chr 2:47,403,067...47,709,830
Ensembl chr 2:47,403,067...47,663,146
JBrowse link
G MSH3 mutS homolog 3 NOT|acts_upstream_of_or_within ISO (PMID:10662804) MGI PMID:10662804 NCBI chr 5:80,654,652...80,876,815
Ensembl chr 5:80,654,652...80,876,815
JBrowse link
G MSH6 mutS homolog 6 involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
(PMID:16618598)
(PMID:10662804), (PMID:15238604), (PMID:17015724)
BHF-UCL
MGI
Ensembl
PMID:10662804 PMID:15238604 PMID:16618598 PMID:17015724 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:47,783,145...47,810,101
Ensembl chr 2:47,695,530...47,810,063
JBrowse link
G NUGGC nuclear GTPase, germinal center associated acts_upstream_of_or_within ISO (PMID:22833677) MGI PMID:22833677 NCBI chr 8:28,021,964...28,083,936
Ensembl chr 8:28,021,964...28,083,936
JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(PMID:10429667) Ensembl
MGI
TreeGrafter
GO_Central
PMID:10429667 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:5,970,925...6,009,106
Ensembl chr 7:5,970,925...6,009,130
JBrowse link
G POLB DNA polymerase beta involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:24388753) Ensembl
MGI
PMID:24388753 GO_REF:0000107 NCBI chr 8:42,338,494...42,371,808
Ensembl chr 8:42,338,454...42,371,808
JBrowse link
G POLL DNA polymerase lambda involved_in NAS (PMID:10982892) UniProt PMID:10982892 NCBI chr10:101,578,882...101,588,270
Ensembl chr10:101,578,882...101,588,270
JBrowse link
G POLM DNA polymerase mu acts_upstream_of_or_within ISO (PMID:15789338) MGI PMID:15789338 NCBI chr 7:44,072,062...44,082,530
Ensembl chr 7:44,072,062...44,082,530
JBrowse link
G POLQ DNA polymerase theta involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr 3:121,431,431...121,545,988
Ensembl chr 3:121,431,431...121,545,988
JBrowse link
G SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr20:36,889,773...36,951,708
Ensembl chr20:36,890,229...36,951,893
JBrowse link
G UNG uracil DNA glycosylase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17015724)
(PMID:15494304)
Ensembl
MGI
PMID:15494304 PMID:17015724 GO_REF:0000107 NCBI chr12:109,097,597...109,110,992
Ensembl chr12:109,097,597...109,126,725
JBrowse link
somatic recombination of immunoglobulin gene segments term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:11828012) Ensembl
MGI
PMID:11828012 GO_REF:0000107 NCBI chr 3:36,993,466...37,050,846
Ensembl chr 3:36,993,226...37,050,896
JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
(PMID:11828012)
(PMID:15494304)
(PMID:14568978)
(PMID:14563316), (PMID:15955838)
BHF-UCL
MGI
Ensembl
PMID:11828012 PMID:14563316 PMID:14568978 PMID:15494304 PMID:15955838 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:47,403,067...47,709,830
Ensembl chr 2:47,403,067...47,663,146
JBrowse link
G MSH3 mutS homolog 3 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(PMID:15238604) TreeGrafter
MGI
GO_Central
PMID:15238604 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:80,654,652...80,876,815
Ensembl chr 5:80,654,652...80,876,815
JBrowse link
G MSH6 mutS homolog 6 involved_in
acts_upstream_of_or_within
IEA
ISO
ISS
(PMID:15238604) Ensembl
MGI
BHF-UCL
PMID:15238604 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:47,783,145...47,810,101
Ensembl chr 2:47,695,530...47,810,063
JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:11828012) Ensembl
MGI
PMID:11828012 GO_REF:0000107 NCBI chr 7:5,970,925...6,009,106
Ensembl chr 7:5,970,925...6,009,130
JBrowse link
G UNG uracil DNA glycosylase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15494304) Ensembl
MGI
PMID:15494304 GO_REF:0000107 NCBI chr12:109,097,597...109,110,992
Ensembl chr12:109,097,597...109,126,725
JBrowse link
somatic recombination of immunoglobulin genes involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12743174) Ensembl
MGI
PMID:12743174 GO_REF:0000107 NCBI chr 3:36,993,466...37,050,846
Ensembl chr 3:36,993,226...37,050,896
JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(PMID:12743174) Ensembl
MGI
GO_Central
TreeGrafter
PMID:12743174 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:47,403,067...47,709,830
Ensembl chr 2:47,403,067...47,663,146
JBrowse link
T cell receptor V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL11B BCL11 transcription factor B involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12717433) Ensembl
MGI
PMID:12717433 GO_REF:0000107 NCBI chr14:99,169,287...99,272,197
Ensembl chr14:99,169,287...99,272,197
JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9462507) Ensembl
MGI
PMID:9462507 GO_REF:0000107 NCBI chr 4:108,047,548...108,168,932
Ensembl chr 4:108,047,545...108,168,956
JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
(PMID:10911993) UniProt
MGI
Ensembl
PMID:10911993 GO_REF:0000024 GO_REF:0000107 NCBI chr13:108,207,442...108,218,349
Ensembl chr13:108,207,439...108,218,368
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9768755) Ensembl
MGI
PMID:9768755 GO_REF:0000107 NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178
JBrowse link
G TCF7 transcription factor 7 acts_upstream_of_or_within ISO (PMID:9462507) MGI PMID:9462507 NCBI chr 5:134,108,218...134,148,210
Ensembl chr 5:134,114,681...134,151,865
JBrowse link
V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23836881) Ensembl
MGI
PMID:23836881 GO_REF:0000107 NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,823...108,369,102
JBrowse link
G DCAF1 DDB1 and CUL4 associated factor 1 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 3:51,395,867...51,505,639
Ensembl chr 3:51,395,867...51,500,015
JBrowse link
G DCLRE1C DNA cross-link repair 1C involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23836881) Ensembl
MGI
PMID:23836881 GO_REF:0000107 NCBI chr10:14,897,359...14,954,432
Ensembl chr10:14,897,359...14,954,432
JBrowse link
G HMGB1 high mobility group box 1 involved_in IDA (PMID:9166431) UniProt PMID:9166431 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G HMGB2 high mobility group box 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr 4:173,331,376...173,334,358
Ensembl chr 4:173,331,376...173,334,432
JBrowse link
G LIG1 DNA ligase 1 NOT|involved_in IDA (PMID:9809069) UniProt PMID:9809069 NCBI chr19:48,115,445...48,170,344
Ensembl chr19:48,115,445...48,170,603
JBrowse link
G LIG3 DNA ligase 3 NOT|involved_in IDA (PMID:9809069) UniProt PMID:9809069 NCBI chr17:34,980,512...35,010,872
Ensembl chr17:34,980,512...35,009,743
JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within
IEA
ISO
IDA
(PMID:10716994)
(PMID:15194694)
(PMID:9809069)
Ensembl
MGI
UniProt
PMID:9809069 PMID:10716994 PMID:15194694 GO_REF:0000107 NCBI chr13:108,207,442...108,218,349
Ensembl chr13:108,207,439...108,218,368
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23836881) Ensembl
MGI
PMID:23836881 GO_REF:0000107 NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178
JBrowse link
G RAG1 recombination activating 1 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
ISS
IMP
(PMID:2360047)
(PMID:14670978)
InterPro
MGI
TreeGrafter
GO_Central
UniProt
Ensembl
CACAO
PMID:2360047 PMID:14670978 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr11:36,510,353...36,579,762
Ensembl chr11:36,510,372...36,593,156
JBrowse link
G RAG2 recombination activating 2 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
ISS
(PMID:2360047) Ensembl
MGI
TreeGrafter
GO_Central
UniProt
PMID:2360047 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr11:36,590,996...36,598,236
Ensembl chr11:36,575,574...36,598,279
JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO (PMID:10716994) MGI PMID:10716994 NCBI chr 5:83,077,547...83,374,473
Ensembl chr 5:83,077,498...83,353,787
JBrowse link
G XRCC6 X-ray repair cross complementing 6 acts_upstream_of_or_within ISO (PMID:10716994) MGI PMID:10716994 NCBI chr22:41,621,295...41,664,041
Ensembl chr22:41,621,163...41,664,048
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    immune system process 3226
      somatic diversification of immune receptors 90
        somatic diversification of DSCAM-based immune receptors 0
        somatic diversification of FREP-based immune receptors 0
        somatic diversification of T cell receptor genes + 5
        somatic diversification of immune receptors by N region addition + 0
        somatic diversification of immune receptors via alternate splicing + 0
        somatic diversification of immune receptors via gene conversion + 0
        somatic diversification of immune receptors via germline recombination within a single locus + 81
        somatic diversification of immune receptors via somatic mutation + 18
        somatic diversification of immunoglobulins + 76
        somatic diversification of variable lymphocyte receptors of jawless fish 0
Path 2
Term Annotations click to browse term
  biological_process 19669
    developmental process 7610
      anatomical structure development 7020
        multicellular organism development 5632
          system development 4908
            immune system development 243
              somatic diversification of immune receptors 90
                somatic diversification of DSCAM-based immune receptors 0
                somatic diversification of FREP-based immune receptors 0
                somatic diversification of T cell receptor genes + 5
                somatic diversification of immune receptors by N region addition + 0
                somatic diversification of immune receptors via alternate splicing + 0
                somatic diversification of immune receptors via gene conversion + 0
                somatic diversification of immune receptors via germline recombination within a single locus + 81
                somatic diversification of immune receptors via somatic mutation + 18
                somatic diversification of immunoglobulins + 76
                somatic diversification of variable lymphocyte receptors of jawless fish 0
paths to the root